Subject(s)
Colonoscopy , Colorectal Neoplasms , Humans , Female , Colorectal Neoplasms/pathology , Colorectal Neoplasms/diagnosis , Colorectal Neoplasms/metabolism , Middle Aged , Aged , Adult , Biopsy , Adenocarcinoma/secondary , Adenocarcinoma/diagnosis , Adenocarcinoma/metabolism , Genital Neoplasms, Female/pathology , Genital Neoplasms, Female/diagnosis , Genital Neoplasms, Female/metabolism , Biomarkers, Tumor/metabolism , Uterine Cervical Neoplasms/pathology , Uterine Cervical Neoplasms/metabolism , Uterine Cervical Neoplasms/diagnosis , Keratin-7/metabolism , Cystadenocarcinoma, Serous/secondary , Cystadenocarcinoma, Serous/diagnosis , Cystadenocarcinoma, Serous/metabolism , WT1 Proteins/metabolism , Cyclin-Dependent Kinase Inhibitor p16/metabolism , Diagnosis, Differential , Matrix Attachment Region Binding Proteins/metabolism , Matrix Attachment Region Binding Proteins/genetics , Transcription FactorsABSTRACT
Parenting behaviors and neighborhood environment influence the development of adolescents' brains and behaviors. Simultaneous trajectories of brain and behavior, however, are understudied, especially in these environmental contexts. In this four-wave study spanning 9-18 years of age (N=224 at baseline, N=138 at final assessment) we used longitudinal k-means clustering to identify clusters of participants with distinct trajectories of uncinate fasciculus (UF) fractional anisotropy (FA) and anxiety symptoms; we examined behavioral outcomes and identified environmental factors that predicted cluster membership. We identified three clusters of participants: 1) high UF FA and low symptoms ("low-risk"); 2) low UF FA and high symptoms ("high-risk"); and 3) low UF FA and low symptoms ("resilient"). Adolescents in disadvantaged neighborhoods were more likely to be in the resilient than high-risk cluster if they also experienced maternal warmth. Thus, neighborhood disadvantage may confer neural risk for psychopathology that can be buffered by maternal warmth, highlighting the importance of considering multiple environmental influences in understanding emotional and neural development in youth.