1.
J Org Chem
; 89(12): 8782-8788, 2024 06 21.
Article
in English
| MEDLINE
| ID: mdl-38819141
ABSTRACT
The total synthesis of (-)-piericone D, a potential antithrombotic dihydrochalcone featuring an [3.3.0] octane core, is reported. Salient features of our synthesis include a stereoselective ß-O-glycosylation to install the asebogenin aglycone and a late-stage global deprotection followed by simultaneous lactonization. The convergent synthesis paved the way for further structure-activity relationship (SAR) studies of (-)-piericone D.