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1.
Exploration of pyrrole derivatives to find an effective potassium-competitive acid blocker with moderately long-lasting suppression of gastric acid secretion.
Bioorg Med Chem
; 25(13): 3447-3460, 2017 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28483454
2.
Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action.
Bioorg Med Chem
; 25(13): 3298-3314, 2017 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28442261
3.
Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK).
Bioorg Med Chem Lett
; 26(24): 5947-5950, 2016 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27839918
4.
Synthetic studies of five-membered heteroaromatic derivatives as potassium-competitive acid blockers (P-CABs).
Bioorg Med Chem Lett
; 25(10): 2037-40, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25891103
5.
Molecular modeling, design, synthesis, and biological activity of 1H-pyrrolo[2,3-c]pyridine-7-amine derivatives as potassium-competitive acid blockers.
Chem Pharm Bull (Tokyo)
; 62(4): 336-42, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24695343
6.
Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers.
Bioorg Med Chem
; 20(12): 3925-38, 2012 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22579619
7.
1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases.
J Pharmacol Exp Ther
; 335(1): 231-8, 2010 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-20624992
8.
Bombesin receptor subtype-3-expressing neurons regulate energy homeostasis through a novel neuronal pathway in the hypothalamus.
Brain Behav
; 8(1): e00881, 2018 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29568682
9.
A Selective Bombesin Receptor Subtype 3 Agonist Promotes Weight Loss in Male Diet-Induced-Obese Rats With Circadian Rhythm Change.
Endocrinology
; 158(5): 1298-1313, 2017 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28324017
10.
Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent.
J Med Chem
; 48(19): 5966-79, 2005 Sep 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-16162000
11.
Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB).
J Med Chem
; 55(9): 4446-56, 2012 May 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-22512618
12.
Synthesis and biological activities of 4-phenyl-5-pyridyl-1,3-thiazole derivatives as selective adenosine A3 antagonists.
Chem Pharm Bull (Tokyo)
; 56(8): 1126-37, 2008 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-18670113
13.
Synthesis and biological activities of 4-phenyl-5-pyridyl-1,3-thiazole derivatives as p38 MAP kinase inhibitors.
Chem Pharm Bull (Tokyo)
; 53(4): 410-8, 2005 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-15802841
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