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1.
Proc Natl Acad Sci U S A ; 120(44): e2306497120, 2023 Oct 31.
Article in English | MEDLINE | ID: mdl-37844215

ABSTRACT

Despite significant research on the effects of stress on the hypothalamic-pituitary-adrenal (HPA) axis, questions remain regarding long-term impacts of large-scale stressors. Leveraging data on exposure to an unanticipated major natural disaster, the 2004 Indian Ocean tsunami, we provide causal evidence of its imprint on hair cortisol levels fourteen years later. Data are drawn from the Study of the Tsunami Aftermath and Recovery, a population-representative longitudinal study of tsunami survivors who were living along the coast of Aceh, Indonesia, when the tsunami hit. Annual rounds of data, collected before, the year after and 2 y after the disaster provide detailed information about tsunami exposures and self-reported symptoms of post-traumatic stress. Hair samples collected 14 y after the tsunami from a sample of adult participants provide measures of cortisol levels, integrated over several months. Hair cortisol concentrations are substantially and significantly lower among females who were living, at the time of the tsunami, in communities directly damaged by the tsunami, in comparison with similar females living in other, nearby communities. Differences among males are small and not significant. Cortisol concentrations are lowest among those females living in damaged communities who reported elevated post-traumatic stress symptoms persistently for two years after the tsunami, indicating that the negative effects of exposure were largest for them. Low cortisol is also associated with contemporaneous reports of poor self-rated general and psychosocial health. Taken together, the evidence points to dysregulation in the HPA axis and "burnout" among these females fourteen years after exposure to the disaster.


Subject(s)
Burnout, Psychological , Hypothalamo-Hypophyseal System , Pituitary-Adrenal System , Tsunamis , Adult , Female , Humans , Male , Hydrocortisone , Hypothalamo-Hypophyseal System/physiology , Indian Ocean , Longitudinal Studies , Pituitary-Adrenal System/physiology , Burnout, Psychological/physiopathology
2.
J Nerv Ment Dis ; 208(10): 794-802, 2020 10.
Article in English | MEDLINE | ID: mdl-32833883

ABSTRACT

Our objectives were to investigate alexithymia in burnout patients while controlling for depression and anxiety, as well as to evaluate whether alexithymia may be part of a profound emotional processing disorder or of a mentalization deficit. Alexithymia, depressive, and anxious feelings were compared in patients with burnout, depression, and healthy controls using an age-, sex-, and education-matched cross-sectional design (n = 60). A facial emotion recognition task and an emotional mentalizing performance test as well as physical and emotional violation experiences were conducted. Alexithymia was significantly increased in burnout patients, mediated by negative affect in this group. No impairment of facial emotion recognition or mental attribution could be shown. Burnout patients demonstrated slightly increased emotional abuse experiences in early childhood. The present results corroborate the supposition that alexithymia in burnout primarily depends on affect and may rise due to current strain and overload experience, rather than based on a profound developmental disorder in emotion processing.


Subject(s)
Affective Symptoms/psychology , Burnout, Psychological/psychology , Depressive Disorder/psychology , Facial Recognition , Mentalization , Adult , Affective Symptoms/physiopathology , Anxiety/physiopathology , Anxiety/psychology , Burnout, Psychological/physiopathology , Case-Control Studies , Depression/physiopathology , Depression/psychology , Depressive Disorder/physiopathology , Female , Humans , Male , Middle Aged
3.
New Dir Child Adolesc Dev ; 2020(174): 7-13, 2020 Nov.
Article in English | MEDLINE | ID: mdl-33084244

ABSTRACT

Parental burnout (PB)-a condition characterized by intense exhaustion related to parenting, emotional distancing from one's children, and a loss of parental fulfillment-has received increasing attention in recent years, even more since the worldwide COVID-19 crisis and the confinement of parents with their children. This crisis put the spotlight on parents' suffering, and the need to better understand parental burnout and how to best assess and treat it emerged as a priority. This brief article introduces the Thematic Issue of New Directions in Child and Adolescent Development focused on the measurement of parental burnout across various regions of the world. It briefly reviews the concept of parental burnout, its phenomenological experience, its etiology and consequences, and its measurement.


Subject(s)
Burnout, Psychological/diagnosis , COVID-19 , Parent-Child Relations , Parenting , Adult , Burnout, Psychological/etiology , Burnout, Psychological/physiopathology , Humans , Parenting/psychology
4.
Psychosom Med ; 81(9): 791-798, 2019.
Article in English | MEDLINE | ID: mdl-31592938

ABSTRACT

OBJECTIVE: Previous research indicates a link between burnout symptoms and reduced vagally mediated heart rate variability (HRV); however, the directionality of this relationship is still largely unknown. The objective of the present study was to examine the longitudinal relationship between HRV and burnout symptoms for 1 year, with a special focus on the emotional exhaustion (EE) burnout subdimension, which remains inadequately distinguished from overlapping with depressive symptoms. METHODS: Here we present HRV and behavioral data from 167 individuals (mean [SD] age = 43.43 [11.78] years; 30.5% male) who attended two biomarker samplings (T1 and T2) of the Dresden Burnout Study approximately 12 months apart. RESULTS: In hierarchical linear regression analyses, T1 HRV significantly inversely predicted T2 overall burnout symptoms (ß = -.16; p = .03) and EE (ß = -.23; p = .02), adjusting for age, sex, body mass index, adverse health behaviors, and depressive symptoms. Importantly, only high EE at T1 (ß = -.22; p = .04), and not the T1 Maslach Burnout Inventor total score, predicted reductions in HRV from T1 to T2. CONCLUSIONS: We report for the first time longitudinal evidence that HRV is associated with changes in burnout symptoms, independently of depressive symptoms. Results suggest vagal dysfunction being predictive and specific for burnout symptoms, making HRV a promising starting point for the explanation of biophysiological mechanisms underlying burnout symptoms and cardiovascular diseases. The finding of only EE at T1 being predictive for changes in HRV underscores the importance of exhaustion for modulations in autonomic regulation.


Subject(s)
Autonomic Nervous System/physiopathology , Burnout, Psychological/physiopathology , Depression/physiopathology , Adult , Aged , Female , Heart Rate/physiology , Humans , Longitudinal Studies , Male , Middle Aged , Vagus Nerve/physiopathology , Young Adult
5.
Psychosom Med ; 81(8): 720-730, 2019 10.
Article in English | MEDLINE | ID: mdl-31343581

ABSTRACT

Research on stress and disease has often afforded an important role to emotion, typically conceptualized in broad categories (e.g., negative emotions), viewed as playing a causal role (e.g., anger contributing to pathophysiology of cardiovascular disease), and measured using self-report inventories. In this article, I argue for the value of evaluating specific emotions, considering bidirectional causal influences, and assessing actual emotional responding when considering the role that emotions play in the stress-disease relationship. In terms of specificity, specific emotions (e.g., anger, sadness, and embarrassment) can be linked with particular health outcomes (e.g., cardiovascular disease and musculoskeletal disease). In terms of bidirectionality, the influences of emotions on disease as well as the influences of disease on emotional functioning can be considered. In terms of assessing actual emotional responding, emotions can be studied in vivo under controlled conditions that allow behavioral, physiological, and subjective responses to be measured during different kinds of emotional functioning (e.g., responding to emotional stimuli, interacting with relationship partners, and downregulating emotional responses). With these considerations in mind, I review early theories and empirical studies in psychosomatic medicine that considered the role of specific emotions and emotion-related behaviors. Studies from our laboratory are presented that illustrate a) differences in patterns of autonomic nervous system responding associated with specific emotions, b) relationships between specific emotions and particular health outcomes in the context of social relationships, c) age as a moderator of the relationship between specific emotions and well-being, d) bidirectional influences (emotions influencing disease and disease influencing emotional functioning), and e) impact of changes in emotional functioning in individuals with neurodegenerative diseases on the health of familial caregivers.


Subject(s)
Emotions/physiology , Social Determinants of Health , Stress, Psychological/physiopathology , Aging/physiology , Aging/psychology , Anger/physiology , Autonomic Nervous System/physiology , Behavior/physiology , Brain/physiology , Burnout, Psychological/physiopathology , Burnout, Psychological/psychology , Caregivers/psychology , Causality , Dementia/physiopathology , Dementia/psychology , Disease Susceptibility , Disgust , Embarrassment , Facial Expression , Female , Hemodynamics , Humans , Interpersonal Relations , Life Change Events , Male , Stress, Psychological/psychology
6.
Stress ; 22(1): 1-8, 2019 01.
Article in English | MEDLINE | ID: mdl-30345850

ABSTRACT

With the detrimental relationship between school burnout and physiological and cognitive functioning now well documented, interventions to ameliorate school burnout symptomology are needed. This study examined the effectiveness of a self-regulatory biofeedback intervention program (Heart Rate Variability Coherence Biofeedback Training [HRVCB]) in contrast to a protocol demonstrated to produce cognitive and physiological improvements (a high intensity interval training protocol [HIIT]) as well as a wait-list control condition at decreasing school burnout in an American collegiate sample (N = 90). Intervention training was conducted over a 4-week span (three sessions per week) with accompanying baseline and post-intervention assessments. In addition to measurements of school burnout and negative affect (depression and anxiety), intervention influences on cognition (via a serial subtraction task) and physiology (hemodynamics, electrocardiography, and a submaximal cardiorespiratory fitness test) were explored. Findings indicate HRVCB training significantly decreased school burnout and increased mathematical performance from pre- to post-intervention measurement. These changes did not occur for HIIT or waitlist participants. Brachial and aortic systolic blood pressure decreased pre to post-intervention for HRVCB but not HIIT or waitlist participants. Cardiovascular fitness (VO2max) improved pre to post-intervention for HIIT but not HRVCB or waitlist participants. Also, both HRVCB and HIIT training participants decreased heart rate from pre to post-intervention but not waitlist participants. Finally, all participants decreased cardiac sympathovagal tone from pre to post-intervention. These findings provide evidence that HRVCB training programs can decrease school burnout as well as improve components associated with cardiac health. Study limitations and directions for future research are discussed.


Subject(s)
Biofeedback, Psychology/methods , Burnout, Psychological/physiopathology , Burnout, Psychological/therapy , Heart/physiopathology , Adolescent , Burnout, Psychological/psychology , Cognition , Electrocardiography , Female , Heart Rate/physiology , Hemodynamics , Humans , Male , Self Report , Students/psychology , Universities , Young Adult
7.
Med Sci Monit ; 25: 5237-5240, 2019 Jul 14.
Article in English | MEDLINE | ID: mdl-31302661

ABSTRACT

BACKGROUND The early days of a given experience are associated with typically what might be characterized as an idealized enthusiasm. Conversely burnout syndrome experienced later in the given experience is associated with disillusionment, disappointment, and symptoms which resemble a depression. This very common propensity is a parallel to the concept of "splitting" described by Kernberg with a pronounced "black and white" perceptual dichotomy between the early idealization and later disillusionment. This study intends examination of relationships between burnout syndrome, depression, and Kernberg's concept of splitting. MATERIAL AND METHODS In this present study, we assessed 132 female health care professionals working with a population of diabetic patients utilizing Burnout Measure (BM) Splitting Index (SI), Beck Depression Inventory II (BDI-II), and additional psychometric instruments, the Toronto Alexithymia Scale and the Trauma Symptoms Checklist. RESULTS The study results indicated significant Spearman correlations between burnout syndrome as measured by BM and depression (BDI-II) (R=0.62, P<0.01), and burnout syndrome as measured by BM and splitting (SI) (R=0.45, P<0.01). These findings may have implications for prevention and treatment of burnout syndrome. CONCLUSIONS The current study findings provide implications that the defensive mechanism of splitting may allow for the prediction of burnout symptoms which in turn may allow for the prediction of burnout syndrome. This dynamics may potentially be of use in both the potential detection and prevention of burnout syndrome.


Subject(s)
Burnout, Professional/psychology , Burnout, Psychological/psychology , Health Personnel/psychology , Adult , Burnout, Professional/epidemiology , Burnout, Professional/physiopathology , Burnout, Psychological/epidemiology , Burnout, Psychological/physiopathology , Depression/diagnosis , Depression/epidemiology , Depression/physiopathology , Depressive Disorder , Emotions , Female , Humans , Middle Aged , Stress, Psychological/complications , Surveys and Questionnaires
8.
Clin Gastroenterol Hepatol ; 16(3): 311-317, 2018 03.
Article in English | MEDLINE | ID: mdl-28669661

ABSTRACT

Physician burnout is an under-recognized and under-reported problem. Characterized by a state of mental exhaustion, depersonalization, and a decreased sense of personal accomplishment, burnout may affect more than 60% of family practice providers and at least one third of gastroenterologists. Some studies have shown that younger physicians, physicians performing high-risk procedures, and physicians experiencing work-life conflicts are at greatest risk. If unrecognized, the costs to the physician and to the health care system can be enormous because physician burnout is associated with increased rates of depression, alcohol and drug abuse, divorce, suicide, medical errors, difficult relationships with coworkers, and patient dissatisfaction, as well as physician attrition. If properly recognized, appropriate treatments are available. This article presents a case study of a physician suffering from burnout, reviews how burnout is defined, identifies those providers at greatest risk, discusses root causes, and outlines a treatment program.


Subject(s)
Burnout, Psychological/epidemiology , Gastroenterologists/psychology , Burnout, Psychological/pathology , Burnout, Psychological/physiopathology , Humans
9.
Stress ; 21(3): 211-216, 2018 05.
Article in English | MEDLINE | ID: mdl-29382258

ABSTRACT

Emerging research documents the relationship between school burnout and some indicators of increased cardiovascular risk. Indicators of cardiovascular functioning assessed via ambulatory blood pressure and heart rate variability (HRV) have not been thoroughly explored in this research domain. Therefore, the current study examined relationships between school burnout and indicators of cardiac functioning via 24 h ambulatory blood pressure (BP) and electrocardiogram monitoring in a sample of young adult female undergraduates (N = 88). Two hypotheses were tested: (1) that independent of related negative affective symptomology (depression and anxiety), increased school burnout would be related to greater systolic and diastolic BP, higher low frequency (LF) HRV and lower very low frequency (VLF) HRV, and (2) that lower VLF would be related to greater school burnout independently of LF HRV. Hierarchical multiple regression analyzes showed that school burnout was significantly related to elevated ambulatory BP (systolic and diastolic) and HRV markers of increased cardiac sympathovagal tone. These findings support the hypotheses and suggest that school burnout might be implicated in the development of pre-hypertension or early cardiovascular disease. Study limitations and the need for future longitudinal research are discussed.


Subject(s)
Burnout, Psychological/physiopathology , Burnout, Psychological/psychology , Cardiovascular Diseases/physiopathology , Cardiovascular Diseases/psychology , Heart Rate , Hypertension/physiopathology , Hypertension/psychology , Schools , Anxiety/psychology , Depression/psychology , Electrocardiography , Female , Humans , Students , Sympathetic Nervous System/physiopathology , Universities , Young Adult
10.
BMC Fam Pract ; 19(1): 172, 2018 10 30.
Article in English | MEDLINE | ID: mdl-30376811

ABSTRACT

BACKGROUND: Mental illness, and particularly stress-related disorders such as exhaustion disorder, is continuously increasing in today's society. It is important to identify patients who consult for potentially stress-related symptoms early, before the stress condition develops into an exhaustion disorder. The purpose of the study was to investigate the frequency of different presenting complaints for which patients had consulted in the two years preceding receipt of their exhaustion disorder diagnosis, and to explore potential associations between stress-related presenting complaints and demographic factors, as well as comorbidity and other potentially stress-inducing factors. METHODS: This was a retrospective medical chart review of presenting complaints of adult patients with exhaustion disorder two years preceding receipt of diagnosis at a primary healthcare centre in western Sweden. RESULTS: Exhaustion disorder was diagnosed in 126 patients at the healthcare centre during the study period. Charts were available for 115 patients (76% women, mean age 47 years). Charts were reviewed with regard to presenting complaints, demographic data and comorbidity. Average number of general practitioner visits during the two years preceding the diagnosis was 5.2 (SD 3.7). The two most common complaints were infection and anxiety/depression, presented by 49% and 46%, respectively. Other stress-related complaints seen to in more than 30% of the patients were stress, other pain, fatigue, gastrointestinal symptoms, and sleep disturbances. Back pain and fatigue were more frequent in patients over 40 years. A majority of the patients also had mental (53%) or somatic (61%) comorbidity. Comorbidity was more frequent in older patients. No significant gender differences were found. CONCLUSIONS: Patients with exhaustion disorder appear to consult their general practitioner numerous times with stress-related complaints in the years preceding their diagnosis. The findings indicate which presenting complaints general practitioners may need to be more attentive to so that patients at risk of developing exhaustion disorder can be identified earlier and get the support they need. Addressing stress factors earlier in the course of illness and preventing the development of exhaustion disorder may contribute to a reduced burden for both individual patients and for society, with a reduction in sick leave and societal costs for mental illness.


Subject(s)
Anxiety/epidemiology , Burnout, Psychological/epidemiology , Depression/epidemiology , Infections/epidemiology , Primary Health Care , Referral and Consultation/statistics & numerical data , Adult , Anxiety/physiopathology , Anxiety/psychology , Burnout, Psychological/physiopathology , Burnout, Psychological/psychology , Comorbidity , Depression/physiopathology , Depression/psychology , Early Diagnosis , Fatigue/epidemiology , Fatigue/physiopathology , Fatigue/psychology , Female , Gastrointestinal Diseases/epidemiology , Gastrointestinal Diseases/physiopathology , Humans , Male , Middle Aged , Office Visits , Pain/epidemiology , Pain/physiopathology , Pain/psychology , Retrospective Studies , Sick Leave , Sleep Wake Disorders/epidemiology , Sleep Wake Disorders/physiopathology , Sleep Wake Disorders/psychology , Stress, Psychological/epidemiology , Stress, Psychological/physiopathology , Stress, Psychological/psychology , Sweden/epidemiology
12.
PLoS One ; 16(6): e0253552, 2021.
Article in English | MEDLINE | ID: mdl-34166434

ABSTRACT

Low performance of high school students and repeating a year are major problems in the education system. Low performance in the classroom generates negative emotions in young people and has been related to development of school burnout. The objective of this study was to analyze the repercussions of academic performance on burnout in high school students, and establish the role of emotional intelligence in this relationship. The sample was made up of 1287 high school students aged 14 to 18, who filled out questionnaires for evaluation of these variables. The results showed that youths who had failed a subject or had repeated a year showed more exhaustion and cynicism than their classmates with better performance and higher academic efficacy. A relationship was also found between school burnout and emotional intelligence in these adolescents, positive for self-efficacy and negative for cynicism and exhaustion. The model results showed that low academic performance affected burnout level, and that stress management and mood in emotional intelligence acted as a mediator in this relationship. In conclusion, development of emotional intelligence programs in the educational context is proposed as a measure for preventing burnout in the face of adverse high school academic events, such as failing or repeating a year.


Subject(s)
Academic Performance/psychology , Burnout, Psychological/psychology , Emotional Intelligence , Students/psychology , Surveys and Questionnaires , Adolescent , Burnout, Psychological/physiopathology , Female , Humans , Male
13.
PLoS One ; 15(4): e0231906, 2020.
Article in English | MEDLINE | ID: mdl-32325479

ABSTRACT

We investigated the relationship between cognitive functioning, work performance, and sleep in non-clinical burnout. In a working population, an online survey was conducted with additional online neuropsychological tests of varying complexity, measuring attention and different components of working memory, of which the coordinating subcomponent the 'Central Executive' is thought to be the most vulnerable to stress. Results indicate that non-clinical burnout is associated with more-though not severe-sleep problems, more depressive complaints, impaired work performance, and with both subjective and objective cognitive impairments. Compared with healthy respondents (N = 107), people with non-clinical burnout (N = 17) had a significantly poorer performance on the tests of the visuospatial sketchpad and the Central Executive of the working memory. Our study also indicates that more complex tests may be more sensitive in detecting cognitive dysfunction in non-clinical burnout. Furthermore, a relationship was found between dual-task performance and work performance. Regarding to sleep quality, in our sample of people with non-clinical burnout, there were no severe sleep problems. In the entire sample, however, insomnia was significantly related to subjective, but not objective, cognitive functioning, and also not to work performance.


Subject(s)
Burnout, Psychological/physiopathology , Cognition/physiology , Memory, Short-Term , Sleep/physiology , Work Performance , Attention , Case-Control Studies , Female , Humans , Male , Middle Aged , Surveys and Questionnaires
14.
Aging (Albany NY) ; 12(24): 26012-26028, 2020 11 21.
Article in English | MEDLINE | ID: mdl-33234733

ABSTRACT

Late-onset hypogonadism (LOH) is a syndrome in middle-aged and elderly men caused by age-related testosterone deficiency. Age-related change of total testosterone (TT) of Asian males is different from Caucasian population, suggesting difference for LOH identification in Asians. A nationwide cross-sectional study involving six centers in China was conducted. Totally 6296 men aged 40-79 were recruited. After exclusions 5980 men were left for analyses. The serum TT level, was neither decreased with aging nor correlated with most hypogonadal symptoms. Instead, ten hypogonadal symptoms were found to be significantly correlated with free testosterone and testosterone secretion index, thus were chosen to form a concise scale. Further analysis identified a level of free testosterone <210 pmol/L, testosterone secretion index <1.8, and the concise scale score ≧17 could be diagnosed as having significantly aggravated LOH. This study developed an evidence-based criteria for LOH identification in Chinese population and may be adopted in other Asians. It includes the impaired testosterone secretion ability and deficiency of bioavailable testosterone, which should be the main cause in LOH pathogenesis despite normal TT levels, as well as correlated multiple hypogonadal symptoms. Our results may guide the LOH treatment to increase testicular function of testosterone secretion and bioavailable testosterone.


Subject(s)
Aging/blood , Hypogonadism/blood , Hypogonadism/physiopathology , Testosterone/blood , Adult , Aged , Aging/physiology , Asian People , Burnout, Psychological/physiopathology , China , Fatigue/physiopathology , Humans , Irritable Mood , Libido , Luteinizing Hormone/blood , Male , Middle Aged , Sex Hormone-Binding Globulin/metabolism , Sexual Dysfunction, Physiological/physiopathology , Testosterone/deficiency
15.
Aerosp Med Hum Perform ; 90(7): 601-605, 2019 Jul 01.
Article in English | MEDLINE | ID: mdl-31227032

ABSTRACT

BACKGROUND: Work ability is an important component of occupational health assessments and reflects how a persons' physical and mental health affect their ability to perform their job. However, little is known about factors relating to the work ability status of flight attendants. The aim of this study was to investigate the physical, mental, and work-related factors that affect flight attendants' work ability.METHODS: A questionnaire-based cross-sectional study and simple random sampling was conducted with participants employed at a Taiwan-based airline for longer than 1 yr. Analysis of variance and Pearson correlation tests were carried out to analyze work ability according to the flight attendants' social demographics, physical and mental health, and work-related factors. Multiple regression analysis was used to predict the flight attendants' work abilities.RESULTS: A total of 472 flight attendants were recruited and the response rate was 78.67%. The work ability of the flight attendants ranged from 'moderate' to 'excellent' (WAI score, 34.1 ± 1.8 to 45.1 ± 1.5). In a regression analysis, work ability was positively associated with gender, age, and good eating habits; in contrast, insomnia and work-related burnout were negatively associated with work ability (R² = 32.4%).DISCUSSION: Insomnia, work-related burnout, and eating habits had a significant impact on flight attendants' work abilities. Hence, it is important to address insomnia and high workloads and maintain a healthy lifestyle in the workplace.Hu C-J, Hong R-M, Yeh G-L, Hsieh I-C. Insomnia, work-related burnout, and eating habits affecting the work ability of flight attendants. Aerosp Med Hum Perform. 2019; 90(7):601-605.


Subject(s)
Aerospace Medicine/statistics & numerical data , Burnout, Psychological/epidemiology , Feeding Behavior/physiology , Sleep Initiation and Maintenance Disorders/epidemiology , Work Capacity Evaluation , Adult , Age Factors , Aviation/statistics & numerical data , Burnout, Psychological/physiopathology , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Occupational Health/statistics & numerical data , Sex Factors , Sleep Initiation and Maintenance Disorders/physiopathology , Taiwan/epidemiology
16.
Biomed Res Int ; 2019: 3764354, 2019.
Article in English | MEDLINE | ID: mdl-31467886

ABSTRACT

INTRODUCTION: The consequences of chronic work-related stress are related to various emotional, cognitive, and behavioral symptoms. Occupational burnout as a complex syndrome is characterized by exhaustion, cynicism, and lower professional efficacy. Moreover, the growing amount of research on the neural correlates of burnout broadens the existing knowledge on the mechanisms underlying this syndrome. AIM OF THE STUDY: The aim of the study is to explore possible differences in brain activity between burnout and nonburnout employees. Frequency-specific EEG power analyses in a resting-state condition in burnout subjects and controls are presented. MATERIALS AND METHODS: Burnout employees (N=46; 19 men) were matched with the control group (N=49; 19 men; mean age: 36.14 years, SD=7.89). The Maslach Burnout Inventory-General Survey (MBI-GS) and the Areas of Worklife Survey (AWS) scale were used to measure burnout symptoms and work conditions, respectively. A 256-channel EEG (EGI System 300) was used to collect psychophysiological data. A repeated measures ANOVA was performed with condition (eyes-open vs. eyes-closed) and region (6 levels: extracted scalp regions) factors; burnout (2 levels: burnout vs. no burnout) was the grouping factor. RESULTS: A significant difference was observed only in the alpha frequency band: the burnout group revealed significantly lower alpha power in the eyes-open condition compared to the controls (p<0.05). The correlation analysis revealed that gender may significantly change the pattern of relations between EEG spectral characteristics and burnout symptoms. CONCLUSIONS: Reduced alpha power in burnout individuals suggests cortical hyperactivity and may be related to greater mental effort and the possible development of compensatory mechanisms by burnout subjects.


Subject(s)
Burnout, Professional/physiopathology , Burnout, Psychological/physiopathology , Electroencephalography , Occupational Stress/physiopathology , Adult , Brain Mapping , Burnout, Professional/psychology , Burnout, Psychological/psychology , Female , Humans , Male , Occupational Stress/psychology , Psychophysiology/methods , Rest/physiology , Surveys and Questionnaires
17.
J Psychiatr Res ; 110: 45-50, 2019 03.
Article in English | MEDLINE | ID: mdl-30583085

ABSTRACT

Toxoplasma gondii (TOX) is a common parasite which infects approximately one third of the human population. In recent years, it has been suggested that latent toxoplasmosis may be a risk factor for the development of mental disorders, particularly schizophrenia and anxiety. With regards to depression the results have been varied. The main objective of this study was to examine subpopulations from the Danish PRISME and GENDEP populations for TOX IgG antibodies. These consisted of: a group with symptoms of anxiety, a group suffering from burnout syndrome, as well as two different subpopulations with depression of differing severity. The secondary objective of this study was to examine whether tryptophan metabolism was altered in TOX-positive subjects within each subpopulation. Our results show that the anxiety and burnout populations were more likely to be TOX IgG seropositive. Furthermore, we find that the moderate-severe but not mild-moderate depressive subpopulation were associated with TOX seropositivety, suggesting a possible role of symptom severity. Additionally, we found that TOX positive subjects in the anxiety and burnout subpopulations had altered tryptophan metabolism. This relationship did not exist in the mild-moderate depressive subpopulation. These results suggest that TOX seropositivity may be related to anxiety, burnout and potentially to severity of depression. We furthermore show that the psychiatric symptoms could be associated with an altered tryptophan metabolism.


Subject(s)
Antibodies, Protozoan/blood , Anxiety Disorders , Burnout, Psychological , Depressive Disorder , Toxoplasma/immunology , Toxoplasmosis , Tryptophan/metabolism , Adult , Anxiety Disorders/immunology , Anxiety Disorders/metabolism , Anxiety Disorders/physiopathology , Burnout, Psychological/immunology , Burnout, Psychological/metabolism , Burnout, Psychological/physiopathology , Depressive Disorder/immunology , Depressive Disorder/metabolism , Depressive Disorder/physiopathology , Female , Humans , Immunoglobulin G , Male , Middle Aged , Severity of Illness Index , Toxoplasmosis/immunology , Toxoplasmosis/metabolism
18.
Psychoneuroendocrinology ; 100: 41-47, 2019 02.
Article in English | MEDLINE | ID: mdl-30290284

ABSTRACT

The objective was to investigate the relationship between various aspects of informal caregiving and diurnal patterns of salivary cortisol, with special attention to the moderating effect of sex and work status. The study population was composed of 3727 men and women from the British Whitehall II study. Salivary cortisol was measured six times during a weekday. Aspects of caregiving included the relationship of caregiver to recipient, weekly hours of caregiving, and length of caregiving. Diurnal cortisol profiles were assessed using the cortisol awakening response (CAR) and diurnal cortisol slopes. Results showed that men, but not women, providing informal care had a blunted CAR compared with non-caregivers (PInteraction = 0.03). Furthermore, we found a dose-response relationship showing that more weekly hours of informal care was associated with a more blunted CAR for men (Ptrend = 0.03). Also, the blunted CAR for men was especially pronounced in short-term caregivers and those in paid work. In women, the steepest cortisol slope was seen among those in paid work who provided informal care (PInteraction = 0.01). To conclude, we found different cortisol profiles in male and female informal caregivers. Male caregivers had a blunted CAR, which has previously been associated with chronic stress and burnout. Future research should investigate whether results are generalizable beyond UK citizens with a working history in the civil service.


Subject(s)
Caregivers , Circadian Rhythm/physiology , Family , Hydrocortisone/metabolism , Stress, Psychological/metabolism , Aged , Burnout, Psychological/epidemiology , Burnout, Psychological/metabolism , Burnout, Psychological/physiopathology , Burnout, Psychological/psychology , Caregivers/psychology , Caregivers/statistics & numerical data , Cohort Studies , Family/psychology , Female , Humans , Male , Middle Aged , Saliva/metabolism , Stress, Psychological/physiopathology , United Kingdom/epidemiology , Work/psychology , Work/statistics & numerical data
19.
Psychoneuroendocrinology ; 100: 156-163, 2019 02.
Article in English | MEDLINE | ID: mdl-30340064

ABSTRACT

Chronic stress exposure has been shown to alter hypothalamic-pituitary-adrenal (HPA) axis functioning, which may mediate its effects on psychopathology and negative health outcomes. The nature of the chronic stress-HPA axis dysregulation is unclear and individuals likely vary in the extent to and manner in which indices of HPA axis regulation, such as diurnal cortisol slope, are influenced by chronic stress. We examined whether HPA-axis-linked genetic variation moderates the association between chronic stress and diurnal cortisol slope, and potential implications for mood and fatigue (possible manifestations of negative clinical outcomes). 211 adolescents (M age 15.89, 54.5% female) completed chronic stress interviews and provided DNA samples. Participants then provided saliva samples at waking and 12 h post-waking for two consecutive weekdays. HPA-axis genetic variation was calculated using a multilocus genetic profile score (MGPS) approach, using ten SNPs from CRHR1, NR3C1, NR3C2, and FKBP5 to generate an additive score of HPA-axis-linked genetic risk. Neither chronic stress nor MGPS directly predicted diurnal slope, but MGPS moderated the association between chronic stress and diurnal slope, with stress predicting a high waking cortisol followed by steep slope among youth with low but not high MGPS scores. MGPS also interacted with chronic stress to predict both negative affect and fatigue, and moderated the indirect effect of chronic stress on mood and fatigue via diurnal slope. Results suggest that diurnal cortisol regulation may be one mechanism by which genetic risk intensifies the association between chronic stress and negative outcomes.


Subject(s)
Affect/physiology , Fatigue , Genetic Variation/physiology , Hydrocortisone/metabolism , Stress, Psychological , Adolescent , Burnout, Psychological/epidemiology , Burnout, Psychological/genetics , Burnout, Psychological/metabolism , Burnout, Psychological/physiopathology , Chronic Disease , Circadian Rhythm/physiology , Cohort Studies , Fatigue/epidemiology , Fatigue/genetics , Fatigue/metabolism , Fatigue/physiopathology , Female , Genetic Loci , Humans , Hypothalamo-Hypophyseal System/metabolism , Hypothalamo-Hypophyseal System/physiopathology , Interviews as Topic , Male , Multifactorial Inheritance/genetics , Multilocus Sequence Typing , Pituitary-Adrenal System/metabolism , Pituitary-Adrenal System/physiopathology , Polymorphism, Single Nucleotide , Saliva/metabolism , Stress, Psychological/epidemiology , Stress, Psychological/genetics , Stress, Psychological/metabolism , Stress, Psychological/physiopathology
20.
Chronobiol Int ; 35(7): 910-919, 2018 07.
Article in English | MEDLINE | ID: mdl-29658812

ABSTRACT

Chronotypes are associated with shift work tolerance and sleep in shift workers, and sleep mediates the impact of shift work on mental health. However, the role of chronotype in the association between shift work and mental health has not been clarified. In this study, we aimed to examine the association between chronotype and burnout in shift workers, using the validated Munich ChronoType Questionnaire for shift workers (MCTQshift). A total of 288 shift workers with irregular shift frequencies were recruited and completed the Chinese-version MCTQshift and the Morningness-Eveningness Questionnaire (MEQ). Chronotypes were assessed by the calculation of corrected mid-sleep time (MSFSC) from mid-sleep time on free days (MSF) based on their exact shift schedules. Another 26 evening-shift nurses were monitored with actigraphy for at least two consecutive evening shifts and the following two free days. Burnout was evaluated using the Copenhagen Burnout Inventory. We found that MSFESC, MSFE and mid-sleep time on workdays (MSWE) had normal distributions and correlated significantly with MEQ scores (r = - 0.47, -0.45 and -0.47, respectively; all p < 0.001). MSW was more closely correlated with actigraphy-derived mid-sleep time on the free day before workdays than that on workdays (r = 0.61 and 0.48, respectively, p < 0.05). Sleep duration was significantly longer on workdays among evening-shift workers who slept late on workdays than those who slept early (ß = 0.59, p < 0.001). After demographic and work characteristics were adjusted for in linear regression models, late chronotype and high social jetlag were associated with burnout scores in evening-shift workers. In conclusion, the Chinese-version MCTQshift is a valid tool for chronotype assessment. Interventions to improve sleep in shift workers should be tailored to chronotype due to variations in sleep behavior. Late chronotype may be an inherent feature of mental health problems, because the association with burnout was significant in both day workers in previous studies and shift workers.


Subject(s)
Burnout, Psychological/physiopathology , Circadian Rhythm/physiology , Sleep Wake Disorders/physiopathology , Sleep/physiology , Adult , Aged , Asian People , Female , Humans , Male , Middle Aged , Surveys and Questionnaires , Time Factors , Wakefulness/physiology
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