Autologous Minimally Manipulated Homologous Adipose Tissue (AMHAT) for Treatment of Nonhealing Diabetic Foot Ulcers.

Diabetic foot complications are increasingly burdensome for patients, clinicians, and society. Development of innovative therapies to support good quality basic care is a priority among those with an interest in this area. One of these involves scanning and printing tissues to match and conform to a defect (so-called 3D printing). Methods: A single-arm pilot study of ten consecutive patients with a history of a chronic diabetic foot ulcer (DFU), treated with autologous minimally manipulated homologous adipose tissue (AMHAT), dispensed by a specialized 3D bioprinter, Dr. INVIVO, was performed. Patients with nonhealing DFUs present for more than 4 weeks and refractory to standard-of-care therapies were included. Wounds were treated with a single application of AMHAT, and then followed up weekly for up to 12 weeks, or until the wounds healed. The primary outcome measure was complete epithelialization of the wound up to 12 weeks after the treatment. Secondary outcome measures included wound size and/or volume reduction, assessment of ulcer grade, and time to closure. Results: Five wounds were healed by 5 weeks and one at 8 weeks. The mean percent area reduction at 12 weeks was 78.3% (SD: 33.23). Complete closure was achieved in 60% of wounds. The mean time to closure in these wounds was 49.1 days (95% CI, 29.9-68.3). No adverse events were reported. Conclusions: Single treatment of bioprinted AMHAT appears to be a safe and potentially effective treatment modality for patients with chronic DFUs. Further studies are warranted to explore the full potential of 3D bioprinting for tissue repair in this high-risk population.

Surface binding vs. sequestration; the uptake of benzohydroxamic acid at iron(iii) oxide surfaces.

Benzohydroxamic acid is shown to be an unexpectedly good ligand for iron(iii) oxides, favouring surface attachment to the formation of trisbenzohydroxamato complexes, which are known to have very high thermodynamic stability in solution.

Synthetic and magnetic studies of a dodecanuclear cobalt wheel.

The synthesis, structural characterisation and preliminary magnetic studies of a Co12 wheel are reported; the magnetic investigations reveal that the electronic ground state has a spin S = 6, which corresponds to ferromagnetic interactions between the twelve Co(II) ions.

Modeling Surface Engineering: Use of Polymetallic Iron Cages and Computer Graphics To Understand the Mode of Action of a Corrosion Inhibitor.

Simple organic molecules can have many functions. The active ingredient in the corrosion inhibitor 3-(4-methylbenzoyl)propionate works because it addresses the metal sites of a surface through carboxylate groups, forms hydrogen bonds with surface hydroxide groups (see picture), and provides excellent surface coverage through efficient packing of substituted aromatic groups.