ABSTRACT
In vitro maturation (IVM) of immature oocytes retrieved from surgically resected ovaries has been proposed as a method of fertility preservation in ovarian cancer patients undergoing definitive surgery. While there had been several reports of successful derivation of mature oocytes and or embryos, there have been no reports as yet of successful pregnancies. In this case report, we present a pregnancy and live birth from a young patient, with stage IIIC ovarian cancer, who had undergone fertility sparing surgery. The immature oocytes recovered after oophorectomy were fertilized after IVM. The embryos obtained were cryopreserved and later transferred to achieve a singleton healthy pregnancy leading to a live birth.
Subject(s)
Cryopreservation , Embryo Transfer , In Vitro Oocyte Maturation Techniques , Oocytes/cytology , Ovarian Neoplasms/complications , Ovarian Neoplasms/therapy , Ovariectomy , Female , Fertility Preservation , Humans , Infertility, Female/etiology , Infertility, Female/therapy , Ovary/surgery , Pregnancy , Pregnancy Complications , Pregnancy Outcome , Young AdultABSTRACT
Chronic low back and neck pain remain prevalent medical concerns, with much debate regarding the effective evaluation and treatment. Facet disease has been implicated as a source of axial nonradiating low back pain. We discuss patient evaluation, the role of imaging, current and emerging image-guided therapies for facet-related pain, and the increasing importance of outcome-related research in this arena.