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1.
BMC Pulm Med ; 22(1): 303, 2022 Aug 08.
Artículo en Inglés | MEDLINE | ID: mdl-35941624

RESUMEN

BACKGROUND: Hospital work environment contains various biological and chemical exposures that can affect indoor air quality and have impact on respiratory health of the staff. The objective of this study was to investigate potential effects of occupational exposures on the risk of respiratory symptoms and lung function in hospital work, and to evaluate potential interaction between smoking and occupational exposures. METHODS: We conducted a cross-sectional study of 228 staff members in a hospital and 228 employees of an office building as the reference group in Shiraz, Iran. All subjects completed a standardized ATS respiratory questionnaire and performed a spirometry test. RESULTS: In Poisson regression, the adjusted prevalence ratios (aPR) among the hospital staff were elevated for cough (aPR 1.90, 95% CI 1.15, 3.16), phlegm production (aPR 3.21, 95% CI 1.63, 6.32), productive cough (aPR 2.83, 95% CI 1.48, 5.43), wheezing (aPR 3.18, 95% CI 1.04, 9.66), shortness of breath (aPR 1.40, 95% CI 0.93, 2.12), and chest tightness (aPR 1.73, 95% CI 0.73, 4.12). Particularly laboratory personnel experienced increased risks of most symptoms. In linear regression adjusting for confounding, there were no significant differences in lung function between the hospital and office workers. There was an indication of synergism between hospital exposures and current smoking on FEV1/FVC% (interaction term ß = - 5.37, 95% CI - 10.27, - 0.47). CONCLUSIONS: We present significant relations between hospital work, especially in laboratories, and increased risks of respiratory symptoms. Smoking appears to enhance these effects considerably. Our findings suggest that policymakers should implement evidence-based measures to prevent these occupational exposures.


Asunto(s)
Enfermedades Profesionales , Exposición Profesional , Tos/epidemiología , Estudios Transversales , Hospitales , Humanos , Pulmón , Enfermedades Profesionales/epidemiología , Exposición Profesional/efectos adversos , Personal de Hospital
2.
Occup Environ Med ; 78(9): 661-668, 2021 09.
Artículo en Inglés | MEDLINE | ID: mdl-34282040

RESUMEN

BACKGROUND: We hypothesised that occupational exposures differently affect subtypes of adult-onset asthma. OBJECTIVE: We investigated potential relations between occupation and three subtypes of adult asthma, namely atopic asthma, non-atopic asthma and asthma-COPD overlap syndrome (ACOS). METHODS: This is a population-based case-control study of incident asthma among working-age adults living in Pirkanmaa Hospital District in Southern Finland. The determinant of interest was occupation at the time of diagnosis of asthma or the job that the subject had quit due to respiratory symptoms. Asthma was divided into three mutually exclusive subtypes on the basis of any positive IgE antibody (atopic and non-atopic asthma) and presence of persistent airways obstruction in spirometry (ACOS). We applied unconditional logistic regression analysis to estimate adjusted OR (aOR), taking into account gender, age and smoking. RESULTS: The following occupational groups showed significantly increased risk of atopic asthma: chemical industry workers (aOR 15.76, 95% CI 2.64 to 94.12), bakers and food processors (aOR 4.69, 95% CI 1.18 to 18.69), waiters (aOR 4.67, 95% CI 1.40 to 15.56) and those unemployed (aOR 3.06, 95% CI 1.52 to 6.17). The following occupations showed clearly increased risk of non-atopic asthma: metal workers (aOR 8.37, 95% CI 3.77 to 18.59) and farmers and other agricultural workers (aOR 2.36, 95% CI 1.10 to 5.06). Some occupational groups showed statistically significantly increased OR of ACOS: electrical and electronic production workers (aOR 30.6, 95% CI 6.10 to 153.35), fur and leather workers (aOR 16.41, 95% CI 1.25 to 215.85) and those retired (aOR 5.55, 95% CI 1.63 to 18.97). CONCLUSIONS: Our results show that different occupations are associated with different subtypes of adult-onset asthma.


Asunto(s)
Asma Ocupacional/etiología , Adulto , Factores de Edad , Asma Ocupacional/clasificación , Asma Ocupacional/epidemiología , Síndrome de Superposición de la Enfermedad Pulmonar Obstructiva Crónica-Asmática/epidemiología , Síndrome de Superposición de la Enfermedad Pulmonar Obstructiva Crónica-Asmática/etiología , Estudios de Casos y Controles , Industria Química , Agricultores , Femenino , Finlandia/epidemiología , Industria de Alimentos , Humanos , Masculino , Persona de Mediana Edad , Restaurantes , Factores de Riesgo , Factores Sexuales , Fumar/efectos adversos , Adulto Joven
3.
Occup Environ Med ; 78(4): 262-268, 2021 04.
Artículo en Inglés | MEDLINE | ID: mdl-33455922

RESUMEN

OBJECTIVE: The objective of this study was to investigate the potential effects of occupational exposures among fruit and vegetable market workers on the occurrence of respiratory symptoms and on the level of lung function parameters. METHODS: We conducted a cross-sectional study of 140 men working as fruit and vegetable market workers (response rate 100%) and a reference group of 77 male office workers as the reference group (response rate 55%) from Shiraz, Iran. The outcomes of interest included occurrence of respiratory symptoms assessed by a standard respiratory questionnaire and lung function assessed by spirometry. RESULTS: In Poisson regression analyses, the exposed group showed increased prevalence ratio (PR) of wheezing (adjusted PR 5.32, 95% CI 1.40 to 20.26), after controlling for confounding. Cough (PR 3.30, 95% CI 1.16 to 9.40) and wheezing (PR 9.40, 95% CI 2.28 to 38.64) showed increased PRs among vegetable distributors. Forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity were significantly decreased among exposed workers after controlling for confounders. The absolute value of FEV1 level was reduced significantly among fruit and vegetable carters (-0.99, 95% CI -1.68 to -0.32) and vegetable (-0.51, 95% CI -0.93 to -0.10) and fruit (-0.51, 95% CI -0.86 to -0.15) distributors in comparison with the reference group in the adjusted full model. CONCLUSIONS: This study provides evidence that fruit and vegetable market workers are at an increased risk of respiratory symptoms and reduced lung function. Workplace conditions and safety training clearly need improvement, and there is a likely role for proper use of personal protective equipment.


Asunto(s)
Enfermedades de los Trabajadores Agrícolas/fisiopatología , Exposición Profesional/análisis , Enfermedades Respiratorias/fisiopatología , Estudios Transversales , Frutas , Humanos , Irán , Masculino , Pruebas de Función Respiratoria , Encuestas y Cuestionarios , Verduras
4.
Int Arch Occup Environ Health ; 94(5): 877-887, 2021 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-33459872

RESUMEN

OBJECTIVE: Exposures at hairdressers' work have been reported to lead to an increased risk of several health outcomes. The present study aimed to investigate the relations between occupational exposures and respiratory symptoms and lung function among hairdressers in Iran. METHODS: We conducted a cross-sectional study to compare potential respiratory effects among 140 women working as hairdressers to such effects among 140 women working as office workers (administrative personnel). Both groups worked in Shiraz, Iran. Respiratory symptoms were assessed by a standard respiratory questionnaire. The questionnaire also inquired about substances used and workspace conditions, including ventilation type. Lung function levels were measured by spirometry. RESULTS: Respiratory symptoms, including cough, wheezing, shortness of breath, and chest tightness were significantly more frequent in hairdressers compared to the reference group (p < 0.05). After controlling for potential confounders, hairdressers had a prevalence ratio (PR) of 2.18 (95% CI 1.26-3.77) for cough, 9.59 (95% CI 1.004-91.73) for wheezing, 2.06 (95% CI 1.25-3.39) for shortness of breath, and 3.31 (95% CI 1.84-5.97) for chest tightness compared to the reference group. Lung function parameters (including VC, FVC, and FEV1) were significantly reduced in hairdressers (p < 0.001). Absence of air conditioning predicted greater reduction in lung function (p < 0.05) in the exposed. Decrease in FVC with normal FEV1/FVC in the exposed group suggested existence of restrictive lung function. CONCLUSIONS: This study provides evidence of increased prevalence of respiratory symptoms and restrictive lung function impairment among hairdressers in Iran.


Asunto(s)
Peluquería , Tos/epidemiología , Disnea/epidemiología , Pulmón/fisiopatología , Enfermedades Profesionales/epidemiología , Exposición Profesional , Adulto , Tos/fisiopatología , Estudios Transversales , Disnea/fisiopatología , Femenino , Humanos , Irán/epidemiología , Enfermedades Profesionales/fisiopatología , Prevalencia , Pruebas de Función Respiratoria , Ruidos Respiratorios/fisiopatología
5.
Environ Monit Assess ; 193(8): 521, 2021 Jul 27.
Artículo en Inglés | MEDLINE | ID: mdl-34313867

RESUMEN

Hospitals host vulnerable people with potentially enhanced sensitivity to air pollutants. We measured particulate matter (PM) including PM1, PM2.5, and PM10 with a portable device in a hospital, a nearby reference building, and ambient air in Shiraz, Iran. Indoor/outdoor (I/O) ratio values were calculated to infer on the origin of size-fractioned PM. The mean hospital indoor concentrations of PM2.5 and PM10 (4.7 and 38.7 µg/m3, respectively) but not PM1 were higher than in the reference building and lower than in ambient air. The highest hospital PM10 mean concentrations were found in the radiotherapy ward (77.5 µg/m3) and radiology ward (70.4 µg/m3) while the lowest were found in the bone marrow transplantation (BMT) ward (18.5 µg/m3) and cardiac surgery ward (19.8 µg/m3). The highest PM2.5 concentrations were found in the radiology (8.7 µg/m3) and orthopaedic wards (7.7 µg/m3) while the lowest were found in the BMT ward (2.8 µg/m3) and cardiac surgery ward (2.8 µg/m3). The I/O ratios and the timing of peak concentrations during the day (7 a.m. to 4 p.m.) indicated the main roles of outdoor air and human activity on the indoor levels. These suggest the need for mechanical ventilation with PM control for a better indoor air quality (IAQ) in the hospital.


Asunto(s)
Contaminantes Atmosféricos , Contaminación del Aire Interior , Contaminantes Atmosféricos/análisis , Contaminación del Aire Interior/análisis , Monitoreo del Ambiente , Hospitales Urbanos , Humanos , Irán , Tamaño de la Partícula , Material Particulado/análisis
6.
Environ Monit Assess ; 191(2): 50, 2019 Jan 05.
Artículo en Inglés | MEDLINE | ID: mdl-30612195

RESUMEN

The ambient air of hospitals contains a wide range of biological and chemical pollutants. Exposure to these indoor pollutants can be hazardous to the health of hospital staff. This study aims to evaluate the factors affecting indoor air quality and their effect on the respiratory health of staff members in a busy Iranian hospital. We surveyed 226 hospital staff as a case group and 222 office staff as a control group. All the subjects were asked to fill in a standard respiratory questionnaire. Pulmonary function parameters were simultaneously measured via a spirometry test. Environmental measurements of bio-aerosols, particulate matter, and volatile organic compounds in the hospital and offices were conducted. T-tests, chi-square tests, and multivariable logistic regressions were used to analyze the data. The concentration of selected air pollutants measured in the hospital wards was more than those in the administrative wards. Parameters of pulmonary functions were not statistically significant (p > 0.05) between the two groups. However, respiratory symptoms such as coughs, phlegm, phlegmatic coughs, and wheezing were more prevalent among the hospital staff. Laboratory staff members were more at risk of respiratory symptoms compared to other occupational groups in the hospital. The prevalence of sputum among nurses was significant, and the odds ratio for the presence of phlegm among nurses was 4.61 times greater than office staff (p = 0.002). The accumulation of indoor pollutants in the hospital environment revealed the failure of hospital ventilation systems. Hence, the design and implementation of an improved ventilation system in the studied hospital is recommended.


Asunto(s)
Contaminación del Aire Interior/análisis , Exposición a Riesgos Ambientales/estadística & datos numéricos , Enfermedades Respiratorias/epidemiología , Aerosoles , Aire Acondicionado , Contaminantes Atmosféricos/análisis , Contaminación del Aire Interior/estadística & datos numéricos , Monitoreo del Ambiente , Humanos , Irán/epidemiología , Cuerpo Médico de Hospitales , Material Particulado/análisis , Compuestos Orgánicos Volátiles/análisis
7.
Ecotoxicol Environ Saf ; 149: 19-25, 2018 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-29145162

RESUMEN

Elevated emissions of volatile organic compounds, including benzene, toluene, ethylbenzene, and o, p, and m-xylenes (BTEX), are an occupational health concern at oil transfer stations. This exploratory study investigated personal exposure to BTEX through environmental air and urine samples collected from 50 male workers at a major oil distribution company in Iran. Airborne BTEX exposures were evaluated over 8h periods during work-shift by using personal passive samplers. Urinary BTEX levels were determined using solid-phase microextraction with gas chromatography mass spectrometry for separation and detection. Mean exposure to ambient concentrations of benzene differed by workers' job type: tanker loading workers (5390µg/m3), tank-gauging workers (830µg/m3), drivers (81.9µg/m3), firefighters (71.2µg/m3) and office workers (19.8µg/m3). Exposure across job type was similarly stratified across all personal exposures to BTEX measured in air samples with maximum concentrations found for tanker loading workers. Average exposures concentrations of BTEX measured in urine were 11.83 ppb benzene, 1.87 ppb toluene, 0.43 ppb ethylebenzene, and 3.76 ppb xylene. Personal air exposure to benzene was found to be positively associated with benzene concentrations measured in urine; however, a relationship was not observed to the other BTEX compounds. Urinary exposure profiles are a potentially useful, noninvasive, and rapid method for assessing exposure to benzene in a developing and relatively remote production region.


Asunto(s)
Contaminantes Ocupacionales del Aire/orina , Monitoreo del Ambiente/métodos , Exposición Profesional/análisis , Petróleo/análisis , Compuestos Orgánicos Volátiles/orina , Benceno/análisis , Derivados del Benceno/orina , Cromatografía de Gases y Espectrometría de Masas , Humanos , Irán , Masculino , Tolueno/orina , Xilenos/orina
8.
Ecotoxicol Environ Saf ; 144: 445-449, 2017 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-28666218

RESUMEN

The aim of this study was to evaluate benzene, toluene, ethylbenzene, and xylene (BTEX) exposure among workers at four stations of a major oil distribution company. Personal BTEX exposure samples were collected over working shift (8h) for 50 workers at four stations of a major oil distribution company in Iran. Measured mean values for workers across four sites were benzene (2437, 992, 584, and 2788µg/m3 respectively), toluene (4415, 2830, 1289, and 9407µg/m3), ethylbenzene (781, 522, 187, and 533µg/m3), and xylene (1134, 678, 322, and 525µg/m3). The maximum mean concentration measured across sites for benzene was 2788µg/m3 (Station 4), toluene was 9407µg/m3 (Station 4), ethylbenzene was 781µg/m3 (Station 1) and xylene was 1134µg/m3 (Station 1). The 8h averaged personal exposure benzene concentration exceeded the recommended value of 1600µg/m3 established by the Iranian Committee for Review and Collection of Occupational Exposure Limit and American Conference of Governmental Industrial Hygienists. Mean values for excess lifetime cancer risk for exposure to benzene were then calculated across workers at each site. Estimates of excess risk ranged from 1.74 ± 4.05 (Station 4) to 8.31 ± 25.81 (Station 3). Risk was assessed by calculation of hazard quotients and hazard indexes, which indicated that xylene and particularly benzene were the strongest contributors. Tanker loading was the highest risk occupation at these facilties. Risk management approaches to reducing exposures to BTEX compounds, especially benzene, will be important to the health of workers in Iran.


Asunto(s)
Contaminantes Ocupacionales del Aire/análisis , Monitoreo del Ambiente/métodos , Exposición Profesional/análisis , Petróleo/análisis , Contaminantes Ocupacionales del Aire/química , Humanos , Irán , Neoplasias/inducido químicamente , Exposición Profesional/efectos adversos , Medición de Riesgo , Lugar de Trabajo/normas
9.
Environ Monit Assess ; 189(5): 235, 2017 May.
Artículo en Inglés | MEDLINE | ID: mdl-28451957

RESUMEN

The relationship between indoor and outdoor particulate air pollution was investigated at an urban background site on the Payambar Azam Campus of Mazandaran University of Medical Sciences in Sari, Northern Iran. The concentration of particulate matter sized with a diameter less than 1 µm (PM1.0), 2.5 µm (PM2.5), and 10 µm (PM10) was evaluated at 5 outdoor and 12 indoor locations. Indoor sites included classrooms, corridors, and office sites in four university buildings. Outdoor PM concentrations were characterized at five locations around the university campus. Indoor and outdoor PM measurements (1-min resolution) were conducted in parallel during weekday mornings and afternoons. No difference found between indoor PM10 (50.1 ± 32.1 µg/m3) and outdoor PM10 concentrations (46.5 ± 26.0 µg/m3), indoor PM2.5 (22.6 ± 17.4 µg/m3) and outdoor PM2.5 concentration (22.2 ± 15.4 µg/m3), or indoor PM1.0 (14.5 ± 13.4 µg/m3) and outdoor mean PM1.0 concentrations (14.2 ± 12.3 µg/m3). Despite these similar concentrations, no correlations were found between outdoor and indoor PM levels. The present findings are not only of importance for the potential health effects of particulate air pollution on people who spend their daytime over a period of several hours in closed and confined spaces located at a university campus but also can inform regulatory about the improvement of indoor air quality, especially in developing countries.


Asunto(s)
Contaminantes Atmosféricos/análisis , Contaminación del Aire Interior/análisis , Monitoreo del Ambiente , Material Particulado/análisis , Países en Desarrollo , Humanos , Irán , Tamaño de la Partícula , Ciencia , Universidades
10.
Environ Res ; 144(Pt A): 99-105, 2016 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-26599588

RESUMEN

Chronic obstructive pulmonary disease (COPD) is an important disease worldwide characterized by chronically poor airflow. The economic burden of COPD on any society can be enormous if not managed. We applied the approach proposed by the World Health Organization (WHO) using the AirQ2.2.3 software developed by the WHO European Center for Environment and Health on air pollutants in Tabriz (Iran) (2011-2012 year). A 1h average of concentrations of ozone (O3), daily average concentrations of nitrogen dioxide (NO2) and sulfur dioxide (SO2) were used to assess human exposure and health effect in terms of attributable proportion of the health outcome and annual number of excess cases of Hospital Admissions for COPD (HA COPD). The results of this study showed that 2% (95% CI: 0.8-3.1%) of HA COPD were attributed to O3 concentrations over 10 µg/m(3). In addition, 0.7 % (95% CI: 0.1-1.8%) and 0.5% (95% CI: 0-1%) of HA COPD were attributed to NO2 and SO2 concentrations over 10 µg/m(3) respectively. In this study, we have shown that O3, NO2 and SO2 have a significant impact on COPD hospitalization. Given these results the policy decisions are needed in order to reduce the chronic pulmonary diseases caused by air pollution and furthermore better quantification studies are recommended.


Asunto(s)
Contaminantes Atmosféricos/toxicidad , Modelos Teóricos , Dióxido de Nitrógeno/toxicidad , Ozono/toxicidad , Enfermedad Pulmonar Obstructiva Crónica/etiología , Dióxido de Azufre/toxicidad , Contaminantes Atmosféricos/análisis , Humanos , Irán/epidemiología , Dióxido de Nitrógeno/análisis , Ozono/análisis , Enfermedad Pulmonar Obstructiva Crónica/epidemiología , Dióxido de Azufre/análisis
11.
Environ Health Perspect ; 132(6): 66001, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38935403

RESUMEN

BACKGROUND: Changes in land use and climate change have been reported to reduce biodiversity of both the environment and human microbiota. These reductions in biodiversity may lead to inadequate and unbalanced stimulation of immunoregulatory circuits and, ultimately, to clinical diseases, such as asthma and allergies. OBJECTIVE: We summarized available empirical evidence on the role of inner (gut, skin, and airways) and outer (air, soil, natural waters, plants, and animals) layers of biodiversity in the development of asthma, wheezing, and allergic sensitization. METHODS: We conducted a systematic search in SciVerse Scopus, PubMed MEDLINE, and Web of Science up to 5 March 2024 to identify relevant human studies assessing the relationships between inner and outer layers of biodiversity and the risk of asthma, wheezing, or allergic sensitization. The protocol was registered in PROSPERO (CRD42022381725). RESULTS: A total of 2,419 studies were screened and, after exclusions and a full-text review of 447 studies, 82 studies were included in the comprehensive, final review. Twenty-nine studies reported a protective effect of outer layer biodiversity in the development of asthma, wheezing, or allergic sensitization. There were also 16 studies suggesting an effect of outer layer biodiversity on increasing asthma, wheezing, or allergic sensitization. However, there was no clear evidence on the role of inner layer biodiversity in the development of asthma, wheezing, and allergic sensitization (13 studies reported a protective effect and 15 reported evidence of an increased risk). CONCLUSIONS: Based on the reviewed literature, a future systematic review could focus more specifically on outer layer biodiversity and asthma. It is unlikely that association with inner layer biodiversity would have enough evidence for systematic review. Based on this comprehensive review, there is a need for population-based longitudinal studies to identify critical periods of exposure in the life course into adulthood and to better understand mechanisms linking environmental exposures and changes in microbiome composition, diversity, and/or function to development of asthma and allergic sensitization. https://doi.org/10.1289/EHP13948.


Asunto(s)
Asma , Biodiversidad , Hipersensibilidad , Animales , Humanos , Asma/epidemiología , Exposición a Riesgos Ambientales/estadística & datos numéricos , Hipersensibilidad/epidemiología , Microbiota
12.
Environ Int ; 178: 108048, 2023 08.
Artículo en Inglés | MEDLINE | ID: mdl-37463540

RESUMEN

BACKGROUND: Oxidative stress and tissue damage (OSD) play a pivotal role as an early-stage process in chronic disease pathogenesis. However, there has been little research to better understand the temporal (χρόνος[chronos]) dimensions of OSD process associated with environmental (non-genetic, including behaviors/lifestyle) and/or occupational stressors, like night shift work. OSD processes have recently attracted attention in relation to time-resolved external stressor trajectories in personalized medicine (prevention) initiatives, as they seem to interact with circadian clock systems towards the improved delineation of the early stages of (chronic) disease process. OBJECTIVES: This work critically reviewed human studies targeting the temporal dynamics of OSD and circadian clock system's activity in response to environmental/occupational stressors; the case of night shift work was examined. METHODS: Being a key stressor influencing OSD processes and circadian rhythm, night shift work was evaluated as part of a scoping review of research in OSD, including inflammatory and metabolic processes to determine the extent of OSD research undertaken in human populations, methodologies, tools and biomarkers used and the extent that the temporal dimensions of exposure and biological effect(s) were accounted for. Online databases were searched for papers published from 2000 onwards, resulting in the selection of 53 original publications. RESULTS AND DISCUSSION: The majority of studies (n = 41) took place in occupational settings, while the rest were conducted in the general population or patient groups. Most occupational studies targeted outcomes of oxidative stress/damage (n = 19), followed by the combination of OSD with inflammatory response (n = 10), and studies focused on metabolic outcomes (n = 12). Only a minor fraction of the studies measured biomarkers related to circadian rhythm, such as, melatonin, its metabolite, or cortisol. Night shift work was associated with select biomarkers of OSD and inflammation, albeit with mixed results. Although much progress in delineating the biological mechanisms of OSD process has been made, an equally thorough investigation on the temporal trajectory of OSD processes as triggered by environmental/occupational stressors in human studies has yet to fully evolve.


Asunto(s)
Horario de Trabajo por Turnos , Humanos , Horario de Trabajo por Turnos/efectos adversos , Ritmo Circadiano , Biomarcadores/metabolismo , Estrés Oxidativo , Hidrocortisona
13.
Front Public Health ; 11: 1082874, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-36866091

RESUMEN

Background: The steel factory work environment contains various chemical exposures that can affect indoor air quality and have impact on respiratory health of the workers. Aims: The objective of this study was to assess potential effects of occupational exposures in steel factory workers in Iran on the respiratory symptoms, occurrence and the lung function levels. Method: This was a cross-sectional study of 133 men working in a steel factory forming the exposed group and 133 male office workers forming the reference group from a steel company in Iran. The participants filled in a questionnaire and underwent spirometry. Work history was used both as dichotomous (exposed/reference) and a quantitative measure of exposure, the latter measured as duration of exposure in the specified work (in years) for the exposed group and zero for the reference group. Results: Multiple linear regression and Poisson regression were used to adjust for confounding. In Poisson regression analyses, an increased prevalence ratio (PR) of all respiratory symptoms was observed in the exposed group. Lung function parameters were significantly reduced in the exposed group (p < 0.001). There was a dose-response relation between duration of occupational exposures and reduction in the predicted value of FEV1/FVC level (0.177, 95% CI -0.198 to -0.156) in all models. Conclusion: The results of these analyses showed that occupational exposures in steel factory work increase the prevalence of respiratory symptoms and reduce lung function. Safety training and workplace conditions were found to need improvement. In addition, use of proper personal protective equipment is recommended.


Asunto(s)
Exposición Profesional , Humanos , Masculino , Estudios Transversales , Exposición Profesional/efectos adversos , Irán/epidemiología , Modelos Lineales , Acero
14.
Toxics ; 10(4)2022 Apr 07.
Artículo en Inglés | MEDLINE | ID: mdl-35448442

RESUMEN

Much evidence on the adverse health effects of endocrine-disrupting chemicals (EDCs) has accumulated during recent decades. EDCs are commonly found in various foods and personal care products (PCP). Data documenting a diurnally varying EDC metabolism in humans is scarce. This study examined (i) the time-of-day effect on the diurnal magnitude and variance of urinary biomarkers of exposure to EDCs, and (ii) the association between EDC exposures and oxidative damage in a Norwegian adult subpopulation. This was a cross-sectional panel study using biobanked samples from the EuroMix project. During a typical weekday, participants were asked to collect all day's urine voids and record dietary and PCP habitual uses in a diary. Collected time stamps of urine voids were classified into three distinct periods in the day (morning 6 a.m.−12 p.m., mid-day 12 p.m.−6 p.m., evening 6 p.m.−6 a.m.). Questionnaires regarding demographic characteristics, personal care product usage, and dietary habits were completed. Urinary levels of EDCs (phthalates, parabens, and bisphenols) were measured using mass spectrometry and adjusted for urinary volume using specific gravity. Urinary 4-hydroxynonenal (4HNE), a lipid peroxidation marker, was measured using an immunoassay kit. Linear mixed-effect models identified EDCs under the influence of a diurnal variation effect that was adjusted for dietary habits and PCP use and examined associations between EDC and 4HNE. p-values were FDR-adjusted. Most phthalates appeared to be diurnally varying with higher urinary levels towards the evening (q < 0.001) than those measured during mid-day; this strong diurnal variation effect was not present for parabens and bisphenols. Significant (q < 0.001) positive associations were observed between all phthalates, parabens, and bisphenols (except bisphenol S) and 4HNE. This study's findings highlighted the diurnal variation of excretion for certain EDC, but not for others, in real-life conditions. The degree of EDC chronotoxicity in distinct diurnal windows of the day warrants further investigation with longitudinal human studies.

15.
Front Public Health ; 8: 605128, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-33718314

RESUMEN

Background: The current coronavirus disease 2019 (COVID-19) is spreading globally at an accelerated rate. There is some previous evidence that weather may influence the incidence of COVID-19 infection. We assessed the role of meteorological factors including temperature (T) and relative humidity (RH) considering the concentrations of two air pollutants, inhalable coarse particles (PM10) and nitrogen dioxide (NO2) in the incidence of COVID-19 infections in Finland, located in arctic-subarctic climatic zone. Methods: We retrieved daily counts of COVID-19 in Finland from Jan 1 to May 31, 2020, nationwide and separately for all 21 hospital districts across the country. The meteorological and air quality data were from the monitoring stations nearest to the central district hospital. A quasi-Poisson generalized additional model (GAM) was fitted to estimate the associations between district-specific meteorological factors and the daily counts of COVID-19 during the study period. Sensitivity analyses were conducted to test the robustness of the results. Results: The incidence rate of COVID-19 gradually increased until a peak around April 6 and then decreased. There were no associations between daily temperature and incidence rate of COVID-19. Daily average RH was negatively associated with daily incidence rate of COVID-19 in two hospital districts located inland. No such association was found nationwide. Conclusions: Weather conditions, such as air temperature and relative humidity, were not related to the COVID-19 incidence during the first wave in the arctic and subarctic winter and spring. The inference is based on a relatively small number of cases and a restricted time period.


Asunto(s)
COVID-19 , Clima Frío , Modelos Estadísticos , Tiempo (Meteorología) , Contaminantes Atmosféricos , COVID-19/epidemiología , COVID-19/transmisión , Finlandia/epidemiología , Humanos , Dióxido de Nitrógeno/análisis , Material Particulado/análisis , Temperatura
16.
Environ Sci Pollut Res Int ; 24(7): 6426-6445, 2017 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-28054264

RESUMEN

Even though clean air is considered as a basic requirement for the maintenance of human health, air pollution continues to pose a significant health threat in developed and developing countries alike. Monitoring and modeling of classic and emerging pollutants is vital to our knowledge of health outcomes in exposed subjects and to our ability to predict them. The ability to anticipate and manage changes in atmospheric pollutant concentrations relies on an accurate representation of the chemical state of the atmosphere. The task of providing the best possible analysis of air pollution thus requires efficient computational tools enabling efficient integration of observational data into models. A number of air quality models have been developed and play an important role in air quality management. Even though a large number of air quality models have been discussed or applied, their heterogeneity makes it difficult to select one approach above the others. This paper provides a brief review on air quality models with respect to several aspects such as prediction of health effects.


Asunto(s)
Contaminantes Atmosféricos/toxicidad , Contaminación del Aire/estadística & datos numéricos , Material Particulado/toxicidad , Simulación por Computador , Monitoreo del Ambiente , Humanos , Hidrodinámica , Modelos Estadísticos , Distribución Normal , Salud Pública , Medición de Riesgo
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