RESUMEN
The tumoricidal effect of hyperthermia was studied in Greene's amelanotic hamster melanoma transplanted into the anterior chamber of rabbit eyes. To achieve optimal depth penetration, hyperthermia was induced with near infrared light of 820-870 nm, during 15 minutes, at a beam diameter of 2.5-6.0 mm resulting in an intermediate level hyperthermia of 45-60 degrees C. At 45 degrees C no tumor destruction occurred, at 50 degrees C the effect varied from no destruction to total thickness tumor destruction. At 55-60 degrees C total tumor destruction with additional lens damage occurred. In comparison photocoagulation with white light revealed only necrosis up to half the tumor thickness.
Asunto(s)
Neoplasias del Ojo/terapia , Hipertermia Inducida , Rayos Infrarrojos/uso terapéutico , Melanoma Experimental/terapia , Animales , Segmento Anterior del Ojo/patología , Neoplasias del Ojo/patología , Rayos Infrarrojos/efectos adversos , Enfermedades del Cristalino/etiología , Enfermedades del Cristalino/patología , Fotocoagulación , Melanoma Experimental/patología , Necrosis , Trasplante de Neoplasias , Conejos , TemperaturaAsunto(s)
Bacterioclorofilas/farmacología , Clorofila/análogos & derivados , Luz , Fármacos Sensibilizantes a Radiaciones , Supervivencia Celular/efectos de los fármacos , Derivado de la Hematoporfirina , Hematoporfirinas/farmacología , Concentración de Iones de Hidrógeno , Oxidación-Reducción , EspectrofotometríaRESUMEN
The transmission of the cornea for light in the wavelength range 450-1000 nm was measured in steps of 50 nm by means of a photodiode implanted into the anterior chamber of whole human donor eyes. In the range from 450 nm up to 600 nm the percentage transmission was found to increase with wavelength from 80% up to 94%. In the range from 60 nm up to 1000 nm the percentage transmission was between 95% and 98%. The corneal transmission for donors younger than 45 yr (n = 3, 22-43 yr) did not differ significantly from that of donors older than 45 yr (n = 5, 67-87 yr) at any wavelength.