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BACKGROUND: Stroke etiology could influence the outcomes in patients with basilar-artery occlusion (BAO). This study aimed to evaluate the differences in efficacy and safety of best medical treatment (BMT) plus endovascular treatment (EVT) versus BMT alone in acute BAO across different stroke etiologies. METHODS: The study was a post hoc analysis of the ATTENTION trial (Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion), which was a multicenter, randomized trial at 36 centers in China from February 2021 to September 2022. Patients with acute BAO were classified into 3 groups according to stroke etiology (large-artery atherosclerosis [LAA], cardioembolism, and undetermined cause/other determined cause [UC/ODC]). The primary outcome was a favorable outcome (modified Rankin Scale score of 0-3) at 90 days. Safety outcomes included symptomatic intracranial hemorrhage and 90-day mortality. RESULTS: A total of 340 patients with BAO were included, 150 (44.1%) had LAA, 72 (21.2%) had cardioembolism, and 118 (34.7%) had UC/ODC. For patients treated with BMT plus EVT and BMT alone, respectively, the rate of favorable outcome at 90 days was 49.1% and 23.8% in the LAA group (odds ratio, 3.08 [95% CI, 1.38-6.89]); 52.2% and 30.8% in the cardioembolism group (odds ratio, 2.45 [95% CI, 0.89-6.77]); and 37.5% and 17.4% in the UC/ODC group (odds ratio, 2.85 [95% CI, 1.16-7.01]), with P=0.89 for the stroke etiology×treatment interaction. The rate of symptomatic intracranial hemorrhage in EVT-treated patients with LAA, cardioembolism, and UC/ODC was 8.3%, 2.2%, and 3.2%, respectively, and none of the BMT-treated patients. Lower 90-day mortality was observed in patients with EVT compared with BMT alone across 3 etiology groups. CONCLUSIONS: Among patients with acute BAO, EVT compared with BMT alone might be associated with favorable outcomes and lower 90-day mortality, regardless of cardioembolism, LAA, or UC/ODC etiologies. The influence of stroke etiology on the benefit of EVT should be explored by further trials. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04751708.
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Procedimientos Endovasculares , Insuficiencia Vertebrobasilar , Humanos , Procedimientos Endovasculares/métodos , Masculino , Femenino , Persona de Mediana Edad , Anciano , Insuficiencia Vertebrobasilar/cirugía , Insuficiencia Vertebrobasilar/complicaciones , Resultado del Tratamiento , Accidente Cerebrovascular/cirugía , Accidente Cerebrovascular/etiología , China/epidemiologíaRESUMEN
Endophytic fungi are an important source of novel antitumor substances. Previously, we isolated an endophytic fungus, Alternaria alstroemeria, from the medicinal plant Artemisia artemisia, whose crude extracts strongly inhibited A549 tumor cells. We obtained a transformant, namely AaLaeAOE26 , which completely loses its antitumor activity due to overexpression of the global regulator AaLaeA. Re-sequencing analysis of the genome revealed that the insertion site was in the noncoding region and did not destroy any other genes. Metabolomics analysis revealed that the level of secondary antitumor metabolic substances was significantly lower in AaLaeAOE26 compared with the wild strain, in particular flavonoids were more downregulated according to the metabolomics analysis. A further comparative transcriptome analysis revealed that a gene encoding FAD-binding domain protein (Fla1) was significantly downregulated. On the other hand, overexpression of AaFla1 led to significant enhancement of antitumor activity against A549 with a sevenfold higher inhibition ratio than the wild strain. At the same time, we also found a significant increase in the accumulation of antitumor metabolites including quercetin, gitogenin, rhodioloside, liensinine, ginsenoside Rg2 and cinobufagin. Our data suggest that the global regulator AaLaeA negatively affects the production of antitumor compounds via controlling the transcription of AaFla1 in endophytic A. alstroemeria.
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Alstroemeria , Alternaria , Alternaria/genética , Metabolismo Secundario , Flavonoides/metabolismo , EndófitosRESUMEN
BACKGROUND: Acute pancreatitis in pregnancy (APIP) with a high risk of death is extremely harmful to mother and fetus. There are few models specifically designed to assess the severity of APIP. Our study aimed to establish a clinical model for early prediction of severity of APIP. METHODS: A retrospective study in a total of 188 patients with APIP was enrolled. The hematological indicators, IAP (intra-abdominal pressure) and clinical data were obtained for statistical analysis and prediction model construction. RESULTS: According to univariate and multivariate logistic regression analysis, we found that red cell distribution width (RDW), neutrophil-lymphocyte ratio (NLR) and Intra-abdominal pressure (IAP) are prediction indexes of the severity in APIP (p-value < 0.05). Our novel clinical prediction model was created by based on the above three risk factors and showed superior predictive power in primary cohort (AUC = 0.895) and validation cohort (AUC = 0.863). A nomogram for severe acute pancreatitis in pregnancy (SAPIP) was created based on the three indicators. The nomogram was well-calibrated. CONCLUSION: RDW, NLR and IAP were the independent risk factors of APIP. Our clinical prediction model of severity in APIP based on RDW, NLR and IAP with predictive evaluation is accurate and effective.
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Pancreatitis , Embarazo , Femenino , Humanos , Pancreatitis/diagnóstico , Pancreatitis/etiología , Neutrófilos , Índices de Eritrocitos , Estudios Retrospectivos , Enfermedad Aguda , Modelos Estadísticos , Pronóstico , LinfocitosRESUMEN
Background: Seed abortion is a common phenomenon in Chinese jujube that seriously hinders the process of cross-breeding. However, the molecular mechanisms of seed abortion remain unclear in jujube. Methods: Here, we performed transcriptome sequencing using eight flower and fruit tissues at different developmental stages in Ziziphus jujuba Mill. 'Zhongqiusucui' to identify key genes related to seed abortion. Histological analysis revealed a critical developmental process of embryo abortion after fertilization. Results: Comparisons of gene expression revealed a total of 14,012 differentially expressed genes. Functional enrichment analyses of differentially expressed genes between various sample types uncovered several important biological processes, such as embryo development, cellular metabolism, and stress response, that were potentially involved in the regulation of seed abortion. Furthermore, gene co-expression network analysis revealed a suite of potential key genes related to ovule and seed development. We focused on three types of candidate genes, agamous subfamily genes, plant ATP-binding cassette subfamily G transporters, and metacaspase enzymes, and showed that the expression profiles of some members were associated with embryo abortion. Conclusion: This work generates a comprehensive gene expression data source for unraveling the molecular mechanisms of seed abortion and aids future cross-breeding efforts in jujube.
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BACKGROUND: Although numerous studies have used functional neuroimaging to identify executive dysfunction in patients with bipolar disorder (BD), the findings are not consistent. The aim of this meta-analysis is to identify the most reliable functional anomalies in BD patients during performance of Executive Function (EF) tasks. METHODS: A web-based search was performed on publication databases to identify functional magnetic resonance imaging studies of BD patients performing EF tasks and a voxel-based meta-analytic method known as anisotropic Effect Size Signed Differential Mapping (ES-SDM) was used to identify brain regions which showed anomalous activity in BD patients compared with healthy controls (HC). RESULTS: Twenty datasets consisting of 463 BD patients and 484 HC were included. Compared with HC, BD patients showed significant hypo-activation or failure of activation in the left striatum (p = 0.00007), supplementary motor area (BA 6, p = 0.00037), precentral gyrus (BA 6, p = 0.0014) and cerebellum (BA 37, p = 0.0019), and hyper-activation in the left gyrus rectus (BA 11, p ≈ 0) and right middle temporal gyrus (BA 22, p = 0.00031) during performance of EF tasks. Sensitivity and subgroup analyses showed that the anomaly of left striatum is consistent across studies and present in both euthymic and BD I patients. CONCLUSIONS: Patients with BD consistently showed abnormal activation in the cortico-striatal system during performance of EF tasks compared with HC. Failure of activation of the striatum may be a reliable marker for impairment in performance of especially inhibition tasks by patients with BD.
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Trastorno Bipolar/fisiopatología , Corteza Cerebral/fisiopatología , Cuerpo Estriado/fisiopatología , Función Ejecutiva/fisiología , Neuroimagen Funcional , Inhibición Psicológica , Metaanálisis como Asunto , Adulto , Trastorno Bipolar/diagnóstico por imagen , Corteza Cerebral/diagnóstico por imagen , Cuerpo Estriado/diagnóstico por imagen , HumanosRESUMEN
Screening appropriate washing agents to remediate soils contaminated with heavy metals is crucial for decreasing metal hazards posing to environment and human health. In this study, two plant washing agents-water-extracted from Fagopyrum esculentum and Fordiophyton faberi, were applied to remove soil Pb, Zn, and Cd by washing. Results indicated that metal removals augmented with increase of washing solution concentrations, decreased with increasing pH values of the solution and followed the pseudo-second-order model depending on contact duration. At concentration of 50â¯g/L, pH 3 and contact duration of 120â¯min, F. esculentum had higher removals of Pb (5.98-6.83%), Zn (21.82-27.94%), and Cd (39.90-40.74%) than those of F. faberi. And metal ions could be removed by binding with carboxyl, hydroxyl, amide, amine and aromatic groups in washing solutions. The potential risks of residual metals declined by 51.35-52.12% for mine soil and 48.51-49.96% for farmland soil with exchangeable and carbonate-bound fractions obviously extracted after a single washing (Pâ¯<â¯0.05). And soil organic carbon and nutrients increased to some extent except for total phosphorus and available potassium. Moreover, soil phytotoxicity lowered except that some adverse effects on seed germination existed. Therefore, the water extract from F. esculentum is a promising washing agent for heavy metal removal.
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Restauración y Remediación Ambiental/métodos , Metales Pesados/química , Extractos Vegetales/química , Contaminantes del Suelo/química , Cadmio/química , Fagopyrum/química , Humanos , Plomo/química , Plomo/aislamiento & purificación , Myrtales/química , Zinc/química , Zinc/aislamiento & purificaciónRESUMEN
It is of great significance for the global navigation satellite system (GNSS) service to detect the polar ionospheric total electron content (TEC) and its variations, particularly under disturbed ionosphere conditions, including different phases of solar activity, the polar day and night alternation, the Weddell Sea anomaly (WSA) as well as geomagnetic storms. In this paper, four different models are utilized to map the ionospheric TEC over the Arctic and Antarctic for about one solar cycle: the polynomial (POLY) model, the generalized trigonometric series function (GTSF) model, the spherical harmonic (SH) model, and the spherical cap harmonic (SCH) model. Compared to other models, the SCH model has the best performance with ±0.8 TECU of residual mean value and 1.5-3.5 TECU of root mean square error. The spatiotemporal distributions and variations of the polar ionospheric TEC are investigated and compared under different ionosphere conditions in the Arctic and Antarctic. The results show that the solar activity significantly affects the TEC variations. During polar days, the ionospheric TEC is more active than it is during polar nights. In polar days over the Antarctic, the maximum value of TEC always appears at night in the Antarctic Peninsula and Weddell Sea area affected by the WSA. In the same year, the ionospheric TEC of the Antarctic has a larger amplitude of annual variation than that of the TEC in the Arctic. In addition, the evolution of the ionization patch during a geomagnetic storm over the Antarctic can be clearly tracked employing the SCH model, which appears to be adequate for mapping the polar TEC, and provides a sound basis for further automatic identification of ionization patches.
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Soil washing is one of the permanent techniques to remove heavy metals, and washing agent is a key influence factor for this technique, but there is still lack of high-efficiency, eco-friendly, and inexpensive agents. In this study, four wastes including pineapple peel (PP), soybean straw (SS), broad bean straw (BBS) and tea residue (TR) were employed to remove cadmium (Cd), lead (Pb) and zinc (Zn) in contaminated soils. The Fourier transform infrared spectroscopy (FTIR) analysis indicated that hydroxyl, carboxyl, amine, carbonyl and amide groups were involved in the interaction with metal ions by complexation or ion exchange. We then investigated the influences of various conditions including washing solution concentration, pH, and washing time. The metal removal efficiencies with these agents increased as the concentration augmented from 5 to 80â¯gâ¯L-1, decreased or presented an asymmetric V-shaped curve with increasing pH from 2.5 to 7.5, and fit intraparticle diffusion or Elovich model with washing time increasing. PP has the highest removals for Cd (90.1%), Pb (18.6%), and Zn (15.2%) in soil A, and 85.8, 24.8, and 69.4% in soil B, respectively. The relatively high metal removal was mainly attributed to effective removal of the exchangeable and acid soluble fractions. Moreover, single washing not only lowered the potential ecological risk of the heavy metals, but moderated the effects on soil chemical properties. Therefore, PP was a feasible washing agent to remediate soils contaminated by heavy metals.
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Metales Pesados/química , Contaminantes del Suelo/química , Cadmio , Contaminación Ambiental , Metales Pesados/aislamiento & purificación , Suelo , Contaminantes del Suelo/aislamiento & purificación , Administración de ResiduosRESUMEN
OBJECTIVE: We investigated the relationship between using a rotary compression device (RCD) with or without sterile gauze and adverse events in transradial access (TRA) for coronary intervention. METHODS: In this study involving 933 patients at Yueyang Hospital, we recorded TRA-related adverse events, such as bleeding, forearm hematoma, swollen palms, radial artery occlusion (RAO) and others. Logistic regression was applied to assess the association. RESULTS: Of the 933 patients (66.7% males, average age 67.8 years), 511 used RCD with sterile gauze, whereas 422 used RCD without sterile gauze. The most common adverse events were radial artery hemorrhage (7.4%), hand swelling (4.8%) and RAO (4.6%). Logistic regression analysis revealed that the use of RCD with sterile gauze was associated with a higher prevalence of adverse events [odds ratio (OR), 1.74; 95% confidence interval (CI), 1.22-2.49), even with the adjustment of potential confounders (OR, 1.71; 95% CI, 1.19-2.45). Moreover, patients who used RCD with sterile gauze exhibited an increased risk of radial artery hemorrhage (OR, 1.83; 95% CI, 1.07-3.12), swelling of the hand (OR, 1.96; 95% CI, 1.02-3.75) and RAO (OR, 3.17; 95% CI, 1.49-6.72). CONCLUSIONS: The use of RCD with sterile gauze in TRA is associated with a higher incidence of adverse events.
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Arteriopatías Oclusivas , Intervención Coronaria Percutánea , Masculino , Humanos , Anciano , Femenino , Estudios Retrospectivos , Hemorragia/epidemiología , Hemorragia/etiología , Hemorragia/prevención & control , Hemostasis , Hematoma/etiología , Hematoma/complicaciones , Intervención Coronaria Percutánea/efectos adversos , Arteria Radial , Arteriopatías Oclusivas/etiología , Resultado del Tratamiento , Angiografía Coronaria/efectos adversosRESUMEN
Spectral preprocessing techniques can, to a certain extent, eliminate irrelevant information, such as current noise and stray light from spectral data, thereby enhancing the performance of prediction models. However, current preprocessing techniques mostly attempt to find the best single preprocessing method or their combination, overlooking the complementary information among different preprocessing methods. These preprocessing techniques fail to maximize the utilization of useful information in spectral data and restrict the performance of prediction models. This study proposed a spectral ensemble preprocessing method based on the rapidly developing ensemble learning methods in recent years and the ridge regression (RR) model, named stacking preprocessing ridge regression (SPRR), to address the aforementioned issues. Different from conventional ensemble learning methods, the proposed SPRR method applied multiple different preprocessing techniques to the original spectral data, generating multiple preprocessed datasets. These datasets were then individually inputted into RR base models for training. Ultimately, RR still served as the meta-model, integrating the output results of each RR base model through stacking. This approach not only produced diversity in base models but also achieved higher accuracy and lower computational complexity by using a single type of base model. On the apple spectral dataset collected by our team, correlation analysis showed significant complementary information among the data produced by different preprocessing techniques. This provided robust theoretical support for the proposed SPRR method. By introducing the currently popular averaging ensemble preprocessing method in a comparative experiment, the results of applying the proposed SPRR method to six datasets (apple, meat, wheat, olive oil, tablet, and corn) demonstrated that compared to the single preprocessing method and averaging ensemble preprocessing method, SPRR yielded the best accuracy and reliability for all six datasets. Furthermore, under the same conditions of the training and test datasets, the proposed SPRR method demonstrated better performance than the four commonly used ensemble preprocessing methods.
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Myocardial infarction (MI) has a 5-year mortality rate of more than 50% due to the lack of effective treatments. Interactions between cardiomyocytes and the MI microenvironment (MIM) can determine the progression and fate of infarcted myocardial tissue. Here, a specially designed Melanin-based composite nanomedicines (MCN) is developed to effectively treat MI by reprogramming the MIM. MCN is a nanocomposite composed of polydopamine (P), Prussian blue (PB) and cerium oxide (CexOy) with a Mayuan-like structure, which reprogramming the MIM by the efficient conversion of detrimental substances (H+, reactive oxygen species, and hypoxia) into beneficial status (O2 and H2O). In coronary artery ligation and ischemia reperfusion models of male mice, intravenously injecting MCN specifically targets the damaged area, resulting in restoration of cardiac function. With its promising therapeutic effects, MCN constitutes a new agent for MI treatment and demonstrates potential for clinical application.
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Cerio , Indoles , Melaninas , Infarto del Miocardio , Nanomedicina , Polímeros , Animales , Melaninas/metabolismo , Infarto del Miocardio/tratamiento farmacológico , Infarto del Miocardio/patología , Masculino , Ratones , Nanomedicina/métodos , Indoles/química , Polímeros/química , Cerio/química , Cerio/farmacología , Cerio/administración & dosificación , Miocitos Cardíacos/efectos de los fármacos , Miocitos Cardíacos/metabolismo , Nanocompuestos/química , Modelos Animales de Enfermedad , Especies Reactivas de Oxígeno/metabolismo , Ratones Endogámicos C57BL , Microambiente Celular/efectos de los fármacos , FerrocianurosRESUMEN
The advent of liquid-solid triboelectric nanogenerators (LS-TENGs) has ushered in a new era for harnessing and using energy derived from water. To date, extensive research has been conducted to enhance the output of LS-TENGs, thereby improving water utilization efficiency and facilitating their practical application. However, in contrast to intricate chemical treatment methods and specialized structures, a straightforward operational process and cost-effective materials are more conducive to the widespread adoption of LS-TENGs in practical applications. This work presents a novel method to enhance the output of LS-TENGs by increasing the liquid-solid contact area. The approach involves creating roughness on the solid surface through sandpaper grinding, which is simple in design and easy to operate and significantly reduces the cost of the experiment. The theory is applied to the solid triboelectric layer commonly used in the LS-TENG, demonstrating its universality and wide applicability to improve the output of the LS-TENG. The practical performance of the device is demonstrated by charging the capacitor and external load and driving the hygrometer and commercial 5 W LED light bulb, which can directly light up 300 commercial light-emitting diodes (LEDs) driven by a drop of water. This work provides a new method for the optimization of LS-TENGs and contributes to the wide application of LS-TENGs. This is a significant step forward in the field of energy harvesting and utilization.
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To proceed proteomic analysis of erythrocyte of the red-eared turtle Trachemys scripta, a method for obtaining turtle erythrocyte ghosts (TEG) was first developed. After hypotonic lysis using a special buffer, forcing the erythrocyte through the syringe with an "N"-shaped needle, applying low speed homogenizing and differential centrifugation, highly purified TEG fractions were obtained. The isolated TEG proteins were treated with in-gel digestion separated by SDS-PAGE or in-solution digestion followed by HPLC predissociation, and then identified by nano-ESI-LC MS/MS techniques. A total of 169 TEG proteins was identified, validated, and categorized. Among these proteins, tubulins, and cell-surface-located F-type ATP synthase revealed important information into the super tolerance of Trachemys scripta in anoxia and low temperature exposure. Altogether, this study not only provided a method to isolate high quality TEG and a dataset of comprehensive characterization of TEG proteins, but also provides a tool for proteomic research of all nucleated red blood cells, and thus opened a new research field for exploring the mechanisms of super tolerance of turtles in harsh environment.
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Separación Celular/métodos , Membrana Eritrocítica/química , Proteoma/química , Proteómica/métodos , Tortugas/sangre , Animales , Proteínas Sanguíneas/análisis , Proteínas Sanguíneas/química , Cromatografía Liquida , Electroforesis en Gel de Poliacrilamida , Proteoma/análisis , Espectrometría de Masas en TándemRESUMEN
INTRODUCTION: Pericardial effusion is a common complication without a standard postoperative effusion treatment after cardiac surgery. The grooved negative pressure drainage tube has many advantages as the emerging alternative for drainage of pericardial effusion, such as it changes the structure of the traditional side hole, uses the capillary function to ensure drainage smooth, etc. The purpose of this study was to assess the feasibility and effectiveness of transthoracic color Doppler ultrasound-guided grooved negative pressure drainage tube implantation in pericardial effusion after cardiac surgery. METHODS: All patients with pericardial effusion after cardiac surgery who underwent transthoracic color Doppler ultrasound-guided grooved negative pressure drainage tube implantation between January 2019 and December 2021 were retrospectively analyzed. Treatment results (including clinical symptoms, effusion volume, color Doppler ultrasonography, and computed tomography scan) were investigated to evaluate the effectiveness and safety of this method. RESULTS: A total of 20 patients successfully underwent transthoracic color Doppler ultrasound-guided grooved negative pressure drainage tube implantation. After the operation, their symptoms (chest tightness, shortness of breath, etc.) were all relieved, and dark red or light red drainage fluid (> 200 ml) appeared in the newly placed drainage bottle. Color Doppler ultrasonography showed that the volume of pericardial effusion decreased significantly. CONCLUSION: The transthoracic color Doppler ultrasound-guided grooved negative pressure drainage tube is a safe and effective method for the treatment of postoperative pericardial effusion with less trauma, faster recovery, shorter in-hospital stay, and fewer complications.
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Procedimientos Quirúrgicos Cardíacos , Derrame Pericárdico , Humanos , Derrame Pericárdico/diagnóstico por imagen , Derrame Pericárdico/etiología , Derrame Pericárdico/cirugía , Estudios Retrospectivos , Complicaciones Posoperatorias/diagnóstico por imagen , Complicaciones Posoperatorias/cirugía , Procedimientos Quirúrgicos Cardíacos/efectos adversos , Procedimientos Quirúrgicos Cardíacos/métodos , Drenaje/métodosRESUMEN
The function of microRNA (miRNA) in neuropathic pain (NP) has received widespread attention. The current research sought to address the contribution of miR4883p in NP and its downstream mechanisms. The NP rat model was constructed by chronic constriction injury (CCI) surgery in rats. Regulation of miR4883p or Rhoassociated coiledcoilcontaining protein kinase 1 (ROCK1) in rats by intrathecal injection of lentivirus or plasmid. Realtime quantitative reverse transcription polymerase chain reaction (RTqPCR) to examine the levels of miR4883p and ROCK1 in the dorsal root ganglion (DRG). Enzymelinked immunosorbent assay (ELISA) to monitor the secretion of proinflammatory and antiinflammatory factors. Paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) for the evaluation of mechanosensitive and thermal nociceptive hypersensitivity of NP behaviors. Validation of molecular mechanism between miR4883p and ROCK1 using RNA immunoprecipitation assay and dualluciferase reporter (DLR) assay. miR4883p was vigorously less expressed in the DRGs of CCI rats, while ROCK1 was upregulated. Elevated miR4883p alleviated the decrease of PWL and PWT in CCI rats, inhibited the secretion of proinflammatory factors, and enhanced antiinflammatory factors levels. Mechanistically, ROCK1 was the target of miR4883p. Raised ROCK1 partially attenuated the mitigating effect of miR4883p on NP behavior and the suppression of inflammatory responses in rats. Current research demonstrated that miR4883p may be a novel therapeutic target for NP.
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MicroARNs , Neuralgia , Animales , Ratas , Antiinflamatorios , Ganglios Espinales , MicroARNs/genética , Neuralgia/genética , Ratas Sprague-Dawley , Quinasas Asociadas a rho/genética , Quinasas Asociadas a rho/metabolismoRESUMEN
OBJECTIVE: Studies have shown that oxidative stress (OS) is related to the pathophysiology of schizophrenia (SCZ), but whether antipsychotics can induce OS has not been investigated well. Moreover, antipsychotics have differential effects on the OS level modulation, i.e., different types of antipsychotics have different effects on the cellular antioxidants or pro-oxidants. METHODS: We followed the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines and investigated the OS indicators including both enzymatic and nonenzymatic markers, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), malondialdehyde (MDA), glutathione (GSH), vitamin C, etc., of SCZ patients at baseline and follow-up of mono-medication. RESULTS: Twenty studies met the inclusion criteria, with a total of 1162 patients enrolled at baseline, and 1105 patients completed the follow-up. OS markers were changed after a period of antipsychotic treatment in SCZ patients. The GPx activity and MDA level decreased in the whole blood (P<0.05), also the serum MDA level decreased (P<0.05). For the first-episode SCZ patients, the activity of GPx and the level of MDA decreased, while the level of vitamin C increased (all P<0.05). The levels of MDA in patients receiving atypical antipsychotics decreased (P<0.05), while the level of GSH in patients with typical antipsychotics decreased (P=0.05). CONCLUSION: Antipsychotic medication may cause changes in the levels of OS markers in different blood samples of SCZ patients. However, the available studies might not be sufficient to reveal the underlying facts accurately due to the poor quality of experimental designs in the published literature.
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Antipsicóticos , Esquizofrenia , Humanos , Antipsicóticos/uso terapéutico , Esquizofrenia/tratamiento farmacológico , Estrés Oxidativo , Antioxidantes/farmacología , Ácido Ascórbico/farmacología , Ácido Ascórbico/uso terapéutico , Glutatión Peroxidasa/metabolismo , Glutatión Peroxidasa/farmacología , Glutatión , BiomarcadoresRESUMEN
Zerovalent iron (ZVI)-based Fenton-like processes have been widely applied in degrading organic contaminants. However, the surface oxyhydroxide passivation layer produced during the preparation and oxidation of ZVI hinders its dissolution and Fe(III)/Fe(II) cycling, and restricts the generation of reactive oxygen species (ROS). In this study, copper sulfide (CuS) was found to effectively enhance the degradation of diverse organic pollutants in the ZVI/H2O2 system. Moreover, the degradation performance for the actual industrial wastewater (i.e., dinitrodiazophenol wastewater) in the ZVI/H2O2 system was impressively improved by 41% with CuS addition, and the COD removal efficiency could reach 97% after 2 h of treatment. Mechanism investigation revealed that the introduction of CuS accelerated the sustainable supply of Fe(II) in the ZVI/H2O2 system. Specifically, Cu(I) and reductive sulfur species (i.e., S2-, S22-, Sn2- and H2S (aq)) from CuS directly induced efficient Fe(III)/Fe(II) cycling. The iron-copper synergistic effect between Cu(II) from CuS and ZVI expedited Fe(II) generation from ZVI dissolution and Fe(III) reduction by formed Cu(I). This study not only elucidates the promotion effects of CuS on ZVI dissolution and Fe(III)/Fe(II) cycling in ZVI-based Fenton-like processes, but also provides a sustainable and high-efficiency iron-based oxidation system for removal of organic contaminants.
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Advanced oxidation technologies based on periodate (PI, IO4-) have garnered significant attention in water decontamination. In this work, we found that electrochemical activation using graphite electrodes (E-GP) can significantly accelerate the degradation of micropollutants by PI. The E-GP/PI system achieved almost complete removal of bisphenol A (BPA) within 15 min, exhibited unprecedented pH tolerance ranging from pH 3.0 to 9.0, and showed more than 90% BPA depletion after 20 h of continuous operation. Additionally, the E-GP/PI system can realize the stoichiometric transformation of PI into iodate, dramatically decreasing the formation of iodinated disinfection by-products. Mechanistic studies confirmed that singlet oxygen (1O2) is the primary reactive oxygen species in the E-GP/PI system. A comprehensive evaluation of the oxidation kinetics of 1O2 with 15 phenolic compounds revealed a dual descriptor model based on quantitative structure-activity relationship (QSAR) analysis. The model corroborates that pollutants exhibiting strong electron-donating capabilities and high pKa values are more susceptible to attack by 1O2 through a proton transfer mechanism. The unique selectivity induced by 1O2 in the E-GP/PI system allows it to exhibit strong resistance to aqueous matrices. Thus, this study demonstrates a green system for the sustainable and effective elimination of pollutants, while providing mechanistic insights into the selective oxidation behaviour of 1O2.
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Contaminantes Ambientales , Grafito , Contaminantes Químicos del Agua , Agua , Grafito/química , Descontaminación , Oxidación-Reducción , Electrodos , Contaminantes Químicos del Agua/químicaRESUMEN
The research presented in this paper introduces a novel environmental energy-harvesting technology that harnesses electricity from the evaporation of water using porous structural materials. Specifically, a strategy employing paper-based hydroelectric generators (p-HEGs) is proposed to capture the energy produced during water evaporation and convert it into usable electricity. The p-HEGs offer several advantages, including simplicity in fabrication, low cost, and reusability. To evaluate their effectiveness, the water evaporation-induced electrical output performance of four different p-HEGs are compared. Among the variants tested, the p-HEG combining wood pulp and polyester fiber exhibits the best output performance. At room temperature, this particular p-HEG generates a short-circuit current and open-circuit voltage of ≈0.4 µA and 0.3 V, respectively, thereby demonstrating excellent electrical stability. Furthermore, the electrical current and voltage generated by the p-HEG through water evaporation are able to power an LED light, both individually and in series and parallel connections. This study delves into the potential of electricity harvesting from water evaporation and establishes it as a viable method for renewable energy applications.
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Objective: This study focused on elucidating the influence of early multidisciplinary collaboration on preventing intensive care unit- (ICU-) acquired weakness (AW) in critically ill patients (CIPs). Methods: Ninety-five CIPs admitted between December 2018 and December 2021 were selected and assigned to the following two groups according to the intervention pattern: the control group (the Con; n = 40) treated with routine early rehabilitation intervention, and the research group (the Res; n = 55) intervened by early multidisciplinary collaborative intervention. The incidence of complications (ICU-AW, deep vein thrombosis (DVT), and pressure ulcers (PSs)) and recovery indices (days of ventilator use, ICU treatment time, and length of hospital stay (LOS)) were recorded. Besides, patients' activity function and quality of life (QoL) were evaluated and compared, among which the former was evaluated by the Barthel Index (BI), ICU Mobility Scale (IMS), and Medical Research Council (MRC) Scale, and the latter was assessed by the World Health Organization Quality of Life Assessment (100-item version) (WHOQOL-100). Results: The data identified statistically a lower incidence of complications (ICU-AW, DVT, and PSs) and shorter time of ventilator use, ICU residence, and LOS in the Res compared with the Con. In addition, BI, IMS, MRC, and WHOQOL-100 scores in the Res elevated statistically after treatment and were higher than those of the Con. Conclusions: Early multidisciplinary collaboration can validly prevent ICU-AW in CIPs, reduce the incidence of DVT and PSs, and promote patients' rehabilitation, mobility, and QoL.