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1.

The PI3K Pathway in Human Disease.

Fruman, David A; Chiu, Honyin; Hopkins, Benjamin D; Bagrodia, Shubha; Cantley, Lewis C; Abraham, Robert T.

Cell ; 170(4): 605-635, 2017 Aug 10.

Artículo en Inglés | MEDLINE | ID: mdl-28802037

2.

Leveraging model-based study designs and serial micro-sampling techniques to understand the oral pharmacokinetics of the potent LTB4 inhibitor, CP-105696, for mouse pharmacology studies.

Spilker, Mary E; Chung, Heekyung; Visswanathan, Ravi; Bagrodia, Shubha; Gernhardt, Steven; Fantin, Valeria R; Ellies, Lesley G.

Xenobiotica ; 47(7): 600-606, 2017 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-27435693

3.

Structure-based design, SAR analysis and antitumor activity of PI3K/mTOR dual inhibitors from 4-methylpyridopyrimidinone series.

Cheng, Hengmiao; Hoffman, Jacqui E; Le, Phuong T; Pairish, Mason; Kania, Robert; Farrell, William; Bagrodia, Shubha; Yuan, Jing; Sun, Shaoxian; Zhang, Eric; Xiang, Cathy; Dalvie, Deepak; Rahavendran, Sadayappan V.

Bioorg Med Chem Lett ; 23(9): 2787-92, 2013 May 01.

Artículo en Inglés | MEDLINE | ID: mdl-23506825

4.

Structural modifications of a 3-methoxy-2-aminopyridine compound to reduce potential for mutagenicity and time-dependent drug-drug interaction.

Palmer, Cynthia; Pairish, Mason; Kephart, Susan; Bouzida, Djamal; Cui, Jingrong; Deal, Judith; Dong, Liming; Gu, Danlin; Linton, Angelica; McAlpine, Indrawan; Yamazaki, Shinji; Smith, Evan; John-Baptiste, Annette; Bagrodia, Shubha; Kania, Robert; Guo, Chuangxing.

Bioorg Med Chem Lett ; 22(24): 7605-9, 2012 Dec 15.

Artículo en Inglés | MEDLINE | ID: mdl-23116892

5.

Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kα and mTOR.

Le, Phuong T; Cheng, Hengmiao; Ninkovic, Sacha; Plewe, Michael; Huang, Xiaojun; Wang, Hai; Bagrodia, Shubha; Sun, Shaoxian; Knighton, Daniel R; LaFleur Rogers, Caroline M; Pannifer, Andrew; Greasley, Samantha; Dalvie, Deepak; Zhang, Eric.

Bioorg Med Chem Lett ; 22(15): 5098-103, 2012 Aug 01.

Artículo en Inglés | MEDLINE | ID: mdl-22749419

6.

PARP1-SNAI2 transcription axis drives resistance to PARP inhibitor, Talazoparib.

Ding, Xia; Zhu, Zhou; Lapek, John; McMillan, Elizabeth A; Zhang, Alexander; Chung, Chi-Yeh; Dubbury, Sara; Lapira, Jennifer; Firdaus, Sarah; Kang, Xiaolin; Gao, Jingjin; Oyer, Jon; Chionis, John; Rollins, Robert A; Li, Lianjie; Niessen, Sherry; Bagrodia, Shubha; Zhang, Lianglin; VanArsdale, Todd.

Sci Rep ; 12(1): 12501, 2022 07 21.

Artículo en Inglés | MEDLINE | ID: mdl-35864202

7.

Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors.

Liu, Kevin K C; Huang, Xiaojun; Bagrodia, Shubha; Chen, Jeffrey H; Greasley, Samantha; Cheng, Hengmiao; Sun, Shaoxian; Knighton, Dan; Rodgers, Caroline; Rafidi, Kristina; Zou, Aihua; Xiao, Jiezhan; Yan, Shengyong.

Bioorg Med Chem Lett ; 21(4): 1270-4, 2011 Feb 15.

Artículo en Inglés | MEDLINE | ID: mdl-21269826

8.

Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195).

Cheng, Hengmiao; Orr, Suvi T M; Bailey, Simon; Brooun, Alexei; Chen, Ping; Deal, Judith G; Deng, Yali L; Edwards, Martin P; Gallego, Gary M; Grodsky, Neil; Huang, Buwen; Jalaie, Mehran; Kaiser, Stephen; Kania, Robert S; Kephart, Susan E; Lafontaine, Jennifer; Ornelas, Martha A; Pairish, Mason; Planken, Simon; Shen, Hong; Sutton, Scott; Zehnder, Luke; Almaden, Chau D; Bagrodia, Shubha; Falk, Matthew D; Gukasyan, Hovhannes J; Ho, Caroline; Kang, Xiaolin; Kosa, Rachel E; Liu, Ling; Spilker, Mary E; Timofeevski, Sergei; Visswanathan, Ravi; Wang, Zhenxiong; Meng, Fanxiu; Ren, Shijian; Shao, Li; Xu, Feng; Kath, John C.

J Med Chem ; 64(1): 644-661, 2021 01 14.

Artículo en Inglés | MEDLINE | ID: mdl-33356246

9.

4-methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors.

Liu, Kevin K-C; Bagrodia, Shubha; Bailey, Simon; Cheng, Hengmiao; Chen, Hui; Gao, Lisa; Greasley, Samantha; Hoffman, Jacqui E; Hu, Qiyue; Johnson, Ted O; Knighton, Dan; Liu, Zhengyu; Marx, Matthew A; Nambu, Mitchell D; Ninkovic, Sacha; Pascual, Bernadette; Rafidi, Kristina; Rodgers, Caroline M-L; Smith, Graham L; Sun, Shaoxian; Wang, Haitao; Yang, Anle; Yuan, Jing; Zou, Aihua.

Bioorg Med Chem Lett ; 20(20): 6096-9, 2010 Oct 15.

Artículo en Inglés | MEDLINE | ID: mdl-20817449

10.

The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins.

Flanders, James A; Feng, Qiyu; Bagrodia, Shubha; Laux, Maria T; Singavarapu, Avinash; Cerione, Richard A.

FEBS Lett ; 550(1-3): 119-23, 2003 Aug 28.

Artículo en Inglés | MEDLINE | ID: mdl-12935897

11.

Antitumor Efficacy of the Dual PI3K/mTOR Inhibitor PF-04691502 in a Human Xenograft Tumor Model Derived from Colorectal Cancer Stem Cells Harboring a PIK3CA Mutation.

Fang, Douglas D; Zhang, Cathy C; Gu, Yin; Jani, Jitesh P; Cao, Joan; Tsaparikos, Konstantinos; Yuan, Jing; Thiel, Melissa; Jackson-Fisher, Amy; Zong, Qing; Lappin, Patrick B; Hayashi, Tomoko; Schwab, Richard B; Wong, Anthony; John-Baptiste, Annette; Bagrodia, Shubha; Los, Geritt; Bender, Steve; Christensen, James; Vanarsdale, Todd.

PLoS One ; 8(6): e67258, 2013.

Artículo en Inglés | MEDLINE | ID: mdl-23826249

12.

Mechanisms of intrinsic and acquired resistance to kinase-targeted therapies.

Bagrodia, Shubha; Smeal, Tod; Abraham, Robert T.

Pigment Cell Melanoma Res ; 25(6): 819-31, 2012 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-22883054

13.

A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through [corrected] MAPK activation.

Lee, Nathan V; Lira, Maruja E; Pavlicek, Adam; Ye, Jingjing; Buckman, Dana; Bagrodia, Shubha; Srinivasa, Sreesha P; Zhao, Yongjun; Aparicio, Samuel; Rejto, Paul A; Christensen, James G; Ching, Keith A.

PLoS One ; 7(6): e39653, 2012.

Artículo en Inglés | MEDLINE | ID: mdl-22745804

14.

Epithelial tissue hyperplasia induced by the RAF inhibitor PF-04880594 is attenuated by a clinically well-tolerated dose of the MEK inhibitor PD-0325901.

Torti, Vince R; Wojciechowicz, Donald; Hu, Wenyue; John-Baptiste, Annette; Evering, Winston; Troche, Gabriel; Marroquin, Lisa D; Smeal, Tod; Yamazaki, Shinji; Palmer, Cynthia L; Burns-Naas, Leigh Ann; Bagrodia, Shubha.

Mol Cancer Ther ; 11(10): 2274-83, 2012 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-22752429

15.

PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity.

Yuan, Jing; Mehta, Pramod P; Yin, Min-Jean; Sun, Shaoxian; Zou, Aihua; Chen, Jeffrey; Rafidi, Kristina; Feng, Zheng; Nickel, Jeffrey; Engebretsen, Jon; Hallin, Jill; Blasina, Alessandra; Zhang, Eric; Nguyen, Leslie; Sun, Minghao; Vogt, Peter K; McHarg, Aileen; Cheng, Hengmiao; Christensen, James G; Kan, Julie L C; Bagrodia, Shubha.

Mol Cancer Ther ; 10(11): 2189-99, 2011 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-21750219

16.

Src and Wnt converge to seal cell's fate.

Taylor, Steve; Bagrodia, Shubha.

Mol Cell ; 10(1): 10-1, 2002 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-12150902

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