Prevalence and risk factors of cardiovascular disease among people living with HIV in the Asia-Pacific region: a systematic review.

BACKGROUND: Cardiovascular diseases (CVD) due to atherosclerosis have become one of the major causes of death among people living with HIV (PLHIV) since effective antiretroviral therapy (ART) has been available throughout the world. However, the epidemiologic evidence of this problem from the Asia-Pacific region remains unclear. We conducted a systematic review of the situation and risk factors for CVD among PLHIV in countries with the greatest impact of CVD attributable to HIV in the Asia-Pacific region. METHODS: A systematic search in PubMed/MEDLINE, EMBASE, and the Cochrane Database of Systematic Reviews databases for articles published before 2019 was conducted. Publications reported situations and risk factors both traditional and HIV-specific for CVD among PLHIV in the region were included. Two reviewers working on duplicate and quality assessments, independently extracted data, and thematically analyzed the data. RESULTS: Among PLHIV, the prevalence of subclinical CVD ranged from 10 to 28% and the incidence rate of clinical CVD ranged from 0.37 to 1.17 /100 person-years. Clinical CVD was frequently observed in the early era of the highly active antiretroviral therapy. A higher prevalence of subclinical CVD such as abnormal cIMT and carotid plaques was frequently observed in the PLHIV rather than in the nonHIV population and a high proportion of early onset of CVD was found among young PLHIV adults. The traditional risk factors for CVD such as hypertension, diabetes and smoking behavior were prevalent in both PLHIV and nonHIV populations ranging from 5 to 45%. HIV-specific risk factor, and lower CD4 presented almost twice the significantly increased risks for CVD while the synergistic interaction among traditional risk factors, i.e., diabetes mellitus, dyslipidemia and family history steeply increased the risk for CVD among PLHIV by almost 20 times. CONCLUSION: The limited existing data suggested the risk of early CVD among PLHIV. We identified the crucial gaps in HIV/CVD work from the Asia-Pacific region and recommended longer prospective studies with larger sample sizes or meta-analyses to better capture CVD risk and interactions of crucial risk factors of this vulnerable population in this region. REGISTRATION NUMBER: INPLASY202290108 ( https://inplasy.com/inplasy-2022-9-0108/ ).

COVID-19 vaccine hesitancy among older adult Thai Muslim people: A case-control study.

The highest death toll during the COVID-19 pandemic in Thailand was among unvaccinated older adults. Deaths among older adults in Narathiwat Province were related to a lower COVID-19 vaccination rate. This study explored the factors influencing COVID-19 vaccination hesitancy in a Muslim community with low vaccination rates. A case-control study was conducted with participants assigned to the unvaccinated "case" group and the vaccinated "control" group. The sample was Thai older adults who practiced Islam and lived in Narathiwat Province. Purposive sampling was conducted by selecting a case house and finding the control around the case house in a 1:2 ratio. This study included 141 participants with a median age of 67 years (interquartile range [IQR], 8). More than 80% of both groups were retired and lived with their extended relatives. More participants in the vaccinated group believed that vaccines could prevent death from COVID-19 than in the unvaccinated group. In the multivariable analysis, factors related to the low perceived importance of the COVID-19 vaccination (odds ratio [OR] = 2.63) and a lack of vaccine recommendation from religious leaders (OR = 4.67) significantly influenced COVID-19 vaccination refusal. The COVID-19 guidance from religious leaders and the perceived importance of COVID-19 vaccination influence vaccination uptake among Muslim older adults in Thailand.

Cross-Cultural Adaptation, Reliability, and Content Validity of Thai Version of Workplace Violence in the Health Sector Country Case Study Questionnaire.

INTRODUCTION/OBJECTIVES: Workplace violence against healthcare workers has been a global problem including Thailand. However, the study has been limited partly due to lack of the standardized tool in Thai context. Therefore, this study aims to translate "Workplace Violence in the Health Sector Country Case Studies Research instruments," conducted by WHO, and to validate Thai version questionnaire. METHODS: The study was conducted to translate Workplace Violence in the Health Sector Questionnaire by WHO from English to Thai. A sample of 92 participants was accidentally selected among physicians, nurses, and health-supporting workers who took part on examined the validity and reliability of the questionnaire. The internal consistency was calculated using Cronbach's Alpha Coefficient. RESULTS: The study demonstrated that the index of item-objective congruence (IOC) of Thai version questionnaire is 0.75 to 1. Cronbach's Alpha Coefficient in Physical violence is .879, Verbal abuse is .934, Bullying/mobbing is .510, and health sector employer is .842. CONCLUSION: The Thai Version of Workplace Violence in the Health Sector Questionnaire apparently shows good validity and reliability. The questionnaire could be applied to be a useful tool for studying workplace violence in the health sector.

Access to Health Service and Social Support Related to Self-Medication.

BACKGROUND: In developing countries including Nepal, medicine is easy to purchase with or without prescription over the counter. People's self-medication practice is a leading cause of antibiotic resistance. The purpose of this study was to assess self-medication practice and its influencing factors among rural people of Nepal. METHODS: A cross-sectional survey was conducted from total 62 wards in rural Rolpa district of Nepal.The probability proportional to size was applied to select 6 wards, then 115 households from each ward was selected by applying systematic random sampling.  Data collection was done by interviewing 720 household heads age 18 to 70 years old using a structured questionnaire in Nepal Results: The proportion of regular self-medication practice was 54.6%. Among them, 96.4% practiced self-medication when they got diarrhea/dysentery and 94.2% when they got a stomach ache. The factors associated with self-medication practice included gender (OR=2.24,95%CI=0.23-0.42), age (OR=5.59,95%CI=3.68-8.47), religion(OR=0.57,95%CI=0.42-0.77), family type (OR=4.00,95%CI=2.93-5.47), average income (OR=7.31,95%CI=5.04-10.56), decision making (OR=0.6,95%CI=0.44-0.82, health insurance(OR=1.64,95%CI=1.22-2.22), overall access to health service (OR=3.53,95%CI=2.55-4.90), and appraisal support(OR=2.24, 95%CI=1.66-3.02) Conclusions: Prevalence of self-medication in rural areas of Rolpa district was high among female, older people Accessibility to health service should be improved to reduce risk of self-medication practice. The health promotion related with benefit and side effect from self-medication are important for high risk group i.e. people over 30 years .