Effects of dietary intervention combined with insulin aspart on serum nesfatin-1 and CTRP12 levels and pregnancy outcomes in pregnant women with gestational diabetes mellitus.

To analyze the effects of dietary intervention combined with insulin aspart on the serum levels of nesfatin-1, C1q/TNF related protein-12 (CTRP12), and pregnancy outcomes in pregnant women with gestational diabetes mellitus (GDM). In this retrospective cohort study, 513 women with GDM admitted to Tangshan Central Hospital (Tangshan, China) between January 2019 and December 2022 were selected and divided into an observation group (dietary intervention combined with insulin aspart therapy; n = 284) and a control group (insulin aspart therapy, n = 229). The general characteristics, clinical outcomes, serum nesfatin-1 and CTRP12 levels, 2-hour postprandial blood glucose levels, pregnancy outcomes, and perinatal outcomes of the 2 groups were compared. After treatment, the total effective rate in the observation group was significantly higher than that of the control group (97.54% vs 86.03%, respectively; P < .001). Compared with the pretreatment levels, nesfatin-1 and CTRP12 levels were decreased in both groups; nesfatin-1 and CTRP12 levels in the observation group were significantly higher than those in the control group. After treatment, the preprandial and 2-hour postprandial blood glucose levels in the observation group were significantly lower than those in the control group. Compared with the control group, the observation group had significantly fewer cesarean sections, and a significantly lower incidence of postpartum hemorrhage, premature rupture of membranes, and other adverse pregnancy outcomes. After treatment, the risks of preterm birth, macrosomia, fetal distress, neonatal asphyxia, neonatal hypoglycemia, and other adverse perinatal outcomes were significantly lower in the observation group than in the control group. In pregnant women with GDM, dietary intervention combined with insulin aspart can improve clinical outcomes; reduce nesfatin-1, CTRP12, and blood glucose levels; and reduce the incidence of adverse pregnancy outcomes.

The carbon reduction effects of stepped carbon emissions trading and carbon capture and storage on hybrid wind-PV-thermal- storage generation operating systems.

To accelerate the low-carbon transformation of the power industry, a range of carbon emission reduction policies and technologies have emerged. However, the current China's carbon emissions trading (CET) policy is inadequate in encouraging power generation enterprises to take proactive measures towards emission reduction due to challenges like fixed and low carbon prices. The high proportion of renewable energy in electricity consumption also faces significant challenges due to the unpredictable nature of wind and PV energy. Therefore, this paper applies stepped CET mechanism, energy storage system (ES) system and carbon capture and storage (CCS) mechanism together to hybrid renewable energy system, aiming to study their synergistic carbon emission reduction effect. Firstly, the paper constructs the stepped CET model considering incentives and penalties. Secondly, the stepped CET model, ES system and CCS are jointly introduced into the hybrid renewable energy system. Finally, a scenario analysis is conducted to investigate the synergistic effect of various carbon emissions reduction policies and technologies in the operation of power generation systems. The results show that: i) compared with traditional CET, the stepped CET increases renewable energy consumption by 0.12% and reduces carbon emissions by 0.6%; ii) the introduction of stepped CET and ES equipment together consumes an additional 36.1% of renewable energy and reduces carbon emissions by 32.4%; iii) based on stepped CET model and ES equipment, the introduction of CCS system reduces carbon emissions by 29.4%.

The effect of vitamin D supplementation on glycemic status and C-reactive protein levels in type 2 diabetic patients with ischemic heart disease: A protocol for systematic review and meta-analysis.

BACKGROUND: Vitamin D might be beneficial in diabetic patients with ischemic heart disease through its favorable effect on metabolic profiles and biomarkers of inflammation and oxidative stress. We performed a protocol for systematic review and meta-analysis to assess whether vitamin D supplementation could improve glucose control and inflammation in type 2 diabetic patients with ischemic heart disease. METHODS: The proposed systematic review and meta-analysis will conform to the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols. Seven electronic databases including Web of Science, Embase, PubMed, Wanfang Data, Scopus, Science Direct, Cochrane Library were searched in October 2022 by 2 independent reviewers. The risk of bias assessment of the included studies was assessed using the tool recommended in the Cochrane Handbook for Systematic Reviews of Interventions (version 5.1.0). Data analysis was performed with Review Manager Software (RevMan Version 5.4, The Cochrane Collaboration, Copenhagen, Denmark). RESULTS: This study will provide a high-quality synthesis to assess the effectiveness and safety of vitamin D supplementation on type 2 diabetic patients with ischemic heart disease. CONCLUSION: This systematic review may lead to several recommendations, for both patients and researchers, as which is the best therapy for type 2 diabetic patients with ischemic heart disease and how future studies need to be designed, considering what is available now and what is the reality of the patient.