Blunted brain responses to neutral faces in healthy first-degree relatives of patients with schizophrenia: an image-based fMRI meta-analysis.

Schizophrenia is characterized by the misattribution of emotional significance to neutral faces, accompanied by overactivations of the limbic system. To understand the disorder's genetic and environmental contributors, investigating healthy first-degree relatives is crucial. However, inconsistent findings exist regarding their ability to recognize neutral faces, with limited research exploring the cerebral correlates of neutral face processing in this population. Thus, we here investigated brain responses to neutral face processing in healthy first-degree relatives through an image-based meta-analysis of functional magnetic resonance imaging studies. We included unthresholded group-level T-maps from 5 studies comprising a total of 120 first-degree relatives and 150 healthy controls. In sensitivity analyses, we ran a combined image- and coordinate-based meta-analysis including 7 studies (157 first-degree relatives, 207 healthy controls) aiming at testing the robustness of the results in a larger sample of studies. Our findings revealed a pattern of decreased brain responses to neutral faces in relatives compared with healthy controls, particularly in limbic areas such as the bilateral amygdala, hippocampus, and insula. The same pattern was observed in sensitivity analyses. These results contrast with the overactivations observed in patients, potentially suggesting that this trait could serve as a protective factor in healthy relatives. However, further research is necessary to test this hypothesis.

Principles and procedures for revising the hierarchical taxonomy of psychopathology.

Quantitative, empirical approaches to establishing the structure of psychopathology hold promise to improve on traditional psychiatric classification systems. The Hierarchical Taxonomy of Psychopathology (HiTOP) is a framework that summarizes the substantial and growing body of quantitative evidence on the structure of psychopathology. To achieve its aims, HiTOP must incorporate emerging research in a systematic, ongoing fashion. In this article, we describe the historical context and grounding of the principles and procedures for revising the HiTOP framework. Informed by strengths and shortcomings of previous classification systems, the proposed revisions protocol is a formalized system focused around three pillars: (a) prioritizing systematic evaluation of quantitative evidence by a set of transparent criteria and processes, (b) balancing stability with flexibility, and (c) promoting inclusion over gatekeeping in all aspects of the process. We detail how the revisions protocol will be applied in practice, including the scientific and administrative aspects of the process. Additionally, we describe areas of the HiTOP structure that will be a focus of early revisions and outline challenges for the revisions protocol moving forward. The proposed revisions protocol is designed to ensure that the HiTOP framework reflects the current state of scientific knowledge on the structure of psychopathology and fulfils its potential to advance clinical research and practice. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

An introduction to the basic elements of the caste system of India.

Oppression, systemic bias, and racism have unfortunately long been part of the human experience. This paper is a review of basic elements of the Indian caste system, understanding its impact on the daily lives of different caste members, the role of colonialism in perpetuating the caste system, the Indian reservation system for mitigating disadvantages created by the caste system, and how categorization and labels can affect individual identity. This paper then discusses the global relevance of the caste system and its impact on mental health and psychological functioning. In India, the caste system is a comprehensive, systematized, and institutionalized form of oppression of members of the lower castes, particularly the Dalits. Formalized during the British colonial period, the caste system brings together two related Indian concepts of varna and jati to create four social orders and multiple subunits. Sitting outside the traditional four orders are the Dalits, who experience social, economic, and religious discrimination due to an inherited status related to traditionally polluting occupations. Since the caste system extends beyond India to other South Asian countries, as well as to communities around the world that are home to the Indian diaspora, the inequities created by the caste system are a global issue. India's affirmative action system provides important insights to policy makers, as well as researchers in the social sciences for how to counteract the effects of systematized oppression. Collectively, this can aid in a better understanding of the effects of discrimination and oppression on identity, self-esteem, and mental health, and how we can develop more targeted policies and procedures in our own local contexts.