RESUMEN
Migraine is characterized by reduced habituation of multimodal evoked potentials, which in turn reflects an abnormal pattern of cortical excitability. We assessed the effects of a 2-month treatment with topiramate or levetiracetam vs placebo on contingent negative variation (CNV) habituation and amplitude in a cohort of migraine without aura (MO) patients. Forty-five MO patients were selected from a university-based outpatient clinic and randomly assigned to 100mg topiramate or 1000mg levetiracetam or placebo in a double-blind design. Twenty-four control subjects were also recruited. The initial CNV (iCNV) amplitude and habituation were assessed by Cz/A1-A2 derivation recordings in the basal condition (T0) and after 2 months of treatment (T1). Both topiramate and levetiracetam produced a significant reduction in migraine frequency compared to placebo, they also reversed the abnormal iCNV habituation pattern which characterized the MO patients in the basal condition and which was not present in controls. For migraine patients, the reduced migraine frequency and habituation index following treatment were significantly correlated. A lack of habituation of evoked responses is an interictal endophenotypic marker in migraine, the reversion of which may improve disease outcome. These results suggest a role for neurophysiological methods in the management of migraine.
Asunto(s)
Anticonvulsivantes/farmacología , Variación Contingente Negativa/efectos de los fármacos , Habituación Psicofisiológica/efectos de los fármacos , Migraña sin Aura/fisiopatología , Piracetam/análogos & derivados , Estimulación Acústica/métodos , Adolescente , Adulto , Análisis de Varianza , Anticonvulsivantes/uso terapéutico , Método Doble Ciego , Electroencefalografía , Femenino , Fructosa/análogos & derivados , Fructosa/uso terapéutico , Humanos , Levetiracetam , Masculino , Persona de Mediana Edad , Migraña sin Aura/tratamiento farmacológico , Piracetam/farmacología , Piracetam/uso terapéutico , Factores de Tiempo , TopiramatoRESUMEN
"Ictal smile" is defined as a facial expression during a seizure, which usually translates happiness, clearly distinct from a tonic deviation of the mouth or other abnormal tonic-clonic movements involving the face, not associated to any happiness emotion (Epilepsia. 1998;39:1357-1360). It is a rare condition (6%-10% of patients; Epilepsia. 1998;39:1357-1360) and seems to be related to seizures arising from temporal or frontal regions (Brain. 2003;126:2121-2138).Anecdotal reports of brain perfusion SPECT performed during ictal and interictal phases (Epilepsia. 1998;39:1357-1360) do not supply, unfortunately, imaging documentation. Thus, we report the first evidence of brain perfusion abnormalities induced by ictal smile seizure.