Increased hair cortisol and antecedent somatic complaints in children with a first epileptic seizure.

OBJECTIVE: Stress is the most frequent seizure-precipitating factor reported by patients with epilepsy, while stressful life events may increase seizure susceptibility in humans. In this study, we investigated the relations between both biological and behavioral measures of stress in children with a first epileptic seizure (hereafter called seizure). We hypothesized that hair cortisol, a biomarker of chronic stress reflecting approximately 3months of preceding exposure, might be increased in children with a first seizure. We also employed standardized questionnaires to examine presence of stress-related behavioral markers. METHODS: This was a cross-sectional clinical study investigating stress-related parameters in children with a first seizure (First Epileptic Seizure Group (FESG), n=22) in comparison to healthy children without seizures (Control Group, n=29). Within 24h after a first seizure, hair samples were collected from children for the determination of cortisol. In parallel, perceived stress and anxiety and depressive symptoms were examined with appropriate self- and parent-completed questionnaires, and history of stressful life events during the past year was recorded. Emotional and behavioral problems were also assessed by parent-reported validated and widely-used questionnaires. RESULTS: Higher hair cortisol measurements were observed in the FESG than control children (7.5 versus 5.0pg/mg respectively, p=0.001). The former were more likely to complain of somatic problems than the latter (59.8 vs. 55.4 according to DSM-oriented Scale, p=0.021); however, there were no differences in perceived stress and anxiety or depressive symptoms between the two groups. Using ROC analysis of hair cortisol measurements for predicting disease status, the maximum sensitivity and specificity were observed for a cut-off point of 5.25pg/mg. SIGNIFICANCE: Increased hair cortisol indicates chronic hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis prior to the first seizure. This might have contributed to the epileptogenesis process and may help explain the higher incidence of antecedent somatic complaints in the first seizure group.

Health knowledge and motives on tattooing: A community-based cross-sectional study in Greece.

BACKGROUND: Tattooing is becoming an increasingly common trend mainly but not merely among the youth. However, the choice of ink body art is associated with an increase of dermatological complications. AIM: To assess young persons' health knowledge and motives toward tattooing. METHODS: The main instrument used was an online structured questionnaire with scaling and dichotomous questions, consisting of three components: (a) the participants' sociodemographic profile, (b) health knowledge assessment, (c) motives toward or against tattooing. Simple univariate techniques and multiple logistic regression were used to data analysis. Two logistic models were developed having as dependent variable whether the respondents have or would like to have a tattoo. The independent variables in the models were sociodemographic characteristics of participants and three variables concerning respondents' health knowledge and motives on tattooing. RESULTS: The study sample amounted to 629 young adults living in Athens, the capital city of Greece. The prevailing age group among tattooed persons was 19-25 years old (69.5%), with females being more likely to be tattooed than males. Among tattooed participants, knowledge in specific health complications appeared high, while in other potential complications was particularly low. The main motives identified were ideology/message and aesthetics/fashion (77% in total). Quite interesting, participants with medium and high health knowledge level showed, respectively 50%, and three times higher probability of having tattoos compared to low level. Only 16.2% of the tattooed participants regarded tattoo as dangerous to health (p < 0.0005). CONCLUSIONS: The likelihood of acquiring ink body art is increasing critically among young adults. Even though this tendency is accompanied with adequate levels of knowledge concerning health hazards, systematic health education programs for more informed and safe choices are needed to be implemented, with particular emphasis on young people.

The Emerging Phenomenon of Nomophobia in Young Adults: A Systematic Review Study.

BACKGROUND: Nomophobia (No MObile PHone PhoBIA) refers to the worry or fear that individuals experience when they are without their mobile phone or they are unable to use it. The term was first coined in 2008 and it is considered a modern type of phobia. The aim of the present study was to retrieve and review the most relevant literature on the prevalence of nomophobia and its relationship with psychosocial and physical health among young adults. METHODS: A systematic literature review was conducted according the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) for original papers on the phenomenon of nomophobia in young adults using the Nomophobia Questionnaire (NMP-Q) as the main measuring instrument. The literature was focused on the 3 main topics of prevalence and level of nomophobia, nomophobia and psychosocial effects, and nomophobia and physical health in young adults. FINDINGS: The initial literature corpus consisted of 370 articles of which 40 met the inclusion criteria and were analyzed in detail. Nomophobia was observed among 15.2%-99.7% of the participants. Research findings indicated increased psychological, emotional, social, and physical side effects due to excessive smartphone use. CONCLUSION: The excessive use of the smartphone is an emerging threat for social, mental, and physical health. There is an increased need for further research in this regard as it is evolving into an epidemic outbreak and concerns directly the field of public health.

Physical, psychological and economic burden of two-wheel users after a road traffic injury: Evidence from intensive care units of three EU countries.

INTRODUCTION: This study aimed to assess the physical, psychological, and economic burden shouldered by severely injured two-wheel users in three European countries as well as the cost resulting from their hospitalization. METHODS: A total of seven public hospitals were involved in three countries: Greece, Italy, and Germany. Participants enrolled during a 12-month period starting in April 2013. Eligibility criteria included an injury sustained at Road Traffic Crashes (RTC) irrespective of the type of vehicle, hospitalization 1 day in the Intensive Care Unit (ICU) or sub-ICU, and age 18 years or over. Patients were interviewed at 1, 6, and 12 months upon admission. The study used widely recommended classifications for injury severity (Abbreviated Injury Severity [AIS]; Maximum Abbreviated Injury Severity [MAIS]) and standardized measures such as the Disability Assessment Schedule II (WHODAS 2.0), "Impact of Event Scale" (IES-R), Center for Epidemiological Studies Depression Scale (CES-D Scale). Health Care Expenditure was assessed through the Monash University Accident Research Centre (MUARC's) framework, which included measures of 'Direct' and 'Indirect' costs. Diagnosis-related groups (DRGs) were used to estimate hospitalization costs. RESULTS: A total of 54 two-wheel users enrolled in the study in all the countries and 32 completed all follow-up questionnaires. Physical disability increased over 12 months following the injury. Post Traumatic Stress Disorder (PTSD) symptoms of avoidance remained at high levels over the study period. PTSD symptoms of intrusion improved significantly during the second half of the year under investigation. The total annual cost of injury for the two-wheel users who were hospitalized in the selected ICU of all the partner countries for severe injury in 2013/2014, was estimated at €714,491 made up of €123,457 direct and €591,034 indirect costs. Men, aged 50-64 years and those who sustained slight injuries primarily at the lower extremities presented higher indirect costs per person. A total of €1032.092 was spent on hospitalization payments. Women, aged 65+ and those who sustained severe injuries at the central body region presented higher direct costs per person. Women, aged 50-64 years, those with severe injuries and a major injury at the central body and the upper body region presented the highest hospitalization costs per person. CONCLUSIONS: There is a need for effective strategies to early detect and treat groups at risk of being confronted with prolonged psychosocial and economic consequences. PRACTICAL IMPLICATIONS: A holistic understanding of the impact of injury on individuals is important in order to achieve effective treatment of psychological co-morbidities in a timely manner.