Impeller geometry definition of the transventricular assist device.

According to the World Health Organization, cardiovascular disease is the number one cause of death worldwide, except Africa, where Acquired Immune Deficiency Syndrome is the leading cause of death. In this scenario, the ventricular assist device (VAD) remains the unique alternative to extend patient life until heart transplantation. At Dante Pazzanese Institute of Cardiology, the research and development of an axial flow VAD to be fully implantable within the heart was started. This pump, denominated Transventricular Assist Device (TVAD), can be surgically implanted through a small left intercostal incision in a minimally invasive manner. The goal of this work is to analyze the impeller geometries of the TVAD, to avoid high shear stresses in the fluid and aim for the best conditions to support the circulatory system using computational fluid dynamics and in vitro tests. Different rotor geometries were selected according to the literature; based on the results, the best rotor was elected. This rotor contains a pair of spiral blades of constant and relatively high pitch, which pumps liquid at a flow rate of 3 L/min at 73 mm Hg. It is also expected that this rotor presents a moderate hemolysis since the shear rate is acceptable.

Single axis controlled hybrid magnetic bearing for left ventricular assist device: hybrid core and closed magnetic circuit.

In previous studies, we presented main strategies for suspending the rotor of a mixed-flow type (centrifugal and axial) ventricular assist device (VAD), originally presented by the Institute Dante Pazzanese of Cardiology (IDPC), Brazil. Magnetic suspension is achieved by the use of a magnetic bearing architecture in which the active control is executed in only one degree of freedom, in the axial direction of the rotor. Remaining degrees of freedom, excepting the rotation, are restricted only by the attraction force between pairs of permanent magnets. This study is part of a joint project in development by IDPC and Escola Politecnica of São Paulo University, Brazil. This article shows advances in that project, presenting two promising solutions for magnetic bearings. One solution uses hybrid cores as electromagnetic actuators, that is, cores that combine iron and permanent magnets. The other solution uses actuators, also of hybrid type, but with the magnetic circuit closed by an iron core. After preliminary analysis, a pump prototype has been developed for each solution and has been tested. For each prototype, a brushless DC motor has been developed as the rotor driver. Each solution was evaluated by in vitro experiments and guidelines are extracted for future improvements. Tests have shown good results and demonstrated that one solution is not isolated from the other. One complements the other for the development of a single-axis-controlled, hybrid-type magnetic bearing for a mixed-flow type VAD.

Magnetic suspension of the rotor of a ventricular assist device of mixed flow type.

This work presents results of preliminary studies concerning application of magnetic bearing in a ventricular assist device (VAD) being developed by Dante Pazzanese Institute of Cardiology-IDPC (São Paulo, Brazil). The VAD-IDPC has a novel architecture that distinguishes from other known VADs. In this, the rotor has a conical geometry with spiral impellers, showing characteristics that are intermediate between a centrifugal VAD and an axial VAD. The effectiveness of this new type of blood pumping principle was showed by tests and by using it in heart surgery for external blood circulation. However, the developed VAD uses a combination of ball bearings and mechanical seals, limiting the life for some 10 h, making impossible its long-term use or its use as an implantable VAD. As a part of development of an implantable VAD, this work aims at the replacement of ball bearings by a magnetic bearing. The most important magnetic bearing principles are studied and the magnetic bearing developed by Escola Politécnica of São Paulo University (EPUSP-MB) is elected because of its very simple architecture. Besides presenting the principle of the EPUSP-MB, this work presents one possible alternative for applying the EPUSP-MB in the IDPC-VAD.

Development of an experimental optoelectronic device to study the amplitude of mandibular movements.

This study aimed to present a wireless mandibular motion tracking device and optoelectronic data acquisition system developed to analyze the real-time spatial motion of the entire mandible during mouth opening and closing with no restriction of any movement. The procedures were divided into three phases: confection of a kinematic arch, dynamic digital video image acquisition, and image processing and analysis by using graphic computation. Four sequences of jaw opening/closing movements were recorded in lateral view: two from the maximum intercuspation (MIC) and the other two from a forced mandibular retruded position. Jaw motion was recorded by a digital video camera and processed as spatial coordinates corresponding to the position variation of the markers in the kinematic arch. The results showed that the method was capable of recording and processing the dynamics of the mandibular movements during jaw opening/closing using pixel-magnitude points. The mandible showed points with less displacement located near the temporomandibular joint during the opening/closing movements from the mandibular retruded position. When the jaw movements were recorded from MIC, these points were located near the mandibular foramen.

Development of an experimental optoelectronic device to study the amplitude of mandibular movements

This study aimed to present a wireless mandibular motion tracking device and optoelectronic data acquisition system developed to analyze the real-time spatial motion of the entire mandible during mouth opening and closing with no restriction of any movement. The procedures were divided into three phases: confection of a kinematic arch, dynamic digital video image acquisition, and image processing and analysis by using graphic computation. Four sequences of jaw opening/closing movements were recorded in lateral view: two from the maximum intercuspation (MIC) and the other two from a forced mandibular retruded position. Jaw motion was recorded by a digital video camera and processed as spatial coordinates corresponding to the position variation of the markers in the kinematic arch. The results showed that the method was capable of recording and processing the dynamics of the mandibular movements during jaw opening/closing using pixel-magnitude points. The mandible showed points with less displacement located near the temporomandibular joint during the opening/closing movements from the mandibular retruded position. When the jaw movements were recorded from MIC, these points were located near the mandibular foramen.