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BACKGROUND: Quality of life (QoL) is a measure to evaluate kidney transplant (KT) results. AIM: To describe the QoL profile in a larger sample of Brazilian patients who underwent KT according to age, sex, and access to KT. METHODS: We conducted a secondary data analysis of the ADHERE BRAZIL multicenter cross-sectional study including 1105 patients from 20 centers, considering KT access region and transplant activity. QoL was assessed by the WHOQOL-BREF. Data was compared using Generalized Estimating Equations. RESULTS: Overall, 58.5 % of the patients were men, mean age of 47.6 ± 12.6 years. The general QoL score was 81 ± 15.1, 58.6 ± 11.6 for physical, 65.5 ± 11.4 for psychological, 68.3 ± 17.1 for social relationships, and 64.2 ± 13.3 for environmental domain. Higher QoL scores were observed in men compared to women in three WHOQOL-BREF domains: psychological (OR:2.62; CI, 1.29 ̶ 3.95, p < 0.0001), social relationships (OR:3.21; CI, 1.2 ̶ 5.23, p = 0.002) and environmental (OR:3.79; CI:2.23 ̶ 5.35, p < 0.0001). Younger patients (18-44 years) had higher scores in the psychological (OR:-2.69; CI, -4.13 ̶ -1.25; p < 0.001; OR:-3.52; CI, -5.39 ̶ -1.66; p < 0.001) and social (OR:-3.46; CI, -5.64 ̶ -1.27; p = 0.002; OR:-7.17; CI, -10 ̶ -4.35; p < 0.0001) domains than older ones (45-59 and > 60 years, respectively). Patients from higher KT access region had higher scores in environmental domain (OR:3.53; CI, 0.28 ̶ 6.78; p = 0.033). CONCLUSIONS: Featuring the results of KT under patient view, the physical and social relationships domains were the most and least affected, respectively. Lower QoL subgroups (females and age > 45 years) should be targeted in future multi-professional interventions.
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Trasplante de Riñón , Calidad de Vida , Humanos , Calidad de Vida/psicología , Masculino , Femenino , Trasplante de Riñón/psicología , Estudios Transversales , Brasil , Persona de Mediana Edad , Adulto , Encuestas y Cuestionarios , Anciano , Adulto JovenRESUMEN
BACKGROUND: Cancer mortality in the U.S. has fallen in recent decades; however, individuals with lower levels of education experienced a smaller decline than more highly educated individuals. This analysis aimed to measure the influence of education lower than a high school diploma, on cancer amenable mortality among Non-Hispanic Whites (NHW) and Non-Hispanic Blacks (NHB) in the U.S. from 1989 to 2018. METHODS: We analyzed data from 8.2 million death certificates of men and women who died from cancer between 1989 and 2018. We examined 5-year and calendar period intervals, as well as annual percent changes (APC). APC was adjusted for each combination of sex, educational level, and race categories (8 models) to separate the general trend from the effects of age. RESULTS: Our study demonstrated an increasing mortality gap between the least and the most educated NHW and NHB males and females who died from all cancers combined and for most other cancer types included in this study. The gap between the least and the most educated was broader among NHW males and females than among NHB males and females, respectively, for most malignancies. CONCLUSIONS: In summary, we reported an increasing gap in the age-adjusted cancer mortality among the most and the least educated NHW and NHB between 25 and 74 years of age. We demonstrated that although NHB exhibited the greatest age-adjusted mortality rates for most cancer locations, the gap between the most and the least educated was shown for NHW.
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Negro o Afroamericano/estadística & datos numéricos , Escolaridad , Disparidades en el Estado de Salud , Hispánicos o Latinos/estadística & datos numéricos , Neoplasias/mortalidad , Población Blanca/estadística & datos numéricos , Adolescente , Adulto , Factores de Edad , Anciano , Niño , Preescolar , Femenino , Estudios de Seguimiento , Humanos , Incidencia , Lactante , Recién Nacido , Masculino , Persona de Mediana Edad , Neoplasias/epidemiología , Neoplasias/patología , Pronóstico , Tasa de Supervivencia , Factores de Tiempo , Estados Unidos/epidemiología , Adulto JovenRESUMEN
OBJECTIVES: The study aimed to evaluate the cost-effectiveness of the Pare de Fumar Conosco software compared with the standard of care adopted in Brazil for the treatment of smoking cessation. METHODS: In the cohort of smokers with multiple chronic conditions, we developed an decision tree model for the benefit measures of smoking cessation. We adopted the perspectives of the Brazilian Unified Health System and the service provider. Resources and costs were measured by primary and secondary sources and effectiveness by a randomized clinical trial. The incremental cost-effectiveness ratio (ICER) was calculated, followed by deterministic and probabilistic sensitivity analyses and deterministic and probabilistic sensitivity analyses. No willingness to pay threshold was adopted. RESULTS: The software had a lower cost and greater effectiveness than its comparator. The ICER was dominant in all of the benefits examined (-R$2 585 178.29 to -R$325 001.20). The cost of the standard of care followed by that of the electronic tool affected the ICER of the benefit measures. In all probabilistic analyses, the software was superior to the standard of care (53.6%-82.5%). CONCLUSION: The Pare de Fumar Conosco software is a technology that results in cost savings in treating smoking cessation.
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Cese del Hábito de Fumar , Nivel de Atención , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Brasil , Análisis de Costo-Efectividad , Toma de Decisiones , Árboles de Decisión , Cese del Hábito de Fumar/métodos , Cese del Hábito de Fumar/economía , Programas Informáticos/normas , Nivel de Atención/economíaRESUMEN
OBJECTIVE: Physical activity is recommended for recipients of a kidney transplant. However, ADHERE BRAZIL study found a high prevalence (69%) of physical inactivity in Brazilian recipients of a kidney transplant. To tackle this behavior, a broad analysis of barriers is needed. This study aimed to identify factors (patient and transplant center levels) associated with physical inactivity among recipients of a kidney transplant. METHODS: This was a subproject of the ADHERE BRAZIL study, a cross-sectional, multicenter study of 1105 recipients of a kidney transplant from 20 kidney transplant centers. Using a multistage sampling method, patients were proportionally and randomly selected. Applying the Brief Physical Activity Assessment questionnaire, patients were classified as physically active (≥150 min/wk) or physically inactive (<150 min/wk). On the basis of an ecological model, 34 factors associated with physical inactivity were analyzed by sequential logistic regression. RESULTS: At the patient level, physical inactivity was associated with smoking (odds ratio = 2.43; 95% CI = 0.97-6.06), obesity (odds ratio = 1.79; 95% CI = 1.26-2.55), peripheral vascular disease (odds ratio = 3.18; 95% CI = 1.20-8.42), >3 posttransplant hospitalizations (odds ratio = 1.58; 95% CI = 1.17-2.13), family income of >1 reference salary ($248.28 per month; odds ratio = 0.66; 95% CI = 0.48-0.90), and student status (odds ratio = 0.58; 95% CI = 0.37-0.92). At the center level, the correlates were having exercise physiologists in the clinical team (odds ratio = 0.54; 95% CI = 0.46-0.64) and being monitored in a teaching hospital (undergraduate students) (odds ratio = 1.47; 95% CI = 1.01-2.13). CONCLUSIONS: This study identified factors associated with physical inactivity after kidney transplantation that may guide future multilevel behavioral change interventions for physical activity. IMPACT: In a multicenter sample of recipients of a kidney transplant with a prevalence of physical inactivity of 69%, we found associations between this behavior and patient- and center-level factors. At the patient level, the chance of physical inactivity was positively associated with smoking, obesity, and patient morbidity (peripheral vascular disease and hospitalization events after kidney transplantation). Conversely, a high family income and a student status negatively correlated with physical inactivity. At the center level, the presence of a dedicated professional to motivate physical activity resulted in a reduced chance of physical inactivity. A broad knowledge of barriers associated with physical inactivity can allow us to identify patients at a high risk of not adhering to the recommended levels of physical activity.
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Trasplante de Riñón , Conducta Sedentaria , Humanos , Brasil/epidemiología , Femenino , Masculino , Estudios Transversales , Persona de Mediana Edad , Adulto , Ejercicio Físico , Factores de Riesgo , Encuestas y Cuestionarios , Obesidad/epidemiología , Fumar/epidemiologíaRESUMEN
BACKGROUND: Diabetes accounted for approximately 10% of all-cause mortality among those 20-79 years of age worldwide in 2019. In 1986-1989, Hispanics in the United States of America (USA) represented 6.9% of the national population with diabetes, and this proportion increased to 15.1% in 2010-2014. Recently published findings demonstrated the impact of attained education on amenable mortality attributable to diabetes among Non-Hispanic Whites (NHWs) and Non-Hispanic Blacks (HNBs). Previous cohort studies have shown that low education is also a detrimental factor for diabetes mortality among the Hispanic population in the USA. However, the long-term impact of low education on diabetes mortality among Hispanics in the USA is yet to be determined. AIMS AND METHODS: The aim of this study was to measure the impact of achieving a 12th-grade education on amenable mortality due to diabetes among Hispanics in the USA from 1989 to 2018. We used a time-series designed to analyze death certificate data of Hispanic-classified men and women, aged 25 to 74 years, whose underlying cause of death was diabetes, between 1989 and 2018. Death certificate data from the USA National Center for Health Statistics was downloaded, as well as USA population estimates by age, sex, and ethnicity from the USA Census Bureau. The analyses were undertaken using JointPoint software and the Age-Period-Cohort Web Tool, both developed by the USA National Cancer Institute. RESULTS: The analyses showed that between 1989 to 2018, age- and sex-standardized diabetes mortality rates among the least educated individuals were higher than those among the most educated individuals (both sexes together, p = 0.036; males, p = 0.053; females, p = 0.036). The difference between the least and most educated individuals became more pronounced in recent years, as shown by independent confidence intervals across the study period. Sex-based analyses revealed that the age-adjUSAted diabetes mortality rate had increased to a greater extent among the least educated males and females, respectively, than among the most educated. CONCLUSIONS: The results of the analyses demonstrated a powerful effect of low education on amenable mortality attributable to diabetes among the Hispanic population in the USA. As an increasing prevalence of diabetes among the least educated Hispanics has been reported, there is a great need to identify and implement effective preventive services, self-management, and quality care practices, that may assist in reducing the growing disparity among those most vulnerable, such as minority populations.
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BACKGROUND: Immunosuppressive nonadherence is a risk factor for worse outcomes after kidney transplantation (KT). Brazil, having the world's largest public, fully covered transplantation system and the second-highest KT volume worldwide, provides a unique setting for studying multilevel correlates of nonadherence (patient, healthcare provider, transplant center, and healthcare system levels) independent of patients' financial burden. METHODS: By applying a multistage sampling approach, we included 1105 patients from 20 KT centers. Nonadherence to immunosuppressives (implementation phase) was defined as any deviation in taking or timing adherence and dose reduction assessed by the Basel Assessment of Adherence to Immunosuppressive Medications Scale. Based on Bronfenbrenner's ecological model, we assessed multilevel factors using established instruments and measures specifically developed for this study and analyzed their independent contribution to nonadherence by performing sequential logistic regression analysis. RESULTS: The nonadherence prevalence rate was 39.7%. The following factors were independently associated with nonadherence: Patient level-having a stable partner (odds ratio [OR]: 0.75; confidence interval [CI]: 0.58-0.97), nonadherence to appointments (OR: 2.98; CI: 2.03-4.39), and nonadherence to physical activity recommendations (OR: 1.84; CI: 1.38-2.46); and transplant center level-satisfaction with the waiting room structure (OR: 0.54; CI: 0.42-0.71), consultation >30 minutes (OR: 1.60; CI: 1.19-2.14), adequacy of the consultation frequency (OR: 0.62; CI: 0.43-0.90), and centers with >500 beds (OR: 0.58; CI: 0.46-0.73). CONCLUSIONS: As the first multicenter study assessing multilevel correlates of nonadherence in KT, our findings point to the need for multilevel interventions beyond the patient level, targeting transplant center practice patterns as an approach to tackle nonadherence.
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Rechazo de Injerto/prevención & control , Supervivencia de Injerto/efectos de los fármacos , Inmunosupresores/uso terapéutico , Trasplante de Riñón , Cumplimiento de la Medicación , Adulto , Brasil , Estudios Transversales , Atención a la Salud , Femenino , Rechazo de Injerto/inmunología , Humanos , Inmunosupresores/efectos adversos , Trasplante de Riñón/efectos adversos , Masculino , Persona de Mediana Edad , Pautas de la Práctica en Medicina , Medición de Riesgo , Factores de Riesgo , Factores de Tiempo , Resultado del TratamientoRESUMEN
BACKGROUND: Cytomegalovirus (CMV) is a common opportunistic infection among HIV-infected individuals, a major source of serious complications among organ-transplant recipients, and a leading cause of hearing loss, vision loss, and mental retardation among congenitally infected children. Women infected for the first time during pregnancy are especially likely to transmit CMV to their fetuses. More children suffer serious disabilities caused by congenital CMV than by several better-known childhood maladies such as Down syndrome or fetal alcohol syndrome METHODS: Using CMV seroprevalence data from the nationally representative Third National Health and Nutrition Examination Survey, we estimated CMV incidence among the general United States population and among pregnant women. We employed catalytic models that used age-specific CMV seroprevalences as cumulative markers of past infections in order to derive estimates of three basic parameters: the force of infection, the basic reproductive rate, and the average age of infection. Our main focus was the force of infection, an instantaneous per capita rate of acquisition of infection that approximates the incidence of infection in the seronegative population. RESULTS: Among the United States population ages 12-49 the force of infection was 1.6 infections per 100 susceptible persons per year (95% confidence interval: 1.2, 2.4). The associated basic reproductive rate of 1.7 indicates that, on average, an infected person transmits CMV to nearly two susceptible people. The average age of CMV infection was 28.6 years. Force of infection was significantly higher among non-Hispanic Blacks (5.7) and Mexican Americans (5.1) than among non-Hispanic Whites (1.4). Force of infection was significantly higher in the low household income group (3.5) than in the middle (2.1) and upper (1.5) household income groups. Based on these CMV incidence estimates, approximately 27,000 new CMV infections occur among seronegative pregnant women in the United States each year. CONCLUSION: These thousands of CMV infections in pregnant women, along with the sharp racial/ethnic disparities in CMV incidence, are compelling reasons for accelerating research on vaccines and other interventions for preventing congenital CMV disease. Nevertheless, the relatively low force of infection provides encouraging evidence that modestly effective vaccines and rates of vaccination could significantly reduce CMV transmission.
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Infecciones por Citomegalovirus/epidemiología , Complicaciones Infecciosas del Embarazo/epidemiología , Adolescente , Adulto , Negro o Afroamericano , Niño , Infecciones por Citomegalovirus/etnología , Femenino , Humanos , Incidencia , Masculino , Americanos Mexicanos , Persona de Mediana Edad , Modelos Biológicos , Encuestas Nutricionales , Embarazo , Complicaciones Infecciosas del Embarazo/etnología , Factores de Riesgo , Estudios Seroepidemiológicos , Estados Unidos/epidemiologíaRESUMEN
OBJECTIVE: To identify biological and sociodemographic factors associated with physical inactivity in public school children. METHODS: Parents of 2,519 children (49.3% of whom were girls), aged 7 to 10 years (mean = 7.6+/-0.9 years), from eight public schools in São Paulo, Brazil, completed a self-administered questionnaire. We used multiple correspondence analysis to identify groups of responses related to levels of physical activity and inactivity and to obtain an optimal scale. The cluster analysis identified groups of active and inactive children. The analysis of the receiver operator characteristic (ROC) curve, for the study of diagnostic properties of a simplified scale for physical inactivity derived from the optimal scale, revealed that a cutoff point of 3 had the best sensitivity and specificity, being therefore used as the outcome variable in the regression model. A multivariate hierarchical model was built, including distal and proximal categorical variables, with a p < 0.05. RESULTS: Physical inactivity was positively associated with biological factors such as being overweight, being older than 7.5 years, being a female, and having a good appetite, and with socioeconomic factors such as having garbage collected less than twice a week and having mothers who work outside the home. CONCLUSION: The results are consistent with published data about determinant factors of physical activity and inactivity among children, showing that questionnaires answered by parents and submitted to a sophisticated statistical analysis can be used in population-based studies involving children younger than 10 years old.
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Conducta Infantil/fisiología , Ejercicio Físico , Actividades Recreativas , Estilo de Vida , Estudiantes/estadística & datos numéricos , Niño , Femenino , Humanos , Masculino , Actividad Motora , Análisis Multivariante , Sobrepeso , Curva ROC , Sensibilidad y Especificidad , Factores Socioeconómicos , Mujeres TrabajadorasRESUMEN
BACKGROUND: Cigarette smoking is an important risk factor for disease onset and progression among the major chronic diseases accounting for most morbidity and mortality in the world. Our objective was to identify characteristics associated with tobacco use among patients with multiple chronic conditions (MCC). METHODS: This cross-sectional study was implemented at the Center HIPERDIA Minas Juiz de Fora, Brazil, which manages patients with high cardiovascular risk, hypertension, diabetes mellitus and chronic kidney disease. RESULTS: Of 1558 participants, 12% were current smokers; 41% former smokers and 47%, never smokers. In univariate analyses, current smoking was associated with gender, age, physical activity, alcohol use, depressive symptoms, overweight, and atherosclerosis. In multinomial analyses, multiple chronic conditions were associated with the current or previous use of tobacco; COPD and atherosclerotic disease were more prevalent among patients who were current smokers. CONCLUSIONS: Cigarette smoking was as prevalent in this high population as in the general population. Smokers had worse clinical profiles compared to former smokers or never smokers. Aggressive smoking cessation support should yield considerable health benefits and health care cost savings within patients with MCC, especially, those with high cardiovascular risk.
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Enfermedades Cardiovasculares , Diabetes Mellitus , Hipertensión , Fumar , Anciano , Brasil/epidemiología , Enfermedades Cardiovasculares/epidemiología , Enfermedades Cardiovasculares/prevención & control , Enfermedades Cardiovasculares/psicología , Estudios Transversales , Diabetes Mellitus/epidemiología , Diabetes Mellitus/prevención & control , Diabetes Mellitus/psicología , Femenino , Humanos , Hipertensión/epidemiología , Hipertensión/prevención & control , Hipertensión/psicología , Masculino , Persona de Mediana Edad , Afecciones Crónicas Múltiples/epidemiología , Afecciones Crónicas Múltiples/prevención & control , Afecciones Crónicas Múltiples/psicología , Prevalencia , Factores de Riesgo , Fumar/epidemiología , Fumar/fisiopatología , Cese del Hábito de FumarRESUMEN
To compare the prevalence of child obesity according to three criteria, a cross-sectional study was performed with 6-to-11-year-old children in eight elementary public schools in the city of São Paulo. Z scores for weight-for-height (W/H) and body mass index (BMI) were calculated from the weight and height variables. Prevalence rates for overweight in males, according to Must, Cole, and WHO criteria, were 10.92%, 10.29%, and 11.94%, respectively, and for obesity 8.17%, 13.67%, and 10.29%. For females, prevalence rates for overweight according to Must, Cole, and WHO criteria were 13.51%, 13.83%, and 13.67%, respectively, and for obesity 8.25%, 16.50%, and 11.73%. The study analyzes the variations in obesity estimates based on different criteria, highlighting the need for clinical and population studies to support the development of a single criterion. Such studies, in addition to identifying individuals with a higher probability of excess body fat, could also correlate body fat to risk of illness and death (similar to the 25 and 30 BMI cutoff points in adults).
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Antropometría , Obesidad/epidemiología , Distribución por Edad , Peso Corporal , Brasil/epidemiología , Niño , Estudios Transversales , Femenino , Humanos , Masculino , Prevalencia , Factores de Riesgo , Distribución por SexoRESUMEN
Health literacy (HL) or basic reading and numeracy that allow an individual to function in the health care environment, is a relatively new topic, yet has increasingly been gaining interest over the past few years both in the research and policy agendas, particularly in the develop countries. Where studied, inadequate HL has been associated with poor health care quality and more cost. Yet many physicians do not recognize the problem or is not skilled enough to approach the subject with their patients. In this review, important aspects of HL, such as its epidemiology, associations with poor outcomes, assessment, determinants and interventions, particularly in nephrology, are discussed. Because it is common and associated to adverse clinical outcomes, inadequate HL should be incorporated into the list of assessments of patients with renal disease.
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Alfabetización en Salud , Enfermedades Renales , Alfabetización en Salud/estadística & datos numéricos , Humanos , Nefrología , Encuestas y CuestionariosRESUMEN
OBJECTIVE: To assess hepatic steatosis by ultrasound method as a concomitant risk factor among overweight adolescents. METHODS: A case-control study including 83 cases (47 overweight and 36 obese) and 89 controls (normal weight), frequency matched by gender, year of birth, pubertal stage (Tanner 4/5), and income. Cases and controls were selected from 1,420 students enrolled in a Vila Mariana public high school, in São Paulo, Brazil. Must et al. criteria were used for nutritional status classification. Nonalcoholic fatty liver disease was diagnosed through hepatic ultrasonography performed and analyzed by one radiologist. Hepatic enzymatic activities (alanine and aspartate transaminases, alkaline phosphatase, gamma-glutamyl transpeptidase) and direct bilirubin were measured. Eight covariables were fitted into logistic regression models; criterion for inclusion of variables was the association with overweight in the bivariate analyses (p < 0.20). A value of p < 0.05 was set as the criterion for inclusion into the final logistic regression models. RESULTS: Prevalence of hepatic steatosis diagnosed through ultrasonography was 27.7% in overweight/obese students and 3.4% in normal weight students. Adjusted odds ratios (95%CI) for images compatible with nonalcoholic fatty liver disease and gamma-glutamyl transpeptidase > 24 U/L were 10.77 (2.45-47.22) and 4.18 (1.46-11.94), respectively. CONCLUSIONS: This is the first population-based study showing that hepatic steatosis is strongly associated with overweight/obesity among adolescents attending a Brazilian public school. The diagnostic tool used in this investigation is a non-invasive method that might be applied to monitor overweight and obese adolescents and to propose actions for preventing more severe hepatic diseases in adulthood.
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Hígado Graso/complicaciones , Obesidad/complicaciones , Adolescente , Brasil/epidemiología , Métodos Epidemiológicos , Hígado Graso/diagnóstico por imagen , Hígado Graso/enzimología , Hígado Graso/epidemiología , Femenino , Humanos , Hígado/enzimología , Masculino , Instituciones Académicas , UltrasonografíaRESUMEN
OBJECTIVES: To identify and quantify isolated and combined risk factors for anemia, providing a comprehensive view of the likelihood of its occurrence. METHODS: Cross-sectional study with 482 children aged 4 to 29 months attending the nurseries of philanthropic and public daycare centers in the city of São Paulo, Brazil, who participated in two surveys (2004 and 2007). Mothers were interviewed, blood was collected using digital puncture, and anthropometry was performed. Anemia was characterized by hemoglobin levels below 11 g/dL. Unconditional logistic regression was adjusted for anemia risk factors. A value of p < or = 0.05 indicated statistically significant associations. Post-test odds and likelihood ratios were calculated to define post-test probabilities. Epi-Info 2000 and Stata 10.0 software packages were used for statistical analysis. RESULTS: Prevalence of anemia was 43.6% (95%CI 39.1-48.1). The final logistic model included five categorical variables: mother's age less than 28 years (OR = 1.50; p = 0.041), per capita income below half a minimum wage (OR = 1.56; p = 0.029), exclusive breastfeeding less than 2 months (OR = 1.71; p = 0.009), decrease in weight/age z score from birth to survey (OR = 1.47; p = 0.050), and age less than 17 months (OR = 2.44; p < 0,001). Post-test probabilities in the associations of isolated and combined risk factors for anemia ranged from 54.5 to 100%. CONCLUSIONS: The probability of anemia progressively increased as the identified risk factors were added. This calculation provides a simple and rapid tool for suspicion of anemia in children both in clinical practice and population screening.
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Anemia Ferropénica/etiología , Factores de Edad , Anemia Ferropénica/sangre , Anemia Ferropénica/epidemiología , Antropometría , Brasil/epidemiología , Lactancia Materna , Guarderías Infantiles , Preescolar , Métodos Epidemiológicos , Humanos , Renta , Lactante , Edad Materna , Casas Cuna , Valores de Referencia , Factores de Riesgo , Factores de TiempoRESUMEN
OBJECTIVE: Despite investigations into the rapid increase in eating disorders across diverse ethnic groups, conclusions concerning ethnicity and eating disorders are contradictory. The objective of the present study was to investigate eating attitudes in ethnic Japanese and Caucasian adolescents in Brazil. The influence of body mass index (BMI), menarche and social-affective relationships on the development of eating disorders was also assessed. METHODS: Questionnaires evaluating the incidence of eating disorders and the influence of social-affective relationships were applied to 544 Japanese-Brazilian and Caucasian adolescent girls: 10 to 11-year-old Japanese-Brazilian (n = 122) and Caucasian (n = 176) pre-menarcheal adolescents, and 16 to 17-year-old Japanese-Brazilian (n = 71) and Caucasian (n = 175) post-menarcheal adolescents. RESULTS: Caucasian girls obtained higher scores on the Eating Attitudes Test (EAT-26), showed greater body image dissatisfaction, dieted more often and had more diet models introduced by their mothers and peers than the Japanese-Brazilian girls. CONCLUSION The Caucasian adolescents overall appeared to be more sensitive to aesthetic and social pressures regarding body image than the Japanese adolescents. The high incidence of EAT-26 scores above 20 in the Caucasian pre-menarcheal group indicates that individual body image concerns are developing at an earlier age. Multiple logistic regression revealed several associations between mother-teen interactions and the development of abnormal eating attitudes.
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Pueblo Asiatico/psicología , Imagen Corporal , Trastornos de Alimentación y de la Ingestión de Alimentos/etnología , Población Blanca/psicología , Adolescente , Pueblo Asiatico/etnología , Índice de Masa Corporal , Brasil/epidemiología , Niño , Estudios Transversales , Trastornos de Alimentación y de la Ingestión de Alimentos/psicología , Femenino , Humanos , Japón/etnología , Conducta Materna , Menarquia/etnología , Menarquia/fisiología , Encuestas y Cuestionarios , Población Blanca/etnologíaRESUMEN
Letramento em Saúde (LS) ou habilidade de leitura e numeramento que permite ao indivíduo transitar no ambiente de saúde, é um tema relativamente novo e que vem ganhando espaço nas agendas de pesquisa e política de saúde, particularmente nos países desenvolvidos. Onde estudado, o LS inadequado associa-se com cuidados de saúde de pior qualidade e maior custo. Mesmo assim, a maioria dos médicos não conseguem identificar o problema e não têm preparo para lidar com o paciente que apresenta LS inadequado. Na presente revisão, os autores discutem aspectos importantes do LS, tais como a sua epidemiologia, associações com desfechos clínicos, avaliação, determinantes e oportunidades de intervenções, particularmente na nefrologia. Por ser comum e associar-se com desfechos clínicos indesejáveis, o LS inadequado deveria ser regularmente avaliado nos pacientes com doença renal.
Health literacy (HL) or basic reading and numeracy that allow an individual to function in the health care environment, is a relatively new topic, yet has increasingly been gaining interest over the past few years both in the research and policy agendas, particularly in the develop countries. Where studied, inadequate HL has been associated with poor health care quality and more cost. Yet many physicians do not recognize the problem or is not skilled enough to approach the subject with their patients. In this review, important aspects of HL, such as its epidemiology, associations with poor outcomes, assessment, determinants and interventions, particularly in nephrology, are discussed. Because it is common and associated to adverse clinical outcomes, inadequate HL should be incorporated into the list of assessments of patients with renal disease.
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Humanos , Alfabetización en Salud , Enfermedades Renales , Alfabetización en Salud/estadística & datos numéricos , Nefrología , Encuestas y CuestionariosRESUMEN
Sleep is hypothesized to play a restorative role on immune system. In addition, disturbed sleep is thought to impair host defense mechanisms. Chronic sleep deprivation is a common occurrence in modern society and has been observed in a number of chronic inflammatory conditions, such as systemic lupus erythematosus (SLE). New Zealand Black/New Zealand White (NZB/NZW) F1 mice develop an autoimmune disease that strongly resembles SLE in humans, exhibiting high titers of antinuclear antibodies associated with the development of rapidly progressive and lethal glomerulonephritis. On the basis of this evidence, the present study examined the onset and progress of lupus in as-yet healthy female mice submitted to sleep deprivation. Sleep deprivation was accomplished by two 96-h periods in the multiple-platform method when mice were 10 wk old, and they were observed until 28 wk of age. Blood samples were collected from the orbital plexus fortnightly to evaluate serum antinuclear antibodies and anti-double-stranded DNA. Proteinuria and longevity as well as body weight were also assessed. The results indicated that mice submitted to sleep deprivation exhibited an earlier onset of the disease, as reflected by the increased number of antinuclear antibodies. However, no statistical difference was found in the other parameters analyzed. According to these results, sleep deprivation could be considered as a risk factor for the onset but not for the evolution of the disease.
Asunto(s)
Enfermedades Autoinmunes/etiología , Lupus Eritematoso Sistémico/etiología , Privación de Sueño/complicaciones , Animales , Anticuerpos Antinucleares/inmunología , Anticuerpos Antinucleares/metabolismo , Enfermedades Autoinmunes/inmunología , Enfermedades Autoinmunes/fisiopatología , Peso Corporal/fisiología , Modelos Animales de Enfermedad , Progresión de la Enfermedad , Femenino , Longevidad/fisiología , Lupus Eritematoso Sistémico/inmunología , Lupus Eritematoso Sistémico/fisiopatología , Masculino , Ratones , Ratones Endogámicos NZB , Ratones Endogámicos , Proteinuria/etiología , Proteinuria/fisiopatología , Factores de Riesgo , Privación de Sueño/inmunología , Privación de Sueño/fisiopatologíaRESUMEN
Objetivo: Avaliar esteatose hepática pelo método de ultrassom como fator de risco concomitante entre adolescentes com sobrepeso. Métodos: Estudo de caso-controle incluindo 83 casos (47 com sobrepeso e 36 obesos) e 89 controles (peso normal), frequência pareada por gênero, ano de nascimento, estágio pubertário (Tanner 4/5) e renda. Casos e controles foram selecionados de 1.420 alunos matriculados em uma escola pública de ensino médio na Vila Mariana, São Paulo. Os critérios de Must et al. foram usados para classificação do estado nutricional. A doença hepática gordurosa não-alcoólica foi diagnosticada por meio de ultrassonografia realizada e analisada por um radiologista. Foram medidas atividades enzimáticas hepáticas (alanina e aspartato transaminases, fosfatase alcalina, gama-glutamil transpeptidase) e bilirrubina direta. Oito co-variáveis foram inseridas em modelos de regressão logística; o critério de inclusão de variáveis foi a associação com sobrepeso nas análises bivariadas (p < 0,20). Um valor de p < 0,05 foi estabelecido como critério de inclusão nos modelos finais de regressão logística. Resultados: A prevalência de esteatose hepática diagnosticada por ultrassonografia foi de 27,7 por cento em alunos com sobrepeso/obesos e de 3,4 por cento em alunos com peso normal. Razões de chances ajustadas (IC95 por cento) para imagens compatíveis com doença hepática gordurosa não-alcoólica e gama-glutamil transpeptidase > 24 U/L foram 10,77 (2,45-47,22) e 4,18 (1,46-11,94), respectivamente. Conclusões: Este é o primeiro estudo populacional mostrando que a esteatose hepática tem forte associação com sobrepeso/obesidade entre adolescentes matriculados em uma escola pública brasileira. A ferramenta de diagnóstico usada nesta investigação é um método não-invasivo que poderia ser aplicado para monitorar adolescentes com sobrepeso e obesos e propor ações para prevenir doenças hepáticas mais graves na fase adulta.
Objective: To assess hepatic steatosis by ultrasound method as a concomitant risk factor among overweight adolescents. Methods: A case-control study including 83 cases (47 overweight and 36 obese) and 89 controls (normal weight), frequency matched by gender, year of birth, pubertal stage (Tanner 4/5), and income. Cases and controls were selected from 1,420 students enrolled in a Vila Mariana public high school, in São Paulo, Brazil. Must et al. criteria were used for nutritional status classification. Nonalcoholic fatty liver disease was diagnosed through hepatic ultrasonography performed and analyzed by one radiologist. Hepatic enzymatic activities (alanine and aspartate transaminases, alkaline phosphatase, gamma-glutamyl transpeptidase) and direct bilirubin were measured. Eight covariables were fitted into logistic regression models; criterion for inclusion of variables was the association with overweight in the bivariate analyses (p < 0.20). A value of p < 0.05 was set as the criterion for inclusion into the final logistic regression models. Results: Prevalence of hepatic steatosis diagnosed through ultrasonography was 27.7 percent in overweight/obese students and 3.4 percent in normal weight students. Adjusted odds ratios (95 percentCI) for images compatible with nonalcoholic fatty liver disease and gamma-glutamyl transpeptidase > 24 U/L were 10.77 (2.45-47.22) and 4.18 (1.46-11.94), respectively. Conclusions: This is the first population-based study showing that hepatic steatosis is strongly associated with overweight/obesity among adolescents attending a Brazilian public school. The diagnostic tool used in this investigation is a non-invasive method that might be applied to monitor overweight and obese adolescents and to propose actions for preventing more severe hepatic diseases in adulthood.
Asunto(s)
Adolescente , Femenino , Humanos , Masculino , Hígado Graso/complicaciones , Obesidad/complicaciones , Brasil/epidemiología , Métodos Epidemiológicos , Hígado Graso/enzimología , Hígado Graso/epidemiología , Hígado Graso , Hígado/enzimología , Instituciones AcadémicasRESUMEN
BACKGROUND: The objective of the study was to identify risk factors of infant anemia and to assess a new indirect method to identify the risks of anemia using a probability curve based on dietary iron density and weight gain rate. METHODS: A cross-sectional study was conducted on 110 term infants in a public health unit in Goiania, Brazil. A socioeconomic, demographic, anthropometric survey and dietary assessment were performed. Hemoglobin, red blood cell distribution width (RDW), ferritin, and C-reactive protein were determined. RESULTS: The risk factors identified by final adjusted logistic regression were male infants (OR = 2.38), infants whose mothers were housewives (OR = 5.01), and households with more than three members (OR = 3.08). Another risk factor was the introduction of meat after 6 months (OR = 3.3). There was a positive dose-response effect between milk consumption and prevalence of anemia adjusted for sex and age (Effect = 0.120; 95% CI: 0.015, 0.225). Dietary iron density (from 6 to 9 months) and weight gain rate (from 9 to 12 months) significantly affected the probability of the infant having anemia. CONCLUSIONS: The probability curve for anemia obtained from dietary iron density and weight gain rate can be used to identify the risks of anemia, and together with the risk factors identified are important for anemia prevention programs.
Asunto(s)
Anemia Ferropénica/etiología , Ferritinas/sangre , Fenómenos Fisiológicos Nutricionales del Lactante , Anemia Ferropénica/sangre , Proteína C-Reactiva/análisis , Estudios Transversales , Conducta Alimentaria , Alimentos Formulados , Humanos , Lactante , Hierro de la Dieta/administración & dosificación , Hierro de la Dieta/sangre , Modelos Logísticos , Factores de Riesgo , Encuestas y Cuestionarios , Aumento de Peso/fisiologíaRESUMEN
OBJETIVO: Há muita controvérsia nos estudos que analisam a relação entre etnia e transtornos alimentares a despeito do rápido aumento desses distúrbios em diversos grupos étnicos. O objetivo do presente estudo foi verificar as atitudes alimentares em adolescentes de ascendência nipônica e caucasiana no Brasil. A influência do índice de massa corporal (IMC), da menarca e das relações socioafetivas no desenvolvimento dos transtornos alimentares também foi discutida. MÉTODOS: Questionários sobre atitudes alimentares e influências socioafetivas foram aplicados a 544 adolescentes de origem nipo-brasileira e caucasiana: adolescentes pré-menarca de 10 e 11 anos nipo-brasileiras (n = 122) e caucasianas (n = 176) e adolescentes pós-menarca de 16 e 17 anos nipo-brasileiras (n = 71) e caucasianas (n = 175). RESULTADOS: Adolescentes caucasianas apresentaram maiores escores no Teste de Atitudes Alimentares (EAT-26), mostraram maior insatisfação com suas imagens corporais, faziam mais dieta e tinham mais modelos de dietas representados pelas mães e pares do que as adolescentes nipo-brasileiras. CONCLUSÃO: As adolescentes caucasianas, de um modo geral, parecem sentir mais as pressões culturais e estéticas sobre a imagem corporal do que as nipônicas. A frequência alta de meninas caucasianas pré-menarca com escore acima de 20 no EAT-26 mostra que a preocupação com a imagem corporal vem ocorrendo cada vez mais cedo. A análise de regressão múltipla revelou muitas associações entre a interação das adolescentes com suas mães e o desenvolvimento de atitudes alimentares inadequadas.
OBJECTIVE: Despite investigations into the rapid increase in eating disorders across diverse ethnic groups, conclusions concerning ethnicity and eating disorders are contradictory. The objective of the present study was to investigate eating attitudes in ethnic Japanese and Caucasian adolescents in Brazil. The influence of body mass index (BMI), menarche and social-affective relationships on the development of eating disorders was also assessed. METHODS: Questionnaires evaluating the incidence of eating disorders and the influence of social-affective relationships were applied to 544 Japanese-Brazilian and Caucasian adolescent girls: 10 to 11-year-old Japanese-Brazilian (n = 122) and Caucasian (n = 176) pre-menarcheal adolescents, and 16 to 17-year-old Japanese-Brazilian (n = 71) and Caucasian (n = 175) post-menarcheal adolescents. RESULTS: Caucasian girls obtained higher scores on the Eating Attitudes Test (EAT-26), showed greater body image dissatisfaction, dieted more often and had more diet models introduced by their mothers and peers than the Japanese-Brazilian girls. CONCLUSION: The Caucasian adolescents overall appeared to be more sensitive to aesthetic and social pressures regarding body image than the Japanese adolescents. The high incidence of EAT-26 scores above 20 in the Caucasian pre-menarcheal group indicates that individual body image concerns are developing at an earlier age. Multiple logistic regression revealed several associations between mother-teen interactions and the development of abnormal eating attitudes.