RESUMEN
The National Institutes of Health Genetic Testing Registry (GTR; available online at http://www.ncbi.nlm.nih.gov/gtr/) maintains comprehensive information about testing offered worldwide for disorders with a genetic basis. Information is voluntarily submitted by test providers. The database provides details of each test (e.g. its purpose, target populations, methods, what it measures, analytical validity, clinical validity, clinical utility, ordering information) and laboratory (e.g. location, contact information, certifications and licenses). Each test is assigned a stable identifier of the format GTR000000000, which is versioned when the submitter updates information. Data submitted by test providers are integrated with basic information maintained in National Center for Biotechnology Information's databases and presented on the web and through FTP (ftp.ncbi.nih.gov/pub/GTR/_README.html).
Asunto(s)
Bases de Datos Genéticas , Pruebas Genéticas , Sistema de Registros , Genes , Variación Genética , Humanos , Internet , FenotipoRESUMEN
OBJECTIVE: This paper focuses on the first two years of operation of Genetics Home Reference (GHR), a Web-based resource
Asunto(s)
Bases de Datos como Asunto , Genética Médica , Educación en Salud/métodos , MedlinePlus , Enfermedades Genéticas Congénitas , Genética Médica/educación , Genética Médica/organización & administración , Humanos , Internet , National Library of Medicine (U.S.) , Desarrollo de Programa , Estados UnidosAsunto(s)
Suplementos Dietéticos/normas , Ejercicio Físico/fisiología , Formulación de Políticas , Deportes/normas , Androstatrienos/administración & dosificación , Estimulantes del Sistema Nervioso Central/administración & dosificación , Seguridad de Productos para el Consumidor , Doping en los Deportes/tendencias , Efedrina/administración & dosificación , Ejercicio Físico/psicología , Guías como Asunto , Conocimientos, Actitudes y Práctica en Salud , Humanos , Deportes/legislación & jurisprudencia , Medicina Deportiva/ética , Medicina Deportiva/tendencias , Estados Unidos , United States Food and Drug AdministrationRESUMEN
As genetic testing technology is integrated into healthcare, increasingly detailed information about individual and population genetic variation is available to patients and providers. Health professionals use genetic testing to diagnose or assess the risk of disease in individuals, families and populations and to guide healthcare decisions. Consumers are beginning to explore personalized genomic services in an effort to learn more about their risk for common diseases. Scientific and technological advances in genetic testing, as with any newly introduced medical technology, present certain challenges to existing frameworks of oversight. In addition, the growing use of genetic testing will require a significant investment in evidence-based assessments to understand the validity and utility of these tests in clinical and personal decisionmaking. To optimize the use of genetic testing in healthcare, all sectors of the oversight system need to be strengthened and yet remain flexible in order to adapt to advances that will inevitably increase the range of genetic tests and methodologies.
RESUMEN
Expanded newborn screening programs and subsequent detection of rare genetic disorders challenge parents and their medical providers to learn about the treatment and management of these disorders. Many people seek medical information on the Internet but may encounter requests for registration or fees, or find that resources are out of date, difficult to understand, or buried in advertisements. The U.S. National Library of Medicine (NLM), a component of the National Institutes of Health, provides web-based resources that address the challenges of newborn screening education. These resources include MedlinePlus, Genetics Home Reference, ClinicalTrials.gov, and PubMed. NLM websites are not commercial, do not require registration or fees, and provide varied levels of information for a continuum of audiences from low-literacy consumers to health professionals. Using phenylketonuria as an example, this study describes the information that parents and their medical providers can find through NLM resources. NLM has embraced the digital age and provides the public with reliable, accurate, and up-to-date educational materials.
Asunto(s)
Pruebas Genéticas , Educación en Salud , Internet , National Library of Medicine (U.S.) , Tamizaje Neonatal , Humanos , Recién Nacido , Discapacidad Intelectual/etiología , Discapacidad Intelectual/genética , Discapacidad Intelectual/prevención & control , MedlinePlus , Multimedia , Fenilcetonurias/diagnóstico , Programas Informáticos , Estados UnidosRESUMEN
The surge of information generated by the Human Genome Project has left many health professionals and their patients struggling to understand the role of genetics in health and disease. To aid the lay public and health professionals, the US National Library of Medicine developed an online resource called 'Genetics Home Reference' (GHR), located at http://ghr.nlm.nih.gov/. Launched in April 2003, GHR's goal is to help the public interpret the health implications of the Human Genome Project. It bridges the clinical questions of consumers and the rich technical data emerging from the sequenced human genome. The GHR web site is designed for easy navigation among summaries for genetic conditions and the related gene(s) and chromosome(s). This design strategy enhances the user's appreciation of how genes, chromosomes, and conditions are interrelated.