RESUMEN
A patient presented with subfoveal choroidal neovascularization associated with angioid streaks and was treated with three intravitreal injections of off-label bevacizumab (1.25 mg) in the right eye. Visual acuity improved from 20/70 to 20/20 and remained at this level for 32 months. In certain patients with choroidal neovascularization from angioid streaks, intravitreal bevacizumab may produce normalization of visual acuity and macular anatomy for an extended period of time.
Asunto(s)
Inhibidores de la Angiogénesis/uso terapéutico , Estrías Angioides/tratamiento farmacológico , Anticuerpos Monoclonales/uso terapéutico , Neovascularización Coroidal/tratamiento farmacológico , Adulto , Estrías Angioides/complicaciones , Estrías Angioides/diagnóstico , Anticuerpos Monoclonales Humanizados , Bevacizumab , Neovascularización Coroidal/diagnóstico , Neovascularización Coroidal/etiología , Angiografía con Fluoresceína , Estudios de Seguimiento , Humanos , Inyecciones , Masculino , Tomografía de Coherencia Óptica , Factor A de Crecimiento Endotelial Vascular/antagonistas & inhibidores , Agudeza Visual , Cuerpo VítreoRESUMEN
A patient with thrombotic thrombocytopenic purpura secondary to adult-onset Still's disease presented with bilateral combined central retinal artery occlusion and central retinal vein occlusion, a rare complication reported only once before. Fundus appearance and fluorescein angiography were similar to the previous case. Optical coherence tomography findings demonstrated aspects consistent with both central retinal artery occlusion and central retinal vein occlusion. Treatment of one eye with intravitreal triamcinolone acetonide (4 mg) was not effective in improving visual acuity. Treatment of both eyes with intravitreal bevacizumab (1.25 mg) and panretinal photocoagulation was effective in eliminating iris neovascularization, although the patient lost all visual function.
Asunto(s)
Anticuerpos Monoclonales/uso terapéutico , Glucocorticoides/uso terapéutico , Púrpura Trombocitopénica Trombótica/complicaciones , Oclusión de la Arteria Retiniana , Oclusión de la Vena Retiniana , Tomografía de Coherencia Óptica , Triamcinolona Acetonida/uso terapéutico , Anticuerpos Monoclonales Humanizados , Bevacizumab , Terapia Combinada , Quimioterapia Combinada , Femenino , Angiografía con Fluoresceína , Humanos , Coagulación con Láser , Persona de Mediana Edad , Oclusión de la Arteria Retiniana/diagnóstico , Oclusión de la Arteria Retiniana/tratamiento farmacológico , Oclusión de la Arteria Retiniana/etiología , Oclusión de la Vena Retiniana/diagnóstico , Oclusión de la Vena Retiniana/tratamiento farmacológico , Oclusión de la Vena Retiniana/etiología , Factor A de Crecimiento Endotelial Vascular/antagonistas & inhibidores , Agudeza VisualRESUMEN
A patient with solitary congenital hypertrophy of the retinal pigment epithelium demonstrated a striking choroidal cavitation on spectral-domain optical coherence tomography (OCT). Although photoreceptor atrophy overlying congenital hypertrophy of the retinal pigment epithelium has been described on time-domain OCT, this patient manifested a previously unrecognized tomographic feature.
Asunto(s)
Enfermedades de la Coroides/diagnóstico , Enfermedades de la Retina/diagnóstico , Epitelio Pigmentado de la Retina/patología , Femenino , Humanos , Hipertrofia/congénito , Persona de Mediana Edad , Enfermedades de la Retina/congénito , Tomografía de Coherencia Óptica/métodosRESUMEN
Best's disease is an autosomal dominant disorder characterized by bilateral vitelliform macular lesions that progress through several stages throughout life. The authors describe a 20-month-old child with hereditary Best's disease inherited from his father. To their knowledge, this is the youngest child to be diagnosed as having Best's disease using photographic documentation.