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Biochem Biophys Res Commun ; 445(2): 439-44, 2014 Mar 07.
Artículo en Inglés | MEDLINE | ID: mdl-24530907

RESUMEN

Autotransporters (ATs) represent a superfamily of proteins produced by a variety of pathogenic bacteria, which include the pathogenic groups of Escherichia coli (E. coli) associated with gastrointestinal and urinary tract infections. We present the first X-ray structure of the passenger domain from the Plasmid-encoded toxin (Pet) a 100 kDa protein at 2.3 Å resolution which is a cause of acute diarrhea in both developing and industrialized countries. Pet is a cytoskeleton-altering toxin that induces loss of actin stress fibers. While Pet (pdb code: 4OM9) shows only a sequence identity of 50% compared to the closest related protein sequence, extracellular serine protease plasmid (EspP) the structural features of both proteins are conserved. A closer structural look reveals that Pet contains a ß-pleaded sheet at the sequence region of residues 181-190, the corresponding structural domain in EspP consists of a coiled loop. Secondary, the Pet passenger domain features a more pronounced beta sheet between residues 135 and 143 compared to the structure of EspP.


Asunto(s)
Toxinas Bacterianas/química , Enterotoxinas/química , Proteínas de Escherichia coli/química , Escherichia coli/química , Serina Endopeptidasas/química , Cristalografía por Rayos X , Modelos Moleculares , Estructura Secundaria de Proteína , Estructura Terciaria de Proteína
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