ABSTRACT
The C*06:99 allele substitutes one nucleotide of C*06:02:01:01 at codon 50 (CCGâCTG), Pro to Leu.
Subject(s)
HLA-C Antigens/genetics , Histocompatibility Testing , Base Sequence , Exons/genetics , Gene Frequency , Genotype , Hematopoietic Stem Cell Transplantation , Humans , Korea , Molecular Sequence Data , Polymerase Chain Reaction , Sequence Alignment , Tissue DonorsABSTRACT
The new allele DQB1*05:50 showed one nucleotide difference with DQB1*05:03:01:01 at codon 39 (CGC/CAC).
Subject(s)
Alleles , Asian People/genetics , HLA-DQ beta-Chains/genetics , Histocompatibility Testing/methods , Sequence Analysis, DNA/methods , Base Sequence , Humans , Molecular Sequence Data , Republic of Korea , Sequence AlignmentABSTRACT
The sequence of the C*03:02:02:03 differs from that of C*03:02:02:01 by one nucleotide substitution in the 5' UTR at position -57 (C>A).
Subject(s)
HLA-C Antigens/genetics , Histocompatibility Testing , 5' Untranslated Regions/genetics , Base Sequence , Cloning, Molecular , Gene Frequency , Genome , Genotype , Humans , Korea , Molecular Sequence Data , Polymerase Chain Reaction , Sequence AlignmentABSTRACT
A novel allele B*13:68 was identified in a Chinese individual by sequence-based typing method.
Subject(s)
Alleles , HLA-B Antigens/genetics , Polymorphism, Single Nucleotide , Asian People , Base Sequence , Bone Marrow Transplantation , Female , Histocompatibility Testing , Humans , Molecular Sequence Data , Sequence Alignment , Sequence Analysis, DNA , Tissue DonorsABSTRACT
The new allele B*46:39 showed a single-nucleotide substitution compared with B*46:01 at codon 185 (CCA/ACA).
Subject(s)
Alleles , HLA-B Antigens/genetics , Histocompatibility Testing , Sequence Analysis, DNA , Base Sequence , Exons/genetics , Humans , Molecular Sequence DataABSTRACT
The novel allele HLA-A*33:131 was identified in a Chinese individual using the sequencing-based typing method.
Subject(s)
HLA-A Antigens , Alleles , Asian People , Base Sequence , China , Exons/genetics , HLA-A Antigens/genetics , Humans , Sequence Analysis, DNAABSTRACT
HLA-A*24:231 has one nucleotide change from HLA-A*24:02:01:01 at position 784 G>C.
ABSTRACT
One nucleotide replacement at nucleotide 811 of HLA-A*02:01:01:01 results in a new allele, HLA-A*02:692.
Subject(s)
Alleles , HLA-A2 Antigen/genetics , Histocompatibility Testing , Sequence Analysis, DNA , Female , Humans , MaleABSTRACT
The novel allele, A*11:264, was identified in a Chinese individual by sequence-based typing.
Subject(s)
Asian People , Bone Marrow/physiology , HLA-A11 Antigen/genetics , Alleles , Bone Marrow Transplantation , China , Histocompatibility Testing , Humans , Male , Polymorphism, Genetic , Sequence Alignment , Sequence Analysis, DNA , Tissue Donors , World Health OrganizationABSTRACT
A novel allele A*24:337 was identified in a Chinese individual by sequence-based typing.
Subject(s)
Alleles , Exons , HLA-A24 Antigen/genetics , Point Mutation , Unrelated Donors , Amino Acid Substitution , Asian People , Base Sequence , Cloning, Molecular , Gene Expression , Genotype , HLA-A24 Antigen/immunology , Hematopoietic Stem Cell Transplantation , Histocompatibility Testing , Humans , Male , Sequence Alignment , Sequence Analysis, DNAABSTRACT
A novel allele A*02:436 was identified in a Chinese individual by sequence-based typing method.
Subject(s)
Alleles , Exons , HLA-A2 Antigen/genetics , Point Mutation , Tissue Donors , Amino Acid Substitution , Asian People , Base Sequence , Codon/chemistry , Female , Genotype , HLA-A2 Antigen/immunology , Hematopoietic Stem Cell Transplantation , Histocompatibility Testing , Humans , Sequence Alignment , Sequence Analysis, DNAABSTRACT
HLA-A*33:88 differs from HLA-A*33:03:01 by one nucleotide exchange at position 475, G>A (codon 135 GCG>ACG).
Subject(s)
Alleles , Exons , HLA-A Antigens/genetics , Polymorphism, Single Nucleotide , Tissue Donors , Adult , Amino Acid Substitution , Base Sequence , China , Codon/chemistry , Ethnicity , Female , Genotype , HLA-A Antigens/immunology , Hematopoietic Stem Cell Transplantation , Histocompatibility Testing , Humans , Polymerase Chain Reaction , Sequence Alignment , Sequence Analysis, DNAABSTRACT
The novel allele HLA-C*07:445 has 1 nucleotide change from HLA-C*07:01 at nucleotide 277 C>A in exon 2.
Subject(s)
Alleles , HLA-C Antigens/genetics , Hematopoietic Stem Cells/metabolism , Tissue Donors , Amino Acid Sequence , Base Sequence , France , HLA-C Antigens/chemistry , HumansABSTRACT
HLA-DRB1*14:150 shows one nucleotide difference when compared with DRB1*14:54:01 at codon 49 (A > P).
Subject(s)
Alleles , Asian People/genetics , Exons/genetics , HLA-DRB1 Chains/genetics , Base Sequence , Humans , Sequence AlignmentABSTRACT
A novel allele DRB1*04:01:17 was identified in a Chinese individual by sequence-based typing method.