[Application of adhesive compositions in surgery (in Russian only)]. / Primenenie kleevykh kompozitsii v khirurgii.

New adhesive compositions will almost completely prevent leakage of surgical sutures and undue tissue damage, improve healing and postoperative rehabilitation. At present time there is no universal type of bioadhesives that is suitable for all tissues and types of sutures because of various surgeries and their specificity. The article describes the advantages and disadvantages of all common types of bioadhesives, as well as the ways to overcome their disadvantages.

[Evaluation of the conservability of zolpidem and zaleplon in the hepatic tissue].

This paper reports the experimental data on the conservability of zolpidem and zalepion in the samples of the cadaveric liver tissue stored under different conditions. The authors describe the method that includes isolation of the substances of interest from the hepatic tissue by means of acetone extraction, their solvent and chromatographic purification, and subsequent identification with the help of the spectrophotometric technique. It is shown that zolpidem and zaleplon remain in the cadaveric hepatic tissue within 6 months after intoxication regardless of temperature which makes possible their detection, isolation, and identification by the proposed method.

[Determination of olanzapine in cadaveric blood].

The authors present the results of experimental isolation of olanzapine from the biological objects in conjunction with the detailed description of the method for olanzapine extraction from cadaveric blood with the use of one of the amphiphilic solvents (e.g. acetone), purification by solvent extraction, and TLC-screening. Olanzapine was quantitatively determined by UV-spectrophotometry following its chromatography and elution. It was shown that one-step extraction from cadaveric blood by the proposed method made it possible to detect 55% of the total olanzapine content. The method was validated in the studies of blood and liver from the laboratory animals (rats) and can be recommended for the investigation in a chemical toxicological laboratory.

[A chemical-toxicological analysis of combined poisonings by psychotropic preparations with a tricyclic structure]. / Khimiko-toksikologicheskii analiz kombinirovannykh otravlenii nekotorymi psikhotropnymi preparatami tritsiklicheskoi struktury.

Conditions for chromatographic separation of melipramine with aminazine and melipramine with amitriptyline mixtures were stated. Method of chemical toxicological analysis in combined poisonings with psychotropic agents of tricyclic structure (melipramine in combinations with amitriptyline and aminazine) was suggested. Method was tested experimentally using animals.

[The comparative characteristics of the extractive capacity of solvents in removing aminazine from liver tissue]. / Sravnitel'naia kharakteristika ékstragiruiushchei sposobnosti nekotorykh rastvoritelei pri izvlechenii aminazina iz tkani pecheni.

Comparative assessment of extractive ability of some solvents with different physical and chemical properties is presented. Use of amphiphilic solvent acetone to isolate aminazine gave higher results. Experimental works (on dogs) showed that use of aqueous acid solutions for aminazine extraction in chemical toxicological investigation is unsuitable.