Detalles de la búsqueda
1.
In Vitro ADME and Preclinical Pharmacokinetics of Ulotaront, a TAAR1/5-HT1A Receptor Agonist for the Treatment of Schizophrenia.
Pharm Res
; 39(5): 837-850, 2022 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-35484370
2.
Population pharmacokinetic and pharmacodynamic analysis of BIIB023, an anti-TNF-like weak inducer of apoptosis (anti-TWEAK) monoclonal antibody.
Br J Clin Pharmacol
; 82(1): 118-28, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-26896828
3.
A phase 1, open-label, dose-escalation study of BIIB022 (anti-IGF-1R monoclonal antibody) in subjects with relapsed or refractory solid tumors.
Invest New Drugs
; 32(3): 518-25, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24458261
4.
Evaluation of OCT2-mediated drug-drug interactions between ulotaront and metformin in subjects with schizophrenia.
Pharmacol Res Perspect
; 12(2): e1191, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-38527949
5.
Considerations for Industry-Preparing for the FDA Model-Informed Drug Development (MIDD) Paired Meeting Program.
Clin Pharmacol Ther
; 2024 Mar 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-38519861
6.
Discovery and Model-Informed Drug Development of a Controlled-Release Formulation of Nonracemic Amisulpride that Reduces Plasma Exposure but Achieves Pharmacodynamic Bioequivalence in the Brain.
Clin Pharmacol Ther
; 2024 May 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-38822554
7.
Comparative Bioequivalence of Tablet and Capsule Formulations of Ulotaront and the Effect of Food on the Pharmacokinetics of the Tablet Form in Humans.
Neurol Ther
; 12(3): 815-832, 2023 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-36932300
8.
A randomized, single-dose, crossover study of the effects of ulotaront on electrocardiogram intervals in subjects with schizophrenia.
Clin Transl Sci
; 16(6): 1063-1074, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-36949248
9.
A Phase I, Open-Label, Fixed Sequence Study to Investigate the Effect of Cytochrome P450 2D6 Inhibition on the Pharmacokinetics of Ulotaront in Healthy Subjects.
Clin Pharmacokinet
; 62(12): 1755-1763, 2023 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37882999
10.
A sensitive LC-MS/MS method for simultaneous quantification of ulotaront and its N-desmethyl metabolite in human plasma and application to a clinical study.
J Pharm Biomed Anal
; 207: 114404, 2022 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-34700199
11.
ECG Evaluation as Part of the Clinical Pharmacology Strategy in the Development of New Drugs: A Review of Current Practices and Opportunities Based on Five Case Studies.
J Clin Pharmacol
; 62(12): 1480-1500, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-35665514
12.
Population pharmacokinetic analysis of ulotaront in subjects with schizophrenia.
CPT Pharmacometrics Syst Pharmacol
; 10(10): 1245-1254, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34292664
13.
Acute lymphoid and gastrointestinal toxicity induced by selective p38alpha map kinase and map kinase-activated protein kinase-2 (MK2) inhibitors in the dog.
Toxicol Pathol
; 38(4): 606-18, 2010 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-20448081
14.
Industrial Perspective on the Benefits Realized From the FDA's Model-Informed Drug Development Paired Meeting Pilot Program.
Clin Pharmacol Ther
; 110(5): 1172-1175, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-33991429
15.
Modulation of the sustained delivery of myelopoietin (Leridistim) encapsulated in multivesicular liposomes (DepoFoam).
J Control Release
; 89(1): 87-99, 2003 Apr 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-12695065
16.
Interferon beta assessment in non-Chinese and Chinese subjects: pharmacokinetics and pharmacodynamic activity of an endogenous cytokine are not race dependent.
J Clin Pharmacol
; 54(10): 1153-61, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-24737408
17.
Safety, tolerability, pharmacokinetics, and pharmacodynamics of anti-TWEAK monoclonal antibody in patients with rheumatoid arthritis.
Clin Ther
; 35(8): 1137-49, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23928094
18.
Plasma protein binding in drug discovery and development.
Comb Chem High Throughput Screen
; 13(2): 170-87, 2010 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-20053162
Resultados
1 -
18
de 18
1
Próxima >
>>