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1.
Arch Orthop Trauma Surg ; 143(4): 1825-1832, 2023 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-35152332

RESUMEN

INTRODUCTION: Septic arthritis of the hip can appear isolated or concomitant with pelvic osteomyelitis. Delay in the diagnosis of a concomitant osteomyelitis increases the number of required surgeries and of possible complications. PURPOSE: This study aims to establish relevant factors in the diagnosis of concomitant osteomyelitis in cases with septic arthritis of the hip among paediatric patients. METHODS: The data were collected between 2005 and 2020. 41 pediatric patients with suspicion of septic arthritis of the hip joint, treated arthroscopically, were included. The following diagnostic test parameters were collected: ultrasound, MRI, X-Rays, blood samples, temperature, and incapacity to bear weight. The data were analysed with the sensitive analysis method using descriptive statistic. RESULTS: 41 patients were analyzed, with an average age of 6.04 y (7 months to 14 years), of which ten patients (24.39%) presented concomitant osteomyelitis. 6 out of ten patients needed secondary surgery. Regarding age, concomitant osteomyelitis was most common in the age group 4-14 years old. Average number of days of clinical symptoms before admission was 6.2 days. 36/41 cases showed CRP values higher than 2 mg/dl. 9/10 cases with concomitant osteomyelitis showed a CRP > 2 mg/dl, with an average value of 8.9 mg/dl. 22/41 patients underwent an MRI, of which nine cases presented a concomitant osteomyelitis. The probability of a child to have septic arthritis of the hip with adjacent osteomyelitis was analysed through a score based on four factors: impossibility to bear weight and/or hip pain in children in the non-walking age category, CRP > 2 mg/dl, age older than > 4 y, symptoms longer than 4 days. CONCLUSIONS: Children at the age of walking, with incapacity to bear weight, presenting symptoms longer than 4 days and a CRP > 2 mg/dl, should receive an MRI before surgery to exclude adjacent osteomyelitis. LEVEL OF EVIDENCE: IV.


Asunto(s)
Artritis Infecciosa , Osteomielitis , Niño , Humanos , Preescolar , Adolescente , Recién Nacido , Artroscopía/métodos , Radiografía , Imagen por Resonancia Magnética , Artritis Infecciosa/complicaciones , Artritis Infecciosa/diagnóstico , Artritis Infecciosa/cirugía , Osteomielitis/complicaciones , Osteomielitis/diagnóstico , Osteomielitis/cirugía
2.
Orthopade ; 48(8): 677-684, 2019 Aug.
Artículo en Alemán | MEDLINE | ID: mdl-31025044

RESUMEN

BACKGROUND: Slipped capital femoral epiphysis (SCFE) remains a challenge for the treating surgeon. First of all, SCFE should be diagnosed as early as possible. The earlier the diagnosis is made in adolescents, the lower the slip angle will be. Mild slips show more favourable long-term courses than moderate and severe SCFE. COMPLICATIONS: With increasing slip angle, the risk of complications increases. The complications of SCFE are diverse, the most severe of which are avascular necrosis (AVN) and chondrolysis. AVN is more common in surgically treated than in non-operatively managed patients and unstable SCFE bears the highest risk of AVN. THERAPY: Adequate treatment of AVN is still controversial. For surgical treatments, variable rates of AVN have been reported. There is a wide spectrum of surgeries for treating AVN, from hip joint-preserving techniques to total hip replacement. In central Europe there is wide consensus in favour of treating the contralateral side, but this is not without complications. Surgical treatment with in-situ pinning must be carried out with great care to take into consideration the morphology of the femoral head and not to perforate it. It should always be ensured that no osteosynthesis material penetrates the hip joint.


Asunto(s)
Epífisis Desprendida de Cabeza Femoral , Adolescente , Cartílago Articular , Europa (Continente) , Necrosis de la Cabeza Femoral , Articulación de la Cadera , Humanos
3.
Unfallchirurg ; 119(7): 570-4, 2016 Jul.
Artículo en Alemán | MEDLINE | ID: mdl-25277731

RESUMEN

BACKGROUND: Sternal fractures in childhood are rare. The aim of the study was to investigate the accident mechanism, the detection of radiological and sonographical criteria and consideration of associated injuries. METHOD: In the period from January 2010 to December 2012 all inpatients and outpatients with sternal fractures were recorded according to the documentation. RESULTS: A total of 4 children aged 5-14 years with a sternal fracture were treated in 2 years, 2 children were hospitalized for pain management and 2 remained in outpatient care. CONCLUSION: Isolated sternal fractures in childhood are often due to typical age-related traumatic incidents. Ultrasonography is a useful diagnostic tool for fracture detection and radiography is the method of choice for visualization of the extent of the dislocation.


Asunto(s)
Dolor en el Pecho/prevención & control , Fracturas Óseas/diagnóstico por imagen , Fracturas Óseas/terapia , Esternón/diagnóstico por imagen , Esternón/lesiones , Adolescente , Dolor en el Pecho/diagnóstico , Dolor en el Pecho/etiología , Niño , Preescolar , Diagnóstico Diferencial , Fracturas Óseas/complicaciones , Humanos , Masculino , Enfermedades Raras/complicaciones , Enfermedades Raras/diagnóstico , Enfermedades Raras/terapia
4.
Orthopade ; 42(12): 1001-7, 2013 Dec.
Artículo en Alemán | MEDLINE | ID: mdl-24154657

RESUMEN

In the last decade treatment of foot deformities has changed from extensive surgery to casting and minimally invasive surgery. The Ponseti method has become the most preferred treatment for clubfoot deformities and early evaluations showed promising results. Mid-term results for idiopathic clubfoot revealed the need for additional surgery by anterior tibial tendon transfer in 11-32% of cases depending on the duration of bracing. Anterior tibial tendon transfer is the most important surgical procedure for relapses in the Ponseti concept. Casting, recasting in cases of relapses, bracing and anterior tibial tendon transfer altogether represent the Ponseti method and cannot be considered as single entities.The Dobbs method is a new concept for the treatment of vertical talus. Treatment of vertical talus should start with the Dobbs method but in comparison to clubfoot treatment there has not been a complete change to minimally invasive treatment. Especially in non-idiopathic vertical talus cases open reduction of the talonavicular and calcaneocuboid joint are often necessary.


Asunto(s)
Deformidades Congénitas del Pie/cirugía , Inmovilización/métodos , Procedimientos Quirúrgicos Mínimamente Invasivos/métodos , Procedimientos de Cirugía Plástica/métodos , Transferencia Tendinosa/métodos , Moldes Quirúrgicos , Terapia Combinada/métodos , Deformidades Congénitas del Pie/diagnóstico , Humanos , Inmovilización/instrumentación , Lactante , Recién Nacido , Resultado del Tratamiento
5.
Rev Gastroenterol Mex (Engl Ed) ; 88(2): 100-106, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-35661638

RESUMEN

INTRODUCTION: Helicobacter pylori (H. pylori) eradication treatment includes a proton pump inhibitor and two antibiotics: amoxicillin and clarithromycin. The goal of that treatment is to eradicate the infection in at least 90% of the patients. Failure to eradicate the infection can have multiple causes, among which is the presence of point mutations in the antimicrobial target genes. OBJECTIVE: To characterize the mutations present in the pbp1a gene and their possible association with resistance to amoxicillin in vitro. METHODOLOGY: Susceptibility to amoxicillin was evaluated in 147 isolates of H. pylori from the Colombian municipality of Túquerres. PCR amplification and sequencing of the glycosyltransferase domain of the pbp1a gene were carried out on Túquerres isolates, and the association between mutations and resistance was evaluated. RESULTS: A total of 5.4% (8/147) Túquerres isolates were resistant to amoxicillin in vitro. PCR amplification of the glycosyltransferase domain of the pbp1A gene was performed on 87.5% of the amoxicillin-resistant isolates in vitro, and in the DNA sequencing analysis, a total of 2 changes of amino acids from 3 DNA mutations that encoded the PBP1A-1 protein were observed. CONCLUSION: The present study is the first report on pbp1a gene mutations in H. pylori isolates coming from a population in Túquerres. Mutations that have not been reported in previous studies were found.


Asunto(s)
Infecciones por Helicobacter , Helicobacter pylori , Humanos , Amoxicilina/farmacología , Mutación Puntual , Helicobacter pylori/genética , Glicosiltransferasas/genética , Infecciones por Helicobacter/tratamiento farmacológico , Pruebas de Sensibilidad Microbiana
6.
Eur J Trauma Emerg Surg ; 49(4): 1803-1810, 2023 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-36422659

RESUMEN

PURPOSE: Missed monteggia-type injuries in children can result in chronic radial head dislocation with anatomic changes and osteoarticular remodeling of the radial head. In later stages, joint reconstruction is impossible and a functional radial head distalization can be a therapy option in symptomatic patients. METHODS: From 2010 to 2018, 46 patients (18 female and 28 male, mean age 11.8 (4-20)) with chronic radius head dislocation treated in our institution were retrospectively analyzed. A radial head distalization was performed in symptomatic patients at the time of ulna lengthening and angulation by use of an external ring fixator. We analyzed the surgical and radiographic data as well as the clinical outcome of the patients measured by DASH and Mayo Elbow score. RESULTS: 16 patients (6 female, 10 male) fulfilled the criteria for functional radial head distalization. Main reason was Monteggia injury in 11 cases, and radial head fracture in 5 cases. Average follow-up was 5.1 years (range 1-9, SD 2.1). Mean time from injury was 4.14 years (range: 4 months to 12 years, SD 3.5 years). Mean duration of external fixation was 106 days (range 56-182, SD 31.2), lengthening was 21.3 mm (range 12-42, SD 8.8). Average degree of sagittal angulation 14.8° (0-32°, SD 10.7°), coronal angulation 4.4° (0-25°, SD 7.3°). DASH score showed a good result with 2.4, and the MAYO Elbow Score was excellent (95/100). No secondary luxation of the radius head was detected. CONCLUSION: Radial head distalization with external ring fixator can be a therapy option for chronic radius head dislocations in symptomatic patients without losing stability of the elbow joint in contrast to radial head resection.


Asunto(s)
Articulación del Codo , Luxaciones Articulares , Fractura de Monteggia , Humanos , Masculino , Niño , Femenino , Radio (Anatomía)/diagnóstico por imagen , Radio (Anatomía)/cirugía , Radio (Anatomía)/lesiones , Articulación del Codo/diagnóstico por imagen , Articulación del Codo/cirugía , Fractura de Monteggia/diagnóstico por imagen , Fractura de Monteggia/cirugía , Fractura de Monteggia/complicaciones , Estudios Retrospectivos , Cúbito/cirugía , Luxaciones Articulares/diagnóstico por imagen , Luxaciones Articulares/cirugía
7.
Unfallchirurg ; 115(9): 830-5, 2012 Sep.
Artículo en Alemán | MEDLINE | ID: mdl-22038236

RESUMEN

We report about the first hip arthroscopies of extracapsular neglected hip dislocations with concomitant injuries in two children (2 and 4 years old). The major problem of traumatic hip dislocation is avascular necrosis. Further problems are possible concomitant injuries. It is important not to cause further damage by therapeutic procedures. In a 4-year-old child the hip could be reduced under visualization and in a 2-year-old child with epiphyseal fracture the extent of the operation could be reduced. In both children large avulsion injuries of the ligamentum capitis femoris could be resected via hip arthroscopy. Hip arthroscopy can reduce surgical morbidity considerably and can possibly contribute to prevention of the feared avascular necrosis of the femoral head.


Asunto(s)
Luxación de la Cadera/diagnóstico por imagen , Luxación de la Cadera/cirugía , Lesiones de la Cadera/diagnóstico por imagen , Lesiones de la Cadera/cirugía , Traumatismo Múltiple/diagnóstico por imagen , Traumatismo Múltiple/cirugía , Enfermedad Aguda , Preescolar , Femenino , Humanos , Masculino , Radiografía , Resultado del Tratamiento
8.
Unfallchirurg ; 114(4): 311-22, 2011 Apr.
Artículo en Alemán | MEDLINE | ID: mdl-21465417

RESUMEN

Although the so-called Monteggia-injury, defined as an isolated fracture of the Ulna accompanying a sub- or complete dislocation of the radial head - is already known more than one hundred years - this injury is anyway often assessed completely wrong! Not the overlooked ulna fracture there is the problem but the not realized dislocation of the radial head. The prognosis of such an overlooked Monteggia-lesion is depending of different factors: age of the patient, duration of the dislocation, the amount of the morphological alteration in the elbow joint. The presented article describes the essential criteria with which is necessary for a correct assessment. Due to these criteria the individual therapies are described. This in relation to the existing time of the dislocation of the radial head. The results depend on the surgeon's experience, the accuracy of the planning and the technique chosen. An intensive postoperative physiotherapy is mandatory, frequently with initial application of CPM (continuous passive motion). Loss of correction and residual malalignments are well known and not rare. They occur mostly in instances of insufficient stability and centralization of the radial head, respectively. There are no evident numbers but this is confirmed by clinical experience.


Asunto(s)
Fijación Interna de Fracturas/instrumentación , Fijación Interna de Fracturas/métodos , Curación de Fractura , Fractura de Monteggia/diagnóstico , Fractura de Monteggia/cirugía , Insuficiencia del Tratamiento , Adolescente , Niño , Preescolar , Femenino , Humanos
9.
Rev Neurol ; 72(12): 426-432, 2021 Jun 16.
Artículo en Español, Inglés | MEDLINE | ID: mdl-34109998

RESUMEN

INTRODUCTION: Among other limitations, people with neurological conditions often experience problems with functional mobility. One of the intervention strategies employed to mitigate or compensate this limitation is the use of mobility assistive technology such as manual and electric wheelchairs, walkers, canes, crutches, etc. Although assistive technology is a commonly used intervention strategy among disabled people, the use of this technology is sometimes discontinued or abandoned due to a failure to meet the user's needs or a lack of training, among other reasons. PATIENTS AND METHODS: The sample used in this study comprises 80 users of mobility assistive technology, 14 of whom have abandoned or discontinued their use of Assistive Technology. The study variables include the Psychosocial Impact of Assistive Devices Scale for outcome measurement, as well as specific sociodemographic variables relating to the sample and the assistive device used. RESULTS: Significant values were obtained in the three subscales of the Psychosocial Impact of Assistive Devices Scale. 50% of abandonments of assistive technology occurred among people diagnosed with stroke. CONCLUSION: The Psychosocial Impact of Assistive Devices Scale can be a useful tool for assessing potential abandonment or non-use of Assistive Technology. More longitudinal studies are required to avoid this limitation on the use of assistive technology.


TITLE: Interrupción o abandono en el uso de productos de apoyo para la movilidad en personas con afectación neurológica.Introducción. Las personas con afectación neurológica suelen presentar, entre otras limitaciones, problemas en la movilidad funcional. Por ello, una estrategia de intervención para mitigar o compensar esta limitación es el uso de productos de apoyo para la movilidad, como sillas de ruedas tanto manuales como eléctricas, andadores, bastones, muletas, etc. Aunque los productos de apoyo son una estrategia habitual de intervención en personas con discapacidad, en ocasiones su uso es interrumpido o abandonado por no cubrir las necesidades del usuario o por falta de entrenamiento, entre otras causas. Pacientes y métodos. La muestra del análisis está formada por 80 usuarios de productos de apoyo para la movilidad, de los cuales 14 abandonaron o interrumpieron el uso del producto de apoyo. Las variables del estudio incluyen la escala Psychosocial Impact of Assistive Devices Scale (PIADS) como medida de resultados, además de variables sociodemográficas específicas de la muestra y del producto de apoyo empleado. Resultados. Se obtienen valores significativos en las tres subescalas de la PIADS. Un 50% de los productos de apoyo abandonados corresponde a personas con diagnóstico de ictus. Conclusiones. La PIADS puede ser una herramienta adecuada para evaluar el posible abandono o la falta de uso de los productos de apoyo. Aunque los productos de apoyo son una correcta estrategia de intervención para mitigar las limitaciones en la movilidad, algunos usuarios abandonan o interrumpen su uso por diferentes factores. Es necesario realizar más estudios longitudinales para evitar esta limitación en el uso de productos de apoyo.


Asunto(s)
Enfermedades del Sistema Nervioso/rehabilitación , Pacientes Desistentes del Tratamiento , Dispositivos de Autoayuda , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pacientes Desistentes del Tratamiento/estadística & datos numéricos
10.
Eur Radiol ; 19(10): 2508-17, 2009 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-19444454

RESUMEN

The purpose of this study was to retrospectively correlate the results of dynamic contrast-enhanced magnetic resonance imaging (MRI) with histological and clinical diagnoses in patients with osteoid osteomas. Fifty-four patients with the MR diagnosis of osteoid osteoma were studied. MRI (1.5 Tesla) consisted of thin-section STIR sequences, dynamic 3D T1 gradient echo sequences during application of contrast material, and high-resolution postcontrast T1 spin echo sequences with fat saturation (maximum voxel size 0.6 x 0.6 x 3.0 mm). Evaluation was focused on serial image subtraction during the early phase after contrast injection and on time-intensity curves. The surrounding edema was helpful in finding the nidus in each lesion. In 49 of 54 patients (90.7%), the diagnosis of osteoid osteoma was certain or highly probable (sensitivity 1.0, positive predictive value 0.91). A total of 38 of 54 osteoid osteomas were histologically proven. Five MRI diagnoses were regarded as false positives. A similar proportion has been reported for computed tomography. Tailored high-resolution MR examinations with dynamic contrast enhancement can reliably diagnose osteoid osteomas and exactly localize the nidus without radiation exposure. We propose a stepwise approach with STIR sequences, dynamic contrast-enhanced scanning, and high-resolution postcontrast T1 spin echo sequences with fat saturation.


Asunto(s)
Neoplasias Óseas/diagnóstico , Gadolinio DTPA , Aumento de la Imagen/métodos , Imagenología Tridimensional/métodos , Imagen por Resonancia Magnética/métodos , Osteoma Osteoide/diagnóstico , Técnica de Sustracción , Adolescente , Adulto , Algoritmos , Niño , Preescolar , Medios de Contraste , Femenino , Humanos , Interpretación de Imagen Asistida por Computador/métodos , Lactante , Masculino , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Adulto Joven
11.
Eur J Trauma Emerg Surg ; 45(4): 757-761, 2019 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-29484463

RESUMEN

The medial condyle fracture of the humerus is-in comparison to the lateral condyle fracture-a very rare Salter-Harrison IV-fracture of the elbow. In this prospective study 14 children were included and reviewed. One child had minimal displacement fracture type I, one child had type II, and 12 children had type III-fractures. One patient was treated conservatively by an upper arm cast; thirteen were surgically treated using open reduction and osteosynthetical treatment. Postoperatively the elbow was immobilized in 90° flexion and neutral position in a long-arm cast for 4-6 weeks. In 11 children the diagnosis was made immediately after trauma, in 3 children the fracture was overlooked initially. Medial condyle fractures may be difficult to diagnose in children younger than 6 years and the lesion may be mistaken for a simple avulsion of the medial epicondyle or even missed. The C-sign is a hint for a medial condyle fracture. The development of nonunion happens in consequence of failure to recognize the fractures. Results after an average follow-up of 36 months showed that children who were diagnosed immediately and received operative stabilization had very good functional and aesthetical results. Three children with delayed diagnosis of the fracture had open surgery with reposition and osteosynthetical fixation. In two of the overlooked cases a slight contracture and angular misalignment persisted. If in this injury the diagnosis is made without delay, an appropriate therapy is implemented and radiographical controls are performed until consolidation, good results can be expected. The main risk in medial condyle fractures of the humerus is to overlook them. This can lead to the development of a nonunion with joint malformations.


Asunto(s)
Fracturas del Húmero/terapia , Adolescente , Placas Óseas , Tornillos Óseos , Moldes Quirúrgicos , Niño , Preescolar , Diagnóstico Tardío , Femenino , Fijación Interna de Fracturas/métodos , Humanos , Fracturas del Húmero/diagnóstico , Masculino , Estudios Prospectivos , Resultado del Tratamiento
12.
J Child Orthop ; 13(4): 377-384, 2019 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-31489043

RESUMEN

PURPOSE: Children with sonographic grade IV hip dysplasia according to Graf and with failed conservative treatment usually need surgical reduction afterwards. Surgical reduction of the hip can lead to severe complications, the occurrence of residual acetabular dysplasia, osteonecrosis, redislocation and other postoperative complications. This paper investigates whether arthroscopic reduction is a promising alternative to open reduction. METHODS: We retrospectively examined 66 patients (78 hips) who were not older than two years at the first time of surgery. Arthroscopic reduction was performed on 17 children (19 hips) and open reduction on 49 children (59 hips). Patient records were used to determine redislocation, postoperative complication and residual dysplasia. Radiographs were used to determine Tönnis classification for osteonecrosis and pathological acetabular (AC) angle for residual dysplasia. We considered data up to a two-year follow-up. Statistical evaluation was performed with binary logistic regression. RESULTS: After arthroscopic reduction, 6% showed osteonecrosis, compared with 20% with open reduction (p = 0.334). Redislocation was not observed after arthroscopic reduction but for 29% after open reduction (p = 0.005). An improvement of femoral head coverage was achieved with residual dysplasia of 23.5% after arthroscopic reduction, compared with 62% after open reduction (p = 0.002). CONCLUSION: The arthroscopic procedure represents a meaningful alternative to the open procedure due to a lower complication rate, a safe setting, a lower rate of residual dysplasia, no observed redislocation and occurrence of osteonecrosis only once in the arthroscopic group of developmental dysplasia of the hip. The arthroscopic procedure should be tested in further studies and in other clinics in order to broaden the empirical base. LEVEL OF EVIDENCE: Level III (retrospective cohort study).

13.
Oper Orthop Traumatol ; 27(3): 262-9, 2015 Jun.
Artículo en Alemán | MEDLINE | ID: mdl-25248663

RESUMEN

OBJECTIVE: The treatment goal is to rapidly make a diagnosis and establish an effective arthroscopic therapy in order to allow the hip joint to develop normally throughout childhood with respect to anatomical and functional development. INDICATIONS: Coxarthritis suspected of being septic arthritis CONTRAINDICATIONS: No experience with arthroscopy, osteomyelitis of the dorsal femoral neck requiring an intervention. Relative contraindication: absence of cannulated systems. SURGICAL TECHNIQUE: Arthroscopic lavage of the hip joint, including revision of the femoral neck and debridement of osteomyelitis of the femoral neck with placement of an antibiotic carrier if necessary. The arthroscopy is performed using the two portal technique, placing the patient supine on a normal operation table (traction table not required). POSTOPERATIVE MANAGEMENT: Drain for 2-3 days with mobilization after removal of the drainage. A second look arthroscopy is not normally planned but may become necessary in cases without improvement of the clinical or laboratory test parameters and after follow-up magnetic resonance imaging (MRI). RESULTS: The two portal hip joint arthroscopy using an irrigation volume of 6-9 l is an efficient minimally invasive method to safely treat septic arthritis of the hip joint with or without concomitant femoral neck osteomyelitis. It is associated with low morbidity and offers all advantages of an arthroscopic procedure. Out of 23 children 19 could be sufficiently treated by a single arthroscopic lavage of the hip joint. In three patients an additional osseous component required a second intervention. Out of 23 children 22 achieved an excellent Harris hip score, with one girl only achieving a moderate outcome. The 22 children had an unrestricted hip function at follow-up and could return fully to previous activity levels.


Asunto(s)
Antibacterianos/uso terapéutico , Artritis Infecciosa/cirugía , Artroscopía/métodos , Infecciones Bacterianas/cirugía , Desbridamiento/métodos , Articulación de la Cadera/cirugía , Artritis Infecciosa/prevención & control , Infecciones Bacterianas/prevención & control , Terapia Combinada/métodos , Articulación de la Cadera/efectos de los fármacos , Humanos , Resultado del Tratamiento
14.
Thromb Res ; 40(1): 81-9, 1985 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-4089829

RESUMEN

Low molecular weight heparin fractions (LMWH) are less hemorrhagic but are as effective as standard heparin (SH) in preventing experimentally-induced venous thrombosis. The effect of LMWH in preventing extension of established thrombi is unknown. We have compared the effects of two LMWH's (CY, PK), and a low molecular weight heparinoid (a dermatan/heparan/chondroitin mixture, OH) with SH on the prevention of extension of established venous thrombi, by measuring their ability to inhibit the accretion of 125I-fibrin onto venous thrombi pre-formed in rabbit jugular veins. Anticoagulant activity was assayed ex vivo by the APTT and a chromogenic anti-Xa assay, and the antithrombotic effect of these glycosaminoglycans was related to their anticoagulant effects. Autologous thrombi were formed in both jugular veins of each rabbit. The rabbits were then injected with 125I-fibrinogen and treated with a bolus dose of glycosaminoglycan or saline, followed by a continuous infusion for 4 hours. All four glycosaminoglycans significantly inhibited 125I-fibrin accretion (p less than 0.001). SH, CY and PK were equipotent at doses of 42.5-62.5 anti-Xa U/kg/hr in preventing fibrin accretion by 50%. Higher doses had no further effect. OH was significantly more potent than the other three glycosaminoglycans at any given dose (p less than 0.005). There was no correlation between the antithrombotic effect and the anticoagulant effects. We conclude that these LMWH's are as effective as SH in preventing extension of established thrombosis.


Asunto(s)
Glicosaminoglicanos/uso terapéutico , Heparina/análogos & derivados , Heparina/uso terapéutico , Tromboflebitis/prevención & control , Animales , Anticoagulantes , Modelos Animales de Enfermedad , Femenino , Fibrina/metabolismo , Fibrinógeno/metabolismo , Glicosaminoglicanos/administración & dosificación , Infusiones Parenterales , Inyecciones Intravenosas , Masculino , Conejos , Relación Estructura-Actividad
15.
Laryngoscope ; 108(2): 269-72, 1998 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-9473080

RESUMEN

A retrospective study of a group of 51 patients who underwent surgery for squamous cell carcinoma of the pyriform sinus was performed. Primary tumors and lymph nodes were reviewed histologically. The primary tumors were also examined by flow cytometry for DNA ploidy and cell cycle analysis. Sixteen (33%) of the cases were aneuploid and 64% had a moderate or high S-phase fraction. The overall 3-year survival rate was 49% (25/51). In the univariate analysis, tumor size, lymphatic invasion, inflammatory infiltrate, presence of lymph node metastases, clinical and histologic N status, size and number of lymph nodes involved, and presence of extracapsular extension all correlated with survival. When multivariate analysis was used, the only independent prognostic factors were tumor size, lymphatic invasion, and histologic N status. Ploidy and S-phase fraction did not contribute further prognostic information.


Asunto(s)
Carcinoma de Células Escamosas/patología , ADN de Neoplasias/genética , Neoplasias Faríngeas/patología , Faringe/patología , Aneuploidia , Carcinoma de Células Escamosas/mortalidad , Carcinoma de Células Escamosas/cirugía , Femenino , Citometría de Flujo , Humanos , Metástasis Linfática , Masculino , Persona de Mediana Edad , Neoplasias Faríngeas/mortalidad , Neoplasias Faríngeas/cirugía , Pronóstico , Modelos de Riesgos Proporcionales , Análisis de Supervivencia , Tasa de Supervivencia
16.
Z Orthop Unfall ; 151(6): 596-602, 2013 Dec.
Artículo en Alemán | MEDLINE | ID: mdl-24347414

RESUMEN

GOAL: Irrigation of the hip joint by hip arthrotomy represents the standard treatment for septic arthritis of the hip in childhood and adolescence. Arthroscopic lavages for treating a septic knee, elbow, ankle and glenohumeral joints are well established, but have only reached little acceptance in the therapy of septic hip arthritis in children. The goal of this study is to evaluate the advantages of the minimally invasive arthroscopic high-volume lavage for septic hip arthritis with regards to treatment safety and complication frequency. PATIENTS AND METHODS: 20 children aged 6.4 years on average (2-14 years) with obvious signs of septic arthritis of the hip proven clinically and by blood tests were arthroscopically treated in a 2-portal technique. In a prone position on a standard table the patient had the arthroscopic lavage procedure followed by insertion of a Redon tube. In all cases a histological sample and a bacterial swab were taken. A traction table was not used. In three children there was a stage I according to Stutz and Gächter, in thirteen a stage II and in four patients a stage III. Because of a concomitant femoral neck osteomyelitis in three cases and an osteomyelitis of the os pubis in a single patient, PMMA mini chains were locally administered. The histological samples were reported as purulent in 16 and as non-specific synovitis in four patients. In ten children a positive bacterial result was given, with Staphylococcus aureus found in 7 cases and single cases with Meningococci, Salmonella and Staphylococcus warneri. All patients received an intravenous antibiotic treatment for 14 days followed by four weeks of oral antibiotics. RESULTS: 16 out of 20 children were sufficiently treated by one single arthroscopic lavage. In three cases with additional osteomyelitis a secondary procedure was needed for removal of the antibiotic chain. During follow-up after an average of 2.9 years 19 of 20 children demonstrated a free range of hip joint motion and a full sporting activity without any restrictions. One girl with stage III arthritis and a preoperative duration of symptoms of seven days developed a femoral head necrosis and chondrolysis with hip joint subluxation. The other 19 patients regained an excellent Harris hip score at follow-up, whereas the girl only produced moderate score values. So, 19 children had an unrestricted function of their hips on the same activity level as before. CONCLUSION: The 2-portal hip arthroscopy with high-volume lavage represents a safe and minimally invasive method in order to successfully treat septic arthritis of the hip and concomitant femoral neck osteomyelitis in children and adolescents. This technique leads to a very low morbidity offering all advantages of arthroscopic procedures. The use of cannulated instruments through well established safe portals makes this arthroscopic lavage procedure a simple and easily adoptable technique.


Asunto(s)
Antibacterianos/uso terapéutico , Artritis Infecciosa/terapia , Articulación de la Cadera/cirugía , Adolescente , Artritis Infecciosa/diagnóstico , Artroscopía/métodos , Infecciones Bacterianas , Niño , Preescolar , Terapia Combinada , Femenino , Humanos , Masculino , Irrigación Terapéutica/métodos , Resultado del Tratamiento
17.
Z Orthop Unfall ; 151(6): 585-95, 2013 Dec.
Artículo en Alemán | MEDLINE | ID: mdl-24347413

RESUMEN

BACKGROUND: The treatment of hip instability in patients with Down syndrome is challenging. We have performed different pelvic osteotomies and corrections at the proximal femur for this indication. This retrospective study was conducted to evaluate the clinical and radiological outcome of each intervention. MATERIAL AND METHODS: All in all, 166 patients with Down syndrome were treated at our orthopaedic department in the observation period. Problems related to the hip joint were diagnosed in 63 of those patients. Only patients who underwent surgery were included in this study. The charts and X-rays of these 31 patients were evaluated with respect to the following parameters: incidence of the hip problem, concomitant diseases, temporal progress, kind of operation method and date, duration of stay in the hospital, after-care, follow-on surgery related to complications, AC angle, CE angle, ACM angle, CCD angle, index of migration according to Reimers, classification of Bauer and Kerschbauer and general morphology of the femoral head. The group was compared with an age-matched group of 21 patients with hip dysplasia. Those patients underwent the same sort of operation in the same year. RESULTS: In the Morbus Down group, we performed surgery for preservation of the hip in 49 cases. This included 13 osteotomies according to Chiari, 11 triple osteotomies according to Tönnis, 10 corrections by femoral varus derotation osteotomy, 8 pelvic osteotomies according to Pemberton, 5 pelvic osteotomies according to Salter and 2 open reductions of the hip. With respect to the moment of surgery, we detected three peaks of age. There was no difference in course of disease and quantity of complications between the groups. Satisfactory results concerning clinical and radiological outcome were achieved predominantly by complete redirectional acetabular osteotomies. Half of the patients who were solely treated by femoral varus derotation osteotomy needed follow-on surgery in the form of pelvic osteotomy. Comparison of preoperative and postoperative range of motion of the hip joint between groups detected capsular insufficiency, increased ligamentous laxity and muscular hypotonia in patients with Down syndrome. Comparison of pelvic radiographs demonstrated significant improvement concerning measured angles in both groups. Preoperative values with respect to AC angle and CE angle were demonstrated to be lower in the hip dysplasia group (p < 0.01); whereas values for ACM angle were comparable between groups. CONCLUSION: Hypermobility and secondary dislocation of the hip joint is a common problem in patients with Down syndrome, which often requires surgical intervention at an early stage. According to our data and clinical results we suggest a complete redirectional acetabular osteotomy in combination with capsular plication for treatment of this challenging condition.


Asunto(s)
Síndrome de Down/cirugía , Luxación de la Cadera/cirugía , Articulación de la Cadera/cirugía , Inestabilidad de la Articulación/cirugía , Osteotomía/estadística & datos numéricos , Adolescente , Adulto , Artroplastia/estadística & datos numéricos , Niño , Preescolar , Síndrome de Down/epidemiología , Femenino , Alemania , Luxación de la Cadera/epidemiología , Humanos , Incidencia , Lactante , Inestabilidad de la Articulación/epidemiología , Masculino , Procedimientos de Cirugía Plástica/estadística & datos numéricos , Estudios Retrospectivos , Factores de Riesgo , Resultado del Tratamiento , Adulto Joven
18.
J Bone Joint Surg Br ; 94(6): 842-7, 2012 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-22628603

RESUMEN

We present our early experience of arthroscopic reduction of the dislocated hip in very young infants with developmental dysplasia of the hip (DDH). Eight dislocated hips, which had failed attempts at closed reduction, were treated by arthroscopy of the hip in five children with a mean age of 5.8 months (4 to 7). A two-portal technique was used, with a medial sub-adductor portal for a 2.7 mm cannulated system with a 70° arthroscope and an anterolateral portal for the instruments. Following evaluation of the key intra-articular structures, the hypertrophic ligamentum teres and acetabular pulvinar were resected, and a limited release of the capsule was performed prior to reduction of the hip. All hips were reduced by a single arthroscopic procedure, the reduction being confirmed on MRI scan. None of the hips had an inverted labrum. The greatest obstacle to reduction was a constriction of the capsule. At a mean follow-up of 13.2 months (9 to 24), all eight hips remained stable. Three developed avascular necrosis. The mean acetabular index decreased from 35.5° (30° to 40°) pre-operatively to 23.3° (17° to 28°). This study demonstrates that arthroscopic reduction is feasible using two standardised portals. Longer follow-up studies are necessary to evaluate the functional results.


Asunto(s)
Artroscopía/métodos , Luxación Congénita de la Cadera/cirugía , Estudios de Factibilidad , Femenino , Luxación Congénita de la Cadera/diagnóstico , Luxación Congénita de la Cadera/patología , Humanos , Lactante , Imagen por Resonancia Magnética , Masculino , Resultado del Tratamiento
19.
Z Orthop Unfall ; 150(5): 525-32, 2012 Oct.
Artículo en Alemán | MEDLINE | ID: mdl-23076751

RESUMEN

AIM: Clubfoot is rarely associated with tibial or fibular hemimelia. Treatment is complex and in most of the cases extensive surgery is required. At present experience with Ponseti casting is limited. We describe casting and surgical treatment of 10 clubfeet associated with tibial and fibular hemimelia. MATERIAL AND METHOD: Between 1.1.2004 and 31.12.2009 398 clubfeet were treated with casting in our institution. In the same period 10 clubfeet were associated with fibular or tibial hemimelia. Treatment started in 9 clubfeet with Ponseti manipulation and casting. We used the classification of Weber for tibial hemimelia and the Kalamchi-Achterman classification and Paley classification for fibular hemimelia. Data of all patients were prospectively documented and the result of the foot deformity was evaluated before a first lengthening procedure. Documentation included patient data, associated foot pathologies, surgical procedures, functional results. Functional results were evaluated before the first lengthening procedure started. RESULTS: Three patients had tibial hemimelia, two Weber type 1, one Weber type 2, one Weber type 3. five patients had fibular hemimelia, Paley type IV or Kalamchi-Achterman Type IA. One child had bilateral fibular hemimelia. The prospective leg length discrepancy ranged from 3.2 cm to 14 cm. Four feet had initially a successful treatment with casting. In a type 2 according to Weber we performed an ankle reconstruction procedure to correct tibiofibular diastases. Four feet underwent PMR. We had four relapses. Two equinus relapses were treated with a posterior release. Two severe relapses were finally corrected with resection of the coalition and midfoot osteotomies. In a Weber type 3 case a complex reconstruction was performed using an Ilisarov and a TSF frame. Functional results showed in a mean follow-up of 42.2 months (24-72 months) a dorsiflexion between 5 and 20° (Ø 7.7°) and a plantarflexion between 10 and 40° (Ø 26.1°). CONCLUSION: Treatment of clubfoot associated with tibial or fibular hemimelia with the Ponseti technique is limited because of complex hindfoot deformities including tarsal coalitions. Nevertheless treatment after birth starts with casting. Only mild cases of hemimelia without coalition can be corrected with the Ponseti technique. In a case of tibiofibular diastasis successful casting is possible, but extensive surgery is often necessary. In more severe cases we do not recommend casting. In these cases surgical treatment, including posteromedial release, osteotomies for the hindfoot, resection of coalitions or complex osteotomies with Ilisarov or TSF frame is the treatment of choice.


Asunto(s)
Pie Equinovaro/rehabilitación , Ectromelia/complicaciones , Ectromelia/rehabilitación , Peroné/anomalías , Inmovilización/métodos , Manipulaciones Musculoesqueléticas/métodos , Tibia/anomalías , Adolescente , Adulto , Moldes Quirúrgicos , Pie Equinovaro/etiología , Femenino , Humanos , Masculino , Resultado del Tratamiento , Adulto Joven
20.
Z Orthop Unfall ; 150(2): 190-7, 2012 Apr.
Artículo en Alemán | MEDLINE | ID: mdl-22354441

RESUMEN

AIM: The Ponseti method is accepted worldwide for the treatment of congenital clubfoot. We report about our experience in a 7-year period. The purpose of the study was to evaluate the history of well treated feet between primary correction and the age of 5-6 years with relapse rate and functional results. MATERIAL AND METHOD: Between 1.1.2004 and 31.12.2005 we treated 71 patients with 102 idiopathic clubfeet with the Ponseti method. All patients were prospectively evaluated. We used the Pirani score. The patients' results were documented when the children started to walk and before primary school. The results were compared and statistically evaluated. We used the McKay score and measured the talocalcaneal angle on lateral and a. p. radiographs. RESULTS: 89 % clubfeet were successful treated with the Ponseti method. At walking age plantar flexion was between 30° und 50° (∅ 42°) and dorsiflexion between 5° and 30° (∅ 25°). Before primary school plantar flexion was between 30° and 50° (∅ 37,8°) and dorsiflexion between 0° and 25° (∅ 13,9°). Using the McKay score we had 91 % excellent or good results. 31 % cases had surgical treatment of a relapse. In the relapse group 82 % had an excellent or good result according to the McKay score. CONCLUSION: The Ponseti method is a very effective technique to treat idiopathic clubfeet. In the first 5 to 6 years of age there is a significant loss of range of motion. The relapse rate is comparable to those of other clubfoot treatment concepts. The relapse treatment of the Ponseti technique, with recasting, tibialis anterior tendon transfer and Achilles tendon lengthening leads to good functional results.


Asunto(s)
Pie Equinovaro/rehabilitación , Inmovilización/métodos , Manipulaciones Musculoesqueléticas/métodos , Adolescente , Niño , Preescolar , Femenino , Humanos , Lactante , Estudios Longitudinales , Masculino , Rango del Movimiento Articular , Resultado del Tratamiento
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