ABSTRACT
Several studies have shown that the Brazilian Northeast is a region with high rates of inbreeding as well as a high incidence of autosomal recessive diseases. The elaboration of public health policies focused on the epidemiological surveillance of congenital anomalies and rare genetic diseases in this region is urgently needed. However, the vast territory, socio-demographic heterogeneity, economic difficulties and low number of professionals with expertise in medical genetics make strategic planning a challenging task. Surnames can be compared to a genetic system with multiple neutral alleles and allow some approximation of population structure. Here, surname analysis of more than 37 million people was combined with health and socio-demographic indicators covering all 1794 municipalities of the nine states of the region. The data distribution showed a heterogeneous spatial pattern (Global Moran Index, GMI = 0.58; p < 0.001), with higher isonymy rates in the east of the region and the highest rates in the Quilombo dos Palmares region - the largest conglomerate of escaped slaves in Latin America. A positive correlation was found between the isonymy index and the frequency of live births with congenital anomalies (r = 0.268; p < 0.001), and the two indicators were spatially correlated (GMI = 0.50; p < 0.001). With this approach, quantitative information on the genetic structure of the Brazilian Northeast population was obtained, which may represent an economical and useful tool for decision-making in the medical field.
Subject(s)
Genetics, Medical/statistics & numerical data , Genetics, Population/statistics & numerical data , Names , Adolescent , Adult , Aged , Brazil , Female , Humans , Male , Middle Aged , Population Dynamics , Young AdultABSTRACT
Spectral information provided by multispectral and hyperspectral sensors has a great impact on remote sensing studies, easing the identification of carbonate outcrops that contribute to a better understanding of petroleum reservoirs. Sensors aboard satellites like Landsat series, which have data freely available usually lack the spatial resolution that suborbital sensors have. Many techniques have been developed to improve spatial resolution through data fusion. However, most of them have serious limitations regarding application and scale. Recently Super-Resolution (SR) convolution neural networks have been tested with encouraging results. However, they require large datasets, more time and computational power for training. To overcome these limitations, this work aims to increase the spatial resolution of multispectral bands from the Landsat satellite database using a modified artificial neural network that uses pixel kernels of a single spatial high-resolution RGB image from Google Earth as input. The methodology was validated with a common dataset of indoor images as well as a specific area of Landsat 8. Different downsized scale inputs were used for training where the validation used the ground truth of the original size images, obtaining comparable results to the recent works. With the method validated, we generated high spatial resolution spectral bands based on RGB images from Google Earth on a carbonated outcrop area, which were then properly classified according to the soil spectral responses making use of the advantage of a higher spatial resolution dataset.
ABSTRACT
Geodetic networks provide accurate three-dimensional control points for mapping activities, geoinformation, and infrastructure works. Accurate computation and adjustment are necessary, as all data collection is vulnerable to outliers. Applying a Least Squares (LS) process can lead to inaccuracy over many points in such conditions. Robust Estimator (RE) methods are less sensitive to outliers and provide an alternative to conventional LS. To solve the RE functions, we propose a new metaheuristic (MH), based on the Vortex Search (IVS) algorithm, along with a novel search space definition scheme. Numerous scenarios for a Global Navigation Satellite Systems (GNSS)-based network are generated to compare and analyze the behavior of several known REs. A classic iterative RE and an LS process are also tested for comparison. We analyze the median and trim position of several estimators, in order to verify their impact on the estimates. The tests show that IVS performs better than the original algorithm; therefore, we adopted it in all subsequent RE computations. Regarding network adjustments, outcomes in the parameter estimation show that REs achieve better results in large-scale outliers' scenarios. For detection, both LS and REs identify most outliers in schemes with large outliers.
ABSTRACT
BACKGROUND: HLA genes are the most polymorphic of the human genome and have distinct allelic frequencies in populations of different geographical regions of the world, serving as genetic markers in ancestry studies. In addition, specific HLA alleles may be associated with various autoimmune and infectious diseases. The bone marrow donor registry in Brazil is the third largest in the world, and it counts with genetic typing of HLA-A, -B, and -DRB1. Since 1991 Brazil has maintained the DATASUS database, a system fed with epidemiological and health data from compulsory registration throughout the country. METHODS: In this work, we perform spatial analysis and georeferencing of HLA genetic data from more than 86,000 bone marrow donors from Rio Grande do Sul (RS) and data of hospitalization for rheumatoid arthritis, multiple sclerosis and Crohn's disease in RS, comprising the period from 1995 to 2016 obtained through the DATASUS system. The allele frequencies were georeferenced using Empirical Bayesian Kriging; the diseases prevalence were georeferenced using Inverse Distance Weighted and cluster analysis for both allele and disease were performed using Getis-Ord Gi* method. Spearman's test was used to test the correlation between each allele and disease. RESULTS: The results indicate a HLA genetic structure compatible with the history of RS colonization, where it is possible to observe differentiation between regions that underwent different colonization processes. Spatial analyzes of autoimmune disease hospitalization data were performed revealing clusters for different regions of the state for each disease analyzed. The correlation test between allelic frequency and the occurrence of autoimmune diseases indicated a significant correlation between the HLA-B*08 allele and rheumatoid arthritis. CONCLUSIONS: Genetic mapping of populations and the spatial analyzes such as those performed in this work have great economic relevance and can be very useful in the formulation of public health campaigns and policies, contributing to the planning and adjustment of clinical actions, as well as informing and educating professionals and the population.
Subject(s)
Autoimmune Diseases/epidemiology , Autoimmune Diseases/genetics , Chromosome Mapping/methods , Databases, Genetic , HLA Antigens/genetics , Spatial Analysis , Brazil/epidemiology , Chromosome Mapping/statistics & numerical data , Databases, Genetic/statistics & numerical data , HumansABSTRACT
The current genetic makeup of Latin America has been shaped by a history of extensive admixture between Africans, Europeans and Native Americans, a process taking place within the context of extensive geographic and social stratification. We estimated individual ancestry proportions in a sample of 7,342 subjects ascertained in five countries (Brazil, Chile, Colombia, México and Perú). These individuals were also characterized for a range of physical appearance traits and for self-perception of ancestry. The geographic distribution of admixture proportions in this sample reveals extensive population structure, illustrating the continuing impact of demographic history on the genetic diversity of Latin America. Significant ancestry effects were detected for most phenotypes studied. However, ancestry generally explains only a modest proportion of total phenotypic variation. Genetically estimated and self-perceived ancestry correlate significantly, but certain physical attributes have a strong impact on self-perception and bias self-perception of ancestry relative to genetically estimated ancestry.
Subject(s)
Ethnicity/genetics , Genetic Variation , Genetics, Population , Phenotype , Biological Evolution , Female , Geography , Humans , Latin America , Male , Quantitative Trait, Heritable , Self ConceptABSTRACT
Estimations of crop area were made based on the temporal profiles of the Enhanced Vegetation Index (EVI) obtained from moderate resolution imaging spectroradiometer (MODIS) images. Evaluation of the ability of the MODIS crop detection algorithm (MCDA) to estimate soybean crop areas was performed for fields in the Mato Grosso state, Brazil. Using the MCDA approach, soybean crop area estimations can be provided for December (first forecast) using images from the sowing period and for February (second forecast) using images from the sowing period and the maximum crop development period. The area estimates were compared to official agricultural statistics from the Brazilian Institute of Geography and Statistics (IBGE) and from the National Company of Food Supply (CONAB) at different crop levels from 2000/2001 to 2010/2011. At the municipality level, the estimates were highly correlated, with R (2) = 0.97 and RMSD = 13,142 ha. The MCDA was validated using field campaign data from the 2006/2007 crop year. The overall map accuracy was 88.25%, and the Kappa Index of Agreement was 0.765. By using pre-defined parameters, MCDA is able to provide the evolution of annual soybean maps, forecast of soybean cropping areas, and the crop area expansion in the Mato Grosso state.
Subject(s)
Agriculture , Crops, Agricultural , Glycine max , Satellite Imagery , Algorithms , Brazil , Geography , HumansABSTRACT
The present study aimed to develop and implement a method for detection and classification of spectral signatures in point clouds obtained from terrestrial laser scanner in order to identify the presence of different rocks in outcrops and to generate a digital outcrop model. To achieve this objective, a software based on cluster analysis was created, named K-Clouds. This software was developed through a partnership between UNISINOS and the company V3D. This tool was designed to begin with an analysis and interpretation of a histogram from a point cloud of the outcrop and subsequently indication of a number of classes provided by the user, to process the intensity return values. This classified information can then be interpreted by geologists, to provide a better understanding and identification from the existing rocks in the outcrop. Beyond the detection of different rocks, this work was able to detect small changes in the physical-chemical characteristics of the rocks, as they were caused by weathering or compositional changes.
Subject(s)
Lasers , Models, Theoretical , Remote Sensing Technology , Software , Brazil , Cluster Analysis , Image Processing, Computer-AssistedABSTRACT
The roughness property of rocks is significant in engineering studies due to their mechanical and hydraulic performance and the possibility of quantifying flow velocity and predicting the performance of wells and rock mass structures. However, the study of roughness in rocks is usually carried out through 2D linear measurements (through mechanical profilometer equipment), obtaining a coefficient that may not represent the entire rock surface. Thus, based on the hypothesis that it is possible to quantify the roughness coefficient in rock plugs reconstructed three-dimensionally by the computer vision technique, this research aims to an alternative method to determine the roughness coefficient in rock plugs. The point cloud generated from the 3D model of the photogrammetry process was used to measure the distance between each point and a calculated fit plane over the entire rock surface. The roughness was quantified using roughness parameters ([Formula: see text]) calculated in hierarchically organized regions. In this hierarchical division, the greater the quantity of division analyzed, the greater the detail of the roughness. The main results show that obtaining the roughness coefficient over the entire surface of the three-dimensional model has peculiarities that would not be observed in the two-dimensional reading. From the 2D measurements, mean roughness values ([Formula: see text]) of [Formula: see text] and [Formula: see text] were obtained for samples 1 and 2, respectively. By the same method, the results of the [Formula: see text] coefficient applied three-dimensionally over the entire rocky surface were at most [Formula: see text] and [Formula: see text], respectively, showing the difference in values along the surface and the importance of this approach.
ABSTRACT
BACKGROUND: Brazil has faced two simultaneous problems related to respiratory health: forest fires and the high mortality rate due to COVID-19 pandemics. The Amazon rain forest is one of the Brazilian biomes that suffers the most with fires caused by droughts and illegal deforestation. These fires can bring respiratory diseases associated with air pollution, and the State of Pará in Brazil is the most affected. COVID-19 pandemics associated with air pollution can potentially increase hospitalizations and deaths related to respiratory diseases. Here, we aimed to evaluate the association of fire occurrences with the COVID-19 mortality rates and general respiratory diseases hospitalizations in the State of Pará, Brazil. METHODS: We employed machine learning technique for clustering k-means accompanied with the elbow method used to identify the ideal quantity of clusters for the k-means algorithm, clustering 10 groups of cities in the State of Pará where we selected the clusters with the highest and lowest fires occurrence from the 2015 to 2019. Next, an Auto-regressive Integrated Moving Average Exogenous (ARIMAX) model was proposed to study the serial correlation of respiratory diseases hospitalizations and their associations with fire occurrences. Regarding the COVID-19 analysis, we computed the mortality risk and its confidence level considering the quarterly incidence rate ratio in clusters with high and low exposure to fires. FINDINGS: Using the k-means algorithm we identified two clusters with similar DHI (Development Human Index) and GDP (Gross Domestic Product) from a group of ten clusters that divided the State of Pará but with diverse behavior considering the hospitalizations and forest fires in the Amazon biome. From the auto-regressive and moving average model (ARIMAX), it was possible to show that besides the serial correlation, the fires occurrences contribute to the respiratory diseases increase, with an observed lag of six months after the fires for the case with high exposure to fires. A highlight that deserves attention concerns the relationship between fire occurrences and deaths. Historically, the risk of mortality by respiratory diseases is higher (about the double) in regions and periods with high exposure to fires than the ones with low exposure to fires. The same pattern remains in the period of the COVID-19 pandemic, where the risk of mortality for COVID-19 was 80% higher in the region and period with high exposure to fires. Regarding the SARS-COV-2 analysis, the risk of mortality related to COVID-19 is higher in the period with high exposure to fires than in the period with low exposure to fires. Another highlight concerns the relationship between fire occurrences and COVID-19 deaths. The results show that regions with high fire occurrences are associated with more cases of COVID deaths. INTERPRETATION: The decision-make process is a critical problem mainly when it involves environmental and health control policies. Environmental policies are often more cost-effective as health measures than the use of public health services. This highlight the importance of data analyses to support the decision making and to identify population in need of better infrastructure due to historical environmental factors and the knowledge of associated health risk. The results suggest that The fires occurrences contribute to the increase of the respiratory diseases hospitalization. The mortality rate related to COVID-19 was higher for the period with high exposure to fires than the period with low exposure to fires. The regions with high fire occurrences is associated with more COVID-19 deaths, mainly in the months with high number of fires. FUNDING: No additional funding source was required for this study.
ABSTRACT
The quantitative determination of average roughness parameters, from the determination of height variations of the surface points, is frequently used to estimate the adhesion between an adhesive and the surface of a substrate. However, to determine the interaction between an adhesive and a surface of a heterogeneous material, such as a red ceramic, it is essential to define other roughness parameters. This work proposes a method for determining the roughness of red ceramic blocks from a three-dimensional evaluation, with the objective of estimating the contact area that the ceramic substrate can provide for a cementitious matrix. The study determines the average surface roughness from multiple planes and proposes the adoption of 2 more roughness parameters, the valley area index and the average valley area. The results demonstrate that there are advantages in using the proposed multiple plane method for roughness computation and that the valley area parameters are efficient to estimate the extent of adhesion between the materials involved.
ABSTRACT
Reliability analysis allows for the estimation of a system's probability of detecting and identifying outliers. Failure to identify an outlier can jeopardize the reliability level of a system. Due to its importance, outliers must be appropriately treated to ensure the normal operation of a system. System models are usually developed from certain constraints. Constraints play a central role in model precision and validity. In this work, we present a detailed investigation of the effects of the hard and soft constraints on the reliability of a measurement system model. Hard constraints represent a case in which there exist known functional relations between the unknown model parameters, whereas the soft constraints are employed where such functional relations can be slightly violated depending on their uncertainty. The results highlighted that the success rate of identifying an outlier for the case of hard constraints is larger than soft constraints. This suggested that hard constraints be used in the stage of pre-processing data for the purpose of identifying and removing possible outlying measurements. After identifying and removing possible outliers, one should set up the soft constraints to propagate their uncertainties to the model parameters during the data processing.
Subject(s)
Data Interpretation, Statistical , Models, Biological , Models, Statistical , Algorithms , Data Collection , Image Processing, Computer-AssistedABSTRACT
Quality evaluation of a material's surface is performed through roughness analysis of surface samples. Several techniques have been presented to achieve this goal, including geometrical analysis and surface roughness analysis. Geometric analysis allows a visual and subjective evaluation of roughness (a qualitative assessment), whereas computation of the roughness parameters is a quantitative assessment and allows a standardized analysis of the surfaces. In civil engineering, the process is performed with mechanical profilometer equipment (2D) without adequate accuracy and laser profilometer (3D) with no consensus on how to interpret the result quantitatively. This work proposes a new method to evaluate surface roughness, starting from the generation of a visual surface roughness signature, which is calculated through the roughness parameters computed in hierarchically organized regions. The evaluation tools presented in this new method provide a local and more accurate evaluation of the computed coefficients. In the tests performed it was possible to quantitatively analyze roughness differences between ceramic blocks and to find that a quantitative microscale analysis allows to identify the largest variation of roughness parameters Raavg, Rasdv, Ramin and Ramax between samples, which benefit the evaluation and comparison of the sampled surfaces.
ABSTRACT
Industrial districts became important instruments which are used by the Public Power to induce economic decentralization and create new development poles. For this reason the legislative process is an indispensable means to define the priorities in the uses of soil, also to conduct and follow the process of industrial registration. However, the industrial district establishment shall not be analyzed by taking into account just the economic factor, but also the environmental issue of the enterprise. Thus, this research has the objective of determining adequate places for industrial districts implantation, having as a pilot area the city of São Leopoldo, Rio Grande do Sul State, Brazil. A Geographic Information System for execution of spatial analysis and criteria creation on a large volume of environmental information will be used as a tool, which will be guided by the Municipal, State and Federal legislation and a Quickbird satellite image that covers the interest area. The main information used on this research are: altimeter, hydrography, soil use, pedology, geology and infrastructure. The results are visualized in scenarios modeled in accordance with the restrictions imposed upon the information, allowing at the end, to combine all scenarios and create through the multiple criteria method a map that indicates adequate places for implantation of industrial districts.