Asunto(s)
Antígenos CD13/metabolismo , Hipoxia/metabolismo , Leucemia Mieloide Aguda/metabolismo , Infiltración Leucémica/metabolismo , Pulmón/patología , Insuficiencia Respiratoria/metabolismo , Enfermedad Aguda , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Citometría de Flujo , Humanos , Hipoxia/etiología , Leucemia Mieloide Aguda/complicaciones , Infiltración Leucémica/complicaciones , Masculino , Persona de Mediana Edad , Insuficiencia Respiratoria/etiología , Adulto JovenRESUMEN
Dural extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a rare entity without an associated recurrent genetic abnormality. Only one case has been described in a woman with history of breast carcinoma without a known genetic predisposition. Here, we report a case of a 56-year-old woman heterozygous for XRCC2 mutation with a history of Graves' disease and bilateral breast carcinomas, who was found to have a diffusely infiltrative extra-axial mass in the high parietal convexity with infiltration into the adjacent superior sagittal sinus. The morphologic, immunophenotypic, and molecular findings were diagnostic of MALT lymphoma. Staging bone marrow demonstrated involvement by the neoplasm. Although the study was limited to only the clinically significant laboratory evaluation, it may serve as an important addition to the current knowledge of the pathogenic potential of a loss of function mutation in this rarely reported cancer predisposition gene.