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1.
Proc Natl Acad Sci U S A ; 100(9): 5455-60, 2003 Apr 29.
Artículo en Inglés | MEDLINE | ID: mdl-12704232

RESUMEN

The 1,995,275-bp genome of Coxiella burnetii, Nine Mile phase I RSA493, a highly virulent zoonotic pathogen and category B bioterrorism agent, was sequenced by the random shotgun method. This bacterium is an obligate intracellular acidophile that is highly adapted for life within the eukaryotic phagolysosome. Genome analysis revealed many genes with potential roles in adhesion, invasion, intracellular trafficking, host-cell modulation, and detoxification. A previously uncharacterized 13-member family of ankyrin repeat-containing proteins is implicated in the pathogenesis of this organism. Although the lifestyle and parasitic strategies of C. burnetii resemble that of Rickettsiae and Chlamydiae, their genome architectures differ considerably in terms of presence of mobile elements, extent of genome reduction, metabolic capabilities, and transporter profiles. The presence of 83 pseudogenes displays an ongoing process of gene degradation. Unlike other obligate intracellular bacteria, 32 insertion sequences are found dispersed in the chromosome, indicating some plasticity in the C. burnetii genome. These analyses suggest that the obligate intracellular lifestyle of C. burnetii may be a relatively recent innovation.


Asunto(s)
Coxiella burnetii/genética , Genoma Bacteriano , Adhesión Bacteriana , Coxiella burnetii/fisiología , Datos de Secuencia Molecular
2.
Proc Natl Acad Sci U S A ; 99(19): 12391-6, 2002 Sep 17.
Artículo en Inglés | MEDLINE | ID: mdl-12200547

RESUMEN

The 2,160,267 bp genome sequence of Streptococcus agalactiae, the leading cause of bacterial sepsis, pneumonia, and meningitis in neonates in the U.S. and Europe, is predicted to encode 2,175 genes. Genome comparisons among S. agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes, and the other completely sequenced genomes identified genes specific to the streptococci and to S. agalactiae. These in silico analyses, combined with comparative genome hybridization experiments between the sequenced serotype V strain 2603 V/R and 19 S. agalactiae strains from several serotypes using whole-genome microarrays, revealed the genetic heterogeneity among S. agalactiae strains, even of the same serotype, and provided insights into the evolution of virulence mechanisms.


Asunto(s)
Genoma Bacteriano , Streptococcus agalactiae/genética , Streptococcus agalactiae/patogenicidad , Secuencia de Aminoácidos , Evolución Biológica , Humanos , Datos de Secuencia Molecular , Análisis de Secuencia por Matrices de Oligonucleótidos , Filogenia , Serotipificación , Especificidad de la Especie , Infecciones Estreptocócicas/microbiología , Streptococcus agalactiae/clasificación , Streptococcus pneumoniae/genética , Streptococcus pyogenes/genética , Virulencia/genética
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