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Plastic recycling reduces the wastage of potentially useful materials as well as the consumption of virgin materials, thereby lowering the energy consumption, air pollution by incineration, soil and water pollution by landfilling. Plastics used in the biomedical sector have played a significant role. Reducing the transmission of the virus while protecting the human life in particular the frontline workers. Enormous volumes of plastics in biomedical waste have been observed during the outbreak of the pandemic COVID-19. This has resulted from the extensive use of personal protective equipment such as masks, gloves, face shields, bottles, sanitizers, gowns, and other medical plastics which has created challenges to the existing waste management system in the developing countries. The current review focuses on the biomedical waste and its classification, disinfection, and recycling technology of different types of plastics waste generated in the sector and their corresponding approaches toward end-of-life option and value addition. This review provides a broader overview of the process to reduce the volume of plastics from biomedical waste directly entering the landfill while providing a knowledge step toward the conversion of "waste" to "wealth." An average of 25% of the recyclable plastics are present in biomedical waste. All the processes discussed in this article accounts for cleaner techniques and a sustainable approach to the treatment of biomedical waste.
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BACKGROUND: An unprecedented rise in the number of COVID-19-associated mucormycosis (CAM) cases has been reported in India. Myriad hypotheses are proposed for the outbreak. We recently reported uncontrolled diabetes and inappropriate steroid therapy as significant risk factors for the outbreak. However, Mucorales contamination of hospital environment was not studied. AIM: To perform a multi-centre study across India to determine possible Mucorales contamination of hospital environment during the outbreak. METHODS: Eleven hospitals from four zones of India representing high to low incidence for mucormycosis cases were included in the study. Samples from a variety of equipment used by the patients and ambient air were collected during May 19th, 2021 through August 25th, 2021. FINDINGS: None of the hospital equipment sampled was contaminated with Mucorales. However, Mucorales were isolated from 11.1% air-conditioning vents and 1.7% of patients' used masks. Other fungi were isolated from 18% of hospital equipment and surfaces, and 8.1% of used masks. Mucorales grew from 21.7% indoor and 53.8% outdoor air samples. Spore counts of Mucorales in air were significantly higher in the hospitals of North and South zones compared to West and East zones (P < 0.0001). Among Mucorales isolated from the environment, Rhizopus spp. were the most frequent genus. CONCLUSION: Contamination of air-conditioning vents and hospital air by Mucorales was found. Presence of Mucorales in these areas demands regular surveillance and improvement of hospital environment, as contamination may contribute to healthcare-associated mucormycosis outbreaks, especially among immunocompromised patients.
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COVID-19 , Mucorales , Mucormicosis , Brotes de Enfermedades , Hospitales , Humanos , India/epidemiología , Mucormicosis/epidemiologíaRESUMEN
INTRODUCTION: In India, due to manpower constraints, patients' family members are often actively involved in healthcare activities of their near and dear ones. They have significant contact with the patient at all World Health Organization (WHO) 'five moments for hand hygiene'. This study analysed the impact of decade-long awareness campaigns on the hand hygiene compliance (HHC) by our patients' carers. METHODS: Trained infection control nurses observed the HHC at each of the five moments for patients' attendants in different hospital settings from January 2014 to December 2018. Compliance was calculated as percentage of events divided by total opportunities. FINDINGS: A total of 7302 opportunities were observed with an overall compliance of 46.1% (35.5% in 2014 to 48.2% in 2018, P < 0.0001). Compliance at WHO moments 1, 2, 3, 4, and 5 was 51.0%, 47.4%, 67.6%, 48.8%, and 24.3% respectively. Among family members, mothers of newborns had a much higher HHC (77%) than others (44.5%) (P < 0.0001). Also, the compliance was higher in medical versus surgical wards and in paediatric wards versus adult wards (P < 0.0001 in both). CONCLUSION: This is the first study on family members' HHC in a hospital setting in a low- and middle-income country. The study shows that family members, once trained, exhibit fairly good HHC while caring for their patients, especially mothers of newborns. It is worthwhile empowering and educating patient attendants about the importance and process of hand hygiene as it is likely to result in immense benefit for patients.
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Adhesión a Directriz/estadística & datos numéricos , Higiene de las Manos/estadística & datos numéricos , Visitas a Pacientes/estadística & datos numéricos , Infección Hospitalaria/prevención & control , Familia , Educación en Salud , Personal de Salud , Hospitales , Humanos , IndiaRESUMEN
The H1N1 influenza infection usually coincides with the typical scrub typhus season in North India. This leads to diagnostic difficulties due to their similar and non-specific symptoms. We describe three patients with confirmed co-infection of pandemic (H1N1) influenza and scrub typhus who had presented with acute respiratory distress syndrome. A systematic review of database yielded one case of scrub typhus and H1N1 influenza co-infection reported from South Korea. Co-infection of influenza with tropical infections may not be uncommon in endemic countries and hence a high index of suspicion on the part of physicians coupled with appropriate investigations are needed. The true burden of co-infections needs to be evaluated during outbreaks of influenza in a systematic manner.
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Coinfección/diagnóstico , Gripe Humana/diagnóstico , Tifus por Ácaros/diagnóstico , Adulto , Femenino , Humanos , Subtipo H1N1 del Virus de la Influenza A/aislamiento & purificación , Gripe Humana/microbiología , Masculino , Persona de Mediana Edad , República de Corea , Síndrome de Dificultad Respiratoria/etiología , Tifus por Ácaros/virología , Adulto JovenRESUMEN
Bevacizumab, a recombinant humanized monoclonal antibody to inhibit tumour angiogenesis, is available for off-label use for treating choroidal neovascularization. Outbreaks have been reported after use of this drug, either because of contamination during manufacturing or the practice of multiple doses being administered from a single vial to different patients. In our institute we investigated one endophthalmitis outbreak following intravitreal injection of bevacizumab, rapidly identified the Stenotrophomonas maltophilia as the causative agent, and established the contaminated bevacizumab vial as the source using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-TOF-MS) typing. The study emphasizes the need for early diagnosis of the source and pathogen for appropriate control measures.
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Brotes de Enfermedades , Contaminación de Medicamentos , Endoftalmitis/epidemiología , Infecciones por Bacterias Gramnegativas/epidemiología , Inyecciones Intravítreas/efectos adversos , Espectrometría de Masa por Láser de Matriz Asistida de Ionización Desorción/métodos , Stenotrophomonas maltophilia/aislamiento & purificación , Técnicas Bacteriológicas/métodos , Bevacizumab/administración & dosificación , Estudios de Cohortes , Endoftalmitis/microbiología , Infecciones por Bacterias Gramnegativas/microbiología , Humanos , Factores Inmunológicos/metabolismo , Stenotrophomonas maltophilia/químicaRESUMEN
BACKGROUND: Multidrug-resistant Candida auris infection has been reported from five continents in recent years. The prevalence of C. auris invasive infection has been estimated at 5.3% for intensive-care-acquired candidaemia in India. The transmission of the organism between the patients and from environment to patients is rapid. AIM: To understand the intra-hospital dynamics of C. auris transmission and to determine the possible interventions to prevent its spread. METHODS: Surveillance of intensive care units was carried out to assess patient colonization, environmental contamination and hand carriage of the yeast among healthcare workers. Interventions including chlorhexidine washing of patients and decontamination of environmental surfaces with stabilized hydrogen peroxide disinfectant (Ecoshield) were undertaken. We further evaluated the effectiveness of frequently used disinfectants in the hospital against C. auris on various inanimate surfaces, and its persistence on hospital fabrics. FINDINGS: Three cases of C. auris bloodstream infection were detected over a period of three months. Many patients admitted at the same time, in the same area, were colonized by C. auris. Surveillance detected C. auris contamination of environmental surfaces and hands of healthcare workers. Interventions such as chlorhexidine washing and appropriate use of disinfectants could eradicate C. auris from patients and hospital environment. CONCLUSION: The frequently used disinfectants in our hospital and current hand hygiene practices were efficient against C. auris if proper contact time and procedures were followed. Evaluation of possible persistence of C. auris on dry fabrics showed that they can persist for up to seven days.
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Candida/aislamiento & purificación , Candidiasis Invasiva/epidemiología , Infección Hospitalaria/epidemiología , Brotes de Enfermedades , Transmisión de Enfermedad Infecciosa/prevención & control , Control de Infecciones/métodos , Anciano , Candidiasis Invasiva/microbiología , Candidiasis Invasiva/transmisión , Infección Hospitalaria/microbiología , Infección Hospitalaria/transmisión , Desinfectantes/administración & dosificación , Microbiología Ambiental , Femenino , Estudios de Seguimiento , Mano/microbiología , Humanos , India , Masculino , Persona de Mediana Edad , Adulto JovenRESUMEN
The threat posed by increased transmission of drug-resistant pathogens within healthcare settings and from healthcare settings to the community is very real and alarming. Although the developed world has taken strong steps to curb this menace, there has been little pressure on developing countries to take any corrective action. If the reporting of alarming rates of healthcare-associated infections (HCAIs) from hospitals in India and many other developing countries was made mandatory, it would help to force stakeholders (e.g. healthcare workers, legislators, administrators and policy makers in hospitals) to acknowledge and tackle the problem. This would introduce quality control in a long neglected area of health care, and enable patient empowerment which is practically non-existent in India. Healthcare institutions should commit towards enforcing 'zero tolerance' towards lapses in prevention of HCAIs. Public pressure would force the Indian Government to acknowledge the problem, and to allocate more funds to improve resources and infrastructure; this could substantially elevate the standard of health care given to the average Indian. Despite the numerous challenges, overall public benchmarking of HCAIs is a commendable goal that would go a long way towards tackling this menace in developing countries such as India.
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Infección Hospitalaria/epidemiología , Infección Hospitalaria/prevención & control , Notificación Obligatoria/ética , Benchmarking/normas , Adaptabilidad , Países Desarrollados , Países en Desarrollo , Personal de Salud , Hospitales/ética , Humanos , India , Control de Infecciones/legislación & jurisprudencia , Legislación Hospitalaria/normasRESUMEN
BACKGROUND: Isolation of free-living amoebae (FLA) is reported sparsely from water taps, ventilators, air conditioners, haemodialysis units and dental irrigation systems of hospitals worldwide. Their prevalence in hospital environment especially in wards having immunocompromised patients may pose a risk to this group of susceptible population as they may cause disease themselves or may carry pathogens inside them. No study from India has performed such surveillance. OBJECTIVE: To evaluate extent of FLA contamination in water sources of bone marrow transplant (BMT) intensive care unit (ICU), transplant ICU, haemodialysis unit and high dependency unit in a tertiary care hospital in India. MATERIALS AND METHODS: A total of hundred samples including fifty each of tap water samples and swabs from mouth of taps used for drinking, bathing and hand washing purposes in these units were collected according to standard procedure. Samples were inoculated onto non-nutrient agar plates at room temperature followed by morphological confirmation. Molecular identification including polymerase chain reaction (PCR) and sequencing was performed in culture positive samples. RESULTS: Four tap water samples and ten swab samples showed growth of trophozoites and cyst formation. Morphologically, four amoebae resembled Acanthamoeba spp. which was further confirmed by PCR and sequencing showed them to be of T3 and T4 genotypes. CONCLUSION: The presence of these FLA in hospital water sources emphasises the urgent need of implementing effective preventive measures. Further studies are required to estimate the true prevalence of FLA in Indian hospitals by taking larger number of samples.
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Acanthamoeba/aislamiento & purificación , Departamentos de Hospitales , Agua/parasitología , Humanos , India , Técnicas Microbiológicas , Parasitología/métodos , Reacción en Cadena de la Polimerasa , Análisis de Secuencia de ADN , Centros de Atención TerciariaRESUMEN
BACKGROUND: There is a huge need to develop molecular typing methods which are simple to perform, rapid and cost effective to confirm clonality of nosocomial isolates in outbreak situations. OBJECTIVES: The aim of the study was to investigate a hospital outbreak of multi-drug resistant (MDR) Klebsiellapneumoniae septicemia in a paediatric surgery intensive care unit (PSICU) using a repetitive extragenic palindromic polymerase chain reaction (REP-PCR). MATERIALS AND METHODS: MDR Klebsiella pneumoniae isolates from an outbreak of nosocomial sepsis were typed byREP-PCR using consensus primers. Isolates from different intensive care units (ICUs) but with similar antibiogram were also genotyped for comparison. RESULTS AND CONCLUSION: A cluster of twelve MDR K Pneumoniae septicemia cases was identiï¬ed at the PSICU by genotyping using REP-PCR. Surveillance cultures failed to pick up any source of infection. REP-PCR was found to be a rapid and simple tool for investigation outbreaks in hospitals. Due to early detection we could initiate infection control practices with focus on hand washing and prevent the further transmission of the organism.
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Infecciones Bacterianas/diagnóstico , Infección Hospitalaria/diagnóstico , Brotes de Enfermedades , Farmacorresistencia Bacteriana Múltiple , Klebsiella pneumoniae/aislamiento & purificación , Tipificación Molecular/métodos , Reacción en Cadena de la Polimerasa/métodos , Infecciones Bacterianas/epidemiología , Infecciones Bacterianas/microbiología , Análisis por Conglomerados , Infección Hospitalaria/epidemiología , Infección Hospitalaria/microbiología , Genotipo , Humanos , India/epidemiología , Lactante , Recién Nacido , Klebsiella pneumoniae/efectos de los fármacos , Klebsiella pneumoniae/genética , Masculino , Epidemiología Molecular/métodos , Estudios Retrospectivos , Centros de Atención Terciaria , Factores de TiempoRESUMEN
Few hospitals in India perform regular surveillance for healthcare-associated infections (HAIs) and use of indwelling devices and antimicrobials. The aim of this study was to conduct two one-day point prevalence surveys of HAIs and use of indwelling devices and antimicrobials in a large 1800-bed tertiary care hospital in India. The overall prevalence of HAIs was 7%, and surgical site infections were the most common (33%). Indwelling devices were present in 497 (27%) patients, and 915 (50%) patients were receiving antimicrobials. This study helped to generate robust baseline data on the prevalence of HAIs and use of indwelling devices and antimicrobials in the study hospital.
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Antiinfecciosos/uso terapéutico , Catéteres de Permanencia , Infección Hospitalaria/epidemiología , Utilización de Medicamentos , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , India/epidemiología , Masculino , Persona de Mediana Edad , Prevalencia , Centros de Atención Terciaria , Adulto JovenRESUMEN
Overcrowding and patient overload in emergency services areas often mean that inadequate attention is paid to thorough cleaning, disinfection of rooms and air-conditioning ducts, which would require closing the area concerned. Over a period of time, this leads to accumulation of lint, fibre, dust and fungal growth. This study assessed the effectiveness of hydrogen peroxide fog to decontaminate the air-conditioning ducts as well as for room disinfection without having to close down the area. The Postgraduate Institute of Medical Education and Research emergency complex, Chandigarh, is distributed over three floors housing nine air-handling units (AHUs) and seven wards. The work was carried out over a period of seven days and involved cleaning of air-conditioning ducts and wards, cleaning and disinfection of fittings and furniture, vacuuming and fogging of AHU, ducts and room air. Fogging was done with 20% Ecoshield fog, a complex formulation of stabilised hydrogen peroxide 11% w/v with 0.015% w/v silver nitrate. Pre- and post-fogging samples were taken for microbiological culture, and air samples were also collected. Hydrogen peroxide fogging was highly effective for disinfection of room air, furniture and other articles. It decontaminated the air-conditioning ducts effectively, was rapid and cheaper than formalin, and no adverse effects were noted. There was minimum disturbance to the patients and the treated areas were ready to be populated again after 5-6h. Hydrogen peroxide has the advantage of being safer, less irritating, and has shorter cycle times compared with formalin fumigation which is more commonly practised in India.
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Aerosoles/farmacología , Aire Acondicionado , Desinfectantes/farmacología , Desinfección/métodos , Microbiología Ambiental , Peróxido de Hidrógeno/farmacología , Descontaminación/métodos , Servicio de Urgencia en Hospital , Investigación sobre Servicios de Salud , Humanos , India , Nitrato de Plata/farmacologíaAsunto(s)
Antiinfecciosos Locales , Desinfección/métodos , Contaminación de Equipos/prevención & control , Servicio de Limpieza en Hospital/métodos , Peróxido de Hidrógeno , Control de Infecciones/métodos , Aire Acondicionado , Infección Hospitalaria/microbiología , Infección Hospitalaria/prevención & control , Aglomeración , Contaminación de Equipos/estadística & datos numéricos , Humanos , Resistencia a la Meticilina , Derivación y Consulta , Infecciones Estafilocócicas/microbiología , Infecciones Estafilocócicas/prevención & control , Staphylococcus aureusRESUMEN
Three cases of external ophthalmomyiasis are reported here. The larvae were identified to be Oestrus ovis in two cases and Cochliomyia hominivorax in one. Two of the patients were immunocompetent while one was undergoing treatment for squamous cell carcinoma of eyelid. In the latter myiasis led to complete destruction of the eye.