1.
Bioorg Med Chem Lett
; 19(2): 397-400, 2009 Jan 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19059779
RESUMEN
A series of quinoxaline inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and optimisation of the series was performed on the basis of this structure. Future directions for development of the series are discussed together with the identification of a novel quinoline scaffold.
Asunto(s)
Inhibidores Enzimáticos/farmacología , Proteínas Proto-Oncogénicas c-met/antagonistas & inhibidores , Quinoxalinas/farmacología , Cristalografía por Rayos X , Descubrimiento de Drogas , Inhibidores Enzimáticos/química , Quinoxalinas/química , Relación Estructura-Actividad
2.
Bioorg Med Chem Lett
; 19(10): 2780-4, 2009 May 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19369077
RESUMEN
A series of 4-azaindole inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and series optimisation was performed on the basis of this structure. Future directions for series development are discussed.