1.
Proc Natl Acad Sci U S A
; 101(33): 12054-7, 2004 Aug 17.
Artículo
en Inglés
| MEDLINE
| ID: mdl-15280544
RESUMEN
Securamine A is a structurally intriguing alkaloid possessing a pyrroloindole core joined via a modified isoprene subunit to a functionalized imidazole ring. Recent synthetic efforts in this laboratory have resulted in the efficient construction of key lactone 36, which undergoes tandem azide reduction/ring expansion to macrolactam 37. Macrolactam 37 possesses the complete macrocyclic core of securamine A.