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1.
Invest Radiol ; 55(11): 702-710, 2020 11.
Artículo en Inglés | MEDLINE | ID: mdl-32604388

RESUMEN

OBJECTIVES: The aim of this study was to explore blood deoxygenation across cerebral arteriovenous malformations (AVMs) for functional characterization of AVM vasculature. MATERIALS AND METHODS: Fifteen patients with cerebral arteriovenous vascular malformation were prospectively studied by digital subtraction angiography and using a 3 T magnetic resonance imaging system, with which three-dimensional (3D) gradient echo data for the calculation of quantitative susceptibility maps, velocity-encoded 3D gradient echo data for 3D flow assessment, and contrast-enhanced 3D time-of-flight data were acquired.The nidus, major supplying artery, and major draining veins were identified on digital subtraction angiography, and volumes of interest of the AVM nidus, AVM-related inflow and outflow vessels, and non-AVM-related normal veins were drawn on coregistered contrast-enhanced 3D time-of-flight data. The resulting volumes of interest were applied to quantitative susceptibility mapping and flow data. RESULTS: All patients showed a significant stepwise increase in susceptibility between feeding artery and nidus as well as between nidus and draining vein (Padjusted = 0.035, Padjusted= 0.007, respectively). Results revealed between 9.3% and 50.9% of the normal transcapillary blood deoxygenation-related susceptibility change between the feeding artery and the draining vein of the AVMs. When normalized by nidal blood flow velocity, this change was correlated with the presence of perinidal blood products. The mean susceptibility change across cerebral AVMs normalized with nidal volume inversely correlated with mean nidal flow velocity. CONCLUSIONS: Susceptibility changes indicating blood deoxygenation across cerebral AVMs were shown for the first time in this study and were associated with the presence of perinidal blood products. Deoxygenation measures may serve as functional characterization of AVM vasculature and may offer the potential for individual treatment assessment and possible risk stratification.


Asunto(s)
Malformaciones Arteriovenosas Intracraneales/diagnóstico por imagen , Adolescente , Adulto , Angiografía de Substracción Digital , Velocidad del Flujo Sanguíneo , Susceptibilidad a Enfermedades , Femenino , Humanos , Malformaciones Arteriovenosas Intracraneales/fisiopatología , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad
2.
Clin Neuroradiol ; 30(3): 607-614, 2020 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-31396654

RESUMEN

PURPOSE: To quantify the influence of melanin content on magnetic susceptibility of cerebral melanoma metastases. METHODS: Patients with non-hemorrhagic metastases were included based on the absence of susceptibility blooming artifacts. Susceptibility maps were calculated from 3D gradient echo data, using Laplacian-based phase unwrapping, sophisticated harmonic artefact reduction for phase data (V-SHARP) with varying spherical kernel sizes for background field removal and the iLSQR algorithm for the inversion of phase data. Susceptibility maps were referenced to cerebrospinal fluid. Non-hemorrhagic metastases were identified on contrast-enhanced T1-weighted images and susceptibility weighted images. Metastases masks were drawn on T1-weighted post-contrast images and used to compute mean susceptibility values of each metastasis. RESULTS: A total of 33 non-hemorrhagic melanoma brain metastases in 20 patients were quantitatively evaluated. Metastases without and with hyperintense signal on T1-weighted images, which corresponds to the melanin content, showed median susceptibility values of -0.028 ppm and -0.020 ppm, respectively. The susceptibility differences between metastases without and with T1-weighted hyperintense signal was not statistically significant (p ≥ 0.05). CONCLUSION: Non-hemorrhagic cerebral melanoma metastases showed weak diamagnetic susceptibility values and susceptibility did not significantly correlate to T1-weighted signals. Therefore, melanin does not seem to be a major contributor to susceptibility in cerebral melanoma metastases.


Asunto(s)
Neoplasias Encefálicas/diagnóstico por imagen , Neoplasias Encefálicas/secundario , Imagen por Resonancia Magnética/métodos , Melaninas/metabolismo , Melanoma/diagnóstico por imagen , Melanoma/secundario , Neoplasias Cutáneas/diagnóstico por imagen , Neoplasias Cutáneas/patología , Adulto , Anciano , Anciano de 80 o más Años , Artefactos , Neoplasias Encefálicas/metabolismo , Medios de Contraste , Femenino , Humanos , Imagenología Tridimensional , Masculino , Melanoma/metabolismo , Persona de Mediana Edad , Estudios Retrospectivos , Neoplasias Cutáneas/metabolismo
3.
Med Phys ; 45(4): 1586-1593, 2018 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-29394448

RESUMEN

PURPOSE: To investigate the extent of MR image distortions in the pelvis caused by susceptibility-induced field inhomogeneities in MR images in the context of a study on MR-guided radiotherapy. METHODS: Using a high-bandwidth double-echo gradient echo sequence, field maps and distortion maps of the pelvis were calculated and evaluated for 219 exams (92 of female and 127 of male patients) to investigate patient-related image distortions caused by susceptibility differences in an ongoing study on MR-guided radiotherapy. The evaluation of distortions in the regions "rectum", "prostate", "cervix", and in a reference region in the gluteus maximus was based on masks drawn by two readers. RESULTS: Distortions in the prostate and cervix were smaller than 0.03 px (0.1 mm) for 99% of voxels, and reached a maximum value of 0.09 px (0.3 mm). In the reference region, maximum distortions were smaller than in the prostate and cervix. CONCLUSIONS: Using a geometric uncertainty of 0.2 px (0.6 mm) in margin definition for organs that are close to the rectum like the prostate and the cervix would be a cautious choice to account for susceptibility-induced distortions that can arise during MR-based treatment guidance for the imaging setting used in this study. Since distortions are inversely proportional to the readout bandwidth of the sequence, safety margins need to be adapted adequately. Additional sources of image distortions like gradient nonlinearities are not included in our margin recommendations and should be considered separately.


Asunto(s)
Artefactos , Cuello del Útero/diagnóstico por imagen , Imagen por Resonancia Magnética , Próstata/diagnóstico por imagen , Radioterapia Guiada por Imagen , Femenino , Humanos , Procesamiento de Imagen Asistido por Computador , Masculino , Fantasmas de Imagen , Planificación de la Radioterapia Asistida por Computador
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