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1.
Combination of (M)DSC and surface analysis to study the phase behaviour and drug distribution of ternary solid dispersions.
Pharm Res
; 32(4): 1407-16, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25319105
2.
Surface characteristics of spray-dried microspheres consisting of PLGA and PVP: relating the influence of heat and humidity to the thermal characteristics of these polymers.
Mol Pharm
; 10(8): 3213-24, 2013 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-23844639
3.
Design and synthesis of HIV-1 protease inhibitors for a long-acting injectable drug application.
Bioorg Med Chem Lett
; 23(1): 310-7, 2013 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23177258
4.
TMC647055, a potent nonnucleoside hepatitis C virus NS5B polymerase inhibitor with cross-genotypic coverage.
Antimicrob Agents Chemother
; 56(9): 4676-84, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22710121
5.
Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055.
Bioorg Med Chem Lett
; 22(13): 4437-43, 2012 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22633687
6.
Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series.
Bioorg Med Chem Lett
; 22(13): 4431-6, 2012 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22542193
7.
1,5-Benzodiazepine inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett
; 19(9): 2492-6, 2009 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19342234
8.
Development of a Stable Respiratory Syncytial Virus Pre-Fusion Protein Powder Suitable for a Core-Shell Implant with a Delayed Release in Mice: A Proof of Concept Study.
Pharmaceutics
; 11(10)2019 Oct 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31623333
9.
Ovalbumin-containing core-shell implants suitable to obtain a delayed IgG1 antibody response in support of a biphasic pulsatile release profile in mice.
PLoS One
; 13(8): e0202961, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30161264
10.
The mechanism behind the biphasic pulsatile drug release from physically mixed poly(dl-lactic(-co-glycolic) acid)-based compacts.
Int J Pharm
; 551(1-2): 195-202, 2018 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30223077
11.
2,4-Diaminoquinazolines as Dual Toll-like Receptor (TLR) 7/8 Modulators for the Treatment of Hepatitis B Virus.
J Med Chem
; 61(14): 6236-6246, 2018 07 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-29965759
12.
Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic properties.
Angew Chem Int Ed Engl
; 51(19): 4637-40, 2012 May 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-22473861
13.
Sustained release of the candidate antiretroviral peptides T-1249 and JNJ54310516-AFP from a rod insert vaginal ring.
Drug Deliv Transl Res
; 6(3): 234-42, 2016 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-26787615
14.
Design and optimization of tricyclic phtalimide analogues as novel inhibitors of HIV-1 integrase.
J Med Chem
; 48(6): 1930-40, 2005 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-15771437
15.
Influence of formulation composition and process on the characteristics and in vitro release from PLGA-based sustained release injectables.
Eur J Pharm Biopharm
; 90: 22-9, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25448071
16.
The influence of spray-drying parameters on phase behavior, drug distribution, and in vitro release of injectable microspheres for sustained release.
J Pharm Sci
; 104(4): 1451-60, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25648704
17.
In vivo evaluation of different formulation strategies for sustained release injectables of a poorly soluble HIV protease inhibitor.
J Control Release
; 199: 1-9, 2015 Feb 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-25485732
18.
Discovery and early development of TMC647055, a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase.
J Med Chem
; 57(5): 1880-92, 2014 Mar 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-24144360
19.
Nanoscale surface characterization and miscibility study of a spray-dried injectable polymeric matrix consisting of poly(lactic-co-glycolic acid) and polyvinylpyrrolidone.
J Pharm Sci
; 101(9): 3473-85, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22447580
20.
Humanized mice recapitulate key features of HIV-1 infection: a novel concept using long-acting anti-retroviral drugs for treating HIV-1.
PLoS One
; 7(6): e38853, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22719966