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1.
South Med J ; 110(4): 257-264, 2017 04.
Artículo en Inglés | MEDLINE | ID: mdl-28376522

RESUMEN

OBJECTIVE: To evaluate associations between changing energy prices and US hospital patient outcomes. METHODS: Generalized estimating equations were used to analyze relationships between changes in energy prices and subsequent changes in hospital patient outcomes measures for the years 2008 through 2014. Patient outcomes measures included 30-day acute myocardial infarction, heart failure, and pneumonia mortality rates, and 30-day acute myocardial infarction, heart failure, and pneumonia readmission rates. Energy price data included state average distillate fuel, electricity and natural gas prices, and the US average coal price. All of the price data were converted to 2014 dollars using Consumer Price Index multipliers. RESULTS: There was a significant positive association between changes in coal price and both short-term (P = 0.029) and long-term (P = 0.017) changes in the 30-day heart failure mortality rate. There was a similar significant positive association between changes in coal price and both short-term (P <0.001) and long-term (P = 0.002) changes in the 30-day pneumonia mortality rate. Changes in coal prices also were positively associated with long-term changes in the 30-day myocardial infarction readmission rate (P < 0.001). Changes in coal prices (P = 0.20), natural gas prices (P = 0.040), and electricity prices (P = 0.040) were positively associated with long-term changes in the 30-day heart failure readmission rate. CONCLUSIONS: Changing energy prices are associated with subsequent changes in hospital mortality and readmission measures. In light of these data, we encourage hospital, health system, and health policy leaders to pursue patient-support initiatives, energy conservation programs, and reimbursement policy strategies aimed at mitigating those effects.


Asunto(s)
Comercio , Fuentes Generadoras de Energía/economía , Hospitales/normas , Carbón Mineral/economía , Comercio/economía , Electricidad , Insuficiencia Cardíaca/mortalidad , Mortalidad Hospitalaria , Hospitales/estadística & datos numéricos , Humanos , Estudios Longitudinales , Gas Natural/economía , Evaluación del Resultado de la Atención al Paciente , Readmisión del Paciente/estadística & datos numéricos , Neumonía/mortalidad , Estudios Retrospectivos , Estados Unidos/epidemiología
2.
Int J Nurs Pract ; 20(1): 8-16, 2014 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-24580970

RESUMEN

This prospective cross-sectional study investigated Australian women's (n = 104) decision satisfaction with cancer treatment decision for early breast cancer as well as their psychological distress 3-4 months following surgery. Women's satisfaction was surveyed using the Treatment Decision Satisfaction Questionnaire, and the Brief Symptom Inventory-18 was used to measure psychological distress. Women who were living alone, who worked as professionals and who were not involved in the decision-making process by their doctors were less likely to be satisfied with their decision process, outcome and their overall treatment decision. Following treatment, 26.0% of women were distressed; 18.3% experienced anxiety; 19.2% somatization; and 27.9% depression. Women who experienced somatization were more likely to be dissatisfied with the treatment decision (P = 0.003) as were those who reported psychological distress (P = 0.020). Women who were involved in choosing their treatment were more satisfied with their decision. Many women experienced distress following breast cancer treatment and might have required referral for psychological assessment, management and long-term support. Women who experienced distress were more likely to be dissatisfied with the treatment decision (or vice versa).


Asunto(s)
Neoplasias de la Mama/psicología , Técnicas de Apoyo para la Decisión , Rol de la Enfermera , Satisfacción del Paciente , Estrés Psicológico , Anciano , Neoplasias de la Mama/enfermería , Neoplasias de la Mama/terapia , Femenino , Humanos , Persona de Mediana Edad
3.
Collegian ; 21(1): 43-51, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-24772989

RESUMEN

AIMS: To investigate whether self care behaviours, medical outcomes and quality of life of Taiwanese elderly with Type 2 diabetes mellitus (DM) can be improved by delivery of an educational health care package. BACKGROUND: DM is a major health problem in developed and developing countries, with older adults constituting about half of the diabetic population. Type 2 DM is the most rapidly increasing chronic disease in Taiwan. METHODS: During 2005 and 2006, Taiwanese elderly with Type 2 DM (n = 500) were randomly allocated to either an intervention or control group. Data collection using validated instruments occurred at baseline and 6 months follow-up. Main outcome measures were blood glucose levels and diabetic complications. RESULTS: At baseline, 88.4% participants in the control and 78.8% in the experimental group had a blood glucose level above normal range (p = 0.076); respective results at 6 months were 92.4% for the control group and 60.4% for the experimental group (p < 0.001). The multivariate adjusted result showed that the intervention group was 11.1 times less likely to have blood glucose levels above normal (p = 0.002) at 6 months follow-up compared to the control group. Occurrence of complications was significantly fewer in the intervention group at baseline and at 6 month follow-up compared to the control group (baseline: 42.0% versus 82.1%, p = 0.003; 6 month follow-up: 48.4% versus 87.0%; p = 0.006). CONCLUSION: Although overall occurrence of complications remained unchanged, the educational health care package specifically developed for Taiwanese elderly with Type 2 DM improved blood glucose levels.


Asunto(s)
Automonitorización de la Glucosa Sanguínea , Glucemia/análisis , Complicaciones de la Diabetes/terapia , Diabetes Mellitus Tipo 2/tratamiento farmacológico , Hipoglucemiantes/uso terapéutico , Educación del Paciente como Asunto , Autocuidado , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Cumplimiento de la Medicación , Persona de Mediana Edad , Calidad de Vida , Reproducibilidad de los Resultados , Taiwán , Resultado del Tratamiento
4.
Ergonomics ; 56(9): 1474-85, 2013.
Artículo en Inglés | MEDLINE | ID: mdl-23875624

RESUMEN

Currently, there is little information to guide consumers, retailers and health professionals about the length of time it takes for the cervical spine to stabilise when resting on a pillow. The aim of this study was to determine the time required to achieve stabilisation of the cervical spine when supported by a polyester pillow and innerspring mattress in side lying. Twenty-four asymptomatic females rested in a standardised side lying position during the capture of 3D data from markers placed over cervical landmarks. Time to stabilisation was assessed for each axis, each landmark and globally for each participant. A large variation in global stabilisation times was identified between participants; however, 70.8% of participants had stabilised by 15 min or earlier. Fifteen minutes is the best estimate of the time to stabilisation of the cervical spine for young females in a side lying position when resting on a polyester pillow. PRACTITIONER SUMMARY: This study aimed to determine the time required to achieve stabilisation of the cervical spine when supported by a polyester pillow and innerspring mattress in side lying. Through a laboratory study using 3D VICON® motion analysis technology, we identified that 70.8% of participants had stabilised by 15 min.


Asunto(s)
Ropa de Cama y Ropa Blanca , Vértebras Cervicales/fisiología , Equilibrio Postural , Adolescente , Adulto , Femenino , Humanos , Imagenología Tridimensional , Postura , Factores de Tiempo , Adulto Joven
5.
Contemp Nurse ; 46(1): 123-34, 2013 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-24716770

RESUMEN

Indigenous nurses have the potential to improve access to health services for Indigenous people by ensuring that services are culturally safe and respectful of Indigenous peoples' needs. Therefore, developing a well-educated Indigenous nursing workforce is one way to improve the poor health outcomes of Indigenous Australians. A mixed methods study was undertaken to determine the current rates of enrollment, progression and completion of Indigenous nursing students in Australia and to explore student and staff perceptions of barriers to completion and strategies for success. The results indicate that the national average completion rates are 36.3% for Indigenous nursing students and 64.6% for non-Indigenous nursing students - an average difference of 28.3%. Indigenous nursing students and academics identified barriers to completion, which were similar to those identified in previous research. Success strategies, however, revealed the importance of individual student characteristics; academics' knowledge, awareness, and understanding; relationships, connections, and partnerships; institutional structures, systems, and processes; and, family and community knowledge, awareness, and understanding. This paper offers an overview of the integration and interpretation process that makes up the final phase of a mixed methods study.


Asunto(s)
Educación en Enfermería/organización & administración , Nativos de Hawái y Otras Islas del Pacífico , Estudiantes de Enfermería , Australia , Educación en Enfermería/métodos , Humanos
6.
Cancers (Basel) ; 15(6)2023 Mar 14.
Artículo en Inglés | MEDLINE | ID: mdl-36980647

RESUMEN

Numerous pigmented moles are associated with sun exposure and melanomarisk. This cluster randomized controlled trial aimed to determine if sun-protective clothing could prevent a significant proportion of the moles developing in young children (ACTRN12617000621314; Australian New Zealand Clinical Trials Registry. Twenty-five childcare centers in Townsville (19.25° S), Australia, were matched on shade provision and socioeconomic status. One center from each pair was randomized to the intervention arm and the other to the control arm. Children at 13 intervention centers wore study garments and legionnaire hats at childcare and received sun-protective swimwear and hats for home use, while children at the 12 control centers did not. The 1-35-month-old children (334 intervention; 210 control) were examined for moles at baseline (1999-2002) and were re-examined annually for up to 4 years. Both groups were similar at baseline. Children at intervention centers acquired fewer new moles overall (median 12.5 versus 16, p = 0.02; 0.46 versus 0.68 moles/month, p = 0.001) and fewer new moles on clothing-protected skin (6 vs. 8; p = 0.021 adjusted for confounding and cluster sampling) than controls. Intervention children had 24.3% fewer new moles overall (26.5 versus 35) and 31.6% (13 versus 19) fewer moles on clothing-protected skin than controls after 3.5 years. Sunlight's influence on nevogenesis is mitigated when children regularly wear UPF 30-50+ clothing covering half their body, implying that increased clothing cover reduces melanoma risk. Sun-protective clothing standards should mandate reporting of the percentage of garment coverage for childrenswear.

7.
Am J Public Health ; 102(12): e76-82, 2012 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-23078475

RESUMEN

OBJECTIVES: We reviewed the English-language literature on the energy burden and environmental impact of health services. METHODS: We searched all years of the PubMed, CINAHL, and ScienceDirect databases for publications reporting energy consumption, greenhouse gas emissions, or the environmental impact of health-related activities. We extracted and tabulated data to enable cross-comparisons among different activities and services; where possible, we calculated per patient or per event emissions. RESULTS: We identified 38 relevant publications. Per patient or per event, health-related energy consumption and greenhouse gas emissions are quite modest; in the aggregate, however, they are considerable. In England and the United States, health-related emissions account for 3% and 8% of total national emissions, respectively. CONCLUSIONS: Although reducing health-related energy consumption and emissions alone will not resolve all of the problems of energy scarcity and climate change, it could make a meaningful contribution.


Asunto(s)
Fuentes Generadoras de Energía/estadística & datos numéricos , Ambiente , Servicios de Salud/estadística & datos numéricos , Cambio Climático/estadística & datos numéricos , Inglaterra , Efecto Invernadero/estadística & datos numéricos , Instituciones de Salud/estadística & datos numéricos , Humanos , Procedimientos Quirúrgicos Operativos/estadística & datos numéricos , Estados Unidos , Abastecimiento de Agua/estadística & datos numéricos
8.
J Am Acad Dermatol ; 66(1): 37-45, 2012 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-21700361

RESUMEN

BACKGROUND: Knowledge about the risk for recurrence and secondary cutaneous melanoma (CM) is an important basis for patient counseling and planning of follow-up examinations. OBJECTIVES: This study aimed to analyze stage- and time-dependent hazard rates (HR) and discusses current surveillance recommendations. METHODS: Follow-up data of 33,384 patients with incident CM in stages I to III (American Joint Committee on Cancer 2002) were recorded by the German Central Malignant Melanoma Registry in 1976 through 2007. Survival was based on Kaplan-Meier estimates and HRs were calculated. RESULTS: Recurrences were recorded in 4999 patients (stage I, 7.1%; stage II, 32.8%; and stage III, 51.0%). Ten-year recurrence-free survival was 78.9% (95% confidence interval 73.1-90.5); in stage I, 89.0%; stage II, 56.9%; and stage III, 36.0%. Whereas HR for recurrent CM showed a constantly low level less than or equal to 1:125 per year for stage IA, clearly higher HRs of greater than or equal to 1:40 were recorded in stage IB for the first 3 years and generally in stages II to III. Of all patients 2.3% developed secondary melanomas, with a consistently low HR of less than 1:220 per year. LIMITATIONS: As German recommendations discontinued regular follow-up examinations after 10 years, no information can be given beyond this time point. Follow-up data of longer than 5 years were available in 41.4% of patients. CONCLUSION: For patients at stage IA with thin melanoma and low HR for recurrent CM the need for surveillance remains questionable. For patients with higher HR greater than 1:40 per year, intensified surveillance strategies should be taken into account.


Asunto(s)
Melanoma/secundario , Recurrencia Local de Neoplasia/patología , Modelos de Riesgos Proporcionales , Neoplasias Cutáneas/patología , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Melanoma/diagnóstico , Melanoma/patología , Persona de Mediana Edad , Recurrencia Local de Neoplasia/diagnóstico , Factores de Riesgo , Neoplasias Cutáneas/diagnóstico
9.
Arch Phys Med Rehabil ; 93(3): 413-9, 2012 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-22277242

RESUMEN

OBJECTIVE: To track changes in quality of life and function for people with spinal cord injury (SCI) along the lifespan. DESIGN: A wave panel design in which data were collected annually over 5 years across 6 strata that represented different periods since injury. SETTING: Telephone interviews with participants in their home environment. PARTICIPANTS: People (n=270) who had sustained a traumatic SCI in Queensland, Australia, over the previous 60 years. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Quality of life was measured using the World Health Organization Quality of Life-8. Human functioning was measured in 3 components. Body structure/function was measured using the Secondary Conditions Surveillance Instrument. Activity was measured using the motor subscale of the FIM (mFIM) and the Clinical Outcomes Variables Scale. Participation was measured using the Community Integration Measure (CIM) and the Impact on Participation and Autonomy questionnaire. RESULTS: Quality of life remained relatively constant across the lifespan. For body structure/function, there was a significant increase in secondary conditions with time since injury. There was a significant decrease in activity as measured by the mFIM for higher functioning individuals. Participation, as measured by the CIM, showed a significant increase with time since injury, but not when adjusted for the American Spinal Injury Association Impairment Scale, income level, and living situation. CONCLUSIONS: The findings of this study highlight that people with SCI are able to maintain quality of life and participation along the lifespan; however, increases in secondary conditions and a decline in function over time are likely. Rehabilitation services could work more effectively at addressing secondary prevention through enhanced monitoring over time, while broader societal responses are likely to hold the key to optimizing human functioning.


Asunto(s)
Longevidad , Calidad de Vida/psicología , Traumatismos de la Médula Espinal/fisiopatología , Traumatismos de la Médula Espinal/psicología , Adulto , Femenino , Estado de Salud , Humanos , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Limitación de la Movilidad , Queensland , Traumatismos de la Médula Espinal/epidemiología , Factores de Tiempo
10.
Dis Colon Rectum ; 54(5): 535-44, 2011 May.
Artículo en Inglés | MEDLINE | ID: mdl-21471753

RESUMEN

BACKGROUND: Limited information is available on predictors of postoperative mortality, morbidity, and long-term survival in patients with stage IV colorectal cancer. OBJECTIVE: This study aimed to identify independent predictors of postoperative mortality and morbidity as well as independent predictors of long-term survival. DESIGN: This study was planned as a retrospective single-institution review. SETTING: This study took place at the Department of Surgery, The Royal Brisbane and Women's Hospital, Australia, between 1984 and 2004. PARTICIPANTS: Prospectively collected data were extracted from the records of 1867 patients undergoing treatment for colorectal cancer. The outcomes for 379 patients undergoing surgical resection of their primary colon or rectal tumor in the presence of unresectable synchronous metastases were analyzed. MAIN OUTCOME MEASURES: Independent predictive factors for postoperative mortality and morbidity as well as long-term survival were assessed by use of logistic regression and Cox regression analysis. RESULTS: Thirty-five (9.2%) patients died in the postoperative period and morbidity was 48.3%. Median survival was 11 months. Thirty-day postoperative mortality was independently associated with medical complications (P < .001), emergency operations (P = .001), female sex (P = .002), and age (≥ 70; P = .007) on regression analysis. Elderly (≥ 70) patients with either advanced local disease or extrahepatic metastases were at a particularly high risk. Preoperative predictors of surgical morbidity included male sex (P = .028) and advanced local disease (P = .036). Preoperative predictors of medical complications included repeat operations (P < .001), elevated urea levels (P = .017), and emergency operations (P = .003). Independent factors associated with poor overall survival included medical complications (P < .001), nodal stage (N2) (P = .004), poor tumor differentiation (P = .006), and apical lymph node involvement (P = .042). A subgroup of patients with advanced nodal disease (N2) and a poor tumor differentiation had a significantly poorer prognosis. LIMITATIONS: This study was limited by its retrospective nature. CONCLUSION: Elderly patients with advanced local disease or extrahepatic metastases are at high risk of 30-day postoperative mortality. Significant nodal disease and poor tumor differentiation are important predictors of long-term survival.


Asunto(s)
Colectomía , Neoplasias Colorrectales/epidemiología , Cuidados Paliativos/métodos , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Neoplasias Colorrectales/patología , Neoplasias Colorrectales/cirugía , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Morbilidad/tendencias , Estadificación de Neoplasias , Periodo Posoperatorio , Pronóstico , Estudios Prospectivos , Queensland/epidemiología , Tasa de Supervivencia/tendencias , Factores de Tiempo , Adulto Joven
11.
World J Surg ; 35(1): 186-95, 2011 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-20972678

RESUMEN

BACKGROUND: Anastomotic leakage is associated with high mortality, high reoperation rate, and increased hospital length of stay. Although many studies have examined the risk factors for anastomotic leak, large prospective series that report on long-term survival rates are lacking. METHODS: Data of 1576 patients who underwent primary resection and anastomosis for colorectal adenocarcinoma at a single institution from 1984 to 2004 were prospectively collected. Anastomotic leaks (LEK) were classified as radiological (RAD), local (LOC), or generalised (GEN). Logistic regression analysis of 21 variables was undertaken. Overall survival, cancer-related survival, and disease-free survival were analysed using the Kaplan-Meier method. RESULTS: Mean age of the patients was 67 years (SD = 12.5) and 834 (52.9%) were male. An LEK was more likely when relatively major gynaecological (tubo-oophorectomy, P = 0.004; hysterectomy, P = 0.006) or urological (total cystectomy, P = 0.014) procedures were performed during the same operative session. Other significant factors were anterior resection (P < 0.001), anastomosis using an intraluminal stapling device (P = 0.005), abdominal drain via laparoscopic port (P = 0.024), postoperative blood transfusion (P < 0.001), primary cancer site at the rectum (P = 0.016), and TNM stage of T2 or higher (P = 0.026). Having an LEK showed significant impact on overall (P = 0.021), cancer-related (P = 0.006), and disease-free (P = 0.001) survival. CONCLUSION: In this prospective study, advanced tumour stage, distal site, and need for postoperative blood transfusion were associated with increased rates of anastomotic leakage. In addition to their high risk of immediate postoperative morbidity and mortality, both localized and generalized leaks had similarly negative impacts on overall, cancer-related, and disease-free survival.


Asunto(s)
Fuga Anastomótica/epidemiología , Neoplasias Colorrectales/cirugía , Cirugía Colorrectal/métodos , Anciano , Fuga Anastomótica/cirugía , Distribución de Chi-Cuadrado , Femenino , Humanos , Tiempo de Internación/estadística & datos numéricos , Modelos Logísticos , Masculino , Persona de Mediana Edad , Pronóstico , Estudios Prospectivos , Reoperación , Factores de Riesgo , Tasa de Supervivencia , Resultado del Tratamiento
12.
Australas J Dermatol ; 52(3): 191-4, 2011 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-21834814

RESUMEN

BACKGROUND/OBJECTIVES: Tinea nigra is a relatively uncommon dematiaceous fungal infection of the palms and soles, which clinically may mimic a melanocytic lesion. We sought to ascertain how frequently misdiagnosis of this infection occurred and whether the use of dermoscopy helped in its diagnosis. METHODS: Fifty consecutive cases of tinea nigra diagnosed at a dermatopathology laboratory were examined with regard to the clinical diagnosis, use of dermoscopy and the mode of management. RESULTS: Of the 50 cases, 21 (42.0%) were treated by shave or surgical excision. The clinical diagnosis of tinea nigra was made in five cases (10.0%) and suggested along with other diagnoses in a further two cases (4.0%). The dermatologists (n = 9) gave the correct diagnosis in four patients (44.4%), the general practitioners (n = 38) gave the correct diagnosis in one patient (2.6%) and the three surgeons involved did not give the correct diagnosis. When dermoscopy was used, in seven of 13 (53.8%) cases tinea nigra was suggested as a probable diagnosis but when dermoscopy was not used (n = 37) tinea nigra was not clinically diagnosed (P < 0.001). CONCLUSIONS: The diagnosis of tinea nigra is significantly improved by dermoscopy, the disease should be considered as a cause of palmar or plantar pigmentation.


Asunto(s)
Ascomicetos , Dermoscopía , Errores Diagnósticos , Tiña/diagnóstico , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Diagnóstico Diferencial , Femenino , Humanos , Masculino , Persona de Mediana Edad , Tiña/microbiología , Tiña/cirugía , Adulto Joven
13.
Int J Cancer ; 126(11): 2614-21, 2010 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-19856311

RESUMEN

Human papillomaviruses from the genus beta (betaPV) are a possible cause of cutaneous squamous cell carcinoma (SCC). We compared the betaPV infections in SCC and in sets of cutaneous tissues collected from a series of individual SCC patients to determine concordance and to assess the adequacy of eyebrow hairs as noninvasive markers of betaPV infection. Biopsies of SCC tumors, perilesional tissue, normal skin from the mirror image of nonfacial SCC and plucked eyebrow hairs were collected from 21 patients with incident SCC living in Queensland, Australia. These were tested for the presence of DNA from 25 different betaPV types. Overall prevalence of betaPV was high in every sample type, ranging from 81% to 95%. The median number of types was significantly higher in the SCC tumour (6), perilesional skin (5) and eyebrow hairs (5) than in normal skin (2). Comparing SCC tissue with other sample types within patients showed 63 overlapping infections with eyebrow hairs (71%; 95% CI: 60-80); 56 with perilesional skin samples (63%; 95% CI: 52-73) and 23 with normal skin samples (26%; 95% CI: 17-36). The sensitivity of eyebrow hair testing for detection of betaPV in the tumor was 82% (95% CI: 57-96) with concordance defined as 50% of betaPV types in common and 29% (95% CI: 10-56) for 100% concordance. These findings support the concept that perilesional skin represents an area of field change involving betaPV preceding SCC development and indicate that eyebrow hairs can serve to some degree as an easily collected marker of tumor betaPV status in epidemiological studies.


Asunto(s)
Betapapillomavirus/aislamiento & purificación , Carcinoma de Células Escamosas/virología , Cejas/virología , Infecciones por Papillomavirus/epidemiología , Neoplasias Cutáneas/virología , Adulto , Anciano , Anciano de 80 o más Años , Australia , ADN/genética , ADN/aislamiento & purificación , ADN Viral/genética , ADN Viral/aislamiento & purificación , Femenino , Genotipo , Cabello/virología , Humanos , Masculino , Persona de Mediana Edad , Infecciones por Papillomavirus/genética , Reacción en Cadena de la Polimerasa , Piel/virología
14.
J Gen Virol ; 91(Pt 8): 2073-2079, 2010 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-20444998

RESUMEN

Betapapillomavirus (betaPV) DNA and seroresponses are highly prevalent in the general population and both are frequently used as infection markers in epidemiological studies to elucidate an association with cutaneous squamous cell carcinoma (SCC). Little is known about the natural history of betaPV infection and the aspects of infection that drive antibody responses. To investigate the relationship between these markers, this study assessed whether the presence or persistence of betaPV DNA in eyebrow hairs and L1 antibodies of the same betaPV type co-occurred more frequently than would be expected by chance in both a cross-sectional assessment and a longitudinal study. betaPV DNA in plucked eyebrow hairs and L1 antibodies in serum were measured in 416 participants of the Australian community-based Nambour Skin Cancer Study in 1996. Similar data were available for a subset of 148 participants in 2003. Observed co-occurrence of betaPV DNA and antibodies was compared with expected values based on prevalence. A case-wise concordance index was used to calculate the overall concordance of betaPV DNA and antibodies of the same type. No significant associations were found between the presence or persistence of betaPV DNA and antibody responses. The age and sex of the host did not influence the association, and nor did SCC status or a history of sunburns. It was concluded that betaPV antibody responses in adults are not primarily driven by betaPV infection as measured in eyebrow hairs. Other factors, such as viral load, may play a more pivotal role in the induction of detectable seroresponses.


Asunto(s)
Anticuerpos Antivirales/sangre , Betapapillomavirus/genética , Betapapillomavirus/inmunología , ADN Viral/aislamiento & purificación , Cejas/virología , Infecciones por Papillomavirus/epidemiología , Infecciones por Papillomavirus/virología , Adulto , Anciano , Australia/epidemiología , Estudios Transversales , Femenino , Humanos , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Prevalencia , Estadística como Asunto , Adulto Joven
15.
Ann Surg Oncol ; 17(1): 129-37, 2010 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-19866238

RESUMEN

BACKGROUND: In many countries sentinel lymph node dissection (SLND) followed by complete lymphadenectomy if positive is routinely performed treatment for primary cutaneous melanoma. However, the potential survival benefit of SLND is still controversial. METHODS: Patients with primary cutaneous melanoma (tumor thickness 1.00 mm or greater) diagnosed in the Department of Dermatology, University of Tuebingen, Germany between 1991 and 2000 were included in the study. A total of 439 patients who received SLND were compared retrospectively with 440 patients without SLND with regards to occurring patterns of metastases and disease-free and overall survival. SLND-positive cases and SLND-negative patients with subsequent development of regional lymph node metastasis (SLND-LN+) were compared with non-SLND patients who had developed regional lymph node metastasis (non-SLND-LN+). RESULTS: Regional lymph node metastases as the first recurrence occurred more frequently in the non-SLND collective (16.5%) compared with the SLND group (7.3%; P = 0.001), whereas satellite/in-transit metastases and distant metastases did not differ. Driven by the reduction of regional lymph node metastases, disease-free survival was improved in the SLND collective (P = 0.003). No significant difference in overall survival was observed (P = 0.090).The risk of dying from melanoma was 2.2 times higher in the non-SLND-LN+ group than in the SLND-LN+ group (P = 0.009), while the risk of developing distant metastasis was 2.3 times higher (P = 0.002). CONCLUSIONS: SLND reduced subsequent regional lymph node metastases and improved disease-free survival, while overall survival remained unaffected. SLND reduced distant metastases and improved overall survival in the subgroups of patients with regional lymph node involvement.


Asunto(s)
Escisión del Ganglio Linfático , Ganglios Linfáticos/cirugía , Melanoma/cirugía , Recurrencia Local de Neoplasia/cirugía , Neoplasias Cutáneas/cirugía , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Femenino , Humanos , Ganglios Linfáticos/patología , Metástasis Linfática , Masculino , Melanoma/secundario , Persona de Mediana Edad , Recurrencia Local de Neoplasia/patología , Estadificación de Neoplasias , Pronóstico , Estudios Retrospectivos , Biopsia del Ganglio Linfático Centinela , Neoplasias Cutáneas/patología , Tasa de Supervivencia , Resultado del Tratamiento , Adulto Joven
16.
Dermatol Pract Concept ; 9(1): 28-35, 2019 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-30775145

RESUMEN

BACKGROUND: Surgical site infection (SSI) rates for below-knee dermatological surgery are unacceptably high, particularly following complex flap and graft closures. The role of antibiotic prophylaxis for these surgical cases is uncertain. OBJECTIVE: To determine whether SSI following complex dermatological closures on the leg could be reduced by antibiotic prophylaxis administered as a single oral preoperative dose. METHODS: A total of 115 participants were randomized to 2 g of oral cephalexin or placebo 40-60 minutes prior to surgical incision in a prospective, randomized, double-blind, placebo-controlled trial at a primary care skin cancer clinic in North Queensland, Australia. RESULTS: Overall 17/55 (30.9%) controls and 14/55 (25.5%) intervention participants developed infection (P = 0.525). There was no difference between the study groups in adverse symptoms that could be attributed to high-dose antibiotic administration (P = 1). CONCLUSION: A single oral 2-g dose of cephalexin given before complex below-knee dermatological closure did not reduce SSI.

17.
Melanoma Res ; 18(2): 112-9, 2008 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-18337647

RESUMEN

This study analysed the changes of excision margins in correlation with tumour thickness as recorded over the last three decades in Germany. The study also evaluated surgical management in different geographical regions and treatment options for metastasized melanoma. A total of 42 625 patients with invasive primary cutaneous melanoma, recorded by the German Central Malignant Melanoma Registry between 1976 and 2005 were included. Multiple linear regression analysis was used to investigate time trends of excision margins adjusted for tumour thickness. Excision margins of 5.0 cm were widely used in the late 1970s but since then have been replaced by smaller margins that are dependent on tumour thickness. In the case of primary melanoma, one-step surgery dominated until 1985 and was mostly replaced by two-step excisions since the early 1990s. In eastern Germany, one-step management remained common until the late 1990s. During the last three decades loco-regional metastases were predominantly treated by surgery (up to 80%), whereas systemic therapy decreased. The primary treatment of distant metastases has consistently been systemic chemotherapy. This descriptive retrospective study revealed a significant decrease in excision margins to a maximum of 2.00 cm. A significant trend towards two-step excisions in primary cutaneous melanoma was observed throughout Germany. Management of metastasized melanoma showed a tendency towards surgical procedures in limited disease and an ongoing trend to systemic treatment in advanced disease.


Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Melanoma/secundario , Melanoma/terapia , Neoplasias Cutáneas/terapia , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Alemania , Humanos , Modelos Lineales , Masculino , Melanoma/radioterapia , Melanoma/cirugía , Persona de Mediana Edad , Sistema de Registros , Estudios Retrospectivos , Neoplasias Cutáneas/radioterapia , Neoplasias Cutáneas/cirugía
18.
Australas J Dermatol ; 49(3): 142-7, 2008 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-18638221

RESUMEN

An omnibus telephone survey of 1200 adult Australians determined self-reported prevalence of and attitudes to sunburn and sunspots, knowledge of the term solar keratosis and prevalence of skin checks. Half reported they had been sunburnt in the previous year. Seventy-eight per cent considered sunburn to be extremely or very serious, while 73% considered sunspots as serious or very serious. While 29% reported currently having sunspots, 69% had never heard of the term solar keratosis, 30% had never had a skin check and 28% had their last skin check more than 12 months ago. Respondents 18-29 years old (odds ration [OR] = 2.6; P = 0.002) and men (OR = 2.4; P < 0.001) were most likely to experience multiple sunburn. Persons living in capital cities (OR = 0.63; P = 0.006) and having a university degree (OR = 0.52; P = 0.001) had reduced OR for multiple sunburns. Men (OR = 0.45; P < 0.001) were less likely to consider sunburn serious or extremely serious than women. Compared with respondents 18-29 years old, those 55 years or older were 7.4-fold more likely to have had a skin check (P < 0.001). Sun-protection campaigns need to continue using evidence-based interventions targeting younger people and men to reduce sunburn. The terms used in health promotion need to be understood by the target audience.


Asunto(s)
Conocimientos, Actitudes y Práctica en Salud , Queratosis/epidemiología , Quemadura Solar/epidemiología , Adolescente , Adulto , Factores de Edad , Australia/epidemiología , Femenino , Humanos , Masculino , Factores de Riesgo , Factores Sexuales
19.
Am J Health Behav ; 32(2): 201-8, 2008.
Artículo en Inglés | MEDLINE | ID: mdl-18052860

RESUMEN

OBJECTIVES: To investigate whether mandatory sun protection for outdoor workers in tropical regions is associated with reduced sun damage. METHODS: Survey of 26 employees working under mandatory sun protection policy was compared to survey of 21 employees working under voluntary sun protection policy. RESULTS: Voluntary sun protection associated with employees having more solar keratoses on dorsum of right hand (P=0.006) and more previously excised self-reported skin cancers (P=0.008). CONCLUSIONS: Employees working under mandatory sun protection policy had reduced sun damage, a likely consequence of less sun exposure.


Asunto(s)
Dermatitis Profesional/prevención & control , Política de Salud , Neoplasias Inducidas por Radiación/prevención & control , Enfermedades Profesionales/prevención & control , Trastornos por Fotosensibilidad/prevención & control , Neoplasias Cutáneas/prevención & control , Protectores Solares/administración & dosificación , Rayos Ultravioleta/efectos adversos , Lugar de Trabajo , Adulto , Estudios Transversales , Dermatosis de la Mano/prevención & control , Conocimientos, Actitudes y Práctica en Salud , Humanos , Masculino , Persona de Mediana Edad , Queensland , Recreación , Factores de Riesgo
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