1.
J Am Chem Soc
; 132(6): 1792-3, 2010 Feb 17.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20104843
RESUMEN
We have developed an efficient method for the synthesis of 2,3-disubstituted indoles from alkyne iminoethers 1 that employs a domino process involving Ag-catalyzed condensation followed by a tandem Ag-induced cycloisomerization and 1,3-alkenyl shift to Ag-activated carbon. This methodology can be useful in regioselectively constructing 3-alkylated indoles, which are part of the structures of biologically active compounds and important alkaloids.