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Am J Trop Med Hyg ; 91(4): 715-21, 2014 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-25071001

RESUMEN

We report outcomes and 12-month survival for the first cohort of patients to undergo multidrug-resistant tuberculosis (MDR-TB) treatment after the earthquake in Haiti. From March 3, 2010 to March 28, 2013, 110 patients initiated treatment of laboratory-confirmed MDR-TB at the Groupe Haïtien d'Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO) Center in Port-au-Prince, Haiti. Twenty-seven patients (25%) were human immunodeficiency virus (HIV)-positive. As of October 31, 2013, 95 (86%) patients were either cured or alive on treatment, 4 (4%) patients defaulted, and 11 (10%) patients died. Culture conversion occurred by 30 days in 14 (13%) patients, 60 days in 49 (45%) patients, and 90 days in 81 (74%) patients. The probabilities of survival to 12 months were 96% (95% confidence interval [95% CI] = 89-99) and 85% (95% CI = 64-94) for HIV-negative and -positive patients, respectively. Despite adverse conditions, outcomes for patients with MDR-TB are highly encouraging. Major efforts are underway to scale up community directly observed therapy and expand care to other regions of Haiti.


Asunto(s)
Antituberculosos/uso terapéutico , Seronegatividad para VIH , Seropositividad para VIH/complicaciones , Tuberculosis Resistente a Múltiples Medicamentos/tratamiento farmacológico , Adulto , Fármacos Anti-VIH/uso terapéutico , Antituberculosos/efectos adversos , Estudios de Cohortes , Terapia por Observación Directa , Desastres , Terremotos , Femenino , Estudios de Seguimiento , Seropositividad para VIH/tratamiento farmacológico , Haití , Humanos , Estimación de Kaplan-Meier , Masculino , Esputo/microbiología , Resultado del Tratamiento , Tuberculosis Resistente a Múltiples Medicamentos/diagnóstico , Adulto Joven
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