1.
Chemistry
; 23(9): 2225-2230, 2017 Feb 10.
Artículo
en Inglés
| MEDLINE
| ID: mdl-27935197
RESUMEN
Medium-sized rings are widely considered to be under-represented in biological screening libraries for lead identification in medicinal chemistry. To help address this, a library of medium-sized lactams has been generated by using a simple, scalable and versatile ring-expansion protocol. Analysis of the library by using open-access computational tool LLAMA suggested that these lactams and their derivatives have highly promising physicochemical and 3D spatial properties and thus have much potential in drug discovery.