Adalimumab-induced central nervous system demyelination in a patient with rheumatoid arthritis.

Adalimumab (Humira) is a human monoclonal antibody that belongs to the tumor necrosis factor (TNF) alpha antagonist class of medications. Central Nervous System (CNS) demyelination is a rare side effect of adalimumab, and only a few cases have been reported in the literature of patients who developed multiple sclerosis or other demyelinating patterns after using adalimumab. In this report, we present a case of CNS demyelination in a patient with rheumatoid arthritis that developed a few months after using adalimumab. Performing brain MRI for asymptomatic individuals prior to initiating anti-TNF alpha agents to exclude a pre-existing demyelinating disease may be worthwhile. Routine brain MRI for monitoring and surveillance may facilitate detecting cases early and avoid the development of permanent neurological disability. Further studies are needed to clarify the neurological safety of anti-TNF alpha agents.

Retraction: Celiac Artery Compression Syndrome: A Rare Cause of Abdominal Angina.

[This retracts the article DOI: 10.7759/cureus.20011.].

Cerebral Radiation-Induced Vasculopathy Mimicking Primary Central Nervous System Vasculitis.

Cranial irradiation is one of the main treatment modalities for tumors of the CNS. However, it can lead to significant damage to the treated region. Among the late complications of radiation therapy to the brain is vasculopathy of the small and/or large arteries. In this article, we report a case of CNS radiation-induced vasculopathy presenting 30 years after cranial irradiation and mimicking primary CNS vasculitis. The present case illustrates the importance of monitoring and carefully evaluating delayed side effects of radiotherapy as well as emphasizes the importance of obtaining a detailed history of any patient presenting with sudden unexplained symptoms. If a complete proper history of the patient's past medical diagnoses and procedures was taken, medical professionals would not have needed to conduct extensive investigations and implement treatment plans for a less likely diagnosis, in this case, aggressive treatment of a possible primary CNS vasculitis with high-dose steroids. Therefore, it is imperative to raise the possibility of radiation-induced vasculopathy after excluding all possible causes of deterioration in patients with a history of cranial radiation therapy.

Celiac Artery Compression Syndrome: A Rare Cause of Abdominal Angina.

Abdominal angina refers to an abdominal pain that develops shortly after food intake and gradually resolves after a few hours. It is related to insufficient mesenteric blood flow to meet the intestinal demand. In the majority of cases, this syndrome is caused by atherosclerotic narrowing of the mesenteric vessels. We report the case of a 61-year-old man, with a longstanding history of hypertension, diabetes mellitus, and dyslipidemia, who presented to the emergency department with acute abdominal pain that was aggravated by food intake. The patient reported similar but milder episodes of this pain for the last three years that led him to lose significant weight because of fear of eating. Despite this classic history of abdominal angina, his condition was misdiagnosed as indigestion, and was offered symptomatic treatment only. The basic laboratory findings were within the normal limits. The patient underwent a contrast-enhanced abdominal computed tomography scan in the arterial phase which demonstrated focal proximal stenosis of the celiac trunk due to thickened median arcuate ligament. Subsequently, the median arcuate ligament was resected laparoscopically to decompress the celiac artery. The surgical operation resulted in the complete resolution of the abdominal pain. Celiac artery compression syndrome is a rare etiology of abdominal angina. Computed tomography angiography is the imaging study of choice to make the diagnosis accurately. Laparoscopic resection of the median arcuate ligament is a safe and successful approach in the management.