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1.
Dev Psychopathol ; 35(4): 1714-1731, 2023 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-35678173

RESUMEN

Maternal trauma has intergenerational implications, including worse birth outcomes, altered brain morphology, and poorer mental health. Research investigating intergenerational effects of maternal trauma on infant stress reactivity and regulation is limited. Maternal mental health during pregnancy may be a contributor: psychopathology is a sequela of trauma exposure and predictor of altered self-regulatory capacity in offspring of affected mothers. We assessed associations among maternal lifetime trauma and infant stress responsivity, mediated by psychological symptoms in pregnancy. Mothers reported lifetime trauma history and anxiety, depressive, and posttraumatic stress symptoms during pregnancy. At infant age 6 months, stress reactivity and regulation were assessed via maternal behavior ratings (Infant Behavior Questionnaire-Revised, IBQ-R) and behavioral (negative mood) and physiological (respiratory sinus arrhythmia, RSA) markers during a laboratory stressor (Still-Face Paradigm). Maternal trauma was directly associated with lower infant physiological regulation and indirectly associated with lower levels of both infant behavioral and physiological regulation via higher maternal anxiety during pregnancy. Maternal trauma was also indirectly associated with higher infant reactivity via higher maternal anxiety during pregnancy. Post hoc analyses indicated differential contributions of maternal prenatal versus postnatal anxiety to infant outcomes. Findings highlight potential contributory mechanisms toward maladaptive child stress response, which has been associated with poor behavioral, cognitive, and academic outcomes.


Asunto(s)
Trauma Psicológico , Estrés Psicológico , Femenino , Embarazo , Niño , Humanos , Lactante , Estrés Psicológico/psicología , Madres/psicología , Conducta Materna , Ansiedad
2.
Dev Psychopathol ; 34(3): 764-773, 2022 08.
Artículo en Inglés | MEDLINE | ID: mdl-33551015

RESUMEN

Childhood maltreatment (CM) is a known risk factor for adolescent pregnancy. Sleep disturbances and psychological distress, both common negative sequelae of CM, often co-occur during pregnancy, although directionality remains unclear. Furthermore, little is known about how CM affects sleep-distress associations during pregnancy. In pregnant adolescents, we examined: (a) whether there are significant predictive associations from CM to sleep quality and distress and (b) bidirectional influences of distress and sleep quality. Healthy pregnant adolescents (n = 204) were recruited before or during the 2nd trimester. CM was assessed at enrollment; sleep quality and distress were assessed in the 2nd and 3rd trimesters. Hypotheses were tested using path analysis. Findings revealed that CM was associated with worse 2nd trimester sleep quality and distress (ß = .19, p < .05 for sleep; ß = .30, p < .001 for distress). Higher levels of 2nd trimester distress were associated with lower 3rd trimester sleep quality (ß = .19, p < .05). Findings provide novel information about (a) associations from CM to prenatal mood and sleep in pregnant adolescents, and (b) sleep-distress directionality over the course of pregnancy. These results have implications for better understanding the ways in which CM potentially exerts influences later in life, and for targeting interventions to address physical and mental health during pregnancy.


Asunto(s)
Maltrato a los Niños , Embarazo en Adolescencia , Trastornos del Sueño-Vigilia , Adolescente , Niño , Maltrato a los Niños/psicología , Femenino , Humanos , Embarazo , Mujeres Embarazadas , Sueño , Trastornos del Sueño-Vigilia/etiología
3.
Dev Psychobiol ; 63(5): 878-889, 2021 07.
Artículo en Inglés | MEDLINE | ID: mdl-33415750

RESUMEN

Pregnancy is a critical time for the effects of environmental factors on children's development. The effect of added sugar intake on fetal development and pregnancy outcomes remains understudied despite increasing dietary intake in the United States. This study investigated the effect of added sugar on fetal programming by examining the association between maternal added sugar consumption, fetal movement, birth outcomes, and placental DNA methylation. Further, primary human fibroblasts were cultured under normal or high glucose conditions to assess the effect of high glucose exposure on cells' DNA methylation. We found that higher added sugar intake across pregnancy was associated with reduced 3rd-trimester fetal movement (p < .05) and shorter gestation (p < .01). Our sample size was not powered to detect the alteration of individual placental CpG with genome-wide significance. However, a secondary analysis suggested that added sugar consumption was associated with differential methylation of functionally related gene families across pregnancy. Consistent with this, high glucose exposure in primary cultured human fibroblasts altered the methylation of 17% of all CpGs, providing converging evidence for an effect of sugar on DNA methylation. Our results suggest that diets high in added sugar during pregnancy may have implications for offspring health via prenatal programming effects measurable before birth.


Asunto(s)
Metilación de ADN , Placenta , Niño , Epigénesis Genética , Femenino , Desarrollo Fetal , Humanos , Placenta/metabolismo , Embarazo , Azúcares/efectos adversos , Azúcares/metabolismo
4.
Neurosurg Focus ; 47(4): E6, 2019 10 01.
Artículo en Inglés | MEDLINE | ID: mdl-31574480

RESUMEN

This paper describes some of the more common patterns in neurobehavioral deficits and their underlying neuroanatomical basis in myelomeningocele (MMC). Patients with MMC can face a lifetime of specific organ system dysfunction, chief among them spinal cord malformations, orthopedic issues, hydrocephalus, and urological disabilities. In addition, patients can experience specific patterns of neurobehavioral difficulties due to the changes in neuroanatomy associated with the open spinal defect. Although there is variability in these patterns, some trends have been described among MMC patients. It is thought that early recognition of these potential neurobehavioral deficits by treating neurosurgeons and other members of the treatment team could lead to earlier intervention and positively impact the overall outcome for patients. Neurodevelopmental and neurobehavioral follow-up assessments are recommended to help guide planning for relevant treatments or accommodations.


Asunto(s)
Malformación de Arnold-Chiari/cirugía , Hidrocefalia/cirugía , Meningomielocele/cirugía , Médula Espinal/anomalías , Encéfalo/anomalías , Encéfalo/anatomía & histología , Femenino , Humanos , Hidrocefalia/etiología , Masculino , Meningomielocele/etiología , Embarazo/fisiología , Médula Espinal/anatomía & histología
5.
Dev Psychobiol ; 59(5): 668-672, 2017 07.
Artículo en Inglés | MEDLINE | ID: mdl-28436585

RESUMEN

The mobile conjugate reinforcement task was administered to 4-month-old infants in a lab rather than a home setting where it is usually administered. Learning and retention patterns were comparable to those of infants tested in their homes, suggesting flexibility in where this task can be administered. These results pave the way for this task to be used with a broader range of infants for whom home visits are not practical or convenient (e.g., infants in child care). Developmental research conducted with a more diverse population of infants would facilitate our understanding of cognitive development very early in life.


Asunto(s)
Desarrollo Infantil/fisiología , Aprendizaje/fisiología , Refuerzo en Psicología , Femenino , Humanos , Lactante , Masculino , Memoria/fisiología
6.
Dev Neuropsychol ; 47(7): 327-352, 2022 10.
Artículo en Inglés | MEDLINE | ID: mdl-36475997

RESUMEN

We examined effects of maternal and child lifetime traumatic stress exposures, infant temperament, and caregiving quality on parent ratings of preschoolers' executive functioning (EF). Maternal lifetime trauma was associated with preschoolers' EF problems; this association was mediated by greater child trauma exposure. Infant temperament was associated with EF abilities, particularly among females. Among males, infant extraversion/surgency mediated the association of maternal lifetime trauma with poorer child EF. Caregiving quality was negatively associated with maternal and child trauma exposures but did not predict child EF. Findings have implications for interventions to identify children at risk for poor EF and optimize outcomes.


Asunto(s)
Desarrollo Infantil , Temperamento , Masculino , Femenino , Niño , Lactante , Humanos , Función Ejecutiva , Familia , Padres
7.
PLoS One ; 15(12): e0243255, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-33332379

RESUMEN

Age and sex differences in brain metabolite concentrations in early life are not well understood. We examined the associations of age and sex with brain metabolite levels in healthy neonates, and investigated the associations between neonatal brain metabolite concentrations and developmental outcomes. Forty-one infants (36-42 gestational weeks at birth; 39% female) of predominantly Hispanic/Latina mothers (mean 18 years of age) underwent MRI scanning approximately two weeks after birth. Multiplanar chemical shift imaging was used to obtain voxel-wise maps of N-acetylaspartate (NAA), creatine, and choline concentrations across the brain. The Bayley Scales of Infant and Toddler Development, a measure of cognitive, language, and motor skills, and mobile conjugate reinforcement paradigm, a measure of learning and memory, were administered at 4 months of age. Findings indicated that postmenstrual age correlated positively with NAA concentrations in multiple subcortical and white matter regions. Creatine and choline concentrations showed similar but less pronounced age related increases. Females compared with males had higher metabolite levels in white matter and subcortical gray matter. Neonatal NAA concentrations were positively associated with learning and negatively associated with memory at 4 months. Age-related increases in NAA, creatine, and choline suggest rapid development of neuronal viability, cellular energy metabolism, and cell membrane turnover, respectively, during early life. Females may undergo earlier and more rapid regional developmental increases in the density of viable neurons compared to males.


Asunto(s)
Encéfalo/metabolismo , Adolescente , Adulto , Ácido Aspártico/análogos & derivados , Ácido Aspártico/análisis , Ácido Aspártico/metabolismo , Encéfalo/crecimiento & desarrollo , Desarrollo Infantil , Colina/análisis , Colina/metabolismo , Creatina/análisis , Creatina/metabolismo , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Adulto Joven
8.
J Perinatol ; 40(1): 10-24, 2020 01.
Artículo en Inglés | MEDLINE | ID: mdl-31616048

RESUMEN

Exposures to environmental chemicals and psychosocial stressors during pregnancy have been individually associated with adverse perinatal outcomes related to birthweight and gestational age, but are not often considered in combination. We review types of psychosocial stressors and instruments used to assess them and classes of environmental chemical exposures that are known to adversely impact perinatal outcomes, and identify studies relevant studies. We discuss the National Institutes of Health's Environmental influences on Child Health Outcomes (ECHO) program that has combined existing longitudinal cohorts that include more than 50,000 children across the U.S. We describe future opportunities for investigators to use this important new resource for addressing relevant and critical research questions to maternal health. Of the 84 cohorts in ECHO, 38 collected data on environmental chemicals and psychosocial stressors and perinatal outcomes. The diverse ECHO pregnancy cohorts provide capacity to compare regions with distinct place-based environmental and social stressors.


Asunto(s)
Contaminación Ambiental , Exposición Materna , Embarazo/psicología , Efectos Tardíos de la Exposición Prenatal , Estrés Psicológico , Biomarcadores , Peso al Nacer , Monitoreo del Ambiente , Femenino , Humanos , Recién Nacido , Embarazo/efectos de los fármacos , Resultado del Embarazo , Racismo/psicología , Clase Social
9.
Early Hum Dev ; 91(3): 169-72, 2015 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-25658874

RESUMEN

OBJECTIVE: Few studies of maternal prenatal diet and child development examine micronutrient status in relation to fetal assessment. METHODS: Twenty-four-hour dietary recall of zinc and folate and 20min of fetal heart rate were collected from 3rd trimester pregnant adolescents. RESULTS: Deficient zinc was associated with less fetal heart rate variability. Deficient folate had no associations with HRV. Neither deficient zinc nor deficient folate was related to fetal heart rate. CONCLUSIONS: These findings, from naturalistic observation, are consistent with emerging data on prenatal zinc supplementation using a randomized control design. PRACTICAL IMPLICATION: Taken together, the findings suggest that maternal prenatal zinc intake is an important and novel factor for understanding child ANS development.


Asunto(s)
Corazón Fetal/fisiología , Deficiencia de Ácido Fólico/complicaciones , Frecuencia Cardíaca , Zinc/deficiencia , Adolescente , Estudios de Casos y Controles , Suplementos Dietéticos , Femenino , Ácido Fólico/administración & dosificación , Ácido Fólico/sangre , Humanos , Adulto Joven , Zinc/administración & dosificación , Zinc/sangre
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