1.
Org Biomol Chem
; 15(26): 5571-5578, 2017 Jul 05.
Article
in English
| MEDLINE
| ID: mdl-28639676
ABSTRACT
An efficient [3 + 2] cycloaddition of 3-ylideneoxindoles with in situ generated CF2HCHN2 for the syntheses of spirooxindoles has been developed. This methodology gives access to a range of relatively complex spirooxindoles featuring a CF2H group and three contiguous stereogenic centers in up to 84% yield and 99 : 1 trans/cis.
2.
Org Biomol Chem
; 14(4): 1395-401, 2016 Jan 28.
Article
in English
| MEDLINE
| ID: mdl-26677092
ABSTRACT
An unprecedented reaction between indolin-2-ones and α-substituted ketones has been developed. Using this protocol, a wide range of biologically important 3-hydroxy-3-phenacyloxindole derivatives could be obtained in good yield (up to 93%) under mild reaction conditions. A possible mechanism of this reaction was tentatively proposed based on some control experiments and MS spectrometry analysis.