A rare case of hidradenocarcinoma with anaplastic and invasive features arising from a nodulocystic hidradenoma.

A 91-year-old man presented with a cutaneous left abdominal mass. The mass was longstanding (over 5 years) and slow-growing. Examination revealed a violaceous, multinodular, and exophytic non-tender mass surrounded by patchy erythema. Excisional biopsy was performed and revealed a nodular and cystic dermal proliferation of predominately basaloid cells with focal duct formation, surrounded by prominent hyalinized stroma. The superficial portion of the mass was identified as a nodulocystic hidradenoma. Along the deep aspect and in association with the benign hidradenoma, sheets of markedly atypical epithelioid cells invaded the surrounding tissue, consistent with malignant transformation. Perineural and lymphovascular invasion were seen among areas with anaplastic features. This case supports that some hidradenocarcinoma originates from benign counterparts, and as such, ample sampling is required to definitively exclude a more sinister diagnosis. Diagnostic, prognostic, histopathological, and molecular characteristics, and current knowledge limitations are briefly discussed.

Recurrent Malignant Sweat Gland Tumor.

Malignant sweat gland tumors are very rare. Hidradenocarcinoma is an uncommon malignancy arising from the intradermal ductal epithelium of eccrine sweat glands, usually in the sun-exposed parts of the body. It usually arises de novo but may develop from a benign hidradenoma. The diagnosis of hidradenocarcinoma is clinically challenging as it presents with varied consistency and clinically mimics other skin lesions such as chronic sebaceous cysts or epidermoid cysts. Hidradenocarcinoma is a highly aggressive tumor with a tendency for regional and distant spread. It is difficult to treat hidradenocarcinoma as it has high rates of morbidity and mortality and a very high incidence of recurrence. Here, we report a rare case of a 45-year-old woman who presented with a recurrent lump over the left arm diagnosed as primary hidradenocarcinoma.

Hidradenocarcinoma in a Crohn's patient on ustekinumab: A case report.

Hidradenocarcinoma is a locally aggressive malignancy of the sweat glands, most commonly found on the head, neck, and upper body. Although rare, it has been seen in patients with hidradenitis supparativa, who have an increased risk of non-melanoma skin cancers. Ustekinumab, a biologic agent used to treat inflammatory bowel disease, has been associated with development of cancer in some patients. We present a case of a 36-year-old female with hidradenitis supparativa and Crohn's disease who developed hidradenocarcinoma in setting of ustekinumab use, demonstrating the need for further study of the relationship between biologic therapy and malignancy.

Hidradenocarcinoma of Nose: A Rare Case Report.

This report details the surgical management of a rare case of hidradenocarcinoma in a 70-year-old man presenting as a large multilobulated swelling on the dorsum of the nose. Following histopathological confirmation, the patient underwent wide complete excision of the tumour, coupled with sentinel lymph node dissection. Reconstruction involved the use of a paramedian forehead flap and cheek advancement flap. The successful outcome underscores the importance of early diagnosis and a comprehensive surgical approach for managing hidradenocarcinoma on the nasal dorsum.

Hidroadenocarcinoma Mimicking Epidermal Inclusion Cyst of the Palm.

Hidradenocarcinoma is a rare malignant tumor of sweat glands of the skin that has been reported several times in the hand. We report a case of hidradenocarcinoma of the palm in a 55-year-old woman that presented as a painless volar hand mass. A staged rotational forearm flap was used after resection.

Hidradenocarcinoma en miembro inferior: reporte de caso y revision de literatura / Hydradenocarcinoma in lower member: case report and review of literature

RESUMEN Objetivo : Presentación de un caso, consistente en una lesión tumoral, compatible con hidradenocarcinoma, desarrollado en un paciente joven, y revisión de la literatura referida a la entidad mencionada. Métodos : Se valora en el servicio de dermatología un paciente de 17 años con una lesión de crecimiento progresivo, localizada en tercio medio de la pierna derecha, la cual a la inspección muestra secreción hialina y sangrado, manifestando prurito como síntoma ocasional, al inicio de la lesión. Se decide tomar biopsia de la lesión para confirmar diagnóstico. Resultados : Se hace diagnóstico clínico e histopatológico de hidradenocarcinoma siendo este un tumor raro maligno, originado en glándulas sudoríparas que se localiza cualquier parte del cuerpo, el cual en la mayoría de los casos se ha descrito como de origen ecrino. Conclusiones : Aunque no es una patología frecuente tiene altas tasas de recurrencia y riesgo de metástasis. Por lo tanto, es importante considerarla siempre como uno de los diagnósticos diferenciales, y de esa manera ofrecer un oportuno tratamiento quirúrgico, con márgenes amplios de resección.

SUMMARY Objective : Presentation of a case report, consisting of a tumor lesion, compatible with hydradenocarcinoma, developed in a young patient, and review of the literature referring to the mentioned entity. Methods : A 17-year-old patient with a progressive growth lesion, located in the middle third of the right leg, was evaluated in the dermatology service, which upon inspection showed hyaline secretion and bleeding, manifesting pruritus as an occasional symptom. A skin biopsy was performed to confirm the diagnosis. Results : A clinical and histopathological diagnosis of hydradenocarcinoma is made, this being a rare and malignant tumor originating in sweat glands that is located anywhere in the body, which in most cases has been described as of eccrine origin. Conclusions : Although it is not a frequent pathology, it has high recurrence rates and risk of metastasis. Therefore, it is important to always consider it as one of the differential diagnoses, and thus offer timely surgical treatment, with wide resection margins.

Hidradenoma nodular maligno / Malignant nodular hydradenoma

RESUMEN El Hidradenoma nodular maligno o Hidradenocarcinoma es un tumor poco frecuente, derivado de las glándulas sudoríparas ecrinas. Puede surgir de novo o por la transformación de su contraparte benigna. Estos tumores son de crecimiento lento, comportamiento agresivo, con alta incidencia de recurrencias y posibilidad de metástasis. Su prevalencia es en la población adulta, y su pronóstico, incierto. El tratamiento de elección de estos tumores es la escisión quirúrgica con márgenes amplios.

ABSTRACT The Malignant nodular Hydradenoma or Hydradenocarcinoma is a rare tumor, derived from the eccrine sweat glands, may arise de novo or by the transformation of its benign counterpart. These tumors are slow growing, aggressive behavior, with a high incidence of recurrences and the possibility of metastasis; its prevalence being in the adult population, and its prognosis is uncertain. The treatment of choice for these tumors is surgical excision with wide margins.

Hidradenocarcinoma nodular perianal: informe de un caso / Perianal nodular hidradenocarcinoma: case report

Introducción: Las glándulas ecrinas (sudoríparas) se encuentran en todos los sitios de la piel y son más abundantes en las palmas de las manos y plantas de los pies. El hidradenocarcinoma nodular es un tumor raro de las glándulas ecrinas, maligno y agresivo. El objetivo de este trabajo es informar de un caso de hidradenocarcinoma perianal. Caso clínico: Mujer de 75 años de edad, diabética, hipertensa e hipotiroidea. Al examen físico se observó y palpó tumoración perianal pequeña que llegaba hasta canal anal; se tomó biopsia con resultado de hidradenoma perianal. Se llevó a cabo rectosigmoidoscopia hasta 25 cm, normal. Tomografía computarizada: adenopatías de 1 cm en región inguinal e iliaca derecha. Se realizó resección amplia de la tumoración. El informe de patología fue acrospiroma ecrino maligno. Actualmente la paciente se encuentra en tratamiento complementario con quimioterapia. Conclusiones: En pacientes que debuten con lesiones malignas metastásicas en región inguinal debe pensarse en origen del conducto anal.

BACKGROUND: Eccrine glands (sweat glands) appear in all sites of the skin and are more abundant in hands and feet. Nodular hidradenocarcinoma (NH) is a rare malignant and aggressive tumor of the eccrine glands. The objective of this study is to report a case of perianal hidradenocarcinoma. CLINICAL CASE: We present the case of a 75-year-old female with diabetes, hypertension, and hypothyroidism. Physical examination revealed a small perianal tumor that was palpated near the anal canal. Biopsy was done. Pathology report revealed perianal hidradenoma. Rectosigmoidoscopy was normal. Computed tomography showed 1-cm adenopathies in inguinal and right iliac regions. Extensive resection of the tumor was done. Definitive pathology report was malignant eccrine acrospiroma. The patient underwent adjuvant chemotherapy in the Oncology Service and died 1 month later. CONCLUSIONS: In patients with a first symptom of metastases in the inguinal region, suspicion must be directed to the anal canal.