Detalles de la búsqueda
1.
Small-molecule inhibitors of cyclophilin D as potential therapeutics in mitochondria-related diseases.
Med Res Rev
; 42(5): 1822-1855, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35575048
2.
Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities.
J Enzyme Inhib Med Chem
; 37(1): 2605-2620, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36131624
3.
Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimers drugs dealing with cholinergic, amyloid and mitochondrial systems.
Bioorg Chem
; 107: 104596, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33421953
4.
Classification of Ataxic Gait.
Sensors (Basel)
; 21(16)2021 Aug 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-34451018
5.
The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6-O-desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs.
Molecules
; 26(8)2021 Apr 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-33918638
6.
From orexin receptor agonist YNT-185 to novel antagonists with drug-like properties for the treatment of insomnia.
Bioorg Chem
; 103: 104179, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32891860
7.
Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators.
J Enzyme Inhib Med Chem
; 35(1): 478-488, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-31910701
8.
Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17ß-HSD10 with Implications to Alzheimer's Disease Treatment.
Int J Mol Sci
; 21(6)2020 Mar 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-32192199
9.
Wide-Antimicrobial Spectrum of Picolinium Salts.
Molecules
; 25(9)2020 May 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32403238
10.
Orexin supplementation in narcolepsy treatment: A review.
Med Res Rev
; 39(3): 961-975, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30426515
11.
Novel quinazolin-4-one derivatives as potentiating agents of doxorubicin cytotoxicity.
Bioorg Chem
; 82: 204-210, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30326402
12.
In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier.
Molecules
; 24(7)2019 Apr 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30959739
13.
Profiling donepezil template into multipotent hybrids with antioxidant properties.
J Enzyme Inhib Med Chem
; 33(1): 583-606, 2018 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-29529892
14.
Investigation of New Orexin 2 Receptor Modulators Using In Silico and In Vitro Methods.
Molecules
; 23(11)2018 Nov 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30423961
15.
Rational Design of a New Class of Toll-Like Receptor 4 (TLR4) Tryptamine Related Agonists by Means of the Structure- and Ligand-Based Virtual Screening for Vaccine Adjuvant Discovery.
Molecules
; 23(1)2018 Jan 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29300367
16.
Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment.
Bioorg Med Chem
; 25(3): 1143-1152, 2017 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28082069
17.
Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation.
Molecules
; 22(6)2017 Jun 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-28621747
18.
Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy.
Molecules
; 22(8)2017 Jul 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-28788095
19.
Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17ß-HSD10 modulators for Alzheimer's disease treatment.
Bioorg Med Chem Lett
; 26(15): 3675-8, 2016 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27287370
20.
Synthesis, antimicrobial evaluation and molecular modeling of 5-hydroxyisoquinolinium salt series; the effect of the hydroxyl moiety.
Bioorg Med Chem
; 24(4): 841-8, 2016 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26774252