RESUMEN
As animals develop, tissue bending contributes to shape the organs into complex three-dimensional structures. However, the architecture and packing of curved epithelia remains largely unknown. Here we show by means of mathematical modelling that cells in bent epithelia can undergo intercalations along the apico-basal axis. This phenomenon forces cells to have different neighbours in their basal and apical surfaces. As a consequence, epithelial cells adopt a novel shape that we term "scutoid". The detailed analysis of diverse tissues confirms that generation of apico-basal intercalations between cells is a common feature during morphogenesis. Using biophysical arguments, we propose that scutoids make possible the minimization of the tissue energy and stabilize three-dimensional packing. Hence, we conclude that scutoids are one of nature's solutions to achieve epithelial bending. Our findings pave the way to understand the three-dimensional organization of epithelial organs.
Asunto(s)
Forma de la Célula , Células Epiteliales/citología , Epitelio/embriología , Epitelio/fisiología , Modelos Biológicos , Animales , Fenómenos Biofísicos , Biología Computacional , Drosophila , Femenino , Morfogénesis , Glándulas Salivales/citología , Pez CebraRESUMEN
The original version of this Article contained an error in ref. 39, which incorrectly cited 'Fristrom, D. & Fristrom, J. W. in The Development of Drosophila melanogaster (eds. Bate, M. & Martinez-Arias, A.) II, (Cold spring harbor laboratory press, 1993)'. The correct reference is 'Condic, M.L, Fristrom, D. & Fristrom, J.W. Apical cell shape changes during Drosophila imaginal leg disc elongation: a novel morphogenetic mechanism. Development 111: 23-33 (1991)'. Furthermore, the last sentence of the fourth paragraph of the introduction incorrectly omitted citation of work by Rupprecht et al. The correct citation is given below. These errors have now been corrected in both the PDF and HTML versions of the Article. Rupprecht, J.F., Ong, K.H., Yin, J., Huang, A., Dinh, H.H., Singh, A.P., Zhang, S., Yu, W. & Saunders, T.E. Geometric constraints alter cell arrangements within curved epithelial tissues. Mol. Biol. Cell 28, 3582-3594 (2017).