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1.
Postgrad Med J ; 95(1120): 96-101, 2019 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-30787196

RESUMEN

Clinical rotations are an essential part of Internal Medicine (IM) residency programmes, where curricular objectives are carried out. To our knowledge, there are no validated instruments to assess IM clinical rotations. Our objective was to develop an instrument for residents to assess the quality of clinical rotations in an IM residency programme, and to test the psychometric properties of the instrument. A mixed methodology was used, including qualitative and quantitative phases. Items were proposed by a group of experts based on previously identified residency needs, followed by a quantitative phase to generate consensus among educators and residents to define which items would be included in the instrument (Delphi panel). After generating the instrument, psychometric tests were performed to assess construct validity (factor analysis) and reliability (Raykov's reliability coefficient). We obtained a 15-item instrument after two Delphi rounds: Internal Medicine Program Instrument 15-items (IMPRINT-15). Sixty-two residents answered 428 surveys using a Likert scale during 7 months (response rate 98.9%). The median score was 4.3 (IQR 3.9-4.7) (scale from 1 to 5). The factor analysis showed two domains in the clinical rotation assessment: (1) teaching and care activities; (2) evaluation and feedback. The instrument is reliable with Raykov's reliability coefficient of 0.86. Also, Raykov's reliability coefficient for the domains were 0.89 and 0.83, respectively. The IMPRINT-15 instrument is a bi-dimensional, valid and reliable questionnaire to evaluate the perceived quality by residents of the IM clinical rotations. Also, it constitutes the first validated instrument in this field worldwide.


Asunto(s)
Medicina Interna/educación , Internado y Residencia , Satisfacción en el Trabajo , Médicos/psicología , Encuestas y Cuestionarios , Adulto , Técnica Delphi , Retroalimentación , Femenino , Conocimientos, Actitudes y Práctica en Salud , Humanos , Masculino , Psicometría , Reproducibilidad de los Resultados
2.
Rev Med Chil ; 144(9): 1103-1111, 2016 Sep.
Artículo en Español | MEDLINE | ID: mdl-28060970

RESUMEN

BACKGROUND: Atrial fibrillation (AF) generates a hypercoagulable state with an increased thrombin generation and raised levels of thrombin-antithrombin complexes, which results in a high risk of stroke and thromboembolism. AIM: To evaluate the anticoagulant effect of rivaroxaban by anti-Xa factor activity and its correlation with thrombin-antithrombin complexes, thrombin generation and prothrombin time in patients newly diagnosed with non-valvular AF. PATIENTS AND METHODS: Prospective study in patients with indication of anticoagulation. Demographic variables, cardiovascular risk factors, CHA2DS2-VASc and HAS-BLED scores were recorded. Blood samples were taken at baseline, at 3 and 24 hours after the administration of the drug and at 30 days. Rivaroxaban levels, anti-Xa activity, prothrombin time, thrombin generation and plasma levels of thrombin-antithrombin complexes were determined. RESULTS: We studied 20 patients aged 76.3 ± 8.0 years (60% female) with a CHA2DS2-VASc score > 2 points. The anti-Xa factor activity correlated with rivaroxaban plasma levels at 3 hours (r = 0.61, p < 0.01), at 24 hours (r = 0.85, p < 0.01) and at 30 days (r = 0.99, p < 0.01), with prothrombin time at 3 hours (r = -0.86, p = 0.019) and at 30 days (r = -0.63, p = 0.02) and with a sustained decrease in thrombin generation at 30 days of follow-up (r = -0.74, p < 0.01). There was no correlation with thrombin-antithrombin complexes (r = -0.02, p = 0.83). CONCLUSIONS: Rivaroxaban consistently inhibited the mild pro-coagulant state found in newly diagnosed non-valvular AF patients through the first 24 hours and this effect was maintained at 30 days. Plasma levels of the drug correlated with anti-Xa factor activity, thrombin generation and prothrombin time.


Asunto(s)
Antitrombina III/efectos de los fármacos , Fibrilación Atrial/sangre , Inhibidores del Factor Xa/farmacología , Factor Xa/efectos de los fármacos , Péptido Hidrolasas/efectos de los fármacos , Rivaroxabán/farmacología , Trombina/efectos de los fármacos , Administración Oral , Anciano , Anciano de 80 o más Años , Factor Xa/metabolismo , Femenino , Humanos , Masculino , Estudios Prospectivos , Tiempo de Protrombina , Trombina/metabolismo , Factores de Tiempo
3.
Rev Med Chil ; 143(8): 1005-14, 2015 Aug.
Artículo en Español | MEDLINE | ID: mdl-26436929

RESUMEN

BACKGROUND: Feedback is one of the most important tools to improve teaching in medical education. AIM: To develop an instrument to assess the performance of clinical postgraduate teachers in medical specialties. MATERIAL AND METHODS: A qualitative methodology consisting in interviews and focus-groups followed by a quantitative methodology to generate consensus, was employed. After generating the instrument, psychometric tests were performed to assess the construct validity (factor analysis) and reliability (Cronbach’s alpha). RESULTS: Experts in medical education, teachers and residents of a medical school participated in interviews and focus groups. With this information, 26 categories (79 items) were proposed and reduced to 14 items (Likert scale 1-5) by an expert’s Delphi panel, generating the MEDUC-PG14 survey, which was answered by 123 residents from different programs of medical specialties. Construct validity was carried out. Factor analysis showed three domains: Teaching and evaluation, respectful behavior towards patients and health care team, and providing feedback. The global score was 4.46 ± 0.94 (89% of the maximum). One teachers’ strength, as evaluated by their residents was “respectful behavior” with 4.85 ± 0.42 (97% of the maximum). “Providing feedback” obtained 4.09 ± 1.0 points (81.8% of the maximum). MEDUC-PG14 survey had a Cronbach’s alpha coefficient of 0.947. CONCLUSIONS: MEDUC-PG14 survey is a useful and reliable guide for teacher evaluation in medical specialty programs. Also provides feedback to improve educational skills of postgraduate clinical teachers.


Asunto(s)
Educación Médica/normas , Docentes Médicos/normas , Proyectos de Investigación/normas , Grupos Focales , Humanos , Entrevistas como Asunto , Psicometría , Investigación Cualitativa , Reproducibilidad de los Resultados , Encuestas y Cuestionarios , Enseñanza/métodos , Enseñanza/normas
4.
Rev Med Chil ; 142(2): 229-37, 2014 Feb.
Artículo en Español | MEDLINE | ID: mdl-24953112

RESUMEN

Discharge is one of the most important processes that hospitalized patients must endure. This process is complex, requires coordination among several professionals and transfers an overwhelming amount of information to patients. Often, it is limited to the writing of the discharge summary, with a primary emphasis on the drug list. Since the rise of hospitalism in 1996, a greater emphasis has been placed on understanding this process and in developing interventions to make it more effective and safe. In our country, little is known about how this process is taking place. Probably the absence of financial penalties for readmissions has influenced in the lack of study and development of this process. In the USA the knowledge of the discharge process is well advanced, and several strategies have been developed for reducing adverse events, medication errors, and 30-days readmissions. Other interventions have increased patient satisfaction and the degree of knowledge about their conditions. The aim of this paper is to do a comprehensive review of the literature, to provide healthcare teams with various tools that could improve both the discharge process as well as the discharge summary. The final objective is to optimize the safety and satisfaction of our patients and the hospital metrics of quality.


Asunto(s)
Alta del Paciente/normas , Humanos , Errores de Medicación , Readmisión del Paciente
5.
Rev Med Chil ; 142(11): 1392-7, 2014 Nov.
Artículo en Español | MEDLINE | ID: mdl-25694284

RESUMEN

BACKGROUND: The therapeutic range (TR) of activated partial thromboplastin time (aPTT) for unfractionated heparin (UFH) dosing was established in the 1970 decade. Since then aPTT determination has changed. Current TR may be sub or supra-therapeutic depending on the reagents of the test, and therefore, responsible for complications of therapy. AIM: To establish the TR for UFH dosing in our institution using antifactor Xa analysis as reference standard. MATERIAL AND METHODS: After obtaining an informed consent, 43 blood samples were obtained for aPTT determination and antifactor Xa assay in 23 patients treated with intravenous UFH. Samples were processed at Emergency and Hemostasis Labs. We excluded patients receiving other anticoagulants, with thrombophilia, pregnancy or liver disease. RESULTS: Mean aPTT values in the Hemostasis and Emergency labs ​​were 57.1 ± 18.9 and 56.6 ± 18.3 seconds, respectively (p = 0.77). The squared correlation coefficients between aPTT and antifactor Xa at hemostasis and emergency labs were R2 0.5 and 0.45 respectively, p < 0.001. Using a linear regression analysis, therapeutic aPTT range values ​​in our laboratory were established between 50 and 80 seconds, corresponding to antifactor Xa values of 0.3 to 0.7 IU/mL. CONCLUSIONS: According to current recommendations, validation of aPTT determination with reference techniques should be done in every institution.


Asunto(s)
Anticoagulantes/administración & dosificación , Inhibidores del Factor Xa/sangre , Heparina/administración & dosificación , Tiempo de Tromboplastina Parcial/métodos , Humanos , Indicadores y Reactivos , Nomogramas , Estándares de Referencia , Valores de Referencia , Análisis de Regresión , Reproducibilidad de los Resultados , Factores de Tiempo
6.
Rev Med Chil ; 142(10): 1267-74, 2014 Oct.
Artículo en Español | MEDLINE | ID: mdl-25601111

RESUMEN

BACKGROUND: During 2009, new guidelines for the treatment of diabetic ketoacidosis were published by the American Diabetes Association. AIM: To assess the impact of new treatment guidelines on the evolution of patients treated for diabetic ketoacidosis (KAD). PATIENTS AND METHODS: Anonymous data was obtained from computational medical records of patients treated for KAD at our institution two years before ("Traditional Protocol") and TWO years after ("ADA-2009 Protocol") the publication of the 2009 American Diabetes Association (ADA) KAD guidelines. RESULTS: Twenty three patients aged 36.5 ± 15.1 years were treated with the traditional method and 23 patients aged 44.4 ± 21.1 years were treated following 2009 ADA guidelines. Among patients treated with the traditional protocol and treated following ADA 2009 guidelines, the diabetes type 1/type 2 ratio was 18/5 and 19/16 respectively (p = NS), the glycosylated hemoglobin on admission was 12.6 ± 2.5 and 14.3 ± 2.7% respectively (p = 0.03), minimal blood pH was 7.15 ± 0.14 and 7.19 ± 0.09 respectively (p = NS), bicarbonate was required in seven and no patient respectively (p = 0.01), hypokalemia < 3.5 mEq/L occurred in 78.2 and 48.5% of patients (p = 0.03), the lapse until resolution was 28.7 ± 28.0 and 28.8 ± 20.6 hours (p = NS). Only one patient, treated following ADA 2009 guidelines, died. CONCLUSIONS: Introduction of the ADA-2009 protocol for the treatment of KAD resulted in decrease in the use of intravenous bicarbonate and a reduction in the incidence of hypokalemia. There was no impact neither in the lapse until resolution or lethality.


Asunto(s)
Cetoacidosis Diabética/tratamiento farmacológico , Guías de Práctica Clínica como Asunto , Adulto , Protocolos Clínicos , Cetoacidosis Diabética/mortalidad , Femenino , Hemoglobina Glucada/análisis , Humanos , Hipoglucemiantes/uso terapéutico , Insulina/uso terapéutico , Masculino , Sociedades Médicas
7.
Rev Med Chil ; 141(4): 486-94, 2013 Apr.
Artículo en Español | MEDLINE | ID: mdl-23900370

RESUMEN

Massive pulmonary embolism (PE) is associated with high mortality. There is still a broad assortment of severity classifications for patients with PE, which affects the choice of therapies to use. The main clinical criteria for defining a PE as massive is systemic arterial hypotension, which depends on the extent of vascular obstruction and the previous cardiopulmonary status. Right ventricular dysfunction is an important pathogenic element to define the severity of patients and short term clinical prognosis. The recommended treatment is systemic thrombolysis, but in centers with experience and resources, radiological invasive therapies through catheters are useful alternatives that can be used as first choice tools in certain cases.


Asunto(s)
Embolia Pulmonar/terapia , Terapia Trombolítica/métodos , Humanos , Embolia Pulmonar/diagnóstico
8.
Rev Med Chil ; 140(11): 1482-9, 2012 Nov.
Artículo en Español | MEDLINE | ID: mdl-23677197

RESUMEN

The prognosis of pulmonary thromboembolism (PE) is related to the cardiopulmonary reserve of the patient and the magnitude of the embolus that impacts pulmonary circulation. The presence of hemodynamic instability (shock) stratifies a group of patients with high mortality, which should be treated with thrombolysis. Patients without shock but with right ventricular dysfunction can have a dismal evolution and should be managed aggressively. CAT scan, echocardiography and serum markers can be of value to define patients with a higher mortality. The available evidence to define the best diagnostic and therapeutic strategy is scanty, controversial and inconclusive. A good combination of clinical, imaging and biological markers should be defined to identify those patients without shock but with a high rate of complications and mortality, that could benefit from aggressive treatments.


Asunto(s)
Embolia Pulmonar/diagnóstico , Biomarcadores/análisis , Pruebas de Función Cardíaca , Humanos , Embolia Pulmonar/mortalidad , Embolia Pulmonar/fisiopatología , Embolia Pulmonar/terapia , Medición de Riesgo , Disfunción Ventricular Derecha/fisiopatología
9.
Rev Med Chil ; 140(1): 73-7, 2012 Jan.
Artículo en Español | MEDLINE | ID: mdl-22552558

RESUMEN

BACKGROUND: General physicians should be adequately trained to deliver effective resuscitation during ventricular fibrillation (VF). AIM: To assess the degree of knowledge, skills and practical effectiveness in cardiopulmonary resuscitation (CPR) of Chilean general physicians. MATERIALS AND METHODS: Forty eight general physicians starting Anesthesiology or Internal Medicine residency programs were evaluated. They answered a modified American Heart Association Basic Life Support Course written test and individually participated in a witnessed VF cardiac arrest simulated scenario. Execution of resuscitation tasks in the correct order, the quality of the maneuvers and the use of defibrillator were registered. RESULTS: All participants acknowledged the importance of uninterrupted CPR and early defibrillation. Seventy five percent knew the correct frequency of chest compressions, but only 6.25% knew all the effective chest compression characteristics. Ninety eight percent knew the recommended number of breaths per cycle. In practice, 58% performed effective ventilations, 33% performed uninterrupted compressions, 14% did them with adequate frequency and only 8% performed chest compressions adequately. Forty four percent requested a defibrillator within 30 seconds and 31% delivered the first defibrillation within 30 seconds of defibrillator arrival. Airway, breathing, circulation and defibrillation sequence was correctly performed by 12% of participants and 80% acknowledged that their medical training was inadequate or insufficient for managing a cardiac arrest. CONCLUSIONS: Despite an elevated degree of knowledge about key aspects of CPR, this group of Chilean physicians displayed suboptimal practical skills while performing CPR in a simulated scenario, specially delivering effective chest compressions and promptly asking for and using the defibrillator.


Asunto(s)
Reanimación Cardiopulmonar/normas , Competencia Clínica , Medicina General , Chile , Estudios Transversales , Humanos , Internado y Residencia
10.
Rev Med Chil ; 139(9): 1210-27, 2011 Sep.
Artículo en Español | MEDLINE | ID: mdl-22215403

RESUMEN

Thromboembolic disease is the main preventable cause of in-hospital death. Approximately 10% of nosocomial deaths are attributable to pulmonary embolism and in most cases, the diagnosis is not suspected before the autopsy. There are cost effective measures to decrease the incidence of thromboembolic disease. Pharmacological prophylaxis decreases the incidence of deep venous thrombosis by 65% and the incidence of pulmonary embolism by 35 to 55%. Despite this data and the presence of clinical guidelines, prophylaxis of thromboembolic disease is used only in 40% of medical patients and in 65% of surgical patients with recommended indications. We review the evidence that supports the use of thromboprophylaxis and the different strategies that may increase the compliance of physicians with its use. A protocol implemented in our institution is also proposed.


Asunto(s)
Anticoagulantes/farmacología , Anticoagulantes/uso terapéutico , Pautas de la Práctica en Medicina/estadística & datos numéricos , Embolia Pulmonar/prevención & control , Tromboembolia Venosa/prevención & control , Protocolos Clínicos , Adhesión a Directriz/estadística & datos numéricos , Hospitalización , Humanos
11.
Rev Med Chil ; 139(10): 1347-55, 2011 Oct.
Artículo en Español | MEDLINE | ID: mdl-22286737

RESUMEN

Thromboembolic disease (TED) is the leading cause of morbidity and mortality worldwide. The hallmark of oral long-term anticoagulant therapy has been the use of vitamin K antagonists, whose anticoagulant effect is exerted inhibiting vitamin K epoxide reductase. Warfarin and acenocoumarol are the most commonly used. In the last five years several new drugs for long term anticoagulation have been developed, which can inhibit single clotting factors with the purpose of improving drug therapeutic range and, ideally, minimizing bleeding risks. This review addresses the state of the art on the clinical use of inhibitors of activated factor X and thrombin.


Asunto(s)
Anticoagulantes/clasificación , Inhibidores del Factor Xa , Trombina/antagonistas & inhibidores , Vitamina K/antagonistas & inhibidores , Administración Oral , Humanos
12.
Rev Med Chil ; 139(7): 848-3; quiz 854-5, 2011 Jul.
Artículo en Español | MEDLINE | ID: mdl-22051821

RESUMEN

BACKGROUND: A tight glycemic control of hospitalized patients increases the risk of hypoglycemia, whose management is not always optimal. AIM: To assess the hypoglycemia management competences of a multidisciplinary team in a clinical hospital. MATERIAL AND METHODS: An anonymous questionnaire about hypoglycemia management was answered by 11 staff physicians, 42 residents and 28 nurses of the department of medicine and critical care unit ofa university hospital. RESULTS: Respondents had a mean of 60% of correct answers, without significant differences between groups. The capillary blood glucose level that defines hypoglycemia was known by most of the respondents, but the value that defines severe episodes was known only by 60%. The initial management and follow up was well known only for severe episodes. Less than 50%o knew the blood glucose value that required continuing with treatment. CONCLUSIONS: Although most professionals are able to recognize hypoglycemia, the knowledge about is management if insufficient.


Asunto(s)
Competencia Clínica/estadística & datos numéricos , Manejo de la Enfermedad , Hipoglucemia/diagnóstico , Cuerpo Médico de Hospitales/normas , Personal de Enfermería en Hospital/normas , Grupo de Atención al Paciente/normas , Actitud del Personal de Salud , Glucemia/análisis , Estudios Transversales , Femenino , Índice Glucémico , Hospitales Universitarios , Humanos , Hipoglucemia/terapia , Masculino , Índice de Severidad de la Enfermedad , Encuestas y Cuestionarios
13.
Medwave ; 17(Suppl2): e6935, 2017 Apr 28.
Artículo en Español, Inglés | MEDLINE | ID: mdl-28452977

RESUMEN

Some patients who have presented a thromboembolic event persist with a high risk of recurrence despite anticoagulant treatment. It has been suggested that adding an inferior vena cava filter may reduce this risk, but the clinical effects of this measure are not clear. To answer this question we searched in Epistemonikos database, which is maintained by screening multiple information sources. We identified three systematic reviews including four randomized trials answering this question. We extracted data, conducted a meta-analysis and generated a summary of findings table using the GRADE approach. We concluded there might be little or no difference on the occurrence of deep venous thrombosis by adding an inferior vena cava filter in anticoagulated patients, and it is not clear whether there are differences in the occurrence of pulmonary embolism or mortality because the certainty of evidence is very low.


A pesar del tratamiento anticoagulante, algunos pacientes que han presentado un episodio de enfermedad tromboembólica persisten con riesgo elevado de recurrencia. Se ha planteado que adicionar un filtro de vena cava inferior podría disminuir este riesgo, pero la real utilidad clínica no está clara. Para responder esta pregunta utilizamos la base de datos Epistemonikos, la cual es mantenida mediante búsquedas en múltiples fuentes de información. Identificamos tres revisiones sistemáticas que en conjunto incluyen cuatro ensayos aleatorizados que responden la pregunta. Extrajimos los datos, realizamos un metanálisis y preparamos tablas de resumen de los resultados utilizando el método GRADE. Concluimos que podría existir poca o nula diferencia en cuanto a la ocurrencia de trombosis venosa profunda al agregar un filtro de vena cava inferior en pacientes anticoagulados, y que no está claro si existen diferencias en cuanto a la ocurrencia de tromboembolismo pulmonar o mortalidad porque la certeza de la evidencia es muy baja.


Asunto(s)
Anticoagulantes/administración & dosificación , Tromboembolia/terapia , Filtros de Vena Cava , Terapia Combinada , Bases de Datos Factuales , Humanos , Embolia Pulmonar/prevención & control , Embolia Pulmonar/terapia , Ensayos Clínicos Controlados Aleatorios como Asunto , Prevención Secundaria/métodos , Tromboembolia/prevención & control , Vena Cava Inferior , Trombosis de la Vena/prevención & control , Trombosis de la Vena/terapia
14.
Medwave ; 15(3): e6118, 2015 Apr 09.
Artículo en Inglés, Español | MEDLINE | ID: mdl-25918851

RESUMEN

Idiopathic thromboembolic disease presents a high risk of recurrence. There is controversy about the effects of aspirin in reducing this risk after the completion of anticoagulant treatment. Searching in Epistemonikos database, which screens 30 databases, we identified four systematic reviews that together include two randomized trials. We combined the evidence using meta-analysis and generated a summary of findings table following the GRADE approach. We concluded that aspirin administered after having completed anticoagulation reduces the risk of recurrence, probably without importantly increasing the risk of hemorrhage.


La enfermedad tromboembólica idiopática presenta un alto riesgo de recurrencia. Existe controversia respecto a la utilidad de la aspirina para disminuir la recurrencia luego de haber completado el tratamiento anticoagulante. Utilizando la base de datos Epistemonikos, la cual es mantenida mediante búsquedas en 30 bases de datos, identificamos cuatro revisiones sistemáticas que en conjunto incluyen dos estudios aleatorizados. Combinamos la evidencia utilizando metanálisis y generamos una tabla con síntesis de resultados según la metodología GRADE. Concluimos que la indicación de aspirina luego de haber completado el tratamiento anticoagulante disminuye la probabilidad de recurrencia y probablemente no aumenta de manera importante el riesgo de hemorragia.


Asunto(s)
Aspirina/uso terapéutico , Tromboembolia/prevención & control , Anticoagulantes/uso terapéutico , Aspirina/administración & dosificación , Aspirina/efectos adversos , Hemorragia/inducido químicamente , Hemorragia/epidemiología , Humanos , Inhibidores de Agregación Plaquetaria/administración & dosificación , Inhibidores de Agregación Plaquetaria/efectos adversos , Inhibidores de Agregación Plaquetaria/uso terapéutico , Ensayos Clínicos Controlados Aleatorios como Asunto , Recurrencia , Tromboembolia/tratamiento farmacológico
15.
Medwave ; 15 Suppl 3: e6320, 2015 Nov 20.
Artículo en Inglés, Español | MEDLINE | ID: mdl-26609705

RESUMEN

The preferred dosification for low molecular weight heparins is in two doses for most patients with venous thromboembolic disease. A daily dose would make treatment simpler, less expensive and more comfortable while retaining a similar benefit and safety. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified two systematic reviews including five randomized trials. We combined the evidence using meta-analysis and generated a summary of findings table following the GRADE approach. We concluded it is not clear whether the risk of recurrence differs between the two alternatives because the certainty of the evidence is very low, and that administering low molecular weight heparin in two doses might be associated to little or no difference in the risk of major bleeding and mortality.


La heparina de bajo peso molecular administrada cada 12 horas es el tratamiento inicial de elección para muchos pacientes con enfermedad tromboembólica. Sin embargo, la administración cada 24 horas podría facilitar el manejo, disminuir costos y mejorar el confort del paciente manteniendo los mismos beneficios y seguridad. Utilizando la base de datos Epistemonikos, la cual es mantenida mediante búsquedas en 30 bases de datos, identificamos dos revisiones sistemáticas que en conjunto incluyen cinco estudios aleatorizados. Realizamos un metanálisis y tablas de resumen de los resultados utilizando el método GRADE. Concluimos que la certeza de la evidencia es muy baja para determinar si el riesgo de recurrencia es similar entre ambas opciones y que la administración en dos dosis al día podría asociarse a poca o nula disminución en el riesgo de hemorragia mayor y mortalidad.


Asunto(s)
Anticoagulantes/administración & dosificación , Heparina de Bajo-Peso-Molecular/administración & dosificación , Tromboembolia Venosa/tratamiento farmacológico , Anticoagulantes/efectos adversos , Anticoagulantes/uso terapéutico , Esquema de Medicación , Hemorragia/inducido químicamente , Heparina de Bajo-Peso-Molecular/efectos adversos , Heparina de Bajo-Peso-Molecular/uso terapéutico , Humanos , Ensayos Clínicos Controlados Aleatorios como Asunto , Recurrencia , Tromboembolia Venosa/prevención & control
16.
Rev. méd. Chile ; 144(9): 1103-1111, set. 2016. graf, tab
Artículo en Español | LILACS | ID: biblio-830618

RESUMEN

Background: Atrial fibrillation (AF) generates a hypercoagulable state with an increased thrombin generation and raised levels of thrombin-antithrombin complexes, which results in a high risk of stroke and thromboembolism. Aim: To evaluate the anticoagulant effect of rivaroxaban by anti-Xa factor activity and its correlation with thrombin-antithrombin complexes, thrombin generation and prothrombin time in patients newly diagnosed with non-valvular AF. Patients and Methods: Prospective study in patients with indication of anticoagulation. Demographic variables, cardiovascular risk factors, CHA2DS2-VASc and HAS-BLED scores were recorded. Blood samples were taken at baseline, at 3 and 24 hours after the administration of the drug and at 30 days. Rivaroxaban levels, anti-Xa activity, prothrombin time, thrombin generation and plasma levels of thrombin-antithrombin complexes were determined. Results: We studied 20 patients aged 76.3 ± 8.0 years (60% female) with a CHA2DS2-VASc score > 2 points. The anti-Xa factor activity correlated with rivaroxaban plasma levels at 3 hours (r = 0.61, p < 0.01), at 24 hours (r = 0.85, p < 0.01) and at 30 days (r = 0.99, p < 0.01), with prothrombin time at 3 hours (r = -0.86, p = 0.019) and at 30 days (r = -0.63, p = 0.02) and with a sustained decrease in thrombin generation at 30 days of follow-up (r = -0.74, p < 0.01). There was no correlation with thrombin-antithrombin complexes (r = -0.02, p = 0.83). Conclusions: Rivaroxaban consistently inhibited the mild pro-coagulant state found in newly diagnosed non-valvular AF patients through the first 24 hours and this effect was maintained at 30 days. Plasma levels of the drug correlated with anti-Xa factor activity, thrombin generation and prothrombin time


Asunto(s)
Humanos , Masculino , Femenino , Anciano , Anciano de 80 o más Años , Péptido Hidrolasas/efectos de los fármacos , Fibrilación Atrial/sangre , Trombina/efectos de los fármacos , Factor Xa/efectos de los fármacos , Antitrombina III/efectos de los fármacos , Inhibidores del Factor Xa/farmacología , Rivaroxabán/farmacología , Tiempo de Protrombina , Factores de Tiempo , Trombina/metabolismo , Factor Xa/metabolismo , Administración Oral , Estudios Prospectivos
17.
Rev Med Chil ; 138(9): 1144-7, 2010 Sep.
Artículo en Español | MEDLINE | ID: mdl-21249284

RESUMEN

Hyponatremia can be a marker of an underlying disease. We report a 52 years-old male with Diabetes Mellitus who consulted for an episode of nausea and vomiting lasting four days. His baseline serum sodium was 118 mEq/L. He had no neurological deficit. Hyponatremia was initially interpreted in context of gastrointestinal fluid loss but correction with saline solution was poor. His urine sodium was 105 mEq/L and his urine osmolality was 281 mOsm/L, so an Inappropriate Secretion of Antidiuretic Hormone Syndrome was suspected. Later, we found that the patient had a two year history of fatigue, weakness, anorexia, frequent nausea, vomiting and diarrhea, loss of libido and decreased axillary and pubic hair. Thyroid-Stimulating Hormone (TSH) was normal and serum Cortisol < 1 µg/dL. A CT scan showed a sellar mass compatible with a macroadenoma. There was also a moderately high serum prolactin and low testosterone, thyroxin and growth hormone levels. The visual fi eld exami-nation showed right temporal hemianopsia. The patient was treated with steroids with a very good clinical response and serum sodium normalization. Subsequently a transsphenoidal excision of the tumor was performed and replacement of the other hormones was started. Now the patient remains asymptomatic.


Asunto(s)
Insuficiencia Suprarrenal/complicaciones , Hiponatremia/etiología , Adenoma/diagnóstico , Neoplasias de las Glándulas Suprarrenales/diagnóstico , Insuficiencia Suprarrenal/diagnóstico , Diabetes Mellitus Tipo 2/complicaciones , Espacio Extracelular/metabolismo , Humanos , Hidrocortisona/sangre , Hiponatremia/diagnóstico , Síndrome de Secreción Inadecuada de ADH/diagnóstico , Masculino , Persona de Mediana Edad , Tirotropina/sangre
18.
Rev Med Chil ; 138(10): 1285-7, 2010 Oct.
Artículo en Español | MEDLINE | ID: mdl-21279277

RESUMEN

We report a 78 year-old diabetic woman, treated with gliburide and metformin, consulting in the emergency room for a non fuctuating impairment in consciousness. She had a history of similar episodes in the last two months. A brain CAT scan showed an old putamen lacunar infarction. Noteworthy was the presence of a low glycosilated hemoglobin level of 5.2%. Hypoglycemic medications were discontinued and the patient was discharged in good conditions. After six months of follow up, the patient did not have further episodes of impairment of consciousness.


Asunto(s)
Trastornos del Conocimiento/etiología , Hipoglucemia/complicaciones , Anciano , Diabetes Mellitus/tratamiento farmacológico , Femenino , Humanos , Hipoglucemiantes/uso terapéutico
19.
Rev. méd. Chile ; 143(8): 1005-1014, ago. 2015. ilus, graf, tab
Artículo en Español | LILACS | ID: lil-762666

RESUMEN

Background: Feedback is one of the most important tools to improve teaching in medical education. Aim: To develop an instrument to assess the performance of clinical postgraduate teachers in medical specialties. Material and Methods: A qualitative methodology consisting in interviews and focus-groups followed by a quantitative methodology to generate consensus, was employed. After generating the instrument, psychometric tests were performed to assess the construct validity (factor analysis) and reliability (Cronbach’s alpha). Results: Experts in medical education, teachers and residents of a medical school participated in interviews and focus groups. With this information, 26 categories (79 items) were proposed and reduced to 14 items (Likert scale 1-5) by an expert’s Delphi panel, generating the MEDUC-PG14 survey, which was answered by 123 residents from different programs of medical specialties. Construct validity was carried out. Factor analysis showed three domains: Teaching and evaluation, respectful behavior towards patients and health care team, and providing feedback. The global score was 4.46 ± 0.94 (89% of the maximum). One teachers’ strength, as evaluated by their residents was “respectful behavior” with 4.85 ± 0.42 (97% of the maximum). “Providing feedback” obtained 4.09 ± 1.0 points (81.8% of the maximum). MEDUC-PG14 survey had a Cronbach’s alpha coefficient of 0.947. Conclusions: MEDUC-PG14 survey is a useful and reliable guide for teacher evaluation in medical specialty programs. Also provides feedback to improve educational skills of postgraduate clinical teachers.


Asunto(s)
Humanos , Educación Médica/normas , Docentes Médicos/normas , Proyectos de Investigación/normas , Grupos Focales , Entrevistas como Asunto , Psicometría , Investigación Cualitativa , Reproducibilidad de los Resultados , Encuestas y Cuestionarios , Enseñanza/métodos , Enseñanza/normas
20.
Rev Med Chil ; 137(10): 1385-7, 2009 Oct.
Artículo en Español | MEDLINE | ID: mdl-20011948

RESUMEN

Hospital medicine was created over 10 years ago aiming to provide an integral care to hospitalized patients. Hospital specialists are physicians mainly devoted to the global care of hospitalized patients. Their professional functions include patient care, teaching, clinical research and managing activities. The main difference with other specialties is their exclusive dedication to hospital work. The impact of this specialty on patient care has been demonstrated by a significant reduction in the hospitalization days and costs and higher level of patient satisfaction. In clinical hospitals, the presence of tutors during the complete working day, has resulted in better pre and postgraduate teaching activities and a higher availability of supervisors for trainees. Four years ago, hospital medicine was established as a discipline at the Clinical Hospital of Pontificia Universidad Católica de Chile. In this period, these specialists became essential for student training and an integral part of the faculty staff.


Asunto(s)
Médicos Hospitalarios/educación , Chile , Humanos
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