The Low Expression of IL-37 Involved in Multiple Myeloma - Associated Angiogenesis.

BACKGROUND Angiogenesis plays a significant role in complex inflammatory and angiogenic processes and is also involved in multiple myeloma (MM) pathogenesis. IL-37 is a proinflammatory cytokine in antitumor activity. Our purpose was to evaluate the IL-37 clinical significance on MM. MATERIAL AND METHODS We measured serum levels of IL-37 in 45 patients with different stages of MM and 30 healthy control subjects and correlated IL-37 with numerous cytokines, such as angiogenesis factors including vascular endothelial growth factor (VEGF) and angiotensin-2 (Ang-2). We also measured the tube formation of human umbilical vein endothelial cells (HUVECs) after pretreatment with recombinant human IL-37 (rhIL-37). RESULTS Serum IL-37 level was lower in the patients with MM than in the healthy control subjects, whereas VEGF and Ang-2 levels were higher, depending on International Staging System stage. Serum IL-37 level had a negative correlation to VEGF and Ang-2 levels, and VEGF had a positive correlation to Ang-2 level. The tube formation of HUVECs was suppressed by the rhIL-37 pretreatment. CONCLUSIONS Our results indicate that serum level of IL-37 plays a part in the pathophysiology of MM progression. Therefore, IL-37 serum level may be a biomarker for disease stage and angiogenesis processes.

[The clinical research of serum soluble CD40L and high sensitivie C-reactive protein in patients with acute coronary syndrome].

AIM: To explore the clinical significance and mechanism of soluble CD40 Ligand (sCD40L) and high sensitive C-reactive protein (hs-CRP) in patients with acute coronary syndrome(ACS). METHODS: A total of 86 consecutive patients with ACS were included in the study, according to the selection criteria for diagnosis of acute coronary syndrome (ACS), 86 patients were divided into two groups: normal and the ACS, In all patients, sCD40L and CRP levels were evaluated within 12 h. the incidence of acute cardiovascular events were observed after two months follow-up. RESULTS: The ACS group was obviously higher than control group (P<0.01), AMI group slightly higher than the UA group but had no significant difference (P>0.05). sCD40L and hs-CRP group of cardiovascular events increased more than the normal group. CONCLUSION: Acute coronary syndrome patients with early peripheral serum levels of sCD40L and hs-CRP were significantly increased, suggesting that CD40/CD40L system participate the occurrence of ACS, and the inflammatory factors such as C-reactive protein in collaboration, plays an important role on atherosclerotic plaque instability.