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1.

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.

Sykes, David B; Kfoury, Youmna S; Mercier, François E; Wawer, Mathias J; Law, Jason M; Haynes, Mark K; Lewis, Timothy A; Schajnovitz, Amir; Jain, Esha; Lee, Dongjun; Meyer, Hanna; Pierce, Kerry A; Tolliday, Nicola J; Waller, Anna; Ferrara, Steven J; Eheim, Ashley L; Stoeckigt, Detlef; Maxcy, Katrina L; Cobert, Julien M; Bachand, Jacqueline; Szekely, Brian A; Mukherjee, Siddhartha; Sklar, Larry A; Kotz, Joanne D; Clish, Clary B; Sadreyev, Ruslan I; Clemons, Paul A; Janzer, Andreas; Schreiber, Stuart L; Scadden, David T.

Cell ; 167(1): 171-186.e15, 2016 Sep 22.

Artículo en Inglés | MEDLINE | ID: mdl-27641501

2.

Real-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4.

Chigaev, Alexandre; Smagley, Yelena; Zhang, Yinan; Waller, Anna; Haynes, Mark K; Amit, Or; Wang, Wei; Larson, Richard S; Sklar, Larry A.

J Biol Chem ; 286(23): 20375-86, 2011 Jun 10.

Artículo en Inglés | MEDLINE | ID: mdl-21515675

3.

A phenotypic screen for compounds that reverse cAMP-mediated suppression of T cell functions.

Barrett, David; Wyatt, Meghan; Bar, Haim; Haynes, Mark K; Edwards, Bruce S; Sklar, Larry A; Zweifach, Adam.

SLAS Discov ; 27(5): 314-322, 2022 07.

Artículo en Inglés | MEDLINE | ID: mdl-35385793

4.

Drug Repurposing from an Academic Perspective.

Oprea, Tudor I; Bauman, Julie E; Bologa, Cristian G; Buranda, Tione; Chigaev, Alexandre; Edwards, Bruce S; Jarvik, Jonathan W; Gresham, Hattie D; Haynes, Mark K; Hjelle, Brian; Hromas, Robert; Hudson, Laurie; Mackenzie, Debra A; Muller, Carolyn Y; Reed, John C; Simons, Peter C; Smagley, Yelena; Strouse, Juan; Surviladze, Zurab; Thompson, Todd; Ursu, Oleg; Waller, Anna; Wandinger-Ness, Angela; Winter, Stuart S; Wu, Yang; Young, Susan M; Larson, Richard S; Willman, Cheryl; Sklar, Larry A.

Drug Discov Today Ther Strateg ; 8(3-4): 61-69, 2011.

Artículo en Inglés | MEDLINE | ID: mdl-22368688

5.

Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells.

Lopez-Ramirez, Miguel Alejandro; McCurdy, Sara; Li, Wenqing; Haynes, Mark K; Hale, Preston; Francisco, Karol; Oukoloff, Killian; Bautista, Matthew; Choi, Chelsea H J; Sun, Hao; Gongol, Brendan; Shyy, John Y; Ballatore, Carlo; Sklar, Larry A; Gingras, Alexandre R.

FASEB Bioadv ; 3(5): 334-355, 2021 May.

Artículo en Inglés | MEDLINE | ID: mdl-33977234

6.

A Novel Flow Cytometric Assay to Identify Inhibitors of RBPJ-DNA Interactions.

Lake, Robert J; Haynes, Mark K; Dreval, Kostiantyn; Bilkis, Rabeya; Sklar, Larry A; Fan, Hua-Ying.

SLAS Discov ; 25(8): 895-905, 2020 09.

Artículo en Inglés | MEDLINE | ID: mdl-32567455

7.

Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt high-throughput flow cytometry system.

Haynes, Mark K; Strouse, J Jacob; Waller, Anna; Leitao, Andrei; Curpan, Ramona F; Bologa, Cristian; Oprea, Tudor I; Prossnitz, Eric R; Edwards, Bruce S; Sklar, Larry A; Thompson, Todd A.

J Biomol Screen ; 14(6): 596-609, 2009 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-19470718

8.

High-Throughput Screening Approach for Identifying Compounds That Inhibit Nonhomologous End Joining.

Bredemeyer, Andrea L; Edwards, Bruce S; Haynes, Mark K; Morales, Abigail J; Wang, Yinan; Ursu, Oleg; Waller, Anna; Sklar, Larry A; Sleckman, Barry P.

SLAS Discov ; 23(7): 624-633, 2018 08.

Artículo en Inglés | MEDLINE | ID: mdl-29232168

9.

High-Throughput Flow Cytometry Screening of Multidrug Efflux Systems.

Haynes, Mark K; Garcia, Matthew; Peters, Ryan; Waller, Anna; Tedesco, Pietro; Ursu, Oleg; Bologa, Cristian G; Santos, Radleigh G; Pinilla, Clemencia; Wu, Terry H; Lovchik, Julie A; Oprea, Tudor I; Sklar, Larry A; Tegos, George P.

Methods Mol Biol ; 1700: 293-318, 2018.

Artículo en Inglés | MEDLINE | ID: mdl-29177837

10.

Activation of Rho Family GTPases by Small Molecules.

Palsuledesai, Charuta C; Surviladze, Zurab; Waller, Anna; Miscioscia, T Fabiola; Guo, Yuna; Wu, Yang; Strouse, Jake; Romero, Elsa; Salas, Virginia M; Curpan, Ramona; Young, Susan; Carter, Mark; Foutz, Terry; Galochkina, Zhanna; Ames, Harold; Haynes, Mark K; Edwards, Bruce S; Nicolotti, Orazio; Luo, Li; Ursu, Oleg; Bologa, Cristian G; Oprea, Tudor I; Wandinger-Ness, Angela; Sklar, Larry A.

ACS Chem Biol ; 13(6): 1514-1524, 2018 06 15.

Artículo en Inglés | MEDLINE | ID: mdl-29746086

11.

Rheumatoid arthritis--a molecular understanding.

Smith, J Bruce; Haynes, Mark K.

Ann Intern Med ; 136(12): 908-22, 2002 Jun 18.

Artículo en Inglés | MEDLINE | ID: mdl-12069565

12.

A high-throughput phenotypic screen of cytotoxic T lymphocyte lytic granule exocytosis reveals candidate immunosuppressants.

Zhao, Ziyan; Haynes, Mark K; Ursu, Oleg; Edwards, Bruce S; Sklar, Larry A; Zweifach, Adam.

J Biomol Screen ; 20(3): 359-71, 2015 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-25381253

13.

FRET detection of lymphocyte function-associated antigen-1 conformational extension.

Chigaev, Alexandre; Smagley, Yelena; Haynes, Mark K; Ursu, Oleg; Bologa, Cristian G; Halip, Liliana; Oprea, Tudor; Waller, Anna; Carter, Mark B; Zhang, Yinan; Wang, Wei; Buranda, Tione; Sklar, Larry A.

Mol Biol Cell ; 26(1): 43-54, 2015 Jan 01.

Artículo en Inglés | MEDLINE | ID: mdl-25378583

14.

Small Molecule Inhibitors Limit Endothelial Cell Invasion by Staphylococcus aureus.

Cordero, Diana; Fullenkamp, Christopher R; Pelly, Rachel R; Reed, Katie M; Caffo, Lindy M; Zahrt, Ashley N; Newman, Micaleah; Komanapalli, Sarah; Niemeier, Evan M; Bishop, Derron L; Bruns, Heather A; Haynes, Mark K; Sklar, Larry A; Sammelson, Robert E; McDowell, Susan A.

Curr Pharm Biotechnol ; 15(8): 727-37, 2014.

Artículo en Inglés | MEDLINE | ID: mdl-25213310

15.

Flow cytometry enables a high-throughput homogeneous fluorescent antibody-binding assay for cytotoxic T cell lytic granule exocytosis.

Florian, Amy E; Lepensky, Christopher K; Kwon, Ohyun; Haynes, Mark K; Sklar, Larry A; Zweifach, Adam.

J Biomol Screen ; 18(4): 420-9, 2013 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-23160568

16.

Dissecting novel virulent determinants in the Burkholderia cepacia complex.

Tegos, George P; Haynes, Mark K; Schweizer, Herbert P.

Virulence ; 3(3): 234-7, 2012 May 01.

Artículo en Inglés | MEDLINE | ID: mdl-22546904

17.

A novel flow cytometric HTS assay reveals functional modulators of ATP binding cassette transporter ABCB6.

Polireddy, Kishore; Khan, Mohiuddin Md Taimur; Chavan, Hemantkumar; Young, Susan; Ma, Xiaochao; Waller, Anna; Garcia, Matthew; Perez, Dominique; Chavez, Stephanie; Strouse, Jacob J; Haynes, Mark K; Bologa, Cristian G; Oprea, Tudor I; Tegos, George P; Sklar, Larry A; Krishnamurthy, Partha.

PLoS One ; 7(7): e40005, 2012.

Artículo en Inglés | MEDLINE | ID: mdl-22808084

18.

Phenotypic characterization of inflammatory cells from osteoarthritic synovium and synovial fluids.

Haynes, Mark K; Hume, Eric L; Smith, J Bruce.

Clin Immunol ; 105(3): 315-25, 2002 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-12498813

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