ABSTRACT
Oxandrolone, an anabolic steroid, significantly reduced serum triglycerides in type III, IV, and V hyperlipoproteinemia, with a concomitant decrease in pre-beta lipoproteins. Its slightly enhancing effect on serum cholesterol and absolute increase in beta lipoproteins might eventually discourage its administration in type II patients. Alpha lipoproteins always remained at low levels. In addition to its hypotriglyceridemic action,, oxandrolone induced a slight reduction in uric acid and alkaline phosphatases. Untoward side effects were not observed even after prolonger therapy. Therefore, oxandrolone might deserve a place among the few available triglyceride-reducing therapies.
Subject(s)
Hyperlipidemias/drug therapy , Hyperlipidemias/genetics , Oxandrolone/therapeutic use , Adolescent , Adult , Aged , Alkaline Phosphatase/blood , Cholesterol/blood , Clinical Trials as Topic , Female , Humans , Hyperlipidemias/blood , Hyperlipidemias/classification , Lipids/blood , Lipoproteins/blood , Male , Middle Aged , Oxandrolone/pharmacology , Triglycerides/blood , Uric Acid/bloodSubject(s)
Apolipoproteins/metabolism , Chylous Ascites/metabolism , Lipid Metabolism , Lipoproteins/metabolism , Aged , Apolipoproteins/blood , Ascitic Fluid/metabolism , Carbon Radioisotopes , Cholesterol Esters/blood , Cholesterol Esters/metabolism , Female , Humans , Intestinal Mucosa/metabolism , Kinetics , Lipoproteins/blood , Middle Aged , Palmitates/blood , Palmitates/metabolism , Phospholipids/blood , Phospholipids/metabolism , Triglycerides/blood , Triglycerides/metabolism , TritiumABSTRACT
Lipids of fat emboli released in the circulating blood of seven patients undergoing hip prostheses were compared with those of plasma, adipose tissue and bone marrow taken simultaneously. Similar in composition to bone marrow, fat emboli, as compared with plasma lipids, contain negligible amounts of free esterified cholesterol, a relative decrease of oleic acid and an increase of palmitic acid in triglycerides and a lower percentage of linoleic acid in phospholipids. The results of this study validate the theory that fat emboli originate from bone marrow in fractures of the long bone.
Subject(s)
Embolism, Fat/metabolism , Hip/surgery , Prostheses and Implants/adverse effects , Adipose Tissue/analysis , Aged , Bone Marrow/analysis , Cholesterol/blood , Chromatography, Gas , Chromatography, Thin Layer , Embolism, Fat/blood , Embolism, Fat/etiology , Fatty Acids/analysis , Fatty Acids/blood , Fractures, Bone/complications , Humans , Middle Aged , Phospholipids/analysis , Phospholipids/blood , Triglycerides/analysis , Triglycerides/bloodABSTRACT
Human fat emboli, released during total hip prosthesis contained less than 0.1 per cent proteins. Most likely, this was the result of absorption of the fat particle during in vitro procedures.
Subject(s)
Embolism, Fat/metabolism , Hip Joint/surgery , Joint Prosthesis , Proteins/metabolism , Aged , Bone Marrow/analysis , Electrophoresis, Polyacrylamide Gel , Embolism, Fat/etiology , Female , Humans , Proteins/analysisABSTRACT
31 children with cystic fibrosis (CF) subdivided into three groups of age were studied before and after treatment with lyophilized pancreas and compared to 27 controls. CF was characterized by lower phospholipid, cholesterol and polyunsaturated fatty acid plasma concentrations and reduced coefficient of fat absorption. Treatment tended towards normalization of these values. With age polyunsaturated fatty acids increased in normals but not in CF. The significant correlations existing between fat absorption coefficient and polyunsaturated fatty acid percentage in neutral lipids of CF children suggests the use of the latter percentage as index of the stage of malabsorption.