Adoptive T cell therapy: An overview of obstacles and opportunities.

The therapeutic potential of adoptive cell therapy (ACT) in cancer patients was first acknowledged 3 decades ago, but it was an esoteric approach at the time. In recent years, technological advancements have transformed ACT into a viable therapeutic option that can be curative in some patients. In fact, current ACT response rates are 80% to 90% for hematological malignancies and 30% for metastatic melanoma refractory to multiple lines of therapy. Although these results are encouraging, there is still much to be done to fulfill ACT's potential, specifically with regard to improving clinical efficacy, expanding clinical indications, reducing toxicity, and increasing production and cost-effectiveness. This review addresses the current major obstacles to ACT and presents potential solutions. Cancer 2017;123:2154-62. © 2017 American Cancer Society.

Combined penetrating keratoplasty and implantation of iris prosthesis intraocular lenses after ocular trauma.

PURPOSE: To report the outcomes of implantation of intraocular lenses (IOLs) with a prosthetic iris to correct traumatic iris deficiency. SETTING: Department of Ophthalmology, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada. DESIGN: Case series. METHODS: The medical records of consecutive patients who had had implantation of an Ophtec or Morcher IOL combined with corneal transplantation were retrospectively reviewed. Preoperative data collected included demographics, etiology of the iris deficiency, previous surgeries, preoperative eye pathology, and visual acuity. Operative data and postoperative outcomes included visual acuity, subjective perception of glare and photophobia, and postoperative complications. RESULTS: The records of 11 patients were reviewed. The corrected distance visual acuity improved from 2.39 logMAR ± 0.53 (SD) preoperatively to 1.50 ± 1.11 logMAR postoperatively (P=.0037). Four (36.4%) of 9 patients reported an improvement in glare sensation; 5 (45.5%) reported no change in glare (P=.99). Postoperative complications included 2 graft rejection episodes in 2 patients during the first year after surgery, 1 case of increased inflammation that required removal of the IOL, and 2 cases of new-onset glaucoma. At the last follow-up visit, the centration and positioning of the IOLs were excellent. There were no cases of IOL dislocation, macular edema, or retinal detachment. CONCLUSIONS: Implantation IOLs with a prosthetic iris in traumatic aniridia improved visual acuity significantly in most patients and reduced photophobia and glare symptoms in many cases. Graft rejection, glaucoma, and postoperative inflammation are possible complications. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.