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1.
Bull Hist Med ; 94(2): 215-243, 2020.
Article in English | MEDLINE | ID: mdl-33416552

ABSTRACT

This article explores the entangled histories of dengue and yellow fever. It traces how historical conflations of these diseases deepened at the start of the twentieth century in the context of rising fears that yellow fever might spread to Asia. Advances in biomedicine, I suggest, reinforced notions of their kinship and generated competing theories that dengue either foreshadowed yellow fever in Asia or inoculated the region against it. This history in which the language and science of dengue and yellow fever shadowed one another offers a nonlinear narrative of scientific progress. Furthermore, as the so-called neglected tropical diseases resurge in the present, it elucidates how disease threats are read against one another. Thus, the article offers a historical context to ongoing discussions on disease emergence and pandemic preparedness.


Subject(s)
Dengue/history , Yellow Fever/history , Asia , Dengue/virology , History, 19th Century , History, 20th Century , Humans , Yellow Fever/virology
2.
Emerg Infect Dis ; 25(7): 1354-1362, 2019 07.
Article in English | MEDLINE | ID: mdl-31211672

ABSTRACT

We investigated dengue virus (DENV) and asymptomatic DENV infections in rural villages of Kampong Cham Province, Cambodia, during 2012 and 2013. We conducted perifocal investigations in and around households for 149 DENV index cases identified through hospital and village surveillance. We tested participants 0.5-30 years of age by using nonstructural 1 rapid tests and confirmed DENV infections using quantitative reverse transcription PCR or nonstructural 1-capture ELISA. We used multivariable Poisson regressions to explore links between participants' DENV infection status and household characteristics. Of 7,960 study participants, 346 (4.4%) were infected with DENV, among whom 302 (87.3%) were <15 years of age and 225 (65.0%) were <9 years of age. We identified 26 (7.5%) participants with strictly asymptomatic DENV infection at diagnosis and during follow-up. We linked symptomatic DENV infection status to familial relationships with index cases. During the 2-year study, we saw fewer asymptomatic DENV infections than expected based on the literature.


Subject(s)
Asymptomatic Diseases/epidemiology , Dengue Virus , Dengue/epidemiology , Dengue/virology , Adolescent , Adult , Age Factors , Cambodia/epidemiology , Child , Child, Preschool , Dengue/diagnosis , Dengue/history , Disease Outbreaks , Female , History, 21st Century , Humans , Male , Mass Screening , Public Health Surveillance , Sentinel Surveillance , Young Adult
3.
Emerg Infect Dis ; 25(4): 814-816, 2019 04.
Article in English | MEDLINE | ID: mdl-30882327

ABSTRACT

A serosurvey of 600 workers newly arrived in Taiwan from 4 Southeast Asia countries showed that 18 (3%) were positive for Zika virus IgM; 6 (1%) fulfilled the World Health Organization criteria for laboratory-confirmed recent Zika virus infection. The incidence of Zika virus infection in Southeast Asia might be underestimated.


Subject(s)
Antibodies, Viral/immunology , Dengue Virus/immunology , Dengue/epidemiology , Dengue/immunology , Transients and Migrants , Zika Virus Infection/epidemiology , Zika Virus Infection/immunology , Zika Virus/immunology , Antibodies, Neutralizing/immunology , Dengue/history , Dengue/virology , History, 21st Century , Humans , Immunoglobulin G , Neutralization Tests , Seroepidemiologic Studies , Taiwan/epidemiology , Zika Virus Infection/history , Zika Virus Infection/virology
4.
Emerg Infect Dis ; 25(6): 1118-1126, 2019 06.
Article in English | MEDLINE | ID: mdl-31107226

ABSTRACT

We jointly estimated relative risk for dengue and Zika virus disease (Zika) in Colombia, establishing the spatial association between them at the department and city levels for October 2015-December 2016. Cases of dengue and Zika were allocated to the 87 municipalities of 1 department and the 293 census sections of 1 city in Colombia. We fitted 8 hierarchical Bayesian Poisson joint models of relative risk for dengue and Zika, including area- and disease-specific random effects accounting for several spatial patterns of disease risk (clustered or uncorrelated heterogeneity) within and between both diseases. Most of the dengue and Zika high-risk municipalities varied in their risk distribution; those for Zika were in the northern part of the department and dengue in the southern to northeastern parts. At city level, spatially clustered patterns of dengue high-risk census sections indicated Zika high-risk areas. This information can be used to inform public health decision making.


Subject(s)
Dengue/epidemiology , Zika Virus Infection/epidemiology , Adolescent , Adult , Age Distribution , Bayes Theorem , Child , Child, Preschool , Colombia/epidemiology , Dengue/history , Dengue/virology , Dengue Virus , Female , Geography, Medical , History, 21st Century , Humans , Infant , Infant, Newborn , Male , Middle Aged , Prevalence , Risk Assessment , Risk Factors , Young Adult , Zika Virus , Zika Virus Infection/history , Zika Virus Infection/virology
5.
Emerg Infect Dis ; 25(8): 1485-1493, 2019 08.
Article in English | MEDLINE | ID: mdl-31075077

ABSTRACT

The Zika virus outbreak in Latin America resulted in congenital malformations, called congenital Zika syndrome (CZS). For unknown reasons, CZS incidence was highest in northeastern Brazil; one potential explanation is that dengue virus (DENV)-mediated immune enhancement may promote CZS development. In contrast, our analyses of historical DENV genomic data refuted the hypothesis that unique genome signatures for northeastern Brazil explain the uneven dispersion of CZS cases. To confirm our findings, we performed serotype-specific DENV neutralization tests in a case-control framework in northeastern Brazil among 29 Zika virus-seropositive mothers of neonates with CZS and 108 Zika virus-seropositive control mothers. Neutralization titers did not differ significantly between groups. In contrast, DENV seroprevalence and median number of neutralized serotypes were significantly lower among the mothers of neonates with CZS. Supported by model analyses, our results suggest that multitypic DENV infection may protect from, rather than enhance, development of CZS.


Subject(s)
Cross Protection/immunology , Dengue Virus/immunology , Dengue/immunology , Infectious Disease Transmission, Vertical/prevention & control , Pregnancy Complications, Infectious/epidemiology , Zika Virus Infection/epidemiology , Zika Virus Infection/prevention & control , Zika Virus/immunology , Brazil/epidemiology , Dengue/epidemiology , Dengue/history , Dengue Virus/classification , Dengue Virus/genetics , Female , History, 20th Century , History, 21st Century , Humans , Infant, Newborn , Phylogeny , Pregnancy , Prevalence , Public Health Surveillance , Serogroup , Time Factors , Zika Virus Infection/history , Zika Virus Infection/transmission
6.
Rev Med Virol ; 28(1)2018 01.
Article in English | MEDLINE | ID: mdl-29210497

ABSTRACT

The first autochthonous dengue case in Rio Grande do Sul (RS), Southern Brazil, occurred in 2007. In 2008 and 2009, only imported cases were reported in RS, but from 2010 to 2013, reports of autochthonous infections increased significantly. This study analyzes and discusses laboratory, demographic, and clinical data regarding dengue cases in RS, from 2014 to 2016. This study analyzed 13,420 serum samples from notified patients with suspicion of dengue fever in RS from 2014 to 2016. Seasonality of positive cases, viral serotypes, and clinical and epidemiological aspects were analyzed. There was no difference in gender (P = .4); dengue fever occurred mainly in adults, with similar distribution among age groups. The number of dengue virus (DENV) cases increased from 89 cases in 2014 to 2518 in 2016. Dengue virus 1 was the most prevalent circulating serotype during this period (97.5% of cases). Dengue virus infections show peaks in March and April (late summer and early autumn), after periods of high temperatures and rainfall. In 2014, dengue cases were concentrated in the northwestern and eastern regions of RS, and in 2015 and 2016, the northern region also confirmed a high number of cases. With increase in DENV circulation in RS, a rise in the number of autochthonous infections was also observed, mainly in highly urbanized areas. This study revealed that circulation of DENV in RS increased significantly in 2015 and 2016, with a rise in the number of autochthonous infections and cocirculation with Chikungunya and Zika viruses, recently introduced into RS.


Subject(s)
Dengue Virus , Dengue/epidemiology , Dengue/virology , Adolescent , Adult , Aged , Brazil/epidemiology , Child , Child, Preschool , Comorbidity , Dengue/diagnosis , Dengue/history , Dengue Virus/classification , Dengue Virus/genetics , Female , Geography , History, 21st Century , Humans , Infant , Infant, Newborn , Male , Middle Aged , Population Surveillance , Serogroup , Young Adult
7.
J Infect Dis ; 217(7): 1060-1068, 2018 03 13.
Article in English | MEDLINE | ID: mdl-29294035

ABSTRACT

Epidemics of dengue, Zika, and other arboviral diseases are increasing in frequency and severity. Current efforts to rapidly identify and manage these epidemics are limited by the short diagnostic window in acute infection, the extensive serologic cross-reactivity among flaviviruses, and the lack of point-of-care diagnostic tools to detect these viral species in primary care settings. The Partnership for Dengue Control organized a workshop to review the current landscape of Flavivirus diagnostic tools, identified current gaps, and developed strategies to accelerate the adoption of promising novel technologies into national programs. The rate-limiting step to bringing new diagnostic tools to the market is access to reference materials and well-characterized clinical samples to facilitate performance evaluation. We suggest the creation of an international laboratory-response consortium for flaviviruses with a decentralized biobank of well-characterized samples to facilitate assay validation. Access to proficiency panels are needed to ensure quality control, in additional to in-country capacity building.


Subject(s)
Antibodies, Viral/blood , Dengue/diagnosis , Zika Virus Infection/diagnosis , Antibodies, Viral/immunology , Consumer Product Safety , Dengue/history , Dengue/virology , Dengue Virus/genetics , Dengue Virus/immunology , Dengue Virus/isolation & purification , Enzyme-Linked Immunosorbent Assay/history , Enzyme-Linked Immunosorbent Assay/methods , Enzyme-Linked Immunosorbent Assay/trends , History, 20th Century , History, 21st Century , Humans , Population Surveillance , Reverse Transcriptase Polymerase Chain Reaction/history , Reverse Transcriptase Polymerase Chain Reaction/methods , Reverse Transcriptase Polymerase Chain Reaction/trends , Sensitivity and Specificity , Zika Virus/genetics , Zika Virus/immunology , Zika Virus/isolation & purification , Zika Virus Infection/history , Zika Virus Infection/virology
8.
Emerg Infect Dis ; 24(3): 558-561, 2018 03.
Article in English | MEDLINE | ID: mdl-29460745

ABSTRACT

We investigated dengue and chikungunya virus antibody seroprevalence in French Polynesia during 2014-2015. Dengue virus seroprevalence was ≈60% among schoolchildren and >83% among the general population; chikungunya virus seroprevalence was <3% before and 76% after Zika virus emergence (2013). Dengue virus herd immunity may affect Zika virus infection and pathogenesis.


Subject(s)
Antibodies, Viral/immunology , Chikungunya Fever/epidemiology , Chikungunya Fever/immunology , Chikungunya virus/immunology , Dengue Virus/immunology , Dengue/epidemiology , Dengue/immunology , Adolescent , Adult , Antibodies, Neutralizing/immunology , Chikungunya Fever/history , Child , Child, Preschool , Dengue/history , History, 21st Century , Humans , Middle Aged , Neutralization Tests , Polynesia/epidemiology , Seroepidemiologic Studies , Young Adult
9.
PLoS Comput Biol ; 13(7): e1005607, 2017 Jul.
Article in English | MEDLINE | ID: mdl-28727821

ABSTRACT

Dengue is a mosquito-borne disease that threatens over half of the world's population. Despite being endemic to more than 100 countries, government-led efforts and tools for timely identification and tracking of new infections are still lacking in many affected areas. Multiple methodologies that leverage the use of Internet-based data sources have been proposed as a way to complement dengue surveillance efforts. Among these, dengue-related Google search trends have been shown to correlate with dengue activity. We extend a methodological framework, initially proposed and validated for flu surveillance, to produce near real-time estimates of dengue cases in five countries/states: Mexico, Brazil, Thailand, Singapore and Taiwan. Our result shows that our modeling framework can be used to improve the tracking of dengue activity in multiple locations around the world.


Subject(s)
Dengue , Internet , Search Engine , Asia, Southeastern , Brazil , Computational Biology , Databases, Factual , Dengue/epidemiology , Dengue/history , Dengue/transmission , History, 20th Century , History, 21st Century , Humans , Mexico , Population Surveillance
10.
Emerg Infect Dis ; 23(2): 272-275, 2017 02.
Article in English | MEDLINE | ID: mdl-28098525

ABSTRACT

During 2006-2015, we analyzed 70 dengue virus (DENV) strains isolated from febrile travelers returning to Germany. High genetic diversity, including multiple co-circulating DENV lineages and emerging new lineages of DENV-3 and DENV-4, was demonstrated. Our passive surveillance system based on returning travelers yielded substantial information on DENV diversity.


Subject(s)
Dengue Virus/classification , Dengue Virus/genetics , Dengue/epidemiology , Dengue/virology , Genetic Variation , Travel , Dengue/history , Dengue/transmission , Dengue Virus/isolation & purification , Genotype , Geography, Medical , Germany/epidemiology , History, 21st Century , Humans , Phylogeny , Public Health Surveillance , Serogroup
11.
Am J Public Health ; 107(4): 517-524, 2017 04.
Article in English | MEDLINE | ID: mdl-28207332

ABSTRACT

In 1958, the Pan American Health Organization declared that Brazil had successfully eradicated the mosquito Aedes aegypti, responsible for the transmission of yellow fever, dengue fever, chikungunya, and Zika virus. Yet in 2016 the Brazilian minister of health described the situation of dengue fever as "catastrophic." Discussing the recent epidemic of Zika virus, which amplified the crisis produced by the persistence of dengue fever, Brazil's president declared in January 2016 that "we are in the process of losing the war against the mosquito Aedes aegypti." I discuss the reasons for the failure to contain Aedes in Brazil and the consequences of this failure. A longue durée perspective favors a view of the Zika epidemic that does not present it as a health crisis to be contained with a technical solution alone but as a pathology that has the persistence of deeply entrenched structural problems and vulnerabilities.


Subject(s)
Aedes , Chikungunya Fever/history , Dengue/history , Disease Outbreaks/history , Mosquito Control/history , Yellow Fever/history , Zika Virus Infection/history , Animals , Brazil/epidemiology , Chikungunya Fever/epidemiology , Dengue/epidemiology , History, 20th Century , History, 21st Century , Humans , Mosquito Control/methods , Yellow Fever/epidemiology , Zika Virus Infection/epidemiology
12.
Rev Med Virol ; 26(3): 183-96, 2016 May.
Article in English | MEDLINE | ID: mdl-26922851

ABSTRACT

Dengue outbreaks have persistently occurred in eastern African countries for several decades. We assessed each outbreak to identify risk factors and propose a framework for prevention and impact mitigation. Seven out of ten countries in eastern Africa and three islands in the Indian Ocean have experienced dengue outbreaks between 1823 and 2014. Major risk factors associated with past dengue outbreaks include climate, virus and vector genetics and human practices. Appropriate use of dengue diagnostic tools and their interpretation are necessary for both outbreak investigations and sero-epidemiological studies. Serosurvey findings during inter-epidemic periods have not been adequately utilised to prevent re-occurrence of dengue outbreaks. Local weather variables may be used to predict dengue outbreaks, while entomological surveillance can complement other disease-mitigation efforts during outbreaks and identify risk-prone areas during inter-epidemic periods. The limitations of past dengue outbreak responses and the enormous socio-economic impacts of the disease on human health are highlighted. Its repeated occurrence in East Africa refutes previous observations that susceptibility may depend on race. Alternate hypotheses on heterotypic protection among flaviviruses may not be applied to all ecologies. Prevention and mitigation of severe dengue outbreaks should necessarily consider the diverse factors associated with their occurrence. Implementation of phased dengue mitigation activities can enforce timely and judicious use of scarce resources, promote environmental sanitation, and drive behavioural change, hygienic practices and community-based vector control. Understanding dengue epidemiology and clinical symptoms, as determined by its evolution, are significant to preventing future dengue epidemics.


Subject(s)
Dengue Virus , Dengue/epidemiology , Dengue/etiology , Disease Outbreaks , Africa, Eastern/epidemiology , Dengue/history , Dengue/prevention & control , Dengue Virus/immunology , Genetic Predisposition to Disease , History, 19th Century , History, 20th Century , History, 21st Century , Host-Pathogen Interactions/genetics , Host-Pathogen Interactions/immunology , Humans , Risk Factors , Socioeconomic Factors
13.
Emerg Infect Dis ; 22(6): 1002-7, 2016 06.
Article in English | MEDLINE | ID: mdl-27191223

ABSTRACT

During a dengue epidemic in northern Mexico, enhanced surveillance identified 53 laboratory-positive cases in southern Texas; 26 (49%) patients acquired the infection locally, and 29 (55%) were hospitalized. Of 83 patient specimens that were initially IgM negative according to ELISA performed at a commercial laboratory, 14 (17%) were dengue virus positive by real-time reverse transcription PCR performed at the Centers for Disease Control and Prevention. Dengue virus types 1 and 3 were identified, and molecular phylogenetic analysis demonstrated close identity with viruses that had recently circulated in Mexico and Central America. Of 51 household members of 22 dengue case-patients who participated in household investigations, 6 (12%) had been recently infected with a dengue virus and reported no recent travel, suggesting intrahousehold transmission. One household member reported having a recent illness consistent with dengue. This outbreak reinforces emergence of dengue in southern Texas, particularly when incidence is high in northern Mexico.


Subject(s)
Communicable Diseases, Emerging/epidemiology , Communicable Diseases, Emerging/virology , Dengue Virus/genetics , Dengue/epidemiology , Dengue/virology , Communicable Diseases, Emerging/history , Communicable Diseases, Emerging/transmission , Dengue/history , Dengue Virus/classification , Family Characteristics , Female , Genes, Viral , History, 21st Century , Humans , Male , Mexico , Phylogeny , Risk Factors , Texas/epidemiology , Travel
14.
Emerg Infect Dis ; 22(11): 2003-2005, 2016 11.
Article in English | MEDLINE | ID: mdl-27767914

ABSTRACT

We screened serum samples referred to the national reference laboratory in Guatemala that were positive for chikungunya or dengue viruses in June 2015. Co-infection with both viruses was detected by reverse transcription PCR in 46 (32%) of 144 samples. Specimens should be tested for both arboviruses to detect co-infections.


Subject(s)
Chikungunya Fever/epidemiology , Chikungunya Fever/virology , Chikungunya virus , Coinfection/epidemiology , Dengue Virus , Dengue/epidemiology , Dengue/virology , Adolescent , Adult , Aged , Chikungunya Fever/diagnosis , Chikungunya Fever/history , Chikungunya virus/classification , Chikungunya virus/genetics , Child , Child, Preschool , Dengue/diagnosis , Dengue/history , Dengue Virus/classification , Dengue Virus/genetics , Female , Guatemala/epidemiology , History, 21st Century , Humans , Infant , Infant, Newborn , Male , Middle Aged , Population Surveillance , Young Adult
15.
Bull Hist Med ; 90(2): 193-221, 2016.
Article in English | MEDLINE | ID: mdl-27374846

ABSTRACT

In the Autumn of 1780 an epidemic hit the city of Philadelphia. The symptoms of the disease resembled those of present day dengue fever, and subsequent observers argued that the disease was in fact dengue. But was it? The question forces us to confront the challenges of retrospective epidemiology and how we examine the history of a disease. This paper examines the 1780 epidemic from two perspectives. First, it looks at evidence that the disease was dengue and examines what this tells us about the epidemic and the conditions that caused it. Second, it looks at the disease from the perspective of Dr. Benjamin Rush, who treated hundreds of patients during the epidemic. In other words, it examines the disease through the lens of eighteenth century medical ideas. The paper concludes that each approach is valuable and reveals different aspects of the relationship between society and disease.


Subject(s)
Dengue/history , Epidemics/history , Yellow Fever/history , Dengue/epidemiology , Dengue/virology , History, 19th Century , Humans , Philadelphia/epidemiology , Yellow Fever/epidemiology , Yellow Fever/virology
16.
Emerg Infect Dis ; 21(4): 557-61, 2015 Apr.
Article in English | MEDLINE | ID: mdl-25816211

ABSTRACT

After an absence of ≈200 years, chikungunya returned to the American tropics in 2013. The virus is maintained in a complex African zoonotic cycle but escapes into an urban cycle at 40- to 50-year intervals, causing global pandemics. In 1823, classical chikungunya, a viral exanthem in humans, occurred on Zanzibar, and in 1827, it arrived in the Caribbean and spread to North and South America. In Zanzibar, the disease was known as kidenga pepo, Swahili for a sudden cramp-like seizure caused by an evil spirit; in Cuba, it was known as dengue, a Spanish homonym of denga. During the eighteenth century, dengue (present-day chikungunya) was distinguished from breakbone fever (present-day dengue), another febrile exanthem. In the twentieth century, experiments resulted in the recovery and naming of present-day dengue viruses. In 1952, chikungunya virus was recovered during an outbreak in Tanzania, but by then, the virus had lost its original name to present-day dengue viruses.


Subject(s)
Chikungunya Fever/epidemiology , Chikungunya virus , Communicable Diseases, Emerging , Dengue/epidemiology , Americas/epidemiology , Animals , Chikungunya Fever/history , Dengue/history , Dengue Virus , History, 19th Century , Humans , Zoonoses
17.
Infection ; 43(2): 201-6, 2015 Apr.
Article in English | MEDLINE | ID: mdl-25573274

ABSTRACT

We studied serotypes circulating dengue virus (DENV) cases, entomological Breteau index, rain-fall index and epidemiology of groups affected during the 2010 outbreak in Nuevo Leon, Mexico. From 2,271 positive cases, 94% were dengue classic and 6% dengue hemorrhagic fever; DENV1 was mainly isolated (99%) (Central-American lineage of American-African-genotype). We found correlation between two environmental phenomena (Increment of rainfall and vector-indexes) (p ≤ 0.05) with epidemiological, clinical and risk of DENV-1 ongoing transmission.


Subject(s)
Dengue Virus , Dengue/epidemiology , Dengue/virology , Disease Outbreaks , Severe Dengue/virology , Adolescent , Adult , Aged , Aged, 80 and over , Child , Child, Preschool , Dengue/history , Dengue Virus/classification , Dengue Virus/genetics , Female , Genotype , History, 21st Century , Humans , Infant , Male , Mexico/epidemiology , Middle Aged , Phylogeny , Population Surveillance , Seasons , Serogroup , Severe Dengue/epidemiology , Severe Dengue/history , Young Adult
18.
Salud Publica Mex ; 57(6): 555-67, 2015.
Article in Spanish | MEDLINE | ID: mdl-26679319

ABSTRACT

The conceptual models of the public health have bonds with the advance in the knowledge of the VBDs. The establishment of the colonial empires, the sprouting of great scale sanitary interventions, the creation of tie international organisms dedicated to the promotion of the health, the participation of phylantropic institutions financing and organizing different health campaigns are only a few contributions to the field. This body of knowledge contributed to the birth and the progress of several medical disciplines, academic institutions and international organisms dedicated to the education of human resources, research and health services; establishing the production and reproduction bases of this intellectual field. The way that VBDs have been faced has also molded great part of the ideas and the practices in Public Health and its essence has been adopted to elaborate the prevention and control programs of other many problems of health.


Subject(s)
Infectious Disease Medicine/history , Insect Vectors , Models, Theoretical , Preventive Medicine/history , Public Health/history , Animals , Chagas Disease/history , Chagas Disease/prevention & control , Dengue/history , Dengue/prevention & control , History, 16th Century , History, 17th Century , History, 18th Century , History, 19th Century , History, 20th Century , History, 21st Century , History, Ancient , History, Medieval , Humans , Malaria/history , Malaria/prevention & control , Mosquito Control/history
19.
Emerg Infect Dis ; 20(3): 456-9, 2014 Mar.
Article in English | MEDLINE | ID: mdl-24572297

ABSTRACT

An urban epidemic of dengue in Senegal during 2009 affected 196 persons and included 5 cases of dengue hemorrhagic fever and 1 fatal case of dengue shock syndrome. Dengue virus serotype 3 was identified from all patients, and Aedes aegypti mosquitoes were identified as the primary vector of the virus.


Subject(s)
Dengue Virus/classification , Dengue/epidemiology , Urban Population , Adolescent , Adult , Aged , Aged, 80 and over , Child , Child, Preschool , Dengue/history , Dengue Virus/genetics , Female , History, 21st Century , Humans , Infant , Male , Middle Aged , Phylogeny , Senegal/epidemiology , Serotyping , Severe Dengue/epidemiology , Severe Dengue/history , Young Adult
20.
Emerg Infect Dis ; 20(8): 1351-4, 2014 Aug.
Article in English | MEDLINE | ID: mdl-25061762

ABSTRACT

We investigated 400 cases of dengue-like illness in persons hospitalized during an outbreak in Al Hudaydah, Yemen, in 2012. Overall, 116 dengue and 49 chikungunya cases were diagnosed. Dengue virus type 2 was the predominant serotype. The co-circulation of these viruses indicates that mosquitoborne infections represent a public health threat in Yemen.


Subject(s)
Chikungunya Fever/epidemiology , Chikungunya Fever/virology , Chikungunya virus/genetics , Coinfection , Dengue Virus/genetics , Dengue/epidemiology , Dengue/virology , Viremia , Adolescent , Adult , Chikungunya Fever/history , Chikungunya virus/classification , Child , Child, Preschool , Dengue/history , Dengue Virus/classification , Disease Outbreaks , Geography , History, 21st Century , Humans , Incidence , Infant , Middle Aged , Molecular Sequence Data , Seroepidemiologic Studies , Serotyping , Yemen/epidemiology , Young Adult
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