Detalles de la búsqueda
1.
Reversing the direction of drug transport mediated by the human multidrug transporter P-glycoprotein.
Proc Natl Acad Sci U S A
; 117(47): 29609-29617, 2020 11 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-33168729
2.
Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions.
J Biol Chem
; 292(17): 7066-7076, 2017 04 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-28283574
3.
Synthetic Analogs of Curcumin Modulate the Function of Multidrug Resistance-Linked ATP-Binding Cassette Transporter ABCG2.
Drug Metab Dispos
; 45(11): 1166-1177, 2017 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28904007
4.
Human-Mouse Chimeras with Normal Expression and Function Reveal That Major Domain Swapping Is Tolerated by P-Glycoprotein (ABCB1).
Biochemistry
; 55(7): 1010-23, 2016 Feb 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-26820614
5.
Mutations in intracellular loops 1 and 3 lead to misfolding of human P-glycoprotein (ABCB1) that can be rescued by cyclosporine A, which reduces its association with chaperone Hsp70.
J Biol Chem
; 288(45): 32622-32636, 2013 Nov 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-24064216
6.
Design, synthesis, and biological evaluation of (S)-valine thiazole-derived cyclic and noncyclic peptidomimetic oligomers as modulators of human P-glycoprotein (ABCB1).
Chembiochem
; 15(1): 157-69, 2014 Jan 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-24288265
7.
Tivozanib reverses multidrug resistance mediated by ABCB1 (P-glycoprotein) and ABCG2 (BCRP).
Future Oncol
; 10(11): 1827-41, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24295377
8.
Conserved Walker A cysteines 431 and 1074 in human P-glycoprotein are accessible to thiol-specific agents in the apo and ADP-vanadate trapped conformations.
Biochemistry
; 52(41): 7327-38, 2013 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24053441
9.
Differential reactivity between two copper sites in peptidylglycine α-hydroxylating monooxygenase.
J Am Chem Soc
; 132(44): 15565-72, 2010 Nov 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-20958070
10.
Heme-copper-dioxygen complexes: toward understanding ligand-environmental effects on the coordination geometry, electronic structure, and reactivity.
Inorg Chem
; 49(8): 3629-45, 2010 Apr 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-20380465
11.
Evidence for the critical role of transmembrane helices 1 and 7 in substrate transport by human P-glycoprotein (ABCB1).
PLoS One
; 13(9): e0204693, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30265721
12.
Global alteration of the drug-binding pocket of human P-glycoprotein (ABCB1) by substitution of fifteen conserved residues reveals a negative correlation between substrate size and transport efficiency.
Biochem Pharmacol
; 143: 53-64, 2017 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28728917
13.
Drug-protein hydrogen bonds govern the inhibition of the ATP hydrolysis of the multidrug transporter P-glycoprotein.
Biochem Pharmacol
; 101: 40-53, 2016 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26686578
14.
Molecular basis of the polyspecificity of P-glycoprotein (ABCB1): recent biochemical and structural studies.
Adv Cancer Res
; 125: 71-96, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25640267
15.
Design and synthesis of human ABCB1 (P-glycoprotein) inhibitors by peptide coupling of diverse chemical scaffolds on carboxyl and amino termini of (S)-valine-derived thiazole amino acid.
J Med Chem
; 57(10): 4058-72, 2014 May 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-24773054
16.
Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1).
PLoS One
; 8(12): e82463, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-24349290
17.
PD173074, a selective FGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells.
Cancer Chemother Pharmacol
; 72(1): 189-99, 2013 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-23673445
18.
How much binding affinity can be gained by filling a cavity?
Chem Biol Drug Des
; 75(2): 143-51, 2010 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-20028396
19.
Amidation of bioactive peptides: the structure of the lyase domain of the amidating enzyme.
Structure
; 17(7): 965-73, 2009 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19604476
20.
Heme-copper/dioxygen adduct formation, properties, and reactivity.
Acc Chem Res
; 40(7): 563-72, 2007 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-17550225