RESUMEN
PURPOSE: The objective of this study is to evaluate blood glucose (BG) control efficacy and safety of 3 insulin protocols in medical intensive care unit (MICU) patients. METHODS: This was a multicenter randomized controlled trial involving 167 MICU patients with at least one BG measurement >or=150 mg/dL and one or more of the following: mechanical ventilation, systemic inflammatory response syndrome, trauma, or burns. The interventions were computer-assisted insulin protocol (CAIP), with insulin infusion maintaining BG between 100 and 130 mg/dL; Leuven protocol, with insulin maintaining BG between 80 and 110 mg/dL; or conventional treatment-subcutaneous insulin if glucose >150 mg/dL. The main efficacy outcome was the mean of patients' median BG, and the safety outcome was the incidence of hypoglycemia (Asunto(s)
Protocolos Clínicos
, Enfermedad Crítica
, Quimioterapia Asistida por Computador/métodos
, Hipoglucemiantes/administración & dosificación
, Insulina/administración & dosificación
, Unidades de Cuidados Intensivos
, APACHE
, Adulto
, Anciano
, Glucemia/análisis
, Femenino
, Humanos
, Hipoglucemiantes/uso terapéutico
, Infusiones Intravenosas
, Inyecciones Subcutáneas
, Insulina/uso terapéutico
, Masculino
, Persona de Mediana Edad